RHEB (Ras homolog, mTORC1 binding)

Gene: RHEB (Ras homolog, mTORC1 binding) Pan paniscus

Analyze

Symbol:

RHEB

Name:

Ras homolog, mTORC1 binding

RGD ID:

11727190

Description:

ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN cellular response to nutrient levels (ortholog); negative regulation of cold-induced thermogenesis (ortholog); oligodendrocyte differentiation (ortholog); PARTICIPATES IN mTOR signaling pathway; Rheb mediated signaling pathway; ASSOCIATED WITH epilepsy (ortholog); Hemimegalencephaly (ortholog); lethal congenital glycogen storage disease of heart (ortholog); FOUND IN dendrite (ortholog); endomembrane system (ortholog); glutamatergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GTP-binding protein Rheb; LOC100974009; Ras homolog enriched in brain

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,889,998 - 187,943,262 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,900,264 - 39,953,504 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	143,054,747 - 143,108,011 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	155,203,244 - 155,235,404 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

Hemimegalencephaly (ISO)

lethal congenital glycogen storage disease of heart (ISO)

long QT syndrome (ISO)

lung non-small cell carcinoma (ISO)

papillary renal cell carcinoma (ISO)

renal cell carcinoma (ISO)

Renal Cell Carcinoma 1 (ISO)

Sporadic Papillary Renal Cell Carcinoma (ISO)

transitional cell carcinoma (ISO)

uterine cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to nutrient levels (ISO)

negative regulation of cold-induced thermogenesis (ISO)

oligodendrocyte differentiation (ISO)

positive regulation of oligodendrocyte differentiation (ISO)

positive regulation of TOR signaling (ISO)

positive regulation of TORC1 signaling (ISO)

regulation of postsynapse organization (ISO)

regulation of TOR signaling (ISO)

regulation of type B pancreatic cell development (ISO)

signal transduction (IEA)

small GTPase-mediated signal transduction (IEA,ISO)

Cellular Component

dendrite (ISO)

endomembrane system (ISO)

glutamatergic synapse (ISO)

Golgi membrane (ISO)

lysosomal membrane (ISO)

membrane (IEA)

neuronal cell body (ISO)

plasma membrane (IEA)

postsynaptic density (ISO)

spliceosomal complex (ISO)

synapse (ISO)

Molecular Function

GDP binding (IEA,ISO)

GTP binding (IEA,ISO)

GTPase activity (IEA,ISO)

magnesium ion binding (ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activator activity (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

Rheb mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RHEB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,889,998 - 187,943,262 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,900,264 - 39,953,504 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	143,054,747 - 143,108,011 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	155,203,244 - 155,235,404 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

RHEB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	151,466,012 - 151,519,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	151,466,012 - 151,520,120 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	151,163,098 - 151,216,981 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,794,031 - 150,847,943 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	150,601,443 - 150,654,657	NCBI
Celera	7	145,720,573 - 145,774,491 (-)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,974,671 - 145,028,586 (-)	NCBI		HuRef
CHM1_1	7	151,171,499 - 151,225,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,638,843 - 152,692,729 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	150,492,679 - 150,546,598 (-)	NCBI

Rheb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	25,007,821 - 25,047,359 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	25,007,821 - 25,047,622 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	24,802,823 - 24,842,361 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	24,802,823 - 24,842,624 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	24,308,641 - 24,348,179 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	24,312,888 - 24,352,426 (-)	NCBI		MGSCv36	mm8
Celera	5	21,753,578 - 21,793,634 (-)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	11.93	NCBI

Rheb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,012,173 - 11,053,860 (+)	NCBI		GRCr8
mRatBN7.2	4	10,278,970 - 10,320,160 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,279,370 - 10,320,160 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	15,278,765 - 15,319,243 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,093,025 - 11,133,503 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	9,445,606 - 9,486,084 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	6,827,429 - 6,873,384 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	6,827,429 - 6,873,383 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	6,843,897 - 6,889,004 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	4	3,156 - 43,581 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

Rheb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,794,911 - 5,834,912 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	5,795,040 - 5,833,897 (-)	NCBI	ChiLan1.0	ChiLan1.0

RHEB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	15,439,910 - 15,483,489 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	15,434,111 - 15,483,419 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	16,047,342 - 16,090,853 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	17,162,021 - 17,205,547 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	17,156,207 - 17,205,573 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,534,296 - 15,577,817 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	16,115,524 - 16,159,011 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	16,166,245 - 16,209,781 (-)	NCBI		UU_Cfam_GSD_1.0

Rheb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,025,492 - 6,071,143 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,832,169 - 6,878,164 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,832,286 - 6,877,938 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHEB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	5,779,212 - 5,822,257 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	5,779,439 - 5,821,839 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,029,721 - 6,072,123 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RHEB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,652,692 - 119,704,833 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,652,127 - 119,703,458 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	15,623,250 - 15,675,215 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rheb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,221,605 - 5,264,965 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	5,221,630 - 5,262,980 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003815089 ⟹ XP_003815137

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	187,889,998 - 187,942,555 (-)	NCBI
NHGRI_mPanPan1	7	39,900,264 - 39,931,782 (-)	NCBI
Mhudiblu_PPA_v0	7	143,054,747 - 143,086,221 (-)	NCBI
PanPan1.1	7	155,203,244 - 155,235,404 (-)	NCBI

Sequence:

show sequence

TCAAGCCAGGACCTACGCACCTGTTGTCAGTGGTGTTATAGTTCTGCAGGGCGCACAGGTGCAT
CCCCATGGGCACATTTAATTTAGGGAAATCCTCATTGACGATTCAGTTTGTTGAAGGCCAATTT
GTGGACTCCTACGATCCAACCATAGAAAACACTTTTACAAAGTTGATCACAGTAAATGGACAAG
AATATCATCTTCAACTTGTAGACACAGCCGGGCAAGATGAATATTCTATCTTTCCTCAGACATA
CTCCATAGATATTAATGGCTATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTG
ATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGGGAAAGTACAAATACCTATTATGTTGG
TTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGC
AGAATCTTGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTT
TTTCGAAGGATAATTTTGGAGGCAGAAAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCAT
GCTCGGTGATGTGATGCTGCTGCAAAGCCCGAGGACACTGGGAATATATTCTACCTGAAGAAGC
AAACTGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGATAT
CATTTGGGTCAGAGCTCCCCTCCCTTCAGATTATGTTAACTCTGAGTCTGTCCAAATGAGTTCA
CTTCCATTTTCAAATTTTAAGCAATCATATTTTCAATTTATATATTGTATTTCTTAATATTATG
ACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAAATAATGTAATCATCA
AAATGATGCATATTGTTACACTACTATTAACTGGGCTTCAATATATCAGTGTTTATTTCATTGT
GTTAAATGTATACTTGTAAATAAAATAGCTGCAAACCTCAGTCCTTTGTGCTACTTGATGTGGC
TTTCAGAGAAGAGAAGCCTTGTCCTGAGTTTCTCACTTGGCTTCAGGAAGGCCCCAGGTTGGAT
TCCAGAAACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGTGCTGACCGTGGACT
CCCTGCGCAGTGGCCTGCAGATGTTGGGGCTGGGTTACAGCTGATTGAAGCTGAGTGGCCCTGG
GGGGTCTGTGAGGGCAGTTCCTCCCCAGTGATGAGATTCTCTCCTTCCACCCTCAAATCCCGAG
ACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGCTGCTGAGAGGCATT
GTTCGCCCTTGCTCATAGCTTAGCTCGATGTCCGTGTCCGACAGGAGACGATTGAGAACAGCCT
TGCCTGTCACTGTCCTAGAACACCCTGGAGTTTAGTGTTCTGTGTCAGGGTCTTGGGAGCCTCC
TTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAGCAGCTGTAAAGGAGAAGAGGGATTTC
ATTTGTTTGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAAC
GATTCCCTTTTGCAGCTAAAATTTCACAGGGCTATTTCTAATACGTAAGCAAATGTTACCGTTG
ACTTTATTAATAAAATATAGTTTTGCTTTGCA

hide sequence

RefSeq Acc Id:

XM_034965278 ⟹ XP_034821169

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	187,889,998 - 187,943,262 (-)	NCBI
NHGRI_mPanPan1	7	39,900,264 - 39,953,504 (-)	NCBI
Mhudiblu_PPA_v0	7	143,054,747 - 143,108,011 (-)	NCBI

RefSeq Acc Id:

XM_063606424 ⟹ XP_063462494

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	187,889,998 - 187,942,389 (-)	NCBI

RefSeq Acc Id:

XM_063606425 ⟹ XP_063462495

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	187,889,998 - 187,941,253 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003815137	(Get FASTA)	NCBI Sequence Viewer
	XP_034821169	(Get FASTA)	NCBI Sequence Viewer
	XP_063462494	(Get FASTA)	NCBI Sequence Viewer
	XP_063462495	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008640
	ENSPPAP00000008640.1
	ENSPPAP00000017517.1

RefSeq Acc Id:	XP_003815137 ⟸ XM_003815089
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZUJ9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGTFNLGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYS IDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAE SWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM hide sequence

RefSeq Acc Id:	XP_034821169 ⟸ XM_034965278
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063462494 ⟸ XM_063606424
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZUJ9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063462495 ⟸ XM_063606425
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027560	ENTREZGENE, UniProtKB/TrEMBL
	ENSPPAG00000031857	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000031276.1	UniProtKB/TrEMBL
	ENSPPAT00000040224.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
	Small_GTPase_Ras-type	UniProtKB/TrEMBL
KEGG Report	pps:100982968	UniProtKB/TrEMBL
NCBI Gene	RHEB	ENTREZGENE
PANTHER	PTHR24070	UniProtKB/TrEMBL
	PTHR24070:SF264	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A2R8ZUJ9	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9AJH3_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-06-11	RHEB	Ras homolog, mTORC1 binding	LOC100974009	GTP-binding protein Rheb	Data merged from RGD:11976199	737654	PROVISIONAL
2017-08-15	RHEB	Ras homolog, mTORC1 binding		Ras homolog enriched in brain	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)