Rheb (Ras homolog, mTORC1 binding) - Rat Genome Database

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Gene: Rheb (Ras homolog, mTORC1 binding) Rattus norvegicus
Analyze
Symbol: Rheb
Name: Ras homolog, mTORC1 binding
RGD ID: 621840
Description: Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in regulation of postsynapse organization and small GTPase-mediated signal transduction. Located in dendrite and neuronal cell body. Is active in glutamatergic synapse. Orthologous to human RHEB (Ras homolog, mTORC1 binding); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; Rheb mediated signaling pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTP-binding protein Rheb; Ras homolog enriched in brain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,012,173 - 11,053,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,012,643 - 11,053,931 (+)EnsemblGRCr8
mRatBN7.2410,278,970 - 10,320,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,278,765 - 15,319,243 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,093,025 - 11,133,503 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,445,606 - 9,486,084 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,827,429 - 6,873,384 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)Ensemblrn6Rnor6.0
Rnor_5.046,843,897 - 6,889,004 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera43,156 - 43,581 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
Allylamine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lonafarnib  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Rheb family of GTP-binding proteins. Aspuria PJ and Tamanoi F, Cell Signal. 2004 Oct;16(10):1105-12.
2. Regulation of mTORC1 by PI3K signaling. Dibble CC and Cantley LC, Trends Cell Biol. 2015 Sep;25(9):545-55. doi: 10.1016/j.tcb.2015.06.002. Epub 2015 Jul 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, etal., J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.
6. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
7. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
8. Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Meng W, etal., Diabetes. 2017 May;66(5):1198-1213. doi: 10.2337/db16-0886. Epub 2017 Feb 27.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. Takei N, etal., J Neurosci. 2004 Nov 3;24(44):9760-9.
16. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Tzatsos A and Kandror KV, Mol Cell Biol. 2006 Jan;26(1):63-76.
17. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. Yamagata K, etal., J Biol Chem 1994 Jun 10;269(23):16333-9.
18. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Yasuda S, etal., Sci Rep. 2014 Jun 3;4:5155. doi: 10.1038/srep05155.
Additional References at PubMed
PMID:11555636   PMID:12477932   PMID:15489334   PMID:15728574   PMID:17074751   PMID:18722381   PMID:18842593   PMID:19056867   PMID:19258434   PMID:19636840   PMID:20381137   PMID:20458337  
PMID:21336308   PMID:22294621   PMID:23376485   PMID:25385233   PMID:25411504   PMID:25880340   PMID:26245968   PMID:27865617   PMID:27898073   PMID:28025572   PMID:29287199   PMID:30053369  
PMID:34673407  


Genomics

Comparative Map Data
Rheb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,012,173 - 11,053,860 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,012,643 - 11,053,931 (+)EnsemblGRCr8
mRatBN7.2410,278,970 - 10,320,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,278,765 - 15,319,243 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,093,025 - 11,133,503 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,445,606 - 9,486,084 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,827,429 - 6,873,384 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)Ensemblrn6Rnor6.0
Rnor_5.046,843,897 - 6,889,004 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera43,156 - 43,581 (-)NCBICelera
Cytogenetic Map4q11NCBI
RHEB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,466,012 - 151,519,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,466,012 - 151,520,120 (-)Ensemblhg38GRCh38
GRCh377151,163,098 - 151,216,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,794,031 - 150,847,943 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347150,601,443 - 150,654,657NCBI
Celera7145,720,573 - 145,774,491 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,974,671 - 145,028,586 (-)NCBIHuRef
CHM1_17151,171,499 - 151,225,408 (-)NCBICHM1_1
T2T-CHM13v2.07152,638,843 - 152,692,729 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,492,679 - 150,546,598 (-)NCBI
Rheb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,007,821 - 25,047,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,007,821 - 25,047,622 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl525,027,840 - 25,047,856 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38524,802,823 - 24,842,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,802,823 - 24,842,624 (-)Ensemblmm10GRCm38
MGSCv37524,308,641 - 24,348,179 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36524,312,888 - 24,352,426 (-)NCBIMGSCv36mm8
Celera521,753,578 - 21,793,634 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.93NCBI
Rheb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,794,911 - 5,834,912 (-)Ensembl
ChiLan1.0NW_0049554915,795,040 - 5,833,897 (-)NCBIChiLan1.0ChiLan1.0
RHEB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,889,998 - 187,943,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,900,264 - 39,953,504 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07143,054,747 - 143,108,011 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17155,203,244 - 155,235,404 (-)NCBIPanPan1.1PanPan1.1panPan2
RHEB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,439,910 - 15,483,489 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,434,111 - 15,483,419 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1616,047,342 - 16,090,853 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01617,162,021 - 17,205,547 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1617,156,207 - 17,205,573 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,534,296 - 15,577,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,115,524 - 16,159,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,166,245 - 16,209,781 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rheb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,025,492 - 6,071,143 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,832,169 - 6,878,164 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,832,286 - 6,877,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHEB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl185,779,212 - 5,822,257 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1185,779,439 - 5,821,839 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,029,721 - 6,072,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHEB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,652,692 - 119,704,833 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,652,127 - 119,703,458 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607215,623,250 - 15,675,215 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rheb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,221,605 - 5,264,965 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248005,221,630 - 5,262,980 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rheb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16153,994,337 - 154,034,854 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rheb
167 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:278
Count of miRNA genes:207
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000071737
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RHEB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,319,613 - 10,319,858 (+)MAPPERmRatBN7.2
Rnor_6.046,872,910 - 6,873,154NCBIRnor6.0
Rnor_5.046,888,530 - 6,888,774UniSTSRnor5.0
Celera43,386 - 3,630UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071737   ⟹   ENSRNOP00000063915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,013,124 - 11,053,931 (+)Ensembl
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)Ensembl
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108274   ⟹   ENSRNOP00000083387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,027,265 - 11,053,931 (+)Ensembl
mRatBN7.2 Ensembl410,291,585 - 10,320,160 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113919   ⟹   ENSRNOP00000086692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,014,549 - 11,053,931 (+)Ensembl
mRatBN7.2 Ensembl410,279,973 - 10,320,160 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114997   ⟹   ENSRNOP00000095272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,013,124 - 11,053,931 (+)Ensembl
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121312   ⟹   ENSRNOP00000105876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,012,643 - 11,053,931 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144263   ⟹   ENSRNOP00000105653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,013,278 - 11,053,871 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154927   ⟹   ENSRNOP00000104927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,013,408 - 11,053,931 (+)Ensembl
RefSeq Acc Id: NM_013216   ⟹   NP_037348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,013,383 - 11,053,860 (+)NCBI
mRatBN7.2410,279,606 - 10,320,088 (+)NCBI
Rnor_6.046,827,429 - 6,873,384 (+)NCBI
Rnor_5.046,843,897 - 6,889,004 (+)NCBI
Celera43,156 - 43,581 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285650   ⟹   XP_063141720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,012,173 - 11,053,391 (+)NCBI
RefSeq Acc Id: NP_037348   ⟸   NM_013216
- UniProtKB: Q62639 (UniProtKB/Swiss-Prot),   A6KJH3 (UniProtKB/TrEMBL),   M0R3K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063915   ⟸   ENSRNOT00000071737
Ensembl Acc Id: ENSRNOP00000095272   ⟸   ENSRNOT00000114997
Ensembl Acc Id: ENSRNOP00000086692   ⟸   ENSRNOT00000113919
Ensembl Acc Id: ENSRNOP00000083387   ⟸   ENSRNOT00000108274
RefSeq Acc Id: XP_063141720   ⟸   XM_063285650
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000105876   ⟸   ENSRNOT00000121312
Ensembl Acc Id: ENSRNOP00000105653   ⟸   ENSRNOT00000144263
Ensembl Acc Id: ENSRNOP00000104927   ⟸   ENSRNOT00000154927

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62639-F1-model_v2 AlphaFold Q62639 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692784
Promoter ID:EPDNEW_R3307
Type:initiation region
Name:Rheb_1
Description:Ras homolog, mTORC1 binding
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.046,827,394 - 6,827,454EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621840 AgrOrtholog
BioCyc Gene G2FUF-46063 BioCyc
Ensembl Genes ENSRNOG00000050578 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071737 ENTREZGENE
  ENSRNOT00000071737.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7307969 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
KEGG Report rno:26954 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105484 IMAGE-MGC_LOAD
NCBI Gene 26954 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rheb PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050578 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZVS8_RAT UniProtKB/TrEMBL
  A0A8I6A6R1_RAT UniProtKB/TrEMBL
  A0A8I6AN58_RAT UniProtKB/TrEMBL
  A0ABK0L6N4_RAT UniProtKB/TrEMBL
  A0ABK0LHK2_RAT UniProtKB/TrEMBL
  A0ABK0LLQ2_RAT UniProtKB/TrEMBL
  A6KJH2_RAT UniProtKB/TrEMBL
  A6KJH3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJH4_RAT UniProtKB/TrEMBL
  A6KJH5_RAT UniProtKB/TrEMBL
  M0R3K1 ENTREZGENE, UniProtKB/TrEMBL
  Q62639 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Rheb  Ras homolog, mTORC1 binding  Rheb  Ras homolog enriched in brain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rheb  Ras homolog enriched in brain      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rheb  Ras homolog enriched in brain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression increases in response to seizures and to NMDA-dependent synaptic activity 729721