Myo7a (myosin VIIA) - Rat Genome Database

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Gene: Myo7a (myosin VIIA) Rattus norvegicus
Analyze
Symbol: Myo7a
Name: myosin VIIA
RGD ID: 628830
Description: Enables several functions, including adenyl ribonucleotide binding activity; calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in upper tip-link density. Part of myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); myosin-VIIa; unconventional myosin-VIIa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myo7atnd/Hubr
Genetic Models: W-Myo7atnd/Hubr
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,755,110 - 161,825,397 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,755,110 - 161,825,365 (-)EnsemblGRCr8
mRatBN7.21152,342,611 - 152,414,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,331,375 - 160,401,213 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,511,561 - 167,581,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,385,070 - 160,454,912 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,001,313 - 163,071,545 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)Ensemblrn6Rnor6.0
Rnor_5.01169,206,150 - 169,276,706 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41155,292,620 - 155,362,698 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1150,435,342 - 150,505,024 (-)NCBICelera
RGSC_v3.11155,371,025 - 155,441,104 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
fipronil  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
lidocaine  (EXP)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-Nitrosopyrrolidine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Analysis of two Arab families reveals additional support for a DFNB2 nonsyndromic phenotype of MYO7A. Ben-Salem S, etal., Mol Biol Rep. 2014 Jan;41(1):193-200. doi: 10.1007/s11033-013-2851-5. Epub 2013 Nov 6.
2. Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. Boeda B, etal., EMBO J 2002 Dec 16;21(24):6689-99.
3. Myosin7a deficiency results in reduced retinal activity which is improved by gene therapy. Colella P, etal., PLoS One. 2013 Aug 26;8(8):e72027. doi: 10.1371/journal.pone.0072027. eCollection 2013.
4. Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells. el-Amraoui A, etal., Hum Mol Genet. 1996 Aug;5(8):1171-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Grati M and Kachar B, Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11476-81. doi: 10.1073/pnas.1104161108. Epub 2011 Jun 27.
9. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Hasson T, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9815-9.
10. Characterization of the motor activity of mammalian myosin VIIA. Inoue A and Ikebe M, J Biol Chem 2003 Feb 14;278(7):5478-87.
11. Sensing sound: molecules that orchestrate mechanotransduction by hair cells. Kazmierczak P and Muller U, Trends Neurosci. 2012 Apr;35(4):220-9. doi: 10.1016/j.tins.2011.10.007. Epub 2011 Dec 15.
12. Genetic analysis of a four generation Indian family with Usher syndrome: a novel insertion mutation in MYO7A. Kumar A, etal., Mol Vis. 2004 Nov 24;10:910-6.
13. Mutation analysis of the mouse myosin VIIA deafness gene. Mburu P, etal., Genes Funct. 1997 Jun;1(3):191-203.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, respectively. Najera C, etal., Hum Mutat. 2002 Jul;20(1):76-7.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Pruss H, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):63-79.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction. Selvakumar D, etal., J Biol Chem. 2013 Mar 8;288(10):7215-29. doi: 10.1074/jbc.M112.443226. Epub 2013 Jan 17.
22. Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Smits BM, etal., Genetics. 2005 Aug;170(4):1887-96. Epub 2005 Jun 18.
23. Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis. Wang X, etal., Hum Mutat. 2011 Dec;32(12):1450-9. doi: 10.1002/humu.21587. Epub 2011 Sep 23.
24. Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients. Weston MD, etal., Am J Hum Genet. 1996 Nov;59(5):1074-83.
25. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
26. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Zheng QY, etal., Hum Mol Genet. 2012 Jun 1;21(11):2588-98. doi: 10.1093/hmg/dds084. Epub 2012 Feb 29.
Additional References at PubMed
PMID:5795329   PMID:6627025   PMID:7870171   PMID:7870172   PMID:9435277   PMID:9620764   PMID:10414956   PMID:11023859   PMID:11162241   PMID:11222540   PMID:11398101   PMID:11753415  
PMID:11921171   PMID:11964381   PMID:12121736   PMID:12743369   PMID:13336002   PMID:14198707   PMID:14609561   PMID:14978221   PMID:15300860   PMID:15316067   PMID:15389316   PMID:15572405  
PMID:15590703   PMID:15657400   PMID:15905332   PMID:16001398   PMID:16481439   PMID:17050716   PMID:17329413   PMID:17567809   PMID:17666436   PMID:18339676   PMID:18796539   PMID:20016102  
PMID:21146598   PMID:21687988   PMID:23704327   PMID:25535395   PMID:26754646   PMID:27525485   PMID:30649248  


Genomics

Comparative Map Data
Myo7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,755,110 - 161,825,397 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1161,755,110 - 161,825,365 (-)EnsemblGRCr8
mRatBN7.21152,342,611 - 152,414,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1160,331,375 - 160,401,213 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,511,561 - 167,581,393 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,385,070 - 160,454,912 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,001,313 - 163,071,545 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)Ensemblrn6Rnor6.0
Rnor_5.01169,206,150 - 169,276,706 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41155,292,620 - 155,362,698 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1150,435,342 - 150,505,024 (-)NCBICelera
RGSC_v3.11155,371,025 - 155,441,104 (-)NCBI
Cytogenetic Map1q32NCBI
MYO7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,128,246 - 77,215,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,128,245 - 77,215,241 (+)Ensemblhg38GRCh38
GRCh371176,839,292 - 76,926,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,516,964 - 76,603,932 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341176,516,957 - 76,603,931NCBI
Celera1174,146,794 - 74,233,913 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1173,136,682 - 73,224,253 (+)NCBIHuRef
CHM1_11176,722,561 - 76,809,502 (+)NCBICHM1_1
T2T-CHM13v2.01177,058,823 - 77,147,851 (+)NCBIT2T-CHM13v2.0
Myo7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,700,261 - 97,768,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,700,267 - 97,768,731 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38798,051,054 - 98,119,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,051,060 - 98,119,524 (-)Ensemblmm10GRCm38
MGSCv377105,199,570 - 105,268,003 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36797,926,593 - 97,992,926 (-)NCBIMGSCv36mm8
Celera798,371,628 - 98,440,211 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Myo7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,576,356 - 14,647,500 (-)Ensembl
ChiLan1.0NW_00495541414,576,356 - 14,647,500 (-)NCBIChiLan1.0ChiLan1.0
MYO7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,045,811 - 78,134,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,093,985 - 79,182,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,187,024 - 72,265,931 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,834,409 - 75,908,297 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,834,185 - 75,907,752 (+)EnsemblpanPan2panpan1.1
MYO7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,539,735 - 21,624,063 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2121,539,785 - 21,624,279 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2121,371,283 - 21,451,548 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02121,739,388 - 21,823,670 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2121,739,387 - 21,823,979 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12121,514,983 - 21,599,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,731,135 - 21,815,380 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,654,692 - 21,739,052 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myo7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,150,067 - 64,224,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364985,751,779 - 5,824,378 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364985,758,572 - 5,824,526 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,249,075 - 11,666,296 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1911,251,187 - 11,337,618 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,345,556 - 12,430,950 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,334,781 - 68,423,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,350,598 - 68,425,625 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604357,352,101 - 57,439,357 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624863205,478 - 283,839 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624863205,468 - 283,840 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Myo7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1296,333,552 - 96,402,681 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myo7a
716 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000019053
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat

Markers in Region
RH136948  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21152,416,290 - 152,416,441 (+)MAPPERmRatBN7.2
Rnor_6.01163,073,173 - 163,073,323NCBIRnor6.0
Rnor_5.01169,278,369 - 169,278,519UniSTSRnor5.0
RGSC_v3.41155,364,724 - 155,364,874UniSTSRGSC3.4
Celera1150,507,162 - 150,507,312UniSTS
RH 3.4 Map11166.1UniSTS
Cytogenetic Map1q32UniSTS


Genetic Models
This gene Myo7a is modified in the following models/strains:
W-Myo7atnd/Hubr    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 73 59 6 337 173 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019053   ⟹   ENSRNOP00000019053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,755,110 - 161,825,365 (-)Ensembl
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)Ensembl
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103282   ⟹   ENSRNOP00000083122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1161,755,110 - 161,818,577 (-)Ensembl
mRatBN7.2 Ensembl1152,344,448 - 152,407,422 (-)Ensembl
RefSeq Acc Id: NM_001414743   ⟹   NP_001401672
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,818,577 (-)NCBI
mRatBN7.21152,343,886 - 152,407,357 (-)NCBI
RefSeq Acc Id: NM_153473   ⟹   NP_703203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,825,365 (-)NCBI
mRatBN7.21152,343,886 - 152,414,147 (-)NCBI
Rnor_6.01163,001,875 - 163,071,508 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
RGSC_v3.41155,292,620 - 155,362,698 (-)RGD
Celera1150,435,342 - 150,505,024 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229742   ⟹   XP_006229804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,819,225 (-)NCBI
mRatBN7.21152,342,611 - 152,407,989 (-)NCBI
Rnor_6.01163,001,313 - 163,065,331 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229744   ⟹   XP_006229806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,825,397 (-)NCBI
mRatBN7.21152,342,611 - 152,414,171 (-)NCBI
Rnor_6.01163,001,877 - 163,071,545 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102474   ⟹   XP_038958402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,818,078 (-)NCBI
mRatBN7.21152,342,611 - 152,406,858 (-)NCBI
RefSeq Acc Id: XM_039102483   ⟹   XP_038958411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,788,166 (-)NCBI
mRatBN7.21152,342,611 - 152,376,949 (-)NCBI
RefSeq Acc Id: XM_039102487   ⟹   XP_038958415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,795,099 (-)NCBI
mRatBN7.21152,342,611 - 152,383,879 (-)NCBI
RefSeq Acc Id: NP_703203   ⟸   NM_153473
- Peptide Label: isoform 2
- UniProtKB: Q8CJE3 (UniProtKB/TrEMBL),   D4AB24 (UniProtKB/TrEMBL),   A6I6C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229806   ⟸   XM_006229744
- Peptide Label: isoform X2
- UniProtKB: A0A8J8XYU9 (UniProtKB/TrEMBL),   A6I6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229804   ⟸   XM_006229742
- Peptide Label: isoform X1
- UniProtKB: A6I6C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019053   ⟸   ENSRNOT00000019053
RefSeq Acc Id: XP_038958402   ⟸   XM_039102474
- Peptide Label: isoform X3
- UniProtKB: A6I6C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958415   ⟸   XM_039102487
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038958411   ⟸   XM_039102483
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000083122   ⟸   ENSRNOT00000103282
RefSeq Acc Id: NP_001401672   ⟸   NM_001414743
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZWB0 (UniProtKB/TrEMBL),   A6I6C4 (UniProtKB/TrEMBL)
Protein Domains
FERM   Myosin motor   MyTH4   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJE3-F1-model_v2 AlphaFold Q8CJE3 1-2177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690216
Promoter ID:EPDNEW_R741
Type:initiation region
Name:Myo7a_1
Description:myosin VIIA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01163,071,493 - 163,071,553EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628830 AgrOrtholog
BioCyc Gene G2FUF-58430 BioCyc
Ensembl Genes ENSRNOG00000013641 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019053 ENTREZGENE
  ENSRNOT00000019053.8 UniProtKB/TrEMBL
  ENSRNOT00000103282 ENTREZGENE
  ENSRNOT00000103282.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA_bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  IQ_CaM_bd_region UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_VII_N UniProtKB/TrEMBL
  MyoVII_FERM_C1 UniProtKB/TrEMBL
  MyoVII_FERM_C2 UniProtKB/TrEMBL
  MYSc_Myo7 UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  Unconventional_Myosin_ATPase UniProtKB/TrEMBL
NCBI Gene 266714 ENTREZGENE
PANTHER MYOSIN VII, XV UniProtKB/TrEMBL
  MYOSIN VIIA UniProtKB/TrEMBL
Pfam FERM_C1_MyoVII UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  Myosin_head UniProtKB/TrEMBL
  Myosin_VII_N UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RA_2 UniProtKB/TrEMBL
PhenoGen Myo7a PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  MYOSIN_MOTOR UniProtKB/TrEMBL
  MYTH4 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013641 RatGTEx
SMART B41 UniProtKB/TrEMBL
  MYSc UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5ZWB0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XYU9 ENTREZGENE, UniProtKB/TrEMBL
  A6I6C4 ENTREZGENE, UniProtKB/TrEMBL
  A6I6C5 ENTREZGENE, UniProtKB/TrEMBL
  D4AB24 ENTREZGENE
  Q8CJE3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4AB24 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Myo7a  myosin VIIA    myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))  Name updated 1299863 APPROVED
2003-02-27 Myo7a  myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a motor domain, IQ domain, and the coiled-coil domain 633398