Rdh7 (retinol dehydrogenase 7) - Rat Genome Database

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Gene: Rdh7 (retinol dehydrogenase 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rdh7
Name: retinol dehydrogenase 7
RGD ID: 631370
Description: Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RDH16 (retinol dehydrogenase 16); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; INTERACTS WITH N-nitrosodimethylamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical gene supported by NM_133543; LOC360420; MGC108523; MGC112590; Rdh3; retinol dehydrogenase 3; retinol dehydrogenase type III; RGD1307178; RODH I; RODH III; RoDH(III)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,561,259 - 65,574,618 (-)NCBIGRCr8
mRatBN7.2763,676,016 - 63,689,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,675,579 - 63,689,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,565,225 - 65,578,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,767,521 - 67,780,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,561,785 - 67,566,643 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0771,125,358 - 71,164,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,297,358 - 71,533,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,818,370 - 67,831,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera760,810,166 - 60,822,127 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III. Chai X, etal., Gene 1996 Mar 9;169(2):219-22.
2. Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase. Chai X, etal., J Biol Chem 1995 Feb 24;270(8):3900-4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Variants

.
Variants in Rdh7
71 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
D7Rat45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,902,608 - 63,902,784 (+)MAPPERmRatBN7.2
Rnor_6.0771,351,952 - 71,352,127NCBIRnor6.0
Rnor_5.0771,522,185 - 71,522,360UniSTSRnor5.0
RGSC_v3.4768,056,925 - 68,057,251RGDRGSC3.4
RGSC_v3.4768,056,997 - 68,057,172UniSTSRGSC3.4
RGSC_v3.1768,077,655 - 68,077,981RGD
Celera761,034,295 - 61,034,470UniSTS
FHH x ACI Map733.46RGD
FHH x ACI Map733.46UniSTS
Cytogenetic Map7q22UniSTS
D7Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,773,357 - 63,773,500 (+)MAPPERmRatBN7.2
mRatBN7.2763,768,981 - 63,769,114 (+)MAPPERmRatBN7.2
Rnor_6.0771,218,350 - 71,218,482NCBIRnor6.0
Rnor_6.0771,222,726 - 71,222,868NCBIRnor6.0
Rnor_5.0771,390,350 - 71,390,482UniSTSRnor5.0
Rnor_5.0771,394,726 - 71,394,868UniSTSRnor5.0
RGSC_v3.4767,916,939 - 67,917,081UniSTSRGSC3.4
RGSC_v3.4767,916,938 - 67,917,081RGDRGSC3.4
RGSC_v3.4767,912,562 - 67,912,695RGDRGSC3.4
RGSC_v3.4767,912,563 - 67,912,695UniSTSRGSC3.4
RGSC_v3.1767,933,292 - 67,933,425RGD
Celera760,906,045 - 60,906,187UniSTS
Celera760,901,669 - 60,901,801UniSTS
FHH x ACI Map733.38RGD
FHH x ACI Map733.38UniSTS
Cytogenetic Map7q22UniSTS
RH144391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,814,272 - 63,814,395 (+)MAPPERmRatBN7.2
Rnor_6.0771,263,990 - 71,264,112NCBIRnor6.0
Rnor_5.0771,435,990 - 71,436,112UniSTSRnor5.0
RGSC_v3.4767,957,852 - 67,957,974UniSTSRGSC3.4
Celera760,946,935 - 60,947,057UniSTS
Cytogenetic Map7q22UniSTS
RH136995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,908,905 - 63,909,086 (+)MAPPERmRatBN7.2
Rnor_6.0771,358,268 - 71,358,448NCBIRnor6.0
Rnor_5.0771,528,340 - 71,528,520UniSTSRnor5.0
RGSC_v3.4768,065,868 - 68,066,048UniSTSRGSC3.4
Celera761,040,584 - 61,040,764UniSTS
Cytogenetic Map7q22UniSTS
RH130952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,906,389 - 63,906,575 (+)MAPPERmRatBN7.2
Rnor_6.0771,355,752 - 71,355,937NCBIRnor6.0
Rnor_5.0771,525,824 - 71,526,009UniSTSRnor5.0
RGSC_v3.4768,061,791 - 68,061,976UniSTSRGSC3.4
Celera761,038,076 - 61,038,261UniSTS
Cytogenetic Map7q22UniSTS
RH134392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,676,163 - 63,676,343 (+)MAPPERmRatBN7.2
Rnor_6.0771,125,506 - 71,125,685NCBIRnor6.0
Rnor_5.0771,297,506 - 71,297,685UniSTSRnor5.0
RGSC_v3.4767,818,518 - 67,818,697UniSTSRGSC3.4
Celera760,810,314 - 60,810,493UniSTS
Cytogenetic Map7q22UniSTS
AU044268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,906,539 - 63,906,674 (+)MAPPERmRatBN7.2
Rnor_6.0771,355,902 - 71,356,036NCBIRnor6.0
Rnor_5.0771,525,974 - 71,526,108UniSTSRnor5.0
RGSC_v3.4768,061,941 - 68,062,075UniSTSRGSC3.4
Celera761,038,226 - 61,038,360UniSTS
Cytogenetic Map7q22UniSTS
BE106097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,714,099 - 63,714,311 (+)MAPPERmRatBN7.2
Rnor_6.0771,163,151 - 71,163,362NCBIRnor6.0
Rnor_5.0771,335,151 - 71,335,362UniSTSRnor5.0
RGSC_v3.4767,856,449 - 67,856,660UniSTSRGSC3.4
Celera760,846,847 - 60,847,058UniSTS
Cytogenetic Map7q22UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005875   ⟹   ENSRNOP00000005875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,675,579 - 63,689,392 (-)Ensembl
RefSeq Acc Id: NM_133543   ⟹   NP_598227
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,561,259 - 65,574,618 (-)NCBI
mRatBN7.2763,676,016 - 63,689,375 (-)NCBI
Rnor_6.0771,125,358 - 71,164,014 (-)NCBI
Rnor_5.0771,297,358 - 71,533,937 (-)NCBI
RGSC_v3.4767,818,370 - 67,831,729 (-)RGD
Celera760,810,166 - 60,822,127 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598227   ⟸   NM_133543
- UniProtKB: Q4KMB6 (UniProtKB/Swiss-Prot),   P55006 (UniProtKB/Swiss-Prot),   P50169 (UniProtKB/Swiss-Prot),   A0A0U1RVK8 (UniProtKB/TrEMBL),   A6HQX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005875   ⟸   ENSRNOT00000005875

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0U1RVK8-F1-model_v2 AlphaFold A0A0U1RVK8 1-266 view protein structure
AF-P55006-F1-model_v2 AlphaFold P55006 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631370 AgrOrtholog
BioCyc Gene G2FUF-33716 BioCyc
Ensembl Genes ENSRNOG00000004391 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026373 UniProtKB/Swiss-Prot
  ENSRNOG00060008711 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005875 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000005875.8 UniProtKB/Swiss-Prot
  ENSRNOT00055045517 UniProtKB/Swiss-Prot
  ENSRNOT00060014564 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Rdh7 ENTREZGENE
PANTHER RETINOL DEHYDROGENASE 16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rdh7 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004391 RatGTEx
  ENSRNOG00055026373 RatGTEx
  ENSRNOG00060008711 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RVK8 ENTREZGENE, UniProtKB/TrEMBL
  A6HQX7 ENTREZGENE, UniProtKB/TrEMBL
  P50169 ENTREZGENE
  P55006 ENTREZGENE
  Q4KMB6 ENTREZGENE
  RDH7_RAT UniProtKB/Swiss-Prot
UniProt Secondary P50169 UniProtKB/Swiss-Prot
  Q4KMB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Rdh7  retinol dehydrogenase 7  Rdh3  retinol dehydrogenase type III  Symbol and Name updated 1299863 APPROVED
2005-02-23 Rdh3  retinol dehydrogenase type III  RGD1307178_predicted  hypothetical gene supported by NM_133543 (predicted)  Data merged from RGD:1307178 737654 APPROVED
2005-01-20 RGD1307178_predicted  hypothetical gene supported by NM_133543 (predicted)  LOC360420_predicted    Symbol updated 1331353 APPROVED
2005-01-12 LOC360420_predicted  hypothetical gene supported by NM_133543 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 97.8% identity with RoDH(I) and 82.3% identity with RoDH(II) 633812