Advanced Search (OLGA)

Gene: Kcnf1 (potassium voltage-gated channel modifier subfamily F member 1) Rattus norvegicus

Analyze

Symbol:

Kcnf1

Name:

potassium voltage-gated channel modifier subfamily F member 1

RGD ID:

631414

Description:

Enables potassium channel regulator activity. Involved in potassium ion transport and regulation of potassium ion transport. Part of voltage-gated potassium channel complex. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1); INTERACTS WITH bisphenol A; bromobenzene; copper atom.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Kh1; Kv5.1; potassium channel, voltage-gated modifier subfamily F, member 1; potassium voltage-gated channel subfamily F member 1; potassium voltage-gated channel, subfamily F, member 1; voltage-gated potassium channel regulatory subunit KCNF1; voltage-gated potassium channel subunit Kv5.1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Kcnf1 (potassium voltage-gated channel, subfamily F, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kcnf1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kcnf1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Kcnf1 (potassium voltage-gated channel modifier subfamily F member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kcnf1 (potassium voltage-gated channel, subfamily F, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kcnf1b (potassium voltage-gated channel, subfamily F, member 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kcnf1a (potassium voltage-gated channel, subfamily F, member 1a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C32C4.1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C32C4.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	exp-2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	exp-2	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Shab	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	kvs-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	kvs-1	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	kvs-3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	kvs-3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	kvs-4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	kvs-4	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	kcnf1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	45,691,028 - 45,693,706 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	45,688,623 - 45,695,536 (-)	Ensembl				GRCr8
mRatBN7.2	6	39,962,301 - 39,964,979 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	39,962,307 - 39,964,979 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	40,289,685 - 40,292,363 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	40,604,381 - 40,607,059 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	40,037,630 - 40,040,308 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	42,471,060 - 42,473,738 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	42,471,066 - 42,473,738 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	52,191,159 - 52,193,837 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	40,910,390 - 40,913,068 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	39,263,866 - 39,266,544 (-)	NCBI		Celera
RGSC_v3.1	6	40,913,548 - 40,916,021 (-)	NCBI
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

4,4'-diaminodiphenylmethane (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

Butylparaben (ISO)

chlorpyrifos (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

dexamethasone (ISO)

diethylstilbestrol (ISO)

ethanol (ISO)

ethylparaben (ISO)

folic acid (ISO)

genistein (ISO)

heptanal (ISO)

hexanal (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methylparaben (ISO)

niclosamide (ISO)

nonanal (ISO)

octanal (ISO)

ozone (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

propanal (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

non-motile cilium assembly (IEA,ISO)

potassium ion transmembrane transport (IBA,IEA)

potassium ion transport (IDA,IEA)

protein homooligomerization (IEA)

regulation of potassium ion transport (IDA)

transmembrane transport (IEA)

Cellular Component

ciliary base (IEA,ISO)

membrane (IBA,IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IEA)

voltage-gated potassium channel complex (IBA,IDA,IEA)

Molecular Function

monoatomic ion channel activity (IEA)

potassium channel activity (IEA)

potassium channel regulator activity (IBA,IDA)

protein binding (ISO)

voltage-gated potassium channel activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies.	Drewe JA, etal., J Neurosci 1992 Feb;12(2):538-48.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits.	Kramer JW, etal., Am J Physiol. 1998 Jun;274(6):C1501-10. doi: 10.1152/ajpcell.1998.274.6.C1501.
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	New modulatory alpha subunits for mammalian Shab K+ channels.	Salinas M, etal., J Biol Chem 1997 Sep 26;272(39):24371-9.

Genomics

Comparative Map Data

Kcnf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	45,691,028 - 45,693,706 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	45,688,623 - 45,695,536 (-)	Ensembl				GRCr8
mRatBN7.2	6	39,962,301 - 39,964,979 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	39,962,307 - 39,964,979 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	40,289,685 - 40,292,363 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	40,604,381 - 40,607,059 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	40,037,630 - 40,040,308 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	42,471,060 - 42,473,738 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	42,471,066 - 42,473,738 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	52,191,159 - 52,193,837 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	40,910,390 - 40,913,068 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	39,263,866 - 39,266,544 (-)	NCBI		Celera
RGSC_v3.1	6	40,913,548 - 40,916,021 (-)	NCBI
Cytogenetic Map	6	q16	NCBI

KCNF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	10,911,934 - 10,914,225 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	10,911,096 - 10,914,225 (+)	Ensembl			hg38	GRCh38
GRCh37	2	11,052,060 - 11,054,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	10,969,514 - 10,971,802 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	11,002,660 - 11,004,948	NCBI
Celera	2	10,967,196 - 10,969,484 (+)	NCBI		Celera
Cytogenetic Map	2	p25.1	NCBI
HuRef	2	10,903,225 - 10,905,447 (+)	NCBI		HuRef
CHM1_1	2	10,982,228 - 10,984,516 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	10,941,696 - 10,943,987 (+)	NCBI		T2T-CHM13v2.0

Kcnf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	17,222,101 - 17,226,551 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	17,222,101 - 17,226,889 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	17,172,100 - 17,176,888 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	17,172,100 - 17,176,888 (-)	Ensembl			mm10	GRCm38
MGSCv37	12	17,178,906 - 17,183,694 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	17,197,580 - 17,202,005 (-)	NCBI		MGSCv36	mm8
Celera	12	17,493,636 - 17,498,423 (-)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	8.04	NCBI

KCNF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	115,606,651 - 115,608,942 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	115,610,622 - 115,612,913 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	10,906,060 - 10,908,818 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	11,058,115 - 11,061,078 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	11,055,090 - 11,060,758 (+)	Ensembl			panPan2	panpan1.1

KCNF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	7,752,588 - 7,754,482 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	7,752,651 - 7,754,153 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	7,678,062 - 7,679,917 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	7,854,763 - 7,856,618 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	7,817,828 - 7,856,618 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	7,740,520 - 7,742,374 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	7,743,266 - 7,745,121 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	7,757,031 - 7,758,886 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	52,208,228 - 52,213,417 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936532	6,963,912 - 6,968,463 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	125,664,365 - 125,666,656 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	125,664,027 - 125,666,054 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	134,494,122 - 134,495,965 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	96,695,647 - 96,698,931 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	96,695,961 - 96,697,445 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	15,586,797 - 15,590,329 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624865	4,648,711 - 4,653,179 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnf1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	36,976,516 - 36,981,164 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcnf1
9 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	47
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000033327
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	44510974	89510974	Rat
8693632	Alc27	Alcohol consumption QTL 27	2.2	0.791	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	40052411	56848866	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	40957564	85957564	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	45153786	90153786	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	33	133	51	49	22	17	22	5	171	75	5	116	58	92	27	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001169104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M81783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033327 ⟹ ENSRNOP00000033496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	45,688,623 - 45,695,536 (-)	Ensembl
mRatBN7.2 Ensembl	6	39,962,307 - 39,964,979 (-)	Ensembl
Rnor_6.0 Ensembl	6	42,471,066 - 42,473,738 (-)	Ensembl

RefSeq Acc Id:

NM_001169104 ⟹ NP_001162575

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	45,691,028 - 45,693,706 (-)	NCBI
mRatBN7.2	6	39,962,301 - 39,964,979 (-)	NCBI
Rnor_6.0	6	42,471,060 - 42,473,738 (-)	NCBI
Rnor_5.0	6	52,191,159 - 52,193,837 (-)	NCBI
RGSC_v3.4	6	40,910,390 - 40,913,068 (-)	RGD
Celera	6	39,263,866 - 39,266,544 (-)	RGD

Sequence:

show sequence

GGCAGCAGCTGTGCAGGTCTGCCCAAGGGTTAACTCATTCCTGGGCAGCTGCAGCGCGTGCGGT
GCGAAATCTCACCAGAAGAGGGTACAGTAGCAAAGCGTTTGACGTCAGGCTGGAATTCCTATTG
TGTTTCGGACCCGCTCCGGCAAAGCCAGTCCAAGTTAGCTCTCGGTACAGCCCAGATCGCGCAG
CTCTGGGGCTGACCCGTCACTGCCACCGCTCATCCAGGGAAGGAGGACGCTGCCTGCGAGAAAA
ACCTCGTCCTGTCCCGGACCGACCTGAAGGAGCCCGTGGGTGAGTGTCCCCAACACCGAAGCCG
AAGCCACTGGCCGCAGAGTCCCCCGCCAGCACTCCTGGATGCCCGCGTGCAGCCCCGCCACTGG
GTGCATGGCTCCCTTACGGTGCGCCCCAGCCTGCCACCGCCGGTTCTGAGTGCCTTTCCCGGCA
GGTGGTTGTTGTCCCCGAGGGCCTCGCATTGGCAGCGGCTGCGCAGGGAGCATGGAACCGGGGC
TTGCAAGCGAACCCACCAGGAGCATGGACGCATCTGCGGAGCAAAGCCTCCCAGAGCCAGGCAG
CCAGGACTCTGTGGCAGGCGATGACATTGAGATCGTGGTAAATGTGGGGGGCGTGCGGCAGGTG
CTCTATGGAGACCTGCTCAGCCAGTATCCCGAGACGCGGCTGGCAGAGCTCATCAACTGCTTGG
CGGGGGGCTACGACACCATCTTCTCTCTGTGCGATGATTACGACCCAGGCAAGCGCGAATTCTA
CTTTGATCGGGACCCGGACGCGTTCAAGTGTGTCATTGAAGTATACTATTTCGGTGAGGTCCAC
ATGAAGAAAGGCATCTGCCCTATCTGCTTCAAGAACGAGATGGACTTCTGGAAGGTGGACCTCA
AATTCCTGGATGACTGTTGCAAGAGCCATCTGAGTGAGAAGCGCGAGGAACTGGAGGAAATCGC
GCGCAGGGTGCAGCTCATCTTGGACGACCTGGGTGTAGACGCTGCCGAGGGCCGCTGGCGCCGC
TGCCAGAAGTGTGTCTGGAAGTTCCTGGAGAAGCCGGAGTCTTCGTGCCCAGCGCGGGTGGTGG
CAGTTCTATCCTTTTTGCTCATCCTTGTCTCCTCCGTGGTCATGTGCATGGGCACCATACCTGA
GCTGCAAGTGGTGGACTCTGAAGGCAACCGCGTAGAGCACCCGACGCTGGAGAACGTGGAGACT
GCTTGCATCGGCTGGTTCACTCTGGAGTACCTGCTGCGCCTCTTCTCATCGCCCAACAAGCTGC
ACTTTGCCCTGTCCTTCATGAACATTGTGGATGTGCTGGCCATTCTCCCCTTCTATGTGAGCCT
CACACTCACGCATCTGGGTGCAAGAATGATGGAACTGACCAACGTGCAGCAGGCTGTGCAGGCC
CTAAGGATCATGCGCATCGCACGCATCTTCAAGCTAGCCCGCCACTCCTCAGGCCTGCAGACCC
TCACCTACGCTCTCAAGCGCAGTTTCAAGGAACTGGGGCTATTGCTTATGTACCTGGCCGTGGG
CATCTTCGTCTTCTCCGCACTAGGCTACACCATGGAGCAGAGCCACCCTGAAACTCTGTTCAAG
AGCATCCCCCAGTCCTTCTGGTGGGCTATCATCACCATGACCACAGTGGGCTATGGCGACATCT
ACCCCAAGACCACTCTGGGCAAGCTCAACGCGGCCATCAGCTTCTTGTGTGGGGTAATTGCCAT
TGCCTTGCCCATTCACCCCATCATTAACAACTTTGTCAGGTACTACAACAAACAACGTGTCCTG
GAGACGGCAGCCAAGCATGAGCTGGAGCTGATGGAGCTCAACTCCAGCAGCGCAGAAAGCAAGC
CCGGGGGCTCTCGCAGCGACCTGGACACCCTGCCCCCAGAGCCTGCTGCCAGGGAGGGGCCAAG
TTGGGGTAGCCGGCTGAAGCTCTCACACAGCGATACCTTCATTCCCCTGCTGACAGAGGAGAAG
CATCATAGGACCCGGCTACAGAGCTGCAAGTGATGGCTGGGCTCCCTGGCAGGGACAAGACTGG
GCTGTGGATGGACAAACCATTGGGTAGACATGTTAGTAGGCATGTCTATGGTTTCAGAGGAGTC
GCTTGTGTCTTCCAGCCCTCCCCTGAGCAGACCTTTGCCAAGACTGGGTAAGACTCCTTGGGTG
CCAGCTGTCCAGGTGCAGGGGGTCTGGGGAGTGCAGGAGTCACAGGGCCACTTGGGGCTATCAG
AATGGCCTGGCATGAGCCCTTATCTGCTTCTGTGTCCCCTTCAATAAAACCTCCTATCCAGCAT
ACCCTCCATGCTGTGGGTTGTCTCAGGCTGGTTACCCCAAGAGTGACTACTGCACACCCTAGTG
CCAGGCCAGGAAGGAGGTGTGCAGCTCCAGAGGGAGTGGGGGTAGCTATTTTTAGTTGAGAGCT
AATTAAAGAAGGGCTGCAAGGCAGGGTTCAGCTCCAAGGCGCCTTGCCACATTCCAGGAGACAC
TCTCCTGCTTCCTTCTGTGGGAAAGCTGCCTCACTGAGGCTCGGGAAGGAAGGAGAGGTGACAG
AGCCCACTGGTGGGGCACCTAACTCATAGTTGCCACCTGTGGAGTAGGCCTTTTCACACACCCC
TTTTTCCTTTCCAGCTACCCTGGTAGACAGGCATCCCCATTTTACAGGTAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001162575	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4ADX7	(Get FASTA)	NCBI Sequence Viewer
	EDM03146	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033496

RefSeq Acc Id:

NP_001162575 ⟸ NM_001169104

- UniProtKB:

D4ADX7 (UniProtKB/TrEMBL), A6HAU1 (UniProtKB/TrEMBL), A0AAZ6G3W5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPGLASEPTRSMDASAEQSLPEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAEL
INCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFW
KVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCP
ARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRLFSS
PNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSS
GLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVG
YGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSS
AESKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK

hide sequence

Ensembl Acc Id:

ENSRNOP00000033496 ⟸ ENSRNOT00000033327

Protein Domains

Ion transport Potassium channel tetramerisation-type BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ADX7-F1-model_v2	AlphaFold	D4ADX7	1-505	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631414	AgrOrtholog
BioCyc Gene	G2FUF-38059	BioCyc
Ensembl Genes	ENSRNOG00000024310	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000033327	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels. Chain C	UniProtKB/Swiss-Prot
InterPro	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv9	UniProtKB/Swiss-Prot
	KCNF1-like_BTB_POZ	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
	T1-type_BTB	UniProtKB/Swiss-Prot
	VG_K_chnl	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
NCBI Gene	298908	ENTREZGENE
PANTHER	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY F MEMBER 1	UniProtKB/Swiss-Prot
	VOLTAGE-GATED POTASSIUM CHANNEL	UniProtKB/Swiss-Prot
Pfam	BTB_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
PhenoGen	Kcnf1	PhenoGen
PRINTS	KCHANNEL	UniProtKB/Swiss-Prot
	KV9CHANNEL	UniProtKB/Swiss-Prot
	KVCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000024310	RatGTEx
Superfamily-SCOP	POZ domain	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A0AAZ6G3W5	ENTREZGENE, UniProtKB/TrEMBL
	A6HAU1	ENTREZGENE, UniProtKB/TrEMBL
	D4ADX7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcnf1	potassium voltage-gated channel modifier subfamily F member 1	Kcnf1	potassium channel, voltage-gated modifier subfamily F, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcnf1	potassium channel, voltage-gated modifier subfamily F, member 1	Kcnf1	potassium voltage-gated channel, subfamily F, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Kcnf1	potassium voltage-gated channel, subfamily F, member 1			Symbol and Name status set to approved	625702	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	predominantly expressed in the brain	633164

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar