Kcnf1 (potassium voltage-gated channel, subfamily F, member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kcnf1 (potassium voltage-gated channel, subfamily F, member 1) Mus musculus
Analyze
Symbol: Kcnf1
Name: potassium voltage-gated channel, subfamily F, member 1
RGD ID: 1621180
MGI Page MGI
Description: Predicted to enable voltage-gated potassium channel activity. Involved in non-motile cilium assembly. Is active in ciliary base. Is expressed in several structures, including adipose tissue; bone; heart; lung; and spleen. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm1182; Kv5.1; MGC62472; potassium voltage-gated channel subfamily F member 1; voltage-gated potassium channel subunit Kv5.1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,222,101 - 17,226,551 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,222,101 - 17,226,889 (-)EnsemblGRCm39 Ensembl
GRCm381217,172,100 - 17,176,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,172,100 - 17,176,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv371217,178,906 - 17,183,694 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,197,580 - 17,202,005 (-)NCBIMGSCv36mm8
Celera1217,493,636 - 17,498,423 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16985003   PMID:21873635   PMID:24090483   PMID:25798587  
PMID:26546361   PMID:31202927   PMID:36417873  


Genomics

Comparative Map Data
Kcnf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391217,222,101 - 17,226,551 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1217,222,101 - 17,226,889 (-)EnsemblGRCm39 Ensembl
GRCm381217,172,100 - 17,176,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1217,172,100 - 17,176,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv371217,178,906 - 17,183,694 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361217,197,580 - 17,202,005 (-)NCBIMGSCv36mm8
Celera1217,493,636 - 17,498,423 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
KCNF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,911,934 - 10,914,225 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,911,934 - 10,914,225 (+)EnsemblGRCh38hg38GRCh38
GRCh37211,052,060 - 11,054,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,969,514 - 10,971,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 34211,002,660 - 11,004,948NCBI
Celera210,967,196 - 10,969,484 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,903,225 - 10,905,447 (+)NCBIHuRef
CHM1_1210,982,228 - 10,984,516 (+)NCBICHM1_1
T2T-CHM13v2.0210,941,696 - 10,943,987 (+)NCBIT2T-CHM13v2.0
Kcnf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,691,028 - 45,693,706 (-)NCBIGRCr8
mRatBN7.2639,962,301 - 39,964,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,962,307 - 39,964,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx640,289,685 - 40,292,363 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,604,381 - 40,607,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,037,630 - 40,040,308 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,471,060 - 42,473,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,471,066 - 42,473,738 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0652,191,159 - 52,193,837 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,910,390 - 40,913,068 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,913,548 - 40,916,021 (-)NCBI
Celera639,263,866 - 39,266,544 (-)NCBICelera
Cytogenetic Map6q16NCBI
KCNF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,606,651 - 115,608,942 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,610,622 - 115,612,913 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,906,060 - 10,908,818 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,058,115 - 11,061,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,055,090 - 11,060,758 (+)Ensemblpanpan1.1panPan2
KCNF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,752,588 - 7,754,482 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,752,651 - 7,754,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha177,678,062 - 7,679,917 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0177,854,763 - 7,856,618 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,817,828 - 7,856,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,740,520 - 7,742,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,743,266 - 7,745,121 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,757,031 - 7,758,886 (+)NCBIUU_Cfam_GSD_1.0
Kcnf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,208,228 - 52,213,417 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365326,963,912 - 6,968,463 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,664,365 - 125,666,656 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,664,027 - 125,666,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,494,122 - 134,495,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,695,647 - 96,698,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,695,961 - 96,697,445 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604515,586,797 - 15,590,329 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248654,648,711 - 4,653,179 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnf1
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1360
Count of miRNA genes:595
Interacting mature miRNAs:767
Transcripts:ENSMUST00000170580
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
12792982Fbmd4_mfemoral bone mineral density 4, females only (mouse)121004319424365136Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse

Markers in Region
BB251767  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381217,177,785 - 17,177,902UniSTSGRCm38
MGSCv371217,184,591 - 17,184,708UniSTSGRCm37
Celera1217,499,318 - 17,499,435UniSTS
Cytogenetic Map12A1.1UniSTS
Whitehead/MRC_RH12181.91UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000170580   ⟹   ENSMUSP00000131480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1217,222,101 - 17,226,889 (-)Ensembl
GRCm38.p6 Ensembl1217,172,100 - 17,176,888 (-)Ensembl
RefSeq Acc Id: NM_201531   ⟹   NP_963289
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391217,222,101 - 17,226,551 (-)NCBI
GRCm381217,172,100 - 17,176,888 (-)ENTREZGENE
MGSCv371217,178,906 - 17,183,694 (-)RGD
Celera1217,493,636 - 17,498,423 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_963289 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH53089 (Get FASTA)   NCBI Sequence Viewer  
  BAE23327 (Get FASTA)   NCBI Sequence Viewer  
  EDK98486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000131480
  ENSMUSP00000131480.2
  ENSMUSP00000131480.3
GenBank Protein Q7TSH7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_963289   ⟸   NM_201531
- UniProtKB: Q7TSH7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000131480   ⟸   ENSMUST00000170580
Protein Domains
Ion transport   Potassium channel tetramerisation-type BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSH7-F1-model_v2 AlphaFold Q7TSH7 1-493 view protein structure

Promoters
RGD ID:8677962
Promoter ID:EPDNEW_M17012
Type:multiple initiation site
Name:Kcnf1_1
Description:Mus musculus potassium voltage-gated channel, subfamily F, member1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17013  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381217,176,550 - 17,176,610EPDNEW
RGD ID:8677964
Promoter ID:EPDNEW_M17013
Type:single initiation site
Name:Kcnf1_2
Description:Mus musculus potassium voltage-gated channel, subfamily F, member1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17012  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381217,176,957 - 17,177,017EPDNEW
RGD ID:6823085
Promoter ID:MM_KWN:11226
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_201531
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361217,181,886 - 17,182,386 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687399 AgrOrtholog
Ensembl Genes ENSMUSG00000051726 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000170580 ENTREZGENE
  ENSMUST00000170580.3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNF1-like_BTB_POZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:382571 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2687399 ENTREZGENE
NCBI Gene 382571 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY F MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnf1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV9CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PYC0_MOUSE UniProtKB/TrEMBL
  KCNF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE