Retn (resistin) - Rat Genome Database

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Gene: Retn (resistin) Rattus norvegicus
Analyze
Symbol: Retn
Name: resistin
RGD ID: 628781
Description: Predicted to enable hormone activity. Involved in several processes, including negative regulation of feeding behavior; positive regulation of cell communication; and response to insulin. Located in extracellular space. Used to study colitis. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin); INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methylnicotinamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,508,653 - 6,511,115 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,508,801 - 6,511,116 (+)EnsemblGRCr8
mRatBN7.2121,710,881 - 1,712,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,710,881 - 1,712,620 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,377,668 - 2,379,407 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,001,238 - 3,002,977 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,772,202 - 1,773,941 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,201,909 - 2,203,649 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,201,891 - 2,204,249 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,364,007 - 4,365,747 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,499,630 - 2,501,370 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,566,836 - 3,568,576 (+)NCBICelera
RGSC_v3.1122,499,629 - 2,501,370 (-)NCBI
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methylnicotinamide  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
Aloe emodin  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aurothioglucose  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
CL316243  (EXP)
corticosterone  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
disodium cromoglycate  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (ISO)
glycine  (ISO)
herbicide  (ISO)
hesperetin  (ISO)
hydrazine  (ISO)
hydrazines  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
L-methionine  (ISO)
letrozole  (EXP)
lipopolysaccharide  (ISO)
mercaptopurine  (EXP)
metformin  (EXP)
mevalonic acid  (ISO)
monosodium L-glutamate  (ISO)
naproxen  (EXP,ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitric oxide  (EXP,ISO)
nitroprusside  (ISO)
NMN zwitterion  (ISO)
Nonylphenol  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenethyl caffeate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (ISO)
pioglitazone  (ISO)
potassium bromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (EXP)
resveratrol  (EXP,ISO)
SB 203580  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
stilben-4-ol  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
testosterone  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification. Baker JF, etal., J Rheumatol. 2011 Nov;38(11):2369-75. doi: 10.3899/jrheum.110237. Epub 2011 Sep 1.
2. Resistin level in coronary artery disease and heart failure: the central role of kidney function. Baldasseroni S, etal., J Cardiovasc Med (Hagerstown). 2013 Feb;14(2):150-7. doi: 10.2459/JCM.0b013e32834eec93.
3. Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese. Chi S, etal., Mol Cell Biochem. 2009 Apr 21.
4. Low resistin level is associated with poor hospitalization-free survival in hemodialysis patients. Chung W, etal., J Korean Med Sci. 2012 Apr;27(4):377-81. doi: 10.3346/jkms.2012.27.4.377. Epub 2012 Mar 21.
5. Possible common central pathway for resistin and insulin in regulating food intake. Cifani C, etal., Acta Physiol (Oxf). 2009 Aug;196(4):395-400. doi: 10.1111/j.1748-1716.2008.01949.x. Epub 2008 Dec 16.
6. Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis. Clemente TR, etal., Scand J Gastroenterol. 2012 Sep;8-9(47):943-50. doi: 10.3109/00365521.2012.688213. Epub 2012 May 28.
7. Alternative splicing generates a novel non-secretable resistin isoform in Wistar rats. Del Arco A, etal., FEBS Lett. 2003 Dec 4;555(2):243-9.
8. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Delhanty PJ, etal., Endocrinology 2002 Jun;143(6):2445-8.
9. Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Diez JJ, etal., Clin Endocrinol (Oxf). 2005 Feb;62(2):242-9.
10. Inverse association between serum resistin and insulin resistance in humans. Dominguez Coello S, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):256-61. Epub 2008 Sep 11.
11. The expression of rat resistin isoforms is differentially regulated in visceral adipose tissues: effects of aging and food restriction. Fernandez CM, etal., Metabolism. 2009 Feb;58(2):204-11. doi: 10.1016/j.metabol.2008.09.014.
12. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Resistin promotes 3T3-L1 preadipocyte differentiation. Gong H, etal., Eur J Endocrinol. 2004 Jun;150(6):885-92.
16. Impact of uremia on human adipose tissue phenotype. Ho KJ, etal., J Surg Res. 2013 Jan;179(1):175-82. doi: 10.1016/j.jss.2012.08.043. Epub 2012 Sep 6.
17. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Hussain S, etal., Transl Res. 2010 Mar;155(3):142-7. doi: 10.1016/j.trsl.2009.10.002. Epub 2009 Nov 4.
18. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Koch A, etal., Crit Care. 2009;13(3):R95. doi: 10.1186/cc7925. Epub 2009 Jun 19.
19. Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2. Kosari S, etal., J Neuroendocrinol. 2012 Nov;24(11):1432-9. doi: 10.1111/j.1365-2826.2012.02352.x.
20. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications. Kreier F, etal., J Clin Invest 2002 Nov;110(9):1243-50.
21. High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Kuzmicki M, etal., Gynecol Endocrinol. 2009 Apr;25(4):258-63.2: id: 38815448 Error occurred: The following PMID is not available: -13: id: 58220487 Error occurred: The following PMID is not available: -14: id: 77618179 Error occurred: The following PMID is not available: -1
22. Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. Lee SH, etal., Coron Artery Dis. 2009 Jan;20(1):33-9. doi: 10.1097/MCA.0b013e328318ecb0.
23. Lipopolysaccharide increases resistin gene expression in vivo and in vitro. Lu SC, etal., FEBS Lett 2002 Oct 23;530(1-3):158-62.
24. Expression and effect of resistin on bovine and rat granulosa cell steroidogenesis and proliferation. Maillard V, etal., Reproduction. 2011 Apr;141(4):467-79. doi: 10.1530/REP-10-0419. Epub 2011 Jan 14.
25. A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes. Makino H, etal., Endocr J. 2009 Sep 9.
26. Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients. Malyszko J, etal., Transplant Proc. 2006 Dec;38(10):3434-6.
27. Hyperresistinemia - a novel feature in systemic infection during human pregnancy. Mazaki-Tovi S, etal., Am J Reprod Immunol. 2010 May;63(5):358-69. doi: 10.1111/j.1600-0897.2010.00809.x. Epub 2010 Feb 18.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort. Nehus E, etal., J Pediatr. 2012 Aug;161(2):276-80. doi: 10.1016/j.jpeds.2012.01.055. Epub 2012 Mar 14.
30. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. Norata GD, etal., J Intern Med. 2007 Jul;262(1):104-12.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
33. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Osawa H, etal., Biochem Biophys Res Commun. 2007 Apr 6;355(2):342-6. Epub 2007 Feb 5.
34. [The significance of resistin concentration in metabolical diseases]. Rasic D, etal., Vojnosanit Pregl. 2010 Dec;67(12):965-8.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Roth CL, etal., Hepatology. 2012 Apr;55(4):1103-11. doi: 10.1002/hep.24737. Epub 2012 Feb 15.
39. Over expression of resistin in adipose tissue of the obese induces insulin resistance. Sadashiv, etal., World J Diabetes. 2012 Jul 15;3(7):135-41. doi: 10.4239/wjd.v3.i7.135.
40. Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Schaffler A, etal., Horm Metab Res. 2004 Oct;36(10):702-7.
41. Resistin contributes to neointimal formation via oxidative stress after vascular injury. Shyu KG, etal., Clin Sci (Lond). 2011 Feb;120(3):121-9. doi: 10.1042/CS20100226.
42. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Smalley DM, etal., J Proteome Res. 2008 May;7(5):2088-96. doi: 10.1021/pr700775x. Epub 2008 Mar 29.
43. The hormone resistin links obesity to diabetes. Steppan CM, etal., Nature. 2001 Jan 18;409(6818):307-12.
44. The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais. Suriyaprom K, etal., J Clin Biochem Nutr. 2009 Jan;44(1):104-10. Epub 2008 Dec 27.
45. Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. Tan MS, etal., J Clin Endocrinol Metab. 2003 Mar;88(3):1258-63.
46. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Tsioufis C, etal., Am J Hypertens. 2010 Jun;23(6):681-6. doi: 10.1038/ajh.2010.34. Epub 2010 Mar 4.
47. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. Tsukahara T, etal., Diabetes Res Clin Pract. 2009 May;84(2):179-86. Epub 2009 Mar 6.
48. Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells. Wang BW, etal., Clin Sci (Lond). 2009 Oct 26;118(3):221-30.
49. [The relationship between resistin and the peripheral neuropathy in type 2 diabetes]. Wang XH, etal., Zhonghua Yi Xue Za Zhi. 2007 Jul 3;87(25):1755-7.
50. Effects of free fatty acids on plasma resistin and insulin resistance in awake rats. Yang G, etal., Metabolism. 2005 Sep;54(9):1142-6.
51. A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis. Zhao J, etal., Scand J Gastroenterol. 2010 Nov;45(11):1360-71. doi: 10.3109/00365521.2010.497938. Epub 2010 Jun 21.
Additional References at PubMed
PMID:11209052   PMID:12429872   PMID:12477932   PMID:12634438   PMID:12660872   PMID:12885401   PMID:12944409   PMID:14577616   PMID:14592417   PMID:15226398   PMID:15526156   PMID:15642357  
PMID:15737463   PMID:16154759   PMID:16338222   PMID:16404608   PMID:16934751   PMID:17063326   PMID:17241525   PMID:17418807   PMID:17557231   PMID:17573461   PMID:17611902   PMID:17693256  
PMID:17890220   PMID:17922337   PMID:17991727   PMID:18063850   PMID:18176969   PMID:18178314   PMID:18239591   PMID:18499762   PMID:18597775   PMID:19008713   PMID:19041881   PMID:19589870  
PMID:19785957   PMID:20627112   PMID:21478152   PMID:21557150   PMID:21586564   PMID:22372349   PMID:22645452   PMID:22855443   PMID:23376485   PMID:23533145   PMID:23765438   PMID:23867317  
PMID:23901222   PMID:24610624   PMID:25065280   PMID:25217974   PMID:26383117   PMID:26811539   PMID:26846568   PMID:26909974   PMID:27797297   PMID:27959400   PMID:28877872   PMID:29500410  
PMID:30612469   PMID:31053755   PMID:31085594   PMID:32410876  


Genomics

Comparative Map Data
Retn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,508,653 - 6,511,115 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,508,801 - 6,511,116 (+)EnsemblGRCr8
mRatBN7.2121,710,881 - 1,712,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,710,881 - 1,712,620 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,377,668 - 2,379,407 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,001,238 - 3,002,977 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,772,202 - 1,773,941 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,201,909 - 2,203,649 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,201,891 - 2,204,249 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,364,007 - 4,365,747 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,499,630 - 2,501,370 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,566,836 - 3,568,576 (+)NCBICelera
RGSC_v3.1122,499,629 - 2,501,370 (-)NCBI
Cytogenetic Map12p12NCBI
RETN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,669,049 - 7,670,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,669,049 - 7,670,455 (+)Ensemblhg38GRCh38
GRCh37197,733,935 - 7,735,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,639,972 - 7,641,340 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34197,639,971 - 7,641,340NCBI
Celera197,605,160 - 7,606,528 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,403,771 - 7,405,139 (+)NCBIHuRef
CHM1_1197,733,708 - 7,735,063 (+)NCBICHM1_1
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBIT2T-CHM13v2.0
Retn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,705,770 - 3,709,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,705,770 - 3,710,110 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3883,655,770 - 3,659,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,655,770 - 3,660,110 (+)Ensemblmm10GRCm38
MGSCv3783,655,789 - 3,658,096 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3683,655,789 - 3,658,096 (+)NCBIMGSCv36mm8
Celera83,886,118 - 3,888,425 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Retn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,607,814 - 1,609,273 (-)Ensembl
ChiLan1.0NW_0049555631,607,814 - 1,609,273 (-)NCBIChiLan1.0ChiLan1.0
RETN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,339,693 - 12,341,193 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,457,254 - 11,458,754 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,958,536 - 6,960,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,812,942 - 7,814,909 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,812,942 - 7,814,909 (+)EnsemblpanPan2panpan1.1
RETN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,434,148 - 52,435,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,434,271 - 52,435,624 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,238,221 - 52,239,712 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02052,963,476 - 52,964,967 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,963,614 - 52,964,967 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,167,243 - 52,168,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,610,828 - 52,612,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,842,073 - 52,843,564 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Retn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,128,130 - 213,129,482 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,705,119 - 4,706,656 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,705,295 - 4,706,653 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RETN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,484,169 - 71,485,616 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1271,484,164 - 71,485,577 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,871,237 - 71,872,650 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21NCBI
RETN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,154,771 - 7,156,459 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,155,337 - 7,156,505 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081704,895 - 706,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Retn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828735,503 - 737,166 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624828735,562 - 737,166 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Retn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1161,577,707 - 1,579,490 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Retn
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:108
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000001325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat

Markers in Region
RH127742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,712,810 - 1,713,029 (+)MAPPERmRatBN7.2
Rnor_6.0122,203,839 - 2,204,057NCBIRnor6.0
Rnor_5.0124,365,937 - 4,366,155UniSTSRnor5.0
RGSC_v3.4122,499,222 - 2,499,440UniSTSRGSC3.4
Celera123,568,766 - 3,568,984UniSTS
Cytogenetic Map12p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
8 12 29 63 73 72 41 55 41 6 217 117 11 34 43 54 31

Sequence


Ensembl Acc Id: ENSRNOT00000001325   ⟹   ENSRNOP00000001325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,508,801 - 6,511,116 (+)Ensembl
mRatBN7.2 Ensembl121,710,881 - 1,712,620 (+)Ensembl
Rnor_6.0 Ensembl122,201,949 - 2,203,614 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091197   ⟹   ENSRNOP00000073327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl122,201,891 - 2,204,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096056   ⟹   ENSRNOP00000096426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,710,882 - 1,712,620 (+)Ensembl
RefSeq Acc Id: NM_144741   ⟹   NP_653342
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,508,774 - 6,510,514 (+)NCBI
mRatBN7.2121,710,881 - 1,712,621 (+)NCBI
Rnor_6.0122,201,909 - 2,203,649 (+)NCBI
Rnor_5.0124,364,007 - 4,365,747 (+)NCBI
RGSC_v3.4122,499,630 - 2,501,370 (-)RGD
Celera123,566,836 - 3,568,576 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271045   ⟹   XP_063127115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,508,653 - 6,511,115 (+)NCBI
RefSeq Acc Id: NP_653342   ⟸   NM_144741
- Peptide Label: precursor
- UniProtKB: Q8K4J7 (UniProtKB/TrEMBL),   F7EKN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073327   ⟸   ENSRNOT00000091197
Ensembl Acc Id: ENSRNOP00000001325   ⟸   ENSRNOT00000001325
Ensembl Acc Id: ENSRNOP00000096426   ⟸   ENSRNOT00000096056
RefSeq Acc Id: XP_063127115   ⟸   XM_063271045
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4J7-F1-model_v2 AlphaFold Q8K4J7 1-114 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698374
Promoter ID:EPDNEW_R8899
Type:single initiation site
Name:Retn_1
Description:resistin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,201,936 - 2,201,996EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628781 AgrOrtholog
BioCyc Gene G2FUF-20385 BioCyc
Ensembl Genes ENSRNOG00000001001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001325 ENTREZGENE
  ENSRNOT00000001325.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4230 UniProtKB/TrEMBL
  6.10.250.200 UniProtKB/TrEMBL
InterPro Resistin UniProtKB/TrEMBL
  Resistin-like_sf UniProtKB/TrEMBL
KEGG Report rno:246250 UniProtKB/TrEMBL
NCBI Gene 246250 ENTREZGENE
PANTHER Resistin UniProtKB/TrEMBL
  RESISTIN UniProtKB/TrEMBL
Pfam Resistin UniProtKB/TrEMBL
PhenoGen Retn PhenoGen
RatGTEx ENSRNOG00000001001 RatGTEx
Superfamily-SCOP Resistin UniProtKB/TrEMBL
UniProt F7EKN8 ENTREZGENE, UniProtKB/TrEMBL
  Q70Q42_RAT UniProtKB/TrEMBL
  Q8K4J7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Retn  resistin      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Retn  resistin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in white adipose tissue 633881
gene_expression expressed in the adipose tissues 628347
gene_expression expression is induced by growth hormone in the spontaneous dwarf strain 633881
gene_regulation expression of mRNA is decreased by a fat pad specific vagotomy 628347