Nsf (N-ethylmaleimide sensitive factor, vesicle fusing ATPase) - Rat Genome Database

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Gene: Nsf (N-ethylmaleimide sensitive factor, vesicle fusing ATPase) Rattus norvegicus
Analyze
Symbol: Nsf
Name: N-ethylmaleimide sensitive factor, vesicle fusing ATPase
RGD ID: 621594
Description: Enables several functions, including ATP hydrolysis activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including protein-containing complex disassembly; regulation of vesicle-mediated transport; and response to hyperoxia. Located in several cellular components, including Golgi apparatus; dendrite; and postsynaptic density. Is active in GABA-ergic synapse and postsynaptic specialization, intracellular component. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 96. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase); PARTICIPATES IN vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: N-ethylmaleimide sensitive factor; N-ethylmaleimide sensitive fusion protein; N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; vesicle-fusing ATPase; vesicular-fusion protein NSF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,227,937 - 89,357,383 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1089,227,937 - 89,367,621 (-)EnsemblGRCr8
mRatBN7.21088,727,912 - 88,857,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1093,766,004 - 93,896,184 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,231,131 - 93,359,684 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,624,517 - 88,754,710 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,879,608 - 91,986,242 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)Ensemblrn6Rnor6.0
Rnor_5.01091,645,985 - 91,751,551 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,974,385 - 93,082,222 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1087,428,233 - 87,533,296 (-)NCBICelera
RGSC_v3.11092,988,754 - 93,118,400 (-)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinous acid  (ISO)
dizocilpine maleate  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-tocopherol  (ISO)
genistein  (EXP)
haloperidol  (EXP,ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
potassium chromate  (ISO)
Propiverine  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
rutin  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
tocopherol  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of alpha-soluble N-ethylmaleimide-sensitive fusion attachment protein in alveolar type II cells: implications in lung surfactant secretion. Abonyo BO, etal., Am J Respir Cell Mol Biol. 2003 Sep;29(3 Pt 1):273-82. doi: 10.1165/rcmb.2002-0189OC. Epub 2003 Mar 27.
2. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Banerjee A, etal., Am J Physiol Cell Physiol. 2001 Apr;280(4):C775-81.
3. A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. Cabana-Domínguez J, etal., Sci Rep. 2016 Aug 8;6:31033. doi: 10.1038/srep31033.
4. mGluR and NMDAR activation internalize distinct populations of AMPARs. Casimiro TM, etal., Mol Cell Neurosci. 2011 Oct;48(2):161-70. doi: 10.1016/j.mcn.2011.07.007. Epub 2011 Jul 23.
5. Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor. Chen S and Liu F, J Neurosci Res. 2010 Aug 15;88(11):2504-12. doi: 10.1002/jnr.22401.
6. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Presynaptic PICK1 facilitates trafficking of AMPA-receptors between active zone and synaptic vesicle pool. Haglerød C, etal., Neuroscience. 2017 Mar 6;344:102-112. doi: 10.1016/j.neuroscience.2016.12.042. Epub 2017 Jan 3.
9. Identification of Rab6 as an N-ethylmaleimide-sensitive fusion protein-binding protein. Han SY, etal., Biochem J 2000 Nov 15;352 Pt 1:165-73.
10. NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Hanley JG, etal., Neuron 2002 Mar 28;34(1):53-67.
11. NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2. Hanley JG, J Neurochem. 2007 Jun;101(6):1644-50. doi: 10.1111/j.1471-4159.2007.04455.x. Epub 2007 Feb 14.
12. Association of N-ethylmaleimide-sensitive factor with synaptic vesicles. Hong RM, etal., FEBS Lett. 1994 Aug 22;350(2-3):253-7. doi: 10.1016/0014-5793(94)00778-0.
13. Roles that nurses in the community can play in nursing research. Johnson MN and Okunade AO, Int Nurs Rev. 1975 Sep-Oct;22(5):147-9.
14. Vitamin E prevents hyperoxia-induced loss of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor proteins in the rat neuronal cytoplasm. Kaneai N, etal., Biol Pharm Bull. 2013;36(9):1500-2. doi: 10.1248/bpb.b13-00147.
15. The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors. Kittler JT, etal., Mol Cell Neurosci. 2001 Jul;18(1):13-25. doi: 10.1006/mcne.2001.1005.
16. Single and repeated morphine administrations differently regulate expression of N-ethylmaleimide-sensitive factor gene in the rat brain. Li H, etal., Neuroreport. 2006 Jan 23;17(1):71-4. doi: 10.1097/01.wnr.0000192731.62417.be.
17. Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX. Martin HG, etal., J Cell Biochem. 2006 Nov 1;99(4):1203-15. doi: 10.1002/jcb.20998.
18. N-ethylmaleimide-sensitive factor is associated with the nuclear envelope. Mashima J, etal., Biochem Biophys Res Commun. 2000 Aug 2;274(2):559-64. doi: 10.1006/bbrc.2000.3162.
19. Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes. Mastick CC and Falick AL, Endocrinology. 1997 Jun;138(6):2391-7. doi: 10.1210/endo.138.6.5166.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. Narisawa-Saito M, etal., J Biol Chem. 2002 Oct 25;277(43):40901-10. Epub 2002 Jul 18.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. NSF binding to GluR2 regulates synaptic transmission. Nishimune A, etal., Neuron. 1998 Jul;21(1):87-97.
24. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Osten P, etal., Neuron. 1998 Jul;21(1):99-110. doi: 10.1016/s0896-6273(00)80518-8.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
29. Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid. Yin S, etal., Brain Res. 2005 Aug 16;1053(1-2):195-202. doi: 10.1016/j.brainres.2005.06.054.
Additional References at PubMed
PMID:8082782   PMID:9267032   PMID:9334216   PMID:10196135   PMID:11577089   PMID:12554740   PMID:12832401   PMID:14755058   PMID:15613468   PMID:15797712   PMID:15858065   PMID:15935991  
PMID:15944123   PMID:16431922   PMID:16461345   PMID:16724110   PMID:17634366   PMID:17897319   PMID:18598260   PMID:21106836   PMID:21307259   PMID:22045810   PMID:22871113   PMID:23376485  
PMID:23836889   PMID:24599450   PMID:24753224   PMID:25480573   PMID:26766634   PMID:26839712   PMID:29476059   PMID:31932584   PMID:32357304  


Genomics

Comparative Map Data
Nsf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,227,937 - 89,357,383 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1089,227,937 - 89,367,621 (-)EnsemblGRCr8
mRatBN7.21088,727,912 - 88,857,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1093,766,004 - 93,896,184 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,231,131 - 93,359,684 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,624,517 - 88,754,710 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01091,879,608 - 91,986,242 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)Ensemblrn6Rnor6.0
Rnor_5.01091,645,985 - 91,751,551 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41092,974,385 - 93,082,222 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1087,428,233 - 87,533,296 (-)NCBICelera
RGSC_v3.11092,988,754 - 93,118,400 (-)NCBI
Cytogenetic Map10q32.1NCBI
NSF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381746,590,669 - 46,757,464 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1746,590,669 - 46,757,679 (+)Ensemblhg38GRCh38
GRCh371744,668,035 - 44,834,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,023,354 - 42,190,000 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341742,023,397 - 42,189,993NCBI
Celera1741,231,619 - 41,284,321 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1740,092,157 - 40,095,514 (+)NCBIHuRef
HuRef1740,144,350 - 40,213,196 (+)NCBIHuRef
CHM1_11744,732,424 - 44,898,954 (+)NCBICHM1_1
T2T-CHM13v2.01747,452,259 - 47,618,933 (+)NCBIT2T-CHM13v2.0
Nsf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,712,608 - 103,844,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,712,608 - 103,844,882 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811103,821,782 - 103,954,056 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,821,782 - 103,954,056 (-)Ensemblmm10GRCm38
MGSCv3711103,683,096 - 103,815,370 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611103,637,872 - 103,770,146 (-)NCBIMGSCv36mm8
Celera11115,536,808 - 115,669,815 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.54NCBI
Nsf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547810,610,619 - 10,732,656 (+)Ensembl
ChiLan1.0NW_00495547810,610,715 - 10,732,656 (+)NCBIChiLan1.0ChiLan1.0
NSF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21918,259,662 - 18,426,098 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11720,225,947 - 20,392,295 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01710,746,423 - 10,912,784 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11710,923,875 - 11,056,565 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,923,875 - 11,057,426 (-)EnsemblpanPan2panpan1.1
NSF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,927,149 - 10,072,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,927,068 - 10,071,272 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha910,225,793 - 10,371,295 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0911,518,063 - 11,663,166 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl911,517,317 - 11,663,164 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1910,528,956 - 10,674,213 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0916,847,857 - 16,992,907 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0916,795,635 - 16,941,205 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nsf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560217,057,557 - 17,205,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365411,987,326 - 2,137,067 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365411,989,092 - 2,137,006 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,459,077 - 17,705,351 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11217,458,996 - 17,624,335 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,490,697 - 17,656,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11660,308,000 - 60,467,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1660,308,008 - 60,465,731 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607731,029,330 - 31,190,857 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248492,732,792 - 2,865,569 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248492,711,426 - 2,865,569 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsf
555 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:115
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000006361
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AW531537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,814,326 - 88,814,446 (+)MAPPERmRatBN7.2
Rnor_6.01091,965,052 - 91,965,171NCBIRnor6.0
Rnor_5.01091,730,647 - 91,730,766UniSTSRnor5.0
RGSC_v3.41093,061,076 - 93,061,195UniSTSRGSC3.4
Celera1087,512,119 - 87,512,238UniSTS
RH 3.4 Map10917.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH134933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,728,846 - 88,729,060 (+)MAPPERmRatBN7.2
Rnor_6.01091,879,584 - 91,879,797NCBIRnor6.0
Rnor_5.01091,645,961 - 91,646,174UniSTSRnor5.0
RGSC_v3.41092,974,361 - 92,974,574UniSTSRGSC3.4
Celera1087,428,209 - 87,428,422UniSTS
RH 3.4 Map10922.3UniSTS
Cytogenetic Map10q32.1UniSTS
AU049932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21088,827,568 - 88,827,774 (+)MAPPERmRatBN7.2
Rnor_6.01091,978,293 - 91,978,496NCBIRnor6.0
Rnor_5.01091,743,602 - 91,743,805UniSTSRnor5.0
RGSC_v3.41093,074,273 - 93,074,476UniSTSRGSC3.4
Celera1087,525,347 - 87,525,550UniSTS
Cytogenetic Map10q32.1UniSTS
NSF-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81089,275,228 - 89,275,882 (+)Marker Load Pipeline
mRatBN7.21088,775,207 - 88,775,861 (+)MAPPERmRatBN7.2
Rnor_6.01091,925,940 - 91,926,593NCBIRnor6.0
Rnor_5.01091,692,223 - 91,692,876UniSTSRnor5.0
RGSC_v3.41093,021,152 - 93,021,805UniSTSRGSC3.4
Celera1087,474,297 - 87,474,950UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006361   ⟹   ENSRNOP00000006361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1089,227,937 - 89,357,383 (-)Ensembl
mRatBN7.2 Ensembl1088,727,912 - 88,857,386 (-)Ensembl
Rnor_6.0 Ensembl1091,878,633 - 92,008,082 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087824   ⟹   ENSRNOP00000073942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1089,227,937 - 89,335,949 (-)Ensembl
mRatBN7.2 Ensembl1088,727,912 - 88,835,940 (-)Ensembl
Rnor_6.0 Ensembl1091,880,120 - 91,986,632 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099576   ⟹   ENSRNOP00000095949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1089,227,937 - 89,367,621 (-)Ensembl
mRatBN7.2 Ensembl1088,727,912 - 88,835,912 (-)Ensembl
RefSeq Acc Id: NM_021748   ⟹   NP_068516
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81089,227,937 - 89,357,383 (-)NCBI
mRatBN7.21088,727,912 - 88,857,375 (-)NCBI
Rnor_6.01091,879,608 - 91,986,242 (-)NCBI
Rnor_5.01091,645,985 - 91,751,551 (-)NCBI
RGSC_v3.41092,974,385 - 93,082,222 (-)RGD
Celera1087,428,233 - 87,533,296 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_068516 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC61595 (Get FASTA)   NCBI Sequence Viewer  
  AAC63035 (Get FASTA)   NCBI Sequence Viewer  
  AAD39485 (Get FASTA)   NCBI Sequence Viewer  
  AAF01051 (Get FASTA)   NCBI Sequence Viewer  
  EDM06287 (Get FASTA)   NCBI Sequence Viewer  
  EDM06288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006361
GenBank Protein Q9QUL6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068516   ⟸   NM_021748
- UniProtKB: Q9QUL6 (UniProtKB/Swiss-Prot),   F1LQ81 (UniProtKB/TrEMBL),   A6HJT3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006361   ⟸   ENSRNOT00000006361
Ensembl Acc Id: ENSRNOP00000073942   ⟸   ENSRNOT00000087824
Ensembl Acc Id: ENSRNOP00000095949   ⟸   ENSRNOT00000099576
Protein Domains
AAA+ ATPase   CDC48   CDC48 N-terminal subdomain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUL6-F1-model_v2 AlphaFold Q9QUL6 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621594 AgrOrtholog
BioCyc Gene G2FUF-23025 BioCyc
Ensembl Genes ENSRNOG00000003905 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006361 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.40.20 UniProtKB/Swiss-Prot
  3.10.330.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Asp_de-COase-like_dom_sf UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  Cdc48_dom2 UniProtKB/Swiss-Prot
  CDC48_domain_2-like_sf UniProtKB/Swiss-Prot
  CDC4_N-term_subdom UniProtKB/Swiss-Prot
  NSF_ATPase_lid UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Vesicle-fus_ATPase UniProtKB/Swiss-Prot
KEGG Report rno:60355 UniProtKB/Swiss-Prot
NCBI Gene 60355 ENTREZGENE
PANTHER PTHR23078 UniProtKB/Swiss-Prot
  VESICLE-FUSING ATPASE UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  CDC48_2 UniProtKB/Swiss-Prot
  CDC48_N UniProtKB/Swiss-Prot
  NSF_ATPase_lid UniProtKB/Swiss-Prot
PhenoGen Nsf PhenoGen
PRINTS ENDOLAPTASE UniProtKB/Swiss-Prot
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003905 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
  CDC48_2 UniProtKB/Swiss-Prot
  CDC48_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50692 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF54585 UniProtKB/Swiss-Prot
UniProt A0A0G2K6U1_RAT UniProtKB/TrEMBL
  A0A8I6AP08_RAT UniProtKB/TrEMBL
  A6HJT2_RAT UniProtKB/TrEMBL
  A6HJT3 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ81 ENTREZGENE, UniProtKB/TrEMBL
  NSF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-07 Nsf  N-ethylmaleimide sensitive factor, vesicle fusing ATPase  Nsf  N-ethylmaleimide-sensitive factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-12 Nsf  N-ethylmaleimide-sensitive factor  Nsf  N-ethylmaleimide sensitive fusion protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nsf  N-ethylmaleimide sensitive fusion protein    N-ethylmaleimide sensitive factor  Name updated 1299863 APPROVED
2002-08-07 Nsf  N-ethylmaleimide sensitive factor      Symbol and Name status set to provisional 70820 PROVISIONAL