Rdh7 (retinol dehydrogenase 7) - Rat Genome Database

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Gene: Rdh7 (retinol dehydrogenase 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rdh7
Name: retinol dehydrogenase 7
RGD ID: 631370
Description: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human RDH16 (retinol dehydrogenase 16); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical gene supported by NM_133543; LOC360420; MGC108523; MGC112590; Rdh3; retinol dehydrogenase 3; retinol dehydrogenase type III; RGD1307178; RODH I; RODH III; RoDH(III)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,561,259 - 65,574,618 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl765,560,822 - 65,574,635 (-)EnsemblGRCr8
mRatBN7.2763,676,016 - 63,689,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,675,579 - 63,689,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx765,565,225 - 65,578,584 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,767,521 - 67,780,880 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,561,785 - 67,566,643 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0771,125,358 - 71,164,014 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,297,358 - 71,533,937 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4767,818,370 - 67,831,729 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera760,810,166 - 60,822,127 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III. Chai X, etal., Gene 1996 Mar 9;169(2):219-22.
2. Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase. Chai X, etal., J Biol Chem 1995 Feb 24;270(8):3900-4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Variants

.
Variants in Rdh7
78 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Rat45  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8765,787,841 - 65,788,017 (+)Marker Load Pipeline
mRatBN7.2763,902,608 - 63,902,784 (+)MAPPERmRatBN7.2
Rnor_6.0771,351,952 - 71,352,127NCBIRnor6.0
Rnor_5.0771,522,185 - 71,522,360UniSTSRnor5.0
RGSC_v3.4768,056,925 - 68,057,251RGDRGSC3.4
RGSC_v3.4768,056,997 - 68,057,172UniSTSRGSC3.4
Celera761,034,295 - 61,034,470UniSTS
RGSC_v3.1768,077,655 - 68,077,981RGD
FHH x ACI Map733.46UniSTS
FHH x ACI Map733.46RGD
Cytogenetic Map7q22UniSTS
D7Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,773,357 - 63,773,500 (+)MAPPERmRatBN7.2
mRatBN7.2763,768,981 - 63,769,114 (+)MAPPERmRatBN7.2
Rnor_6.0771,218,350 - 71,218,482NCBIRnor6.0
Rnor_6.0771,222,726 - 71,222,868NCBIRnor6.0
Rnor_5.0771,390,350 - 71,390,482UniSTSRnor5.0
Rnor_5.0771,394,726 - 71,394,868UniSTSRnor5.0
RGSC_v3.4767,916,939 - 67,917,081UniSTSRGSC3.4
RGSC_v3.4767,916,938 - 67,917,081RGDRGSC3.4
RGSC_v3.4767,912,562 - 67,912,695RGDRGSC3.4
RGSC_v3.4767,912,563 - 67,912,695UniSTSRGSC3.4
Celera760,906,045 - 60,906,187UniSTS
Celera760,901,669 - 60,901,801UniSTS
RGSC_v3.1767,933,292 - 67,933,425RGD
FHH x ACI Map733.38RGD
FHH x ACI Map733.38UniSTS
Cytogenetic Map7q22UniSTS
RH144391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,814,272 - 63,814,395 (+)MAPPERmRatBN7.2
Rnor_6.0771,263,990 - 71,264,112NCBIRnor6.0
Rnor_5.0771,435,990 - 71,436,112UniSTSRnor5.0
RGSC_v3.4767,957,852 - 67,957,974UniSTSRGSC3.4
Celera760,946,935 - 60,947,057UniSTS
Cytogenetic Map7q22UniSTS
RH136995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,908,905 - 63,909,086 (+)MAPPERmRatBN7.2
Rnor_6.0771,358,268 - 71,358,448NCBIRnor6.0
Rnor_5.0771,528,340 - 71,528,520UniSTSRnor5.0
RGSC_v3.4768,065,868 - 68,066,048UniSTSRGSC3.4
Celera761,040,584 - 61,040,764UniSTS
Cytogenetic Map7q22UniSTS
RH130952  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,906,389 - 63,906,575 (+)MAPPERmRatBN7.2
Rnor_6.0771,355,752 - 71,355,937NCBIRnor6.0
Rnor_5.0771,525,824 - 71,526,009UniSTSRnor5.0
RGSC_v3.4768,061,791 - 68,061,976UniSTSRGSC3.4
Celera761,038,076 - 61,038,261UniSTS
Cytogenetic Map7q22UniSTS
RH134392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,676,163 - 63,676,343 (+)MAPPERmRatBN7.2
Rnor_6.0771,125,506 - 71,125,685NCBIRnor6.0
Rnor_5.0771,297,506 - 71,297,685UniSTSRnor5.0
RGSC_v3.4767,818,518 - 67,818,697UniSTSRGSC3.4
Celera760,810,314 - 60,810,493UniSTS
Cytogenetic Map7q22UniSTS
AU044268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,906,539 - 63,906,674 (+)MAPPERmRatBN7.2
Rnor_6.0771,355,902 - 71,356,036NCBIRnor6.0
Rnor_5.0771,525,974 - 71,526,108UniSTSRnor5.0
RGSC_v3.4768,061,941 - 68,062,075UniSTSRGSC3.4
Celera761,038,226 - 61,038,360UniSTS
Cytogenetic Map7q22UniSTS
BE106097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,714,099 - 63,714,311 (+)MAPPERmRatBN7.2
Rnor_6.0771,163,151 - 71,163,362NCBIRnor6.0
Rnor_5.0771,335,151 - 71,335,362UniSTSRnor5.0
RGSC_v3.4767,856,449 - 67,856,660UniSTSRGSC3.4
Celera760,846,847 - 60,847,058UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 20 6 53 19 7 14 34 63 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000005875   ⟹   ENSRNOP00000005875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl765,560,822 - 65,574,635 (-)Ensembl
mRatBN7.2 Ensembl763,675,579 - 63,689,392 (-)Ensembl
RefSeq Acc Id: NM_133543   ⟹   NP_598227
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,561,259 - 65,574,618 (-)NCBI
mRatBN7.2763,676,016 - 63,689,375 (-)NCBI
Rnor_6.0771,125,358 - 71,164,014 (-)NCBI
Rnor_5.0771,297,358 - 71,533,937 (-)NCBI
RGSC_v3.4767,818,370 - 67,831,729 (-)RGD
Celera760,810,166 - 60,822,127 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB07995 (Get FASTA)   NCBI Sequence Viewer  
  AAB07997 (Get FASTA)   NCBI Sequence Viewer  
  AAH88090 (Get FASTA)   NCBI Sequence Viewer  
  AAH98650 (Get FASTA)   NCBI Sequence Viewer  
  EDM16445 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005875
  ENSRNOP00000005875.7
GenBank Protein P55006 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598227   ⟸   NM_133543
- UniProtKB: Q4KMB6 (UniProtKB/Swiss-Prot),   P55006 (UniProtKB/Swiss-Prot),   P50169 (UniProtKB/Swiss-Prot),   A0A0U1RVK8 (UniProtKB/TrEMBL),   A6HQX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005875   ⟸   ENSRNOT00000005875

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0U1RVK8-F1-model_v2 AlphaFold A0A0U1RVK8 1-266 view protein structure
AF-P55006-F1-model_v2 AlphaFold P55006 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631370 AgrOrtholog
BioCyc Gene G2FUF-33716 BioCyc
Ensembl Genes ENSRNOG00000004391 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005875 ENTREZGENE
  ENSRNOT00000005875.8 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:360420 UniProtKB/Swiss-Prot
NCBI Gene Rdh7 ENTREZGENE
PANTHER RETINOL DEHYDROGENASE 16 UniProtKB/Swiss-Prot
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Rdh7 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004391 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A0U1RVK8 ENTREZGENE, UniProtKB/TrEMBL
  A6HQX7 ENTREZGENE, UniProtKB/TrEMBL
  P50169 ENTREZGENE
  P55006 ENTREZGENE
  Q4KMB6 ENTREZGENE
  RDH7_RAT UniProtKB/Swiss-Prot
UniProt Secondary P50169 UniProtKB/Swiss-Prot
  Q4KMB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Rdh7  retinol dehydrogenase 7  Rdh3  retinol dehydrogenase type III  Symbol and Name updated 1299863 APPROVED
2005-02-23 Rdh3  retinol dehydrogenase type III  RGD1307178_predicted  hypothetical gene supported by NM_133543 (predicted)  Data merged from RGD:1307178 737654 APPROVED
2005-01-20 RGD1307178_predicted  hypothetical gene supported by NM_133543 (predicted)  LOC360420_predicted    Symbol updated 1331353 APPROVED
2005-01-12 LOC360420_predicted  hypothetical gene supported by NM_133543 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 97.8% identity with RoDH(I) and 82.3% identity with RoDH(II) 633812