F13a1 (coagulation factor XIII A1 chain) - Rat Genome Database

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Gene: F13a1 (coagulation factor XIII A1 chain) Rattus norvegicus
Analyze
Symbol: F13a1
Name: coagulation factor XIII A1 chain
RGD ID: 621495
Description: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation and peptide cross-linking. Predicted to act upstream of or within blood coagulation. Predicted to be located in cytoplasm and extracellular region. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coagulation factor XIII A chain; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIIIa; F13a; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81728,021,197 - 28,197,960 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1728,020,845 - 28,197,948 (+)EnsemblGRCr8
mRatBN7.21727,815,723 - 27,992,494 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1727,815,702 - 27,992,700 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1727,681,035 - 27,857,733 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01729,284,581 - 29,461,269 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01727,645,506 - 27,822,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01728,504,650 - 28,680,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1728,504,623 - 28,680,362 (+)Ensemblrn6Rnor6.0
Rnor_5.01730,406,396 - 30,581,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41734,093,525 - 34,270,498 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1727,443,244 - 27,619,724 (+)NCBICelera
RGSC_v3.11734,096,401 - 34,272,682 (+)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
eugenol  (ISO)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
graphite  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Arg703Trp missense mutation in F13A1 is a de novo event. Anwar R and Langlois S, Br J Haematol. 2009 Jun;146(1):118-20. doi: 10.1111/j.1365-2141.2009.07700.x. Epub 2009 Apr 27.
2. Identification of a point mutation in factor XIII A subunit deficiency. Board P, etal., Blood 1992 Aug 15;80(4):937-41.
3. Increased prevalence of microthromboses in retinal capillaries of diabetic individuals. Boeri D, etal., Diabetes. 2001 Jun;50(6):1432-9.
4. Combined carrier status of prothrombin 20210A and factor XIII-A Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction. Butt C, etal., Blood. 2003 Apr 15;101(8):3037-41. Epub 2002 Dec 12.
5. Association of a common polymorphism in the factor XIII gene with venous thrombosis. Catto AJ, etal., Blood. 1999 Feb 1;93(3):906-8.
6. Factor XIII Val 34 Leu: a novel association with primary intracerebral hemorrhage. Catto AJ, etal., Stroke. 1998 Apr;29(4):813-6.
7. Factor XIII Val34Leu polymorphism in primary intracerebral haemorrhage. Corral J, etal., Hematol J. 2000;1(4):269-73.
8. Factor XIII improves gastric stress lesions in rats. D'Argenio G, etal., Digestion 2001;63(4):220-8.
9. Genetic polymorphisms associated with priapism in sickle cell disease. Elliott L, etal., Br J Haematol. 2007 May;137(3):262-7.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. A common mutation in the gene for coagulation factor XIII-A (VAL34Leu): a risk factor for primary intracerebral hemorrhage is protective against atherothrombotic diseases. Gemmati D, etal., Am J Hematol. 2001 Jul;67(3):183-8.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. A common F13A1 intron 1 variant IVS1+12(A) is associated with mild FXIII deficiency in Caucasian population. Ivaskevicius V, etal., Ann Hematol. 2013 Jul;92(7):975-9. doi: 10.1007/s00277-013-1724-2. Epub 2013 Mar 19.
14. Identification of eight novel coagulation factor XIII subunit A mutations: implied consequences for structure and function. Ivaskevicius V, etal., Haematologica. 2010 Jun;95(6):956-62. doi: 10.3324/haematol.2009.017210. Epub 2010 Feb 23.
15. Factor XIII deficiency: complete phenotypic characterization of two cases with novel causative mutations. Katona E, etal., Haemophilia. 2014 Jan;20(1):114-20. doi: 10.1111/hae.12267. Epub 2013 Oct 1.
16. Leukemic lymphoblasts, a novel expression site of coagulation factor XIII subunit A. Kiss F, etal., Thromb Haemost. 2006 Aug;96(2):176-82.
17. Factor XIII A subunit-deficient mice developed severe uterine bleeding events and subsequent spontaneous miscarriages. Koseki-Kuno S, etal., Blood. 2003 Dec 15;102(13):4410-2. Epub 2003 Aug 21.
18. Role of blood coagulation factor XIII in patients with acute pulmonary embolism. Correlation of factor XIII antigen levels with pulmonary occlusion rate, fibrinogen, D-dimer, and clot firmness. Kucher N, etal., Thromb Haemost. 2003 Sep;90(3):434-8.
19. Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Lauer P, etal., Thromb Haemost. 2002 Dec;88(6):967-74.
20. Congenital factor XIII deficiency caused by two mutations in eight Tunisian families: molecular confirmation of a founder effect. Louhichi N, etal., Ann Hematol. 2010 May;89(5):499-504. doi: 10.1007/s00277-009-0863-y. Epub 2009 Nov 24.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels. Mikkola H, etal., Blood. 1994 Jul 15;84(2):517-25.
23. Reduction of REM sleep by a tryptophan-free amino acid diet. Moja EA, etal., Life Sci 1979 Apr 16;24(16):1467-70.
24. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Deficiency of blood coagulation factor XIII in Crohn's disease. Oshitani N, etal., Am J Gastroenterol. 1995 Jul;90(7):1116-8.
28. Biulleten' eksperimental'noi biologii i meditsiny Pastorova VE, etal., Biull Eksp Biol Med. 1979 Feb;87(2):99-101.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women. Reiner AP, etal., Stroke. 2001 Nov;32(11):2580-6.
32. The V34L polymorphism of factor XIII and peripheral arterial disease. Renner W, etal., Int Angiol. 2002 Mar;21(1):53-7.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Comprehensive gene review and curation RGD comprehensive gene curation
37. Plasma factor XIII activity in patients with disseminated intravascular coagulation. Song JW, etal., Yonsei Med J. 2006 Apr 30;47(2):196-200.
38. Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling. Tsujimoto I, etal., Am J Pathol. 2011 Dec;179(6):3011-9. doi: 10.1016/j.ajpath.2011.08.037. Epub 2011 Oct 19.
39. Factor XIII Val34Leu polymorphism, factor XIII antigen levels and activity and the risk of deep venous thrombosis. Van Hylckama Vlieg A, etal., Br J Haematol. 2002 Oct;119(1):169-75.
40. Homozygous intronic mutation leading to inefficient transcription combined with a novel frameshift mutation in F13A1 gene causes FXIII deficiency. Wang W, etal., J Hum Genet. 2011 Jun;56(6):460-3. doi: 10.1038/jhg.2011.41. Epub 2011 Apr 21.
Additional References at PubMed
PMID:8889548   PMID:15507206   PMID:18224415   PMID:22516433   PMID:27363989  


Genomics

Comparative Map Data
F13a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81728,021,197 - 28,197,960 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1728,020,845 - 28,197,948 (+)EnsemblGRCr8
mRatBN7.21727,815,723 - 27,992,494 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1727,815,702 - 27,992,700 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1727,681,035 - 27,857,733 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01729,284,581 - 29,461,269 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01727,645,506 - 27,822,130 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01728,504,650 - 28,680,015 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1728,504,623 - 28,680,362 (+)Ensemblrn6Rnor6.0
Rnor_5.01730,406,396 - 30,581,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41734,093,525 - 34,270,498 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1727,443,244 - 27,619,724 (+)NCBICelera
RGSC_v3.11734,096,401 - 34,272,682 (+)NCBI
Cytogenetic Map17p12NCBI
F13A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3866,144,084 - 6,320,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl66,144,080 - 6,321,013 (-)Ensemblhg38GRCh38
GRCh3766,144,317 - 6,320,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3666,089,310 - 6,265,923 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3466,089,316 - 6,265,901NCBI
Celera67,372,733 - 7,550,578 (-)NCBICelera
Cytogenetic Map6p25.1NCBI
HuRef66,020,217 - 6,197,010 (-)NCBIHuRef
CHM1_166,146,854 - 6,323,031 (-)NCBICHM1_1
T2T-CHM13v2.066,013,258 - 6,189,597 (-)NCBIT2T-CHM13v2.0
F13a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391337,051,150 - 37,234,220 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1337,051,152 - 37,234,220 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381336,867,178 - 37,050,244 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1336,867,178 - 37,050,244 (-)Ensemblmm10GRCm38
MGSCv371336,959,047 - 37,142,113 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361336,874,653 - 37,056,670 (-)NCBIMGSCv36mm8
Celera1337,983,710 - 38,163,470 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1314.44NCBI
F13a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554657,443,166 - 7,617,436 (+)Ensembl
ChiLan1.0NW_0049554657,444,118 - 7,617,366 (+)NCBIChiLan1.0ChiLan1.0
F13A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2520,772,261 - 20,960,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1616,776,810 - 16,955,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v065,978,505 - 6,156,705 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.166,159,012 - 6,337,000 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl66,157,926 - 6,513,961 (-)EnsemblpanPan2panpan1.1
F13A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1356,186,750 - 6,347,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl356,187,235 - 6,349,773 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha356,191,814 - 6,354,808 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0356,267,724 - 6,430,557 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl356,267,724 - 6,428,774 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1356,122,455 - 6,285,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0356,148,410 - 6,311,467 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,481,872 - 7,644,350 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
F13a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494617,930,084 - 18,091,733 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365346,199,066 - 6,361,476 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365346,199,066 - 6,360,374 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F13A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl73,751,292 - 3,900,762 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.173,751,290 - 3,900,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.273,952,957 - 4,102,446 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F13A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11765,885,498 - 66,040,026 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1765,885,658 - 66,040,040 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660446,090,570 - 6,385,150 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F13a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475619,103,327 - 19,259,964 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475619,103,064 - 19,259,632 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
F13a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11455,889,901 - 56,099,130 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in F13a1
1861 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:110
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000021568
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
D17Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81728,040,628 - 28,040,791 (+)Marker Load Pipeline
mRatBN7.21727,835,154 - 27,835,317 (+)MAPPERmRatBN7.2
Rnor_6.01728,523,806 - 28,523,968NCBIRnor6.0
Rnor_5.01730,425,552 - 30,425,714UniSTSRnor5.0
RGSC_v3.41734,113,131 - 34,113,294RGDRGSC3.4
RGSC_v3.41734,113,132 - 34,113,294UniSTSRGSC3.4
Celera1727,462,506 - 27,462,668UniSTS
RGSC_v3.11734,115,973 - 34,116,135RGD
RH 3.4 Map17353.9RGD
RH 3.4 Map17353.9UniSTS
RH 2.0 Map17236.5RGD
SHRSP x BN Map1721.7599RGD
FHH x ACI Map1728.9299RGD
Cytogenetic Map17p12UniSTS
D17Got41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21727,921,600 - 27,921,737 (+)MAPPERmRatBN7.2
Rnor_6.01728,609,970 - 28,610,106NCBIRnor6.0
Rnor_5.01730,511,396 - 30,511,532UniSTSRnor5.0
RGSC_v3.41734,199,600 - 34,199,736RGDRGSC3.4
RGSC_v3.41734,199,601 - 34,199,737UniSTSRGSC3.4
Celera1727,548,846 - 27,548,982UniSTS
RGSC_v3.11734,202,441 - 34,202,577RGD
RH 3.4 Map17325.72RGD
RH 3.4 Map17325.72UniSTS
RH 2.0 Map17256.6RGD
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 67 162 91 90 59 92 59 6 345 192 11 141 75 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021568   ⟹   ENSRNOP00000021568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1728,020,845 - 28,197,948 (+)Ensembl
mRatBN7.2 Ensembl1727,815,702 - 27,992,700 (+)Ensembl
Rnor_6.0 Ensembl1728,504,623 - 28,680,362 (+)Ensembl
RefSeq Acc Id: NM_021698   ⟹   NP_067730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81728,021,197 - 28,197,960 (+)NCBI
mRatBN7.21727,815,723 - 27,992,494 (+)NCBI
Rnor_6.01728,504,650 - 28,680,015 (+)NCBI
Rnor_5.01730,406,396 - 30,581,441 (+)NCBI
RGSC_v3.41734,093,525 - 34,270,498 (+)RGD
Celera1727,443,244 - 27,619,724 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA73104 (Get FASTA)   NCBI Sequence Viewer  
  EDL98278 (Get FASTA)   NCBI Sequence Viewer  
  EDL98279 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021568
GenBank Protein O08619 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067730   ⟸   NM_021698
- UniProtKB: O08619 (UniProtKB/Swiss-Prot),   G3V811 (UniProtKB/TrEMBL),   A6J7C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021568   ⟸   ENSRNOT00000021568
Protein Domains
Transglutaminase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08619-F1-model_v2 AlphaFold O08619 1-732 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700399
Promoter ID:EPDNEW_R10922
Type:single initiation site
Name:F13a1_1
Description:coagulation factor XIII A1 chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01728,504,629 - 28,504,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621495 AgrOrtholog
BioCyc Gene G2FUF-9645 BioCyc
Ensembl Genes ENSRNOG00000015957 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021568 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.90.260.10 UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Transglutaminase UniProtKB/Swiss-Prot
  Transglutaminase-like UniProtKB/Swiss-Prot
  Transglutaminase-like_sf UniProtKB/Swiss-Prot
  Transglutaminase_animal UniProtKB/Swiss-Prot
  Transglutaminase_AS UniProtKB/Swiss-Prot
  Transglutaminase_C UniProtKB/Swiss-Prot
  Transglutaminase_C_sf UniProtKB/Swiss-Prot
  Transglutaminase_N UniProtKB/Swiss-Prot
KEGG Report rno:60327 UniProtKB/Swiss-Prot
NCBI Gene 60327 ENTREZGENE
PANTHER PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR11590:SF42 UniProtKB/Swiss-Prot
Pfam Transglut_C UniProtKB/Swiss-Prot
  Transglut_core UniProtKB/Swiss-Prot
  Transglut_N UniProtKB/Swiss-Prot
PhenoGen F13a1 PhenoGen
PIRSF TGM_EBP42 UniProtKB/Swiss-Prot
PROSITE TRANSGLUTAMINASES UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015957 RatGTEx
SMART TGc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49309 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A6J7C8 ENTREZGENE, UniProtKB/TrEMBL
  F13A_RAT UniProtKB/Swiss-Prot
  G3V811 ENTREZGENE, UniProtKB/TrEMBL
  O08619 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 F13a1  coagulation factor XIII A1 chain  F13a1  coagulation factor XIII, A1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 F13a1  coagulation factor XIII, A1 polypeptide  F13a1  coagulation factor XIII, A1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 F13a1  coagulation factor XIII, A1 subunit  F13a    Symbol updated 1299863 APPROVED
2005-01-20 F13a  coagulation factor XIII, A1 subunit    coagulation factor XIIIa  Name updated 1299863 APPROVED
2002-08-07 F13a  coagulation factor XIIIa      Symbol and Name status set to provisional 70820 PROVISIONAL