Rgs2 (regulator of G-protein signaling 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rgs2 (regulator of G-protein signaling 2) Rattus norvegicus
Analyze
Symbol: Rgs2
Name: regulator of G-protein signaling 2
RGD ID: 621665
Description: Enables beta-tubulin binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of glycine import across plasma membrane; and response to amphetamine. Located in cytoplasmic side of plasma membrane. Biomarker of bladder disease (multiple); glomerulosclerosis; hypertension; liver cirrhosis; and opioid abuse. Orthologous to human RGS2 (regulator of G protein signaling 2); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: regulator of G-protein signaling protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,350,063 - 58,352,666 (-)NCBIGRCr8
mRatBN7.21355,799,749 - 55,802,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,798,829 - 55,802,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,360,545 - 58,363,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,628,437 - 59,631,073 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,918,817 - 56,921,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,846,458 - 60,849,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,846,308 - 60,849,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,831,386 - 65,833,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,891,849 - 57,894,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,905,025 - 57,908,545 (-)NCBI
Celera1355,875,644 - 55,878,228 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP,ISO)
ouabain  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenylephrine  (EXP,ISO)
potassium chromate  (ISO)
profenofos  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quinolinic acid  (EXP)
ranitidine  (EXP)
reserpine  (EXP)
risperidone  (EXP)
rotenone  (EXP,ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytoplasmic side of plasma membrane  (IDA,ISO)
cytosol  (ISO)
membrane  (IEA)
nucleolus  (IEA)
nucleus  (IEA,ISO,ISS)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. RGS2 is a primary terminator of beta(2)-adrenergic receptor-mediated G(i) signaling. Chakir K, etal., J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.
4. The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes. Chidiac P, etal., Cell Signal. 2014 Jun;26(6):1226-34. doi: 10.1016/j.cellsig.2014.02.006. Epub 2014 Feb 24.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Vascular microarray profiling in two models of hypertension identifies Cav-1, Rgs2 and Rgs5 as antihypertensive targets. Grayson TH, etal., BMC Genomics. 2007 Nov 7;8(1):404.
7. RGS2 promotes formation of neurites by stimulating microtubule polymerization. Heo K, etal., Cell Signal. 2006 Dec;18(12):2182-92. Epub 2006 May 23.
8. Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Ingi T and Aoki Y, Eur J Neurosci. 2002 Mar;15(5):929-36.
9. RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. Ji M, etal., Brain Res. 2011 Sep 9;1411:1-8. doi: 10.1016/j.brainres.2011.07.008. Epub 2011 Jul 13.
10. Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells. Ko JK, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):1025-33.
11. Gene expression changes following extinction testing in a heroin behavioral incubation model. Kuntz-Melcavage KL, etal., BMC Neurosci. 2009 Aug 7;10:95. doi: 10.1186/1471-2202-10-95.
12. Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Kveberg L, etal., Immunology. 2005 Jul;115(3):358-65. doi: 10.1111/j.1365-2567.2005.02174.x.
13. RGS2: a "turn-off" in hypertension. Le TH and Coffman TM, J Clin Invest. 2003 Feb;111(4):441-3.
14. Molecular mechanisms related to parturition-induced stress urinary incontinence. Lin G, etal., Eur Urol. 2009 May;55(5):1213-22. doi: 10.1016/j.eururo.2008.02.027. Epub 2008 Mar 18.
15. Chronic intermittent ethanol exposure selectively alters the expression of Ga subunit isoforms and RGS subtypes in rat prefrontal cortex. Luessen DJ, etal., Brain Res. 2017 Oct 1;1672:106-112. doi: 10.1016/j.brainres.2017.07.014. Epub 2017 Jul 21.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Different regulation of RGS2 mRNA by haloperidol and clozapine. Robinet EA, etal., Neuroreport 2001 Jun 13;12(8):1731-5.
23. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition. Suarez VR, etal., Am J Obstet Gynecol. 2003 Apr;188(4):973-7.
26. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
27. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Tang KM, etal., Nat Med. 2003 Dec;9(12):1506-12. doi: 10.1038/nm958. Epub 2003 Nov 9.
28. Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions. Taymans JM, etal., J Neurochem 2003 Mar;84(5):1118-27.
29. Detailed localization of regulator of G protein signaling 2 messenger ribonucleic acid and protein in the rat brain. Taymans JM, etal., Neuroscience 2002;114(1):39-53.
30. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. Thirunavukkarasu K, etal., J Cell Biochem 2002;85(4):837-50.
31. Expression of regulator of G-protein signaling protein-2 gene in the rat ovary at the time of ovulation. Ujioka T, etal., Biol Reprod. 2000 Nov;63(5):1513-7.
32. Impaired response of regulator of Gaq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. Wu Y, etal., Hypertens Res. 2016 Apr;39(4):210-6. doi: 10.1038/hr.2015.132. Epub 2015 Nov 26.
33. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
34. Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. Zhang W, etal., J Biol Chem. 2006 Mar 3;281(9):5811-20. doi: 10.1074/jbc.M507871200. Epub 2005 Dec 26.
Additional References at PubMed
PMID:10692485   PMID:10791963   PMID:11278586   PMID:12746312   PMID:14581517   PMID:15489334   PMID:15793568   PMID:16517124   PMID:17613534   PMID:18207159   PMID:18492766   PMID:19127022  
PMID:19374869   PMID:19478087   PMID:20032508   PMID:21164481   PMID:22057271   PMID:23523917   PMID:23587726  


Genomics

Comparative Map Data
Rgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,350,063 - 58,352,666 (-)NCBIGRCr8
mRatBN7.21355,799,749 - 55,802,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,798,829 - 55,802,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,360,545 - 58,363,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,628,437 - 59,631,073 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,918,817 - 56,921,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,846,458 - 60,849,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,846,308 - 60,849,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,831,386 - 65,833,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,891,849 - 57,894,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,905,025 - 57,908,545 (-)NCBI
Celera1355,875,644 - 55,878,228 (-)NCBICelera
Cytogenetic Map13q21NCBI
RGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,809,039 - 192,812,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,809,039 - 192,812,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371192,778,169 - 192,781,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,044,794 - 191,048,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 341189,509,827 - 189,513,060NCBI
Celera1165,887,766 - 165,891,002 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,013,977 - 164,017,213 (+)NCBIHuRef
CHM1_11194,199,847 - 194,203,081 (+)NCBICHM1_1
T2T-CHM13v2.01192,156,109 - 192,159,345 (+)NCBIT2T-CHM13v2.0
Rgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,875,076 - 143,879,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,875,076 - 143,879,899 (-)EnsemblGRCm39 Ensembl
GRCm381143,999,338 - 144,004,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,999,338 - 144,004,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,846,468 - 145,851,279 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,762,215 - 145,766,367 (-)NCBIMGSCv36mm8
Celera1146,559,706 - 146,564,519 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.56NCBI
Rgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,261,757 - 30,266,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,261,757 - 30,265,389 (+)NCBIChiLan1.0ChiLan1.0
RGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,975,986 - 56,983,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,639,690 - 56,643,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,273,112 - 168,276,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,566,701 - 172,569,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,566,701 - 172,569,955 (+)Ensemblpanpan1.1panPan2
RGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,200,237 - 6,203,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,200,657 - 6,203,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,297,498 - 6,300,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,217,614 - 6,220,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,217,616 - 6,220,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,216,415 - 6,219,748 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,582,061 - 6,585,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,817,823 - 6,821,151 (-)NCBIUU_Cfam_GSD_1.0
Rgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934481,075,734 - 81,079,076 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,065,832 - 1,069,247 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366381,065,866 - 1,068,649 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10936,789 - 940,098 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.110936,836 - 940,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,543,481 - 2,546,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10pNCBI
RGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,620,047 - 36,623,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,619,140 - 36,623,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605537,569,789 - 37,573,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814753,164 - 758,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624814754,743 - 758,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs2
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:230
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000005156
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat

Markers in Region
RH131031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,799,161 - 55,799,361 (+)MAPPERmRatBN7.2
Rnor_6.01360,845,871 - 60,846,070NCBIRnor6.0
Rnor_5.01365,830,799 - 65,830,998UniSTSRnor5.0
RGSC_v3.41357,891,262 - 57,891,461UniSTSRGSC3.4
Celera1355,875,057 - 55,875,256UniSTS
Cytogenetic Map13q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 22 6 19 6 5 5 74 28 38 11 5
Low 3 35 35 35 3 6 7 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005156   ⟹   ENSRNOP00000005156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,798,829 - 55,802,385 (-)Ensembl
Rnor_6.0 Ensembl1360,846,308 - 60,849,094 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093882   ⟹   ENSRNOP00000080043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,800,187 - 55,802,385 (-)Ensembl
RefSeq Acc Id: NM_053453   ⟹   NP_445905
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,350,063 - 58,352,666 (-)NCBI
mRatBN7.21355,799,749 - 55,802,354 (-)NCBI
Rnor_6.01360,846,458 - 60,849,061 (-)NCBI
Rnor_5.01365,831,386 - 65,833,989 (-)NCBI
RGSC_v3.41357,891,849 - 57,894,452 (-)RGD
Celera1355,875,644 - 55,878,228 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_445905   ⟸   NM_053453
- UniProtKB: Q9JHX0 (UniProtKB/Swiss-Prot),   A6ICP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005156   ⟸   ENSRNOT00000005156
RefSeq Acc Id: ENSRNOP00000080043   ⟸   ENSRNOT00000093882
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHX0-F1-model_v2 AlphaFold Q9JHX0 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698875
Promoter ID:EPDNEW_R9400
Type:single initiation site
Name:Rgs2_1
Description:regulator of G-protein signaling 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01360,849,092 - 60,849,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621665 AgrOrtholog
BioCyc Gene G2FUF-18005 BioCyc
Ensembl Genes ENSRNOG00000003687 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000807 UniProtKB/Swiss-Prot
  ENSRNOG00060005468 UniProtKB/Swiss-Prot
  ENSRNOG00065005731 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005156 ENTREZGENE
  ENSRNOT00000005156.7 UniProtKB/Swiss-Prot
  ENSRNOT00000093882.1 UniProtKB/TrEMBL
  ENSRNOT00055001375 UniProtKB/Swiss-Prot
  ENSRNOT00060009093 UniProtKB/Swiss-Prot
  ENSRNOT00065008565 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621945 IMAGE-MGC_LOAD
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84583 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72363 IMAGE-MGC_LOAD
NCBI Gene 84583 ENTREZGENE
PANTHER PTHR10845:SF43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs2 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003687 RatGTEx
  ENSRNOG00055000807 RatGTEx
  ENSRNOG00060005468 RatGTEx
  ENSRNOG00065005731 RatGTEx
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPA2_RAT UniProtKB/TrEMBL
  A6ICP7 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHX0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rgs2  regulator of G-protein signaling 2    regulator of G-protein signaling protein 2  Name updated 1299863 APPROVED
2002-08-07 Rgs2  regulator of G-protein signaling protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is induced by parathyroid hormone 633858