RGD Reference Report - DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. - Rat Genome Database

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DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype.

Authors: Banerjee, S A  Roffler-Tarlov, S  Szabo, M  Frohman, L  Chikaraishi, D M 
Citation: Banerjee SA, etal., Brain Res Mol Brain Res. 1994 Jul;24(1-4):89-106.
RGD ID: 12910126
Pubmed: PMID:7968381   (View Abstract at PubMed)

Transgenic mice bearing 4.8 kilobases (kb) of upstream rat tyrosine hydroxylase (TH) sequences linked to a human growth hormone gene (hGH) exhibited cell-specific expression of hGH in all the appropriate catecholaminergic neurons in the central nervous system (CNS), although with different penetrance in two different mouse lineages. No ectopic expression was observed in any brain or peripheral region in one founder and its progeny. In another founder there was some ectopic expression in addition to appropriate and high levels of tissue-specific expression in all catecholaminergic areas. These results identify regulatory sequences that are sufficient for targeting expression to all catecholaminergic CNS neurons. Also, expression of exogenous hGH in the hypothalamus caused a dwarf phenotype, generating a novel genetic model for GH deficiency of hypothalamic origin.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Dwarfism  IMP 12910126 RGD 
Dwarfism  ISOGHSR (Homo sapiens)12910126; 12910126 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghsr  (growth hormone secretagogue receptor)

Genes (Mus musculus)
Ghsr  (growth hormone secretagogue receptor)

Genes (Homo sapiens)
GHSR  (growth hormone secretagogue receptor)

Objects referenced in this article
Strain SD-Tg(Th-Ghsros) null Rattus norvegicus

Additional Information