Ghsr (growth hormone secretagogue receptor) - Rat Genome Database

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Gene: Ghsr (growth hormone secretagogue receptor) Rattus norvegicus
Analyze
Symbol: Ghsr
Name: growth hormone secretagogue receptor
RGD ID: 621397
Description: Enables growth hormone secretagogue receptor activity and peptide hormone binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; regulation of digestive system process; and regulation of secretion by cell. Acts upstream of or within negative regulation of insulin secretion. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Used to study middle cerebral artery infarction. Biomarker of isolated growth hormone deficiency; multiple endocrine neoplasia; obstructive sleep apnea; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ghrelin system pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GH-releasing peptide receptor; ghrelin receptor; GHRP; GHS-R; growth hormone secretagogue receptor type 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ghsrm1Mcwi ; Ghsrm2Mcwi ; Ghsrm3Mcwi ; Ghsrem1Ottc
Genetic Models: SS-Ghsrm3Mcwi ; FHH-Ghsrm1Mcwi ; SS-Ghsrm2Mcwi ; W-Ghsrem1Ottc
Is Marker For: Strains:   SD-Tg(Th-Ghsros)  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,196,158 - 112,201,666 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2112,196,767 - 112,201,181 (+)EnsemblGRCr8
mRatBN7.22110,268,489 - 110,271,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2116,922,519 - 116,925,893 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,035,078 - 115,038,452 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,749,447 - 109,752,824 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,065,953 - 113,071,265 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)Ensemblrn6Rnor6.0
Rnor_5.02132,784,207 - 132,789,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42113,269,623 - 113,272,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2105,470,925 - 105,474,301 (+)NCBICelera
RGSC_v3.12113,214,584 - 113,217,961 (+)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (IEA,ISO,ISS)
adult feeding behavior  (IEA,ISO,ISS)
cellular response to hormone stimulus  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to thyroid hormone stimulus  (IEP)
decidualization  (IEA,ISO,ISS)
female pregnancy  (IEP)
G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO,ISS)
ghrelin secretion  (IMP)
growth hormone secretion  (ISO)
hormone-mediated signaling pathway  (IBA,IEA,ISO,ISS)
learning or memory  (IDA)
negative regulation of appetite  (IMP)
negative regulation of inflammatory response  (IEA,ISO,ISS)
negative regulation of insulin secretion  (IDA)
negative regulation of interleukin-1 beta production  (IEA,ISO,ISS)
negative regulation of interleukin-6 production  (IEA,ISO,ISS)
negative regulation of locomotion involved in locomotory behavior  (IMP)
negative regulation of macrophage apoptotic process  (IMP)
negative regulation of norepinephrine secretion  (IMP)
negative regulation of tumor necrosis factor production  (IEA,IMP,ISO,ISS)
peptide hormone secretion  (IEA)
positive regulation of appetite  (IEA,ISO,ISS)
positive regulation of eating behavior  (IMP)
positive regulation of fatty acid metabolic process  (IMP)
positive regulation of growth  (IMP)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of multicellular organism growth  (IEA,ISO,ISS)
positive regulation of small intestinal transit  (IMP)
positive regulation of small intestine smooth muscle contraction  (IMP)
positive regulation of sprouting angiogenesis  (IMP)
positive regulation of vascular endothelial cell proliferation  (IMP)
postsynaptic modulation of chemical synaptic transmission  (EXP,IDA)
regulation of appetite  (IEA)
regulation of feeding behavior  (IMP)
regulation of gastric motility  (IMP)
regulation of growth hormone secretion  (IMP)
regulation of hindgut contraction  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (EXP,IDA,IEP)
regulation of postsynapse organization  (EXP,IDA)
regulation of response to food  (IEA)
regulation of synapse assembly  (ISO)
regulation of transmission of nerve impulse  (IMP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to follicle-stimulating hormone  (IEP)
response to food  (ISO)
response to growth hormone  (IEP)
response to hormone  (IEA,ISO,ISS)
response to L-glutamate  (IEP)
signal transduction  (IEA)
spermatogenesis  (IEP)

Cellular Component
cell surface  (IEA,ISO,ISS)
glutamatergic synapse  (EXP,IDA,IEP,IMP)
membrane  (IEA)
membrane raft  (IEA,ISO,ISS)
neuron projection  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,TAS)
postsynapse  (IEA)
Schaffer collateral - CA1 synapse  (EXP,IDA)
synaptic membrane  (IDA,IEP,IMP)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: Evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells. Andreis PG, etal., FEBS Lett 2003 Feb 11;536(1-3):173-9.
2. Cognitive enhancing effects of ghrelin receptor agonists. Atcha Z, etal., Psychopharmacology (Berl). 2009 Oct;206(3):415-27. doi: 10.1007/s00213-009-1620-6. Epub 2009 Aug 4.
3. DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. Banerjee SA, etal., Brain Res Mol Brain Res. 1994 Jul;24(1-4):89-106.
4. Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Barreiro ML, etal., Biol Reprod. 2003 May;68(5):1631-40. Epub 2002 Nov 27.
5. Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Berrout L and Isokawa M, Neurosci Lett. 2012 May 16;516(2):280-4. doi: 10.1016/j.neulet.2012.04.009. Epub 2012 Apr 10.
6. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. Bülbül M, etal., J Gastroenterol. 2011 Apr;46(4):469-78. doi: 10.1007/s00535-010-0366-6. Epub 2011 Jan 22.
7. Involvement of PKA and ERK pathways in ghrelin-induced long-lasting potentiation of excitatory synaptic transmission in the CA1 area of rat hippocampus. Cavalier M, etal., Eur J Neurosci. 2015 Oct;42(8):2568-76. doi: 10.1111/ejn.13013. Epub 2015 Jul 29.
8. The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Choi K, etal., Endocrinology 2003 Mar;144(3):754-9.
9. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Clifford PS, etal., Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25.
10. GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs. Costantini VJ, etal., Neuroendocrinology. 2011;94(2):158-68. doi: 10.1159/000328968. Epub 2011 Jul 22.
11. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Cunha SR and Mayo KE, Endocrinology 2002 Dec;143(12):4570-82.
12. Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro. Depoortere I, etal., Eur J Pharmacol. 2005 May 16;515(1-3):160-8.
13. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Dezaki K, etal., Diabetes. 2006 Dec;55(12):3486-93.
14. Effects of ghrelin on the intracellular calcium concentration in rat aorta vascular smooth muscle cells. Fang H, etal., Cell Physiol Biochem. 2012;30(5):1299-309. doi: 10.1159/000343319. Epub 2012 Oct 22.
15. Estradiol modulates Kiss1 neuronal response to ghrelin. Frazao R, etal., Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E606-14. doi: 10.1152/ajpendo.00211.2013. Epub 2014 Jan 28.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation. Gong Y, etal., J Gastroenterol. 2014 Feb;49(2):219-30. doi: 10.1007/s00535-013-0789-y. Epub 2013 Mar 26.
18. Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. Harris LE, etal., Physiol Rep. 2014 Mar 20;2(3):e00240. doi: 10.1002/phy2.240. Print 2014.
19. Ghrelin receptor mutations--too little height and too much hunger. Holst B and Schwartz TW, J Clin Invest. 2006 Mar;116(3):637-41.
20. Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Hwang S, etal., Endocr J. 2009;56(4):609-17. Epub 2009 Apr 7.
21. Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature. Inoue H, etal., J Clin Endocrinol Metab. 2011 Feb;96(2):E373-8. doi: 10.1210/jc.2010-1570. Epub 2010 Nov 17.
22. Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity. Kaiya H, etal., J Endocrinol. 2003 Mar;176(3):415-23.
23. Thyroid hormones regulate pituitary growth hormone secretagogue receptor gene expression. Kamegai J, etal., J Neuroendocrinol. 2001 Mar;13(3):275-8.
24. Growth hormone-dependent regulation of pituitary GH secretagogue receptor (GHS-R) mRNA levels in the spontaneous dwarf Rat. Kamegai J, etal., Neuroendocrinology. 1998 Nov;68(5):312-8.
25. Insulin-like growth factor-I down-regulates ghrelin receptor (growth hormone secretagogue receptor) expression in the rat pituitary. Kamegai J, etal., Regul Pept. 2005 Apr 15;127(1-3):203-6.
26. Ghrelin: structure and function. Kojima M and Kangawa K, Physiol Rev. 2005 Apr;85(2):495-522.
27. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Kojima M, etal., Nature 1999 Dec 9;402(6762):656-60.
28. Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment. Kovacs M, etal., J Neuroendocrinol. 2000 Apr;12(4):335-41.
29. Ghrelin inhibits BSCB disruption/hemorrhage by attenuating MMP-9 and SUR1/TrpM4 expression and activation after spinal cord injury. Lee JY, etal., Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2403-12. doi: 10.1016/j.bbadis.2014.09.006. Epub 2014 Sep 28.
30. Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun N-terminal kinase and Wnt/ß-catenin signaling and suppresses lung inflammation. Li B, etal., Endocrinology. 2015 Jan;156(1):203-17. doi: 10.1210/en.2014-1539.
31. Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Li L, etal., Acta Pharmacol Sin. 2006 May;27(5):527-35.
32. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. MacKay H, etal., Physiol Behav. 2016 Sep 1;163:88-96. doi: 10.1016/j.physbeh.2016.04.048. Epub 2016 Apr 27.
33. Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. Mano-Otagiri A, etal., Regul Pept. 2010 Feb 25;160(1-3):81-90. doi: 10.1016/j.regpep.2009.11.010. Epub 2009 Nov 18.
34. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. McKee KK, etal., Mol Endocrinol 1997 Apr;11(4):415-23.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Miao Y, etal., Biochem Biophys Res Commun. 2007 Aug 3;359(3):795-800. Epub 2007 Jun 6.
37. Ghrelin augments afferent response to distension in rat isolated jejunum. Murray CD, etal., Neurogastroenterol Motil. 2006 Dec;18(12):1112-20.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. Ribeiro LF, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E149-58. doi: 10.1073/pnas.1313798111. Epub 2013 Dec 23.
44. Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. Shimizu Y, etal., J Physiol. 2006 Oct 1;576(Pt 1):329-38. Epub 2006 Jul 27.
45. Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. Shuto Y, etal., J Clin Invest 2002 Jun;109(11):1429-36.
46. Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat. Szczepankiewicz D, etal., J Physiol Pharmacol. 2010 Aug;61(4):443-9.
47. Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression. Tamura H, etal., J Neuroendocrinol. 2000 Jun;12(6):481-5.
48. Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats. Tarasiuk A, etal., Sleep. 2016 Apr 1;39(4):887-97. doi: 10.5665/sleep.5648.
49. Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity. Wiedemann T, etal., Diabetes. 2016 Feb;65(2):406-20. doi: 10.2337/db15-0374. Epub 2015 Oct 28.
50. Ghrelin inhibits sympathetic nervous activity in sepsis. Wu R, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1697-702. Epub 2007 Oct 2.
51. Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis. Wu R, etal., Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1296-302. Epub 2004 May 20.
52. Effects of ghrelin on gastric distention sensitive neurons in the arcuate nucleus of hypothalamus and gastric motility in diabetic rats. Xu L, etal., Peptides. 2013 Oct;48:137-46. doi: 10.1016/j.peptides.2013.08.010. Epub 2013 Aug 18.
53. Down-regulation of ghrelin receptors in the small intestine delays small intestinal transit in vagotomized rats. Yang CG, etal., Mol Med Rep. 2011 Nov-Dec;4(6):1061-5. doi: 10.3892/mmr.2011.571. Epub 2011 Aug 24.
54. [Relationship between Ghrelin and growth hormone secretagogue receptor expression and catch-up growth in rats with intrauterine growth restriction]. Yang HM, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Jul;12(7):563-8.
55. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. Zallar LJ, etal., Int J Obes (Lond). 2018 Jan 30. pii: 10.1038/s41366-018-0013-5. doi: 10.1038/s41366-018-0013-5.
56. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Zallar LJ, etal., J Neuroendocrinol. 2018 Nov 20:e12663. doi: 10.1111/jne.12663.
57. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Zaniolo K, etal., Invest Ophthalmol Vis Sci. 2011 Jul 23;52(8):5376-86. doi: 10.1167/iovs.10-7152.
58. Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis. Zhang R, etal., Mol Biol Rep. 2013 Jan;40(1):51-8. doi: 10.1007/s11033-012-1993-1. Epub 2012 Nov 6.
Additional References at PubMed
PMID:8688086   PMID:9437732   PMID:12511847   PMID:12876464   PMID:12890514   PMID:14993197   PMID:15070777   PMID:15232612   PMID:15448083   PMID:15919752   PMID:16322794   PMID:16338009  
PMID:16417945   PMID:16484324   PMID:16511605   PMID:16513828   PMID:16728494   PMID:16901923   PMID:17003258   PMID:17060947   PMID:17494105   PMID:17895831   PMID:18208550   PMID:18389390  
PMID:19299444   PMID:19490089   PMID:19540432   PMID:19589870   PMID:19703102   PMID:19819980   PMID:20056829   PMID:20152815   PMID:20164026   PMID:20497419   PMID:20596792   PMID:20600421  
PMID:20646435   PMID:20691233   PMID:21269967   PMID:21713709   PMID:21756973   PMID:22100225   PMID:22537050   PMID:22700774   PMID:22886413   PMID:23112170   PMID:23348715   PMID:23608221  
PMID:23698230   PMID:23755116   PMID:24513955   PMID:24525421   PMID:24531567   PMID:24780389   PMID:24797629   PMID:25049077   PMID:25058156   PMID:25230765   PMID:25727097   PMID:26283199  
PMID:26364514   PMID:26490687   PMID:27095593   PMID:27129257   PMID:28409695   PMID:28410130   PMID:28717967   PMID:28801520   PMID:29222553   PMID:29254662   PMID:29317796   PMID:29876881  
PMID:31185255   PMID:32814069   PMID:33264473   PMID:35255434   PMID:35365872   PMID:38187112  


Genomics

Comparative Map Data
Ghsr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,196,158 - 112,201,666 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2112,196,767 - 112,201,181 (+)EnsemblGRCr8
mRatBN7.22110,268,489 - 110,271,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2116,922,519 - 116,925,893 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02115,035,078 - 115,038,452 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,749,447 - 109,752,824 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,065,953 - 113,071,265 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)Ensemblrn6Rnor6.0
Rnor_5.02132,784,207 - 132,789,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42113,269,623 - 113,272,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2105,470,925 - 105,474,301 (+)NCBICelera
RGSC_v3.12113,214,584 - 113,217,961 (+)NCBI
Cytogenetic Map2q24NCBI
GHSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,443,291 - 172,448,456 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,443,291 - 172,448,456 (-)Ensemblhg38GRCh38
GRCh373172,161,081 - 172,166,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,645,645 - 173,648,897 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343173,648,035 - 173,648,905NCBI
Celera3170,559,676 - 170,564,839 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,531,507 - 169,536,581 (-)NCBIHuRef
CHM1_13172,123,965 - 172,129,130 (-)NCBICHM1_1
T2T-CHM13v2.03175,228,381 - 175,233,536 (-)NCBIT2T-CHM13v2.0
Ghsr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,425,500 - 27,433,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,425,500 - 27,432,159 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38327,371,351 - 27,379,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,371,351 - 27,378,010 (+)Ensemblmm10GRCm38
MGSCv37327,270,273 - 27,276,932 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36327,562,424 - 27,569,083 (+)NCBIMGSCv36mm8
Celera327,331,821 - 27,338,480 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.86NCBI
Ghsr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,478,877 - 2,487,215 (-)Ensembl
ChiLan1.0NW_0049554202,483,173 - 2,486,414 (-)NCBIChiLan1.0ChiLan1.0
GHSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22170,322,815 - 170,331,681 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,327,588 - 170,336,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,448,217 - 169,458,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,633,039 - 177,638,202 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,633,039 - 177,638,202 (-)EnsemblpanPan2panpan1.1
GHSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,691,132 - 36,694,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,690,224 - 36,694,312 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3445,703,894 - 45,707,255 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03436,775,648 - 36,779,007 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,774,740 - 36,779,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,714,573 - 36,717,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,683,080 - 36,686,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,941,135 - 36,944,502 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ghsr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,348,347 - 103,353,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593268,350 - 277,229 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936593268,736 - 273,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113110,981,465 - 111,006,149 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,917,068 - 119,929,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GHSR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11517,008,185 - 17,013,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1517,009,369 - 17,012,618 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606325,770,911 - 25,777,537 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghsr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,488,887 - 50,492,405 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473050,484,763 - 50,492,443 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ghsr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13127,326,738 - 127,330,900 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ghsr
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:111
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000034960
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat


Related Rat Strains
The following Strains have been annotated to Ghsr
SD-Tg(Th-Ghsros)    


Genetic Models
This gene Ghsr is modified in the following models/strains:
SS-Ghsrm3Mcwi     FHH-Ghsrm1Mcwi     SS-Ghsrm2Mcwi     W-Ghsrem1Ottc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 1 1 66 8 5 2 3 2 14 5 65 2 24 3 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000034960   ⟹   ENSRNOP00000038418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2112,196,767 - 112,201,181 (+)Ensembl
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)Ensembl
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)Ensembl
RefSeq Acc Id: NM_032075   ⟹   NP_114464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,197,158 - 112,200,534 (+)NCBI
mRatBN7.22110,268,489 - 110,271,865 (+)NCBI
Rnor_6.02113,066,885 - 113,070,261 (+)NCBI
Rnor_5.02132,784,207 - 132,789,319 (+)NCBI
RGSC_v3.42113,269,623 - 113,272,999 (+)RGD
Celera2105,470,925 - 105,474,301 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282641   ⟹   XP_063138711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,196,346 - 112,201,666 (+)NCBI
RefSeq Acc Id: XM_063282642   ⟹   XP_063138712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82112,196,158 - 112,201,666 (+)NCBI
RefSeq Acc Id: NP_114464   ⟸   NM_032075
- UniProtKB: O08725 (UniProtKB/Swiss-Prot),   A6IHG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038418   ⟸   ENSRNOT00000034960
RefSeq Acc Id: XP_063138712   ⟸   XM_063282642
- Peptide Label: isoform X1
- UniProtKB: O08725 (UniProtKB/Swiss-Prot),   A6IHG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138711   ⟸   XM_063282641
- Peptide Label: isoform X1
- UniProtKB: O08725 (UniProtKB/Swiss-Prot),   A6IHG7 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08725-F1-model_v2 AlphaFold O08725 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621397 AgrOrtholog
BioCyc Gene G2FUF-53506 BioCyc
Ensembl Genes ENSRNOG00000024119 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034960 ENTREZGENE
  ENSRNOT00000034960.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GHS-R/MTLR UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:84022 UniProtKB/Swiss-Prot
NCBI Gene 84022 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR24243:SF7 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ghsr PhenoGen
PRINTS GHSRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024119 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6IHG7 ENTREZGENE, UniProtKB/TrEMBL
  GHSR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ghsr  growth hormone secretagogue receptor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ghsr  growth hormone secretagogue receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the hypothalamus and pituitary 625699
gene_function an endogenous receptor for ghrelin (GH-releasing peptide) 625699
gene_process mediates growth hormone secretion, food intake, and adiposity in the arcuate nucleus (Arc) of the hypothalamus 625699
gene_product member of of the G protein coupled receptor superfamily 625699