Pycard (PYD and CARD domain containing) - Rat Genome Database

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Gene: Pycard (PYD and CARD domain containing) Rattus norvegicus
Analyze
Symbol: Pycard
Name: PYD and CARD domain containing
RGD ID: 628637
Description: Enables protease binding activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; regulation of cytokine production; and regulation of signal transduction. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of cytokine production; and regulation of autophagy. Located in cytoplasm and neuronal cell body. Part of NLRP1 inflammasome complex. Orthologous to human PYCARD (PYD and CARD domain containing); PARTICIPATES IN interleukin-1 signaling pathway; influenza A pathway; NOD-like receptor signaling pathway; INTERACTS WITH (R)-carnitine; (S)-colchicine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apoptosis-associated speck-like protein containing a CARD; Asc
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,032,124 - 192,033,419 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,032,124 - 192,033,419 (-)EnsemblGRCr8
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,252,771 - 180,253,804 (-)NCBICelera
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
acetamide  (EXP)
acetate ester  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP,ISO)
allyl methyl disulfide  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
anthocyanin  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
baicalin  (ISO)
Bavachinin  (ISO)
bellidifolin  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-cyclodextrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chlorquinaldol  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corilagin  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
dieldrin  (EXP)
dimethyl fumarate  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ergosterol  (EXP)
ethanol  (EXP,ISO)
Evodiamine  (EXP)
febuxostat  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furfural  (ISO)
galangin  (EXP)
gallic acid  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
icariin  (EXP)
indometacin  (ISO)
iohexol  (ISO)
iron dextran  (EXP)
isobutanol  (ISO)
isoflurane  (EXP,ISO)
kaempferol  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonidamine  (ISO)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (ISO)
magnesium dihydroxide  (ISO)
malvidin  (ISO)
melatonin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
microcystin-LR  (ISO)
minocycline  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
Neoisoliquiritin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nigericin  (EXP,ISO)
nitrofen  (EXP)
NMN zwitterion  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paeoniflorin  (ISO)
Palbinone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosgene  (EXP)
pirinixic acid  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
procyanidin B2  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
Ruscogenin  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
Salidroside  (EXP,ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
tabersonine  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)
water  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IBA,IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (ISO)
defense response to virus  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IBA,IEA,ISO)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway  (IBA)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
macropinocytosis  (IEA,ISO)
myeloid dendritic cell activation  (IEA,ISO)
myeloid dendritic cell activation involved in immune response  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of interferon-beta production  (IEA,ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
NLRP3 inflammasome complex assembly  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of adaptive immune response  (IEA,ISO)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of defense response to virus by host  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of T cell migration  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
protein homooligomerization  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of autophagy  (ISO)
regulation of inflammatory response  (IEA,ISO)
regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
regulation of protein stability  (IEA,ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
response to bacterium  (ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury. Choudhury A, etal., Alcohol Clin Exp Res. 2020 Jun;44(6):1300-1311. doi: 10.1111/acer.14338. Epub 2020 May 18.
2. Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. de Rivero Vaccari JP, etal., J Cereb Blood Flow Metab. 2009 Jul;29(7):1251-61. Epub 2009 Apr 29.
3. A molecular platform in neurons regulates inflammation after spinal cord injury. de Rivero Vaccari JP, etal., J Neurosci. 2008 Mar 26;28(13):3404-14.
4. Immunological and inflammatory functions of the interleukin-1 family. Dinarello CA Annu Rev Immunol. 2009;27:519-50.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Masumoto J, etal., Exp Cell Res 2001 Jan 15;262(2):128-33.
7. Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. Masumoto J, etal., J Biol Chem 2003 Feb 7;278(6):4268-76.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
13. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. Silverman WR, etal., J Biol Chem. 2009 Jul 3;284(27):18143-51. Epub 2009 May 5.
Additional References at PubMed
PMID:12191486   PMID:12486103   PMID:12646168   PMID:12656673   PMID:14730312   PMID:15030775   PMID:15190255   PMID:15817483   PMID:16585594   PMID:16964285   PMID:16982856   PMID:17008311  
PMID:19158675   PMID:19158676   PMID:19158679   PMID:19494289   PMID:21487011   PMID:21575908   PMID:21892172   PMID:22002608   PMID:22267217   PMID:22297845   PMID:22732093   PMID:23229815  
PMID:23302887   PMID:23997220   PMID:24287373   PMID:24407287   PMID:24531343   PMID:24581500   PMID:24630722   PMID:25006247   PMID:25416956   PMID:29884910   PMID:37549514  


Genomics

Comparative Map Data
Pycard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,032,124 - 192,033,419 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,032,124 - 192,033,419 (-)EnsemblGRCr8
mRatBN7.21182,601,657 - 182,603,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,952,277 - 190,953,310 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,138,364 - 198,139,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,808,830 - 190,809,863 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,438,029 - 199,439,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,460,883 - 206,461,916 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,276,089 - 187,277,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,252,771 - 180,253,804 (-)NCBICelera
RGSC_v3.11187,425,969 - 187,427,003 (-)NCBI
Cytogenetic Map1q37NCBI
PYCARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,201,486 - 31,202,760 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,201,486 - 31,203,450 (-)Ensemblhg38GRCh38
GRCh371631,212,807 - 31,214,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,120,308 - 31,121,752 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1629,083,777 - 29,085,221 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,774,423 - 28,775,713 (-)NCBIHuRef
CHM1_11632,530,520 - 32,531,810 (-)NCBICHM1_1
T2T-CHM13v2.01631,588,907 - 31,590,181 (-)NCBIT2T-CHM13v2.0
Pycard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,590,545 - 127,593,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,588,880 - 127,593,039 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387127,991,373 - 127,993,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,989,708 - 127,993,867 (-)Ensemblmm10GRCm38
MGSCv377135,134,887 - 135,137,381 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367127,783,251 - 127,784,895 (-)NCBIMGSCv36mm8
Celera7127,826,342 - 127,828,839 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.88NCBI
PYCARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,409,182 - 34,410,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,210,581 - 39,211,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,764,386 - 23,765,732 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,572,332 - 31,573,828 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,571,363 - 31,573,828 (-)EnsemblpanPan2panpan1.1
PYCARD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,049,352 - 17,051,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,049,705 - 17,051,240 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha618,624,878 - 18,626,631 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0617,180,447 - 17,182,202 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,180,546 - 17,182,254 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,980,664 - 16,982,415 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,899,792 - 16,901,536 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,211,709 - 17,213,472 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pycard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,452,827 - 125,454,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,550,679 - 13,552,805 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,550,702 - 13,552,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYCARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,306,099 - 17,307,786 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1317,305,921 - 17,307,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,564,758 - 17,566,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYCARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,892,332 - 27,894,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,889,230 - 27,893,697 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660681,569,924 - 1,571,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pycard
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,247,864 - 14,249,000 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478214,247,333 - 14,249,861 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pycard
1 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000026699
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
BI282953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,601,782 - 182,601,936 (+)MAPPERmRatBN7.2
Rnor_6.01199,438,072 - 199,438,225NCBIRnor6.0
Rnor_5.01206,460,926 - 206,461,079UniSTSRnor5.0
RGSC_v3.41187,276,132 - 187,276,285UniSTSRGSC3.4
Celera1180,252,814 - 180,252,967UniSTS
RH 3.4 Map11417.41UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000026699   ⟹   ENSRNOP00000026699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,032,124 - 192,033,419 (-)Ensembl
mRatBN7.2 Ensembl1182,601,174 - 182,602,955 (-)Ensembl
Rnor_6.0 Ensembl1199,437,832 - 199,439,210 (-)Ensembl
RefSeq Acc Id: NM_172322   ⟹   NP_758825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,032,124 - 192,033,419 (-)NCBI
mRatBN7.21182,601,657 - 182,602,952 (-)NCBI
Rnor_6.01199,438,029 - 199,439,062 (-)NCBI
Rnor_5.01206,460,883 - 206,461,916 (-)NCBI
RGSC_v3.41187,276,089 - 187,277,122 (-)RGD
Celera1180,252,771 - 180,253,804 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_758825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC43754 (Get FASTA)   NCBI Sequence Viewer  
  EDM17200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026699
  ENSRNOP00000026699.3
RefSeq Acc Id: NP_758825   ⟸   NM_172322
- UniProtKB: A6I9Y0 (UniProtKB/TrEMBL),   Q8CHK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026699   ⟸   ENSRNOT00000026699
Protein Domains
CARD   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8L1-F1-model_v2 AlphaFold G3V8L1 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690449
Promoter ID:EPDNEW_R974
Type:initiation region
Name:Pycard_1
Description:PYD and CARD domain containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,439,241 - 199,439,301EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628637 AgrOrtholog
BioCyc Gene G2FUF-57325 BioCyc
Ensembl Genes ENSRNOG00000019675 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026699 ENTREZGENE
  ENSRNOT00000026699.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  NLRP_Inflammasome UniProtKB/TrEMBL
  Pyrin UniProtKB/TrEMBL
KEGG Report rno:282817 UniProtKB/TrEMBL
NCBI Gene 282817 ENTREZGENE
PANTHER APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  PAAD_DAPIN UniProtKB/TrEMBL
PhenoGen Pycard PhenoGen
PROSITE CARD UniProtKB/TrEMBL
  DAPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019675 RatGTEx
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt A6I9Y0 ENTREZGENE, UniProtKB/TrEMBL
  G3V8L1_RAT UniProtKB/TrEMBL
  Q8CHK8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Pycard  PYD and CARD domain containing    apoptosis-associated speck-like protein containing a CARD  Name updated 1299863 APPROVED
2004-09-10 Pycard  apoptosis-associated speck-like protein containing a CARD  Asc    Symbol and Name updated 1299863 APPROVED
2003-02-27 Asc  apoptosis-associated speck-like protein containing a CARD      Symbol and Name status set to provisional 70820 PROVISIONAL