RETN (resistin) - Rat Genome Database

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Gene: RETN (resistin) Homo sapiens
Analyze
Symbol: RETN
Name: resistin
RGD ID: 1349693
HGNC Page HGNC:20389
Description: Predicted to enable hormone activity. Predicted to be involved in several processes, including negative regulation of feeding behavior; positive regulation of cell communication; and response to insulin. Located in extracellular exosome. Implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); diabetic neuropathy; heart disease (multiple); kidney failure (multiple); and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3; FIZZ3; found in inflammatory zone 3; MGC126603; MGC126609; RENT; resistin delta2; RETN1; RSTN; XCP1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,669,049 - 7,670,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,669,049 - 7,670,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,733,935 - 7,735,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,639,972 - 7,641,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,639,971 - 7,641,340NCBI
Celera197,605,160 - 7,606,528 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,403,771 - 7,405,139 (+)NCBIHuRef
CHM1_1197,733,708 - 7,735,063 (+)NCBICHM1_1
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methylnicotinamide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
Aloe emodin  (EXP)
alpha-melanocyte stimulating hormone  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
arachidonic acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
Aurothioglucose  (ISO)
benzo[a]pyrene  (EXP)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
corticosterone  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
disodium cromoglycate  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
herbicide  (ISO)
hesperetin  (EXP)
hydrazine  (ISO)
hydrazines  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP)
mercaptopurine  (ISO)
metformin  (ISO)
mevalonic acid  (EXP)
monosodium L-glutamate  (ISO)
naproxen  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
NMN zwitterion  (ISO)
Nonylphenol  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
phenethyl caffeate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (ISO)
pioglitazone  (ISO)
potassium bromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP,ISO)
purine-6-thiol  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
simvastatin  (EXP)
stilben-4-ol  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sumatriptan  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triptonide  (ISO)
triticonazole  (ISO)
vinclozolin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification. Baker JF, etal., J Rheumatol. 2011 Nov;38(11):2369-75. doi: 10.3899/jrheum.110237. Epub 2011 Sep 1.
2. Resistin level in coronary artery disease and heart failure: the central role of kidney function. Baldasseroni S, etal., J Cardiovasc Med (Hagerstown). 2013 Feb;14(2):150-7. doi: 10.2459/JCM.0b013e32834eec93.
3. Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese. Chi S, etal., Mol Cell Biochem. 2009 Apr 21.
4. Low resistin level is associated with poor hospitalization-free survival in hemodialysis patients. Chung W, etal., J Korean Med Sci. 2012 Apr;27(4):377-81. doi: 10.3346/jkms.2012.27.4.377. Epub 2012 Mar 21.
5. Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis. Clemente TR, etal., Scand J Gastroenterol. 2012 Sep;8-9(47):943-50. doi: 10.3109/00365521.2012.688213. Epub 2012 May 28.
6. Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Diez JJ, etal., Clin Endocrinol (Oxf). 2005 Feb;62(2):242-9.
7. Inverse association between serum resistin and insulin resistance in humans. Dominguez Coello S, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):256-61. Epub 2008 Sep 11.
8. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
10. Impact of uremia on human adipose tissue phenotype. Ho KJ, etal., J Surg Res. 2013 Jan;179(1):175-82. doi: 10.1016/j.jss.2012.08.043. Epub 2012 Sep 6.
11. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Hussain S, etal., Transl Res. 2010 Mar;155(3):142-7. doi: 10.1016/j.trsl.2009.10.002. Epub 2009 Nov 4.
12. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Koch A, etal., Crit Care. 2009;13(3):R95. doi: 10.1186/cc7925. Epub 2009 Jun 19.
13. Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression. Krishnamurthy P, etal., Horm Metab Res. 2008 Mar;40(3):194-8. Epub 2008 Feb 4.
14. High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Kuzmicki M, etal., Gynecol Endocrinol. 2009 Apr;25(4):258-63.2: id: 38815448 Error occurred: The following PMID is not available: -13: id: 58220487 Error occurred: The following PMID is not available: -14: id: 77618179 Error occurred: The following PMID is not available: -1
15. Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. Lee SH, etal., Coron Artery Dis. 2009 Jan;20(1):33-9. doi: 10.1097/MCA.0b013e328318ecb0.
16. A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes. Makino H, etal., Endocr J. 2009 Sep 9.
17. Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients. Malyszko J, etal., Transplant Proc. 2006 Dec;38(10):3434-6.
18. Hyperresistinemia - a novel feature in systemic infection during human pregnancy. Mazaki-Tovi S, etal., Am J Reprod Immunol. 2010 May;63(5):358-69. doi: 10.1111/j.1600-0897.2010.00809.x. Epub 2010 Feb 18.
19. Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort. Nehus E, etal., J Pediatr. 2012 Aug;161(2):276-80. doi: 10.1016/j.jpeds.2012.01.055. Epub 2012 Mar 14.
20. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. Norata GD, etal., J Intern Med. 2007 Jul;262(1):104-12.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Osawa H, etal., Biochem Biophys Res Commun. 2007 Apr 6;355(2):342-6. Epub 2007 Feb 5.
23. [The significance of resistin concentration in metabolical diseases]. Rasic D, etal., Vojnosanit Pregl. 2010 Dec;67(12):965-8.
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Roth CL, etal., Hepatology. 2012 Apr;55(4):1103-11. doi: 10.1002/hep.24737. Epub 2012 Feb 15.
27. Over expression of resistin in adipose tissue of the obese induces insulin resistance. Sadashiv, etal., World J Diabetes. 2012 Jul 15;3(7):135-41. doi: 10.4239/wjd.v3.i7.135.
28. Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Schaffler A, etal., Horm Metab Res. 2004 Oct;36(10):702-7.
29. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. Smalley DM, etal., J Proteome Res. 2008 May;7(5):2088-96. doi: 10.1021/pr700775x. Epub 2008 Mar 29.
30. The hormone resistin links obesity to diabetes. Steppan CM, etal., Nature. 2001 Jan 18;409(6818):307-12.
31. The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais. Suriyaprom K, etal., J Clin Biochem Nutr. 2009 Jan;44(1):104-10. Epub 2008 Dec 27.
32. Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. Tan MS, etal., J Clin Endocrinol Metab. 2003 Mar;88(3):1258-63.
33. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Tsioufis C, etal., Am J Hypertens. 2010 Jun;23(6):681-6. doi: 10.1038/ajh.2010.34. Epub 2010 Mar 4.
34. Polymorphism in resistin promoter region at -420 determines the serum resistin levels and may be a risk marker of stroke in Japanese type 2 diabetic patients. Tsukahara T, etal., Diabetes Res Clin Pract. 2009 May;84(2):179-86. Epub 2009 Mar 6.
35. [The relationship between resistin and the peripheral neuropathy in type 2 diabetes]. Wang XH, etal., Zhonghua Yi Xue Za Zhi. 2007 Jul 3;87(25):1755-7.
36. A novel non-alcoholic steatohepatitis animal model featured with insulin resistance, hepatic inflammation and fibrosis. Zhao J, etal., Scand J Gastroenterol. 2010 Nov;45(11):1360-71. doi: 10.3109/00365521.2010.497938. Epub 2010 Jun 21.
Additional References at PubMed
PMID:8211113   PMID:10921885   PMID:11090083   PMID:11209052   PMID:11358969   PMID:11558907   PMID:11809189   PMID:11872692   PMID:11872693   PMID:11901161   PMID:11978666   PMID:11994397  
PMID:12050208   PMID:12213907   PMID:12213908   PMID:12477932   PMID:12502516   PMID:12504108   PMID:12647275   PMID:12660880   PMID:12679465   PMID:12700889   PMID:12730330   PMID:12829623  
PMID:12874180   PMID:12965109   PMID:12975309   PMID:14514348   PMID:14521959   PMID:14557464   PMID:14602788   PMID:14671216   PMID:14687894   PMID:14688155   PMID:14697240   PMID:14715842  
PMID:14733921   PMID:14740159   PMID:14967374   PMID:15055467   PMID:15064728   PMID:15070954   PMID:15111497   PMID:15130511   PMID:15221446   PMID:15248836   PMID:15326567   PMID:15338456  
PMID:15489334   PMID:15517149   PMID:15526156   PMID:15533384   PMID:15545519   PMID:15598689   PMID:15705777   PMID:15741250   PMID:15754730   PMID:15757855   PMID:15798953   PMID:15842513  
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PMID:28806778   PMID:28845746   PMID:28991224   PMID:29044636   PMID:29101068   PMID:29105498   PMID:29133417   PMID:29191223   PMID:29207892   PMID:29217361   PMID:29228527   PMID:29280648  
PMID:29324260   PMID:29361366   PMID:29363914   PMID:29384942   PMID:29386698   PMID:29442466   PMID:29465158   PMID:29469045   PMID:29561430   PMID:29566726   PMID:29584687   PMID:29604272  
PMID:29605824   PMID:29641286   PMID:29649030   PMID:29730230   PMID:29886799   PMID:29936463   PMID:29969661   PMID:29978502   PMID:30075966   PMID:30131543   PMID:30182920   PMID:30228288  
PMID:30273692   PMID:30292618   PMID:30360595   PMID:30406149   PMID:30410133   PMID:30447052   PMID:30517161   PMID:30563239   PMID:30631040   PMID:30638473   PMID:30778042   PMID:30799148  
PMID:30804122   PMID:30826699   PMID:30885017   PMID:30903575   PMID:31013606   PMID:31085453   PMID:31101494   PMID:31115876   PMID:31207150   PMID:31235129   PMID:31236417   PMID:31416473  
PMID:31433904   PMID:31484628   PMID:31566247   PMID:31645609   PMID:31719210   PMID:31734188   PMID:31820685   PMID:31842758   PMID:31891278   PMID:32000666   PMID:32048158   PMID:32112497  
PMID:32143662   PMID:32179245   PMID:32296183   PMID:32333593   PMID:32418972   PMID:32420377   PMID:32492888   PMID:32513696   PMID:32715745   PMID:32762639   PMID:32790946   PMID:32798443  
PMID:32804001   PMID:32822824   PMID:32876488   PMID:32988848   PMID:32991315   PMID:33089708   PMID:33185388   PMID:33247685   PMID:33269434   PMID:33271386   PMID:33313320   PMID:33318171  
PMID:33356858   PMID:33402915   PMID:33519717   PMID:33651847   PMID:33676378   PMID:33686181   PMID:33740002   PMID:33867330   PMID:33961781   PMID:33980047   PMID:34027809   PMID:34057280  
PMID:34062078   PMID:34082045   PMID:34126816   PMID:34235732   PMID:34292570   PMID:34373451   PMID:34462844   PMID:34509726   PMID:34603198   PMID:34628391   PMID:34717061   PMID:34842580  
PMID:34858392   PMID:34876619   PMID:34886472   PMID:34907604   PMID:35457109   PMID:35467263   PMID:35531645   PMID:35624126   PMID:35992125   PMID:36104403   PMID:36380110   PMID:36515343  
PMID:36619567   PMID:36719007   PMID:36841628   PMID:36867542   PMID:36927008   PMID:37031396   PMID:37202855   PMID:37293998   PMID:37382171   PMID:37516610   PMID:37646261   PMID:37897936  
PMID:38219167  


Genomics

Comparative Map Data
RETN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,669,049 - 7,670,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,669,049 - 7,670,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,733,935 - 7,735,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,639,972 - 7,641,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,639,971 - 7,641,340NCBI
Celera197,605,160 - 7,606,528 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,403,771 - 7,405,139 (+)NCBIHuRef
CHM1_1197,733,708 - 7,735,063 (+)NCBICHM1_1
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBIT2T-CHM13v2.0
Retn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,705,770 - 3,709,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,705,770 - 3,710,110 (+)EnsemblGRCm39 Ensembl
GRCm3883,655,770 - 3,659,818 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,655,770 - 3,660,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,655,789 - 3,658,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,655,789 - 3,658,096 (+)NCBIMGSCv36mm8
Celera83,886,118 - 3,888,425 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Retn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,508,653 - 6,511,115 (+)NCBIGRCr8
mRatBN7.2121,710,881 - 1,712,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,710,881 - 1,712,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,377,668 - 2,379,407 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,001,238 - 3,002,977 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,772,202 - 1,773,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,201,909 - 2,203,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,201,891 - 2,204,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,364,007 - 4,365,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,499,630 - 2,501,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,499,629 - 2,501,370 (-)NCBI
Celera123,566,836 - 3,568,576 (+)NCBICelera
Cytogenetic Map12p12NCBI
Retn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,607,814 - 1,609,273 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,607,814 - 1,609,273 (-)NCBIChiLan1.0ChiLan1.0
RETN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,339,693 - 12,341,193 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,457,254 - 11,458,754 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,958,536 - 6,960,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,812,942 - 7,814,909 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,812,942 - 7,814,909 (+)Ensemblpanpan1.1panPan2
RETN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,434,148 - 52,435,627 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,434,271 - 52,435,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,238,221 - 52,239,712 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,963,476 - 52,964,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,963,614 - 52,964,967 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,167,243 - 52,168,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,610,828 - 52,612,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,842,073 - 52,843,564 (+)NCBIUU_Cfam_GSD_1.0
Retn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,128,130 - 213,129,482 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,705,119 - 4,706,656 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,705,295 - 4,706,653 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RETN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,484,169 - 71,485,616 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,484,164 - 71,485,577 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,871,237 - 71,872,650 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21NCBI
RETN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,154,771 - 7,156,459 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,155,337 - 7,156,505 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081704,895 - 706,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Retn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828735,503 - 737,166 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828735,562 - 737,166 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RETN
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_020415.4(RETN):c.*62G>A single nucleotide variant Diabetes mellitus type 2, susceptibility to [RCV000005160]|HYPERTENSION, INSULIN RESISTANCE-RELATED, SUSCEPTIBILITY TO [RCV000005161] Chr19:7670411 [GRCh38]
Chr19:7735297 [GRCh37]
Chr19:19p13.2
risk factor
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3 copy number gain See cases [RCV000052879] Chr19:1972245..9648879 [GRCh38]
Chr19:1972244..9759555 [GRCh37]
Chr19:1923244..9620555 [NCBI36]
Chr19:19p13.3-13.2
pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:4039158-9176125)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052881]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052881]|See cases [RCV000052881] Chr19:4039158..9176125 [GRCh38]
Chr19:4039156..9286801 [GRCh37]
Chr19:3990156..9147801 [NCBI36]
Chr19:19p13.3-13.2
pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2
pathogenic
GRCh38/hg38 19p13.2(chr19:7194917-7827432)x3 copy number gain See cases [RCV000054108] Chr19:7194917..7827432 [GRCh38]
Chr19:7194928..7892318 [GRCh37]
Chr19:7145928..7798318 [NCBI36]
Chr19:19p13.2
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-13.2(chr19:3120160-9732820)x3 copy number gain not provided [RCV000684096] Chr19:3120160..9732820 [GRCh37]
Chr19:19p13.3-13.2
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NC_000019.9:g.(?_7587617)_(8373194_?)dup duplication Familial hemophagocytic lymphohistiocytosis 5 [RCV001031629] Chr19:7587617..8373194 [GRCh37]
Chr19:19p13.2
uncertain significance
GRCh37/hg19 19p13.2(chr19:7657490-8569762)x3 copy number gain not provided [RCV001007030] Chr19:7657490..8569762 [GRCh37]
Chr19:19p13.2
uncertain significance
NC_000019.9:g.(?_7586521)_(8670595_?)dup duplication Mucolipidosis type IV [RCV003109714] Chr19:7586521..8670595 [GRCh37]
Chr19:19p13.2
uncertain significance
NC_000019.9:g.(?_6361586)_(8212364_?)del deletion Mucolipidosis type IV [RCV003109715] Chr19:6361586..8212364 [GRCh37]
Chr19:19p13.3-13.2
pathogenic
NM_020415.4(RETN):c.127G>A (p.Ala43Thr) single nucleotide variant Inborn genetic diseases [RCV002830481] Chr19:7669829 [GRCh38]
Chr19:7734715 [GRCh37]
Chr19:19p13.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:630
Count of miRNA genes:335
Interacting mature miRNAs:354
Transcripts:ENST00000221515, ENST00000381324
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
UniSTS:483335  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37197,733,989 - 7,735,309UniSTSGRCh37
Celera197,605,177 - 7,606,497UniSTS
HuRef197,403,788 - 7,405,108UniSTS
UniSTS:480729  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37197,733,972 - 7,735,285UniSTSGRCh37
Celera197,605,160 - 7,606,473UniSTS
HuRef197,403,771 - 7,405,084UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 30 32 1
Medium 22 761 36 21 955 17 55 18 11 4 27 569 4 76 13
Low 988 1147 761 247 259 171 1885 761 851 149 558 485 76 937 1139 2
Below cutoff 887 742 622 216 149 163 1502 949 1683 147 507 256 55 1 153 1123 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001193374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB111910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF290874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF323081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY207314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ301958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ604897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OR399980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000221515   ⟹   ENSP00000221515
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl197,669,049 - 7,670,455 (+)Ensembl
RefSeq Acc Id: ENST00000381324   ⟹   ENSP00000370725
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl197,669,327 - 7,670,349 (+)Ensembl
RefSeq Acc Id: ENST00000629642   ⟹   ENSP00000485998
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl197,669,086 - 7,670,454 (+)Ensembl
RefSeq Acc Id: NM_001193374   ⟹   NP_001180303
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,670,455 (+)NCBI
GRCh37197,733,972 - 7,735,340 (+)ENTREZGENE
HuRef197,403,771 - 7,405,139 (+)ENTREZGENE
CHM1_1197,733,708 - 7,735,063 (+)NCBI
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001385725   ⟹   NP_001372654
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,670,455 (+)NCBI
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001385726   ⟹   NP_001372655
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,670,455 (+)NCBI
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001385727   ⟹   NP_001372656
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,670,455 (+)NCBI
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020415   ⟹   NP_065148
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,670,455 (+)NCBI
GRCh37197,733,972 - 7,735,340 (+)ENTREZGENE
Build 36197,639,972 - 7,641,340 (+)NCBI Archive
HuRef197,403,771 - 7,405,139 (+)ENTREZGENE
CHM1_1197,733,708 - 7,735,063 (+)NCBI
T2T-CHM13v2.0197,669,929 - 7,671,334 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001180303 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372654 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372655 (Get FASTA)   NCBI Sequence Viewer  
  NP_001372656 (Get FASTA)   NCBI Sequence Viewer  
  NP_065148 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG02144 (Get FASTA)   NCBI Sequence Viewer  
  AAG59824 (Get FASTA)   NCBI Sequence Viewer  
  AAH69302 (Get FASTA)   NCBI Sequence Viewer  
  AAI01555 (Get FASTA)   NCBI Sequence Viewer  
  AAI01561 (Get FASTA)   NCBI Sequence Viewer  
  AAK18621 (Get FASTA)   NCBI Sequence Viewer  
  AAK83106 (Get FASTA)   NCBI Sequence Viewer  
  AAO38860 (Get FASTA)   NCBI Sequence Viewer  
  AAQ89425 (Get FASTA)   NCBI Sequence Viewer  
  ABB96251 (Get FASTA)   NCBI Sequence Viewer  
  BAD04068 (Get FASTA)   NCBI Sequence Viewer  
  EAW69015 (Get FASTA)   NCBI Sequence Viewer  
  EAW69016 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000221515
  ENSP00000221515.1
  ENSP00000370725.2
  ENSP00000485998
  ENSP00000485998.1
GenBank Protein Q9HD89 (Get FASTA)   NCBI Sequence Viewer  
  UXX61743 (Get FASTA)   NCBI Sequence Viewer  
  UXX61744 (Get FASTA)   NCBI Sequence Viewer  
  UXX61745 (Get FASTA)   NCBI Sequence Viewer  
  UXX61746 (Get FASTA)   NCBI Sequence Viewer  
  UXX61747 (Get FASTA)   NCBI Sequence Viewer  
  UXX61748 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_065148   ⟸   NM_020415
- Peptide Label: isoform a precursor
- UniProtKB: Q540D9 (UniProtKB/Swiss-Prot),   D6W649 (UniProtKB/Swiss-Prot),   Q76B53 (UniProtKB/Swiss-Prot),   Q9HD89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001180303   ⟸   NM_001193374
- Peptide Label: isoform a precursor
- UniProtKB: Q540D9 (UniProtKB/Swiss-Prot),   D6W649 (UniProtKB/Swiss-Prot),   Q76B53 (UniProtKB/Swiss-Prot),   Q9HD89 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000485998   ⟸   ENST00000629642
RefSeq Acc Id: ENSP00000221515   ⟸   ENST00000221515
RefSeq Acc Id: ENSP00000370725   ⟸   ENST00000381324
RefSeq Acc Id: NP_001372655   ⟸   NM_001385726
- Peptide Label: isoform b precursor
RefSeq Acc Id: NP_001372656   ⟸   NM_001385727
- Peptide Label: isoform c precursor
RefSeq Acc Id: NP_001372654   ⟸   NM_001385725
- Peptide Label: isoform a precursor
- UniProtKB: Q9HD89 (UniProtKB/Swiss-Prot),   Q540D9 (UniProtKB/Swiss-Prot),   D6W649 (UniProtKB/Swiss-Prot),   Q76B53 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HD89-F1-model_v2 AlphaFold Q9HD89 1-108 view protein structure

Promoters
RGD ID:6795986
Promoter ID:HG_KWN:28724
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000381324,   NM_020415,   UC002MHG.1,   UC010DVM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36197,639,711 - 7,640,211 (+)MPROMDB
RGD ID:7238309
Promoter ID:EPDNEW_H24900
Type:initiation region
Name:RETN_1
Description:resistin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24901  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,049 - 7,669,109EPDNEW
RGD ID:7238311
Promoter ID:EPDNEW_H24901
Type:multiple initiation site
Name:RETN_2
Description:resistin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24900  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38197,669,310 - 7,669,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20389 AgrOrtholog
COSMIC RETN COSMIC
Ensembl Genes ENSG00000104918 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000221515 ENTREZGENE
  ENST00000221515.6 UniProtKB/Swiss-Prot
  ENST00000381324.2 UniProtKB/Swiss-Prot
  ENST00000629642 ENTREZGENE
  ENST00000629642.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.4230 UniProtKB/Swiss-Prot
GTEx ENSG00000104918 GTEx
HGNC ID HGNC:20389 ENTREZGENE
Human Proteome Map RETN Human Proteome Map
InterPro Resistin UniProtKB/Swiss-Prot
  Resistin-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:56729 UniProtKB/Swiss-Prot
NCBI Gene 56729 ENTREZGENE
OMIM 605565 OMIM
PANTHER PTHR21101 UniProtKB/Swiss-Prot
  RESISTIN UniProtKB/Swiss-Prot
Pfam Resistin UniProtKB/Swiss-Prot
PharmGKB PA422 PharmGKB
Superfamily-SCOP SSF111423 UniProtKB/Swiss-Prot
UniProt D6W649 ENTREZGENE
  Q540D9 ENTREZGENE
  Q76B53 ENTREZGENE
  Q9HD89 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D6W649 UniProtKB/Swiss-Prot
  Q540D9 UniProtKB/Swiss-Prot
  Q76B53 UniProtKB/Swiss-Prot