RGD Reference Report - Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. - Rat Genome Database

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Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population.

Authors: Tan, MS  Chang, SY  Chang, DM  Tsai, JC  Lee, YJ 
Citation: Tan MS, etal., J Clin Endocrinol Metab. 2003 Mar;88(3):1258-63.
RGD ID: 1624968
Pubmed: PMID:12629116   (View Abstract at PubMed)
DOI: DOI:10.1210/jc.2002-021453   (Journal Full-text)

Resistin, a recently discovered polypeptide, antagonizes insulin action and may play a part in the pathogenesis of insulin resistance. This study investigates whether resistin gene polymorphism can be associated with type 2 diabetes. We studied 1102 Chinese type 2 diabetes patients and 743 subjects without diabetes. The resistin 3'-untranslated region (UTR) +62G-->A polymorphism was determined by PCR. Type 2 diabetes subjects had a lower frequency of resistin gene 3'UTR +62A allele (GG:GA/AA, 83.5%:16.5%) than the controls (GG:GA/AA, 75.1%:24.9%; odds ratio, 1.524; 95% confidence interval, 1.268-1.831; P < 0.001). Unexpectedly, diabetic patients with the GG genotype had a higher prevalence of hypertension (GG:GA/AA, 49.8%:36.2%; odds ratio, 1.375; 95% confidence interval, 1.116-1.693; P = 0.001). Logistic regression analysis confirmed that the resistin gene 3'UTR +62G-->A polymorphism acts as an independent contributing factor to type 2 diabetes and hypertension. The mean systolic and diastolic blood pressure levels in diabetic subjects with the GG genotype (144 +/- 21/87 +/- 13 mm Hg) were significantly higher than those in subjects with GA/AA variants (139 +/- 21/84 +/- 14 mm Hg; P = 0.004 and P = 0.002, respectively). Multiple linear regression analysis showed resistin gene polymorphism to be an independent factor associated with systolic and diastolic blood pressures in type 2 diabetes patients. These findings suggest that resistin may play a role in the pathogenesis of type 2 diabetes and insulin resistance-related hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 1624968DNA:SNP:3' utr:*62A>G (human)RGD 
hypertension  ISORETN (Homo sapiens)1624968; 1624968DNA:SNP:3' utr:*62A>G (human)RGD 
type 2 diabetes mellitus  IAGP 1624968DNA:SNP:3' utr:*62A>G (human)RGD 
type 2 diabetes mellitus  ISORETN (Homo sapiens)1624968; 1624968DNA:SNP:3' utr:*62A>G (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Elevated diastolic blood pressure  IAGP 1624968DNA:SNP:3' utr:*62A>G (human)RGD 
Elevated systolic blood pressure  IAGP 1624968DNA:SNP:3' utr:*62A>G (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Retn  (resistin)

Genes (Mus musculus)
Retn  (resistin)

Genes (Homo sapiens)
RETN  (resistin)


Additional Information