RGD Reference Report - Cognitive enhancing effects of ghrelin receptor agonists. - Rat Genome Database

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Cognitive enhancing effects of ghrelin receptor agonists.

Authors: Atcha, Zeenat  Chen, Woei-Shin  Ong, Agnes B  Wong, Fong-Kuan  Neo, Aveline  Browne, Edward R  Witherington, Jason  Pemberton, Darrel J 
Citation: Atcha Z, etal., Psychopharmacology (Berl). 2009 Oct;206(3):415-27. doi: 10.1007/s00213-009-1620-6. Epub 2009 Aug 4.
RGD ID: 12910107
Pubmed: PMID:19652956   (View Abstract at PubMed)
DOI: DOI:10.1007/s00213-009-1620-6   (Journal Full-text)


RATIONALE: Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, has been shown to play a role in multiple physiological processes including appetite regulation, metabolism and, more recently, dendritic spine architecture, long-term potentiation and cognition.
OBJECTIVE: The objective of this study was to determine the effects of two structurally non-peptide ghrelin receptor agonists (GSK894490A and CP-464709-18) on rodent cognition.
METHODS: All experiments were performed in male Lister hooded rats. Effects of the test compounds on rat cognitive performance was determined using the novel object recognition test, a modified water maze paradigm and a scopolamine-induced deficit in cued fear conditioning. These tests were chosen as they each probe a relatively independent cognitive domain and therefore potentially have differing underlying neural substrates.
RESULTS: Both compounds significantly improved performance in the novel object recognition and modified water maze tests but were unable to attenuate a scopolamine deficit in cued fear conditioning.
CONCLUSIONS: These results demonstrate that the small-molecule ghrelin receptor agonists profiled here readily cross the blood/brain barrier and elicit pro-cognitive effects in recognition and spatial learning and memory tests. Based on these observations, the central ghrelin receptor would appear to be a chemically tractable receptor and perhaps should be considered as a new drug target for therapeutic approaches to treat diseases affecting cognition.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
learning or memory  IDA 12910107 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghsr  (growth hormone secretagogue receptor)


Additional Information