Ezr (ezrin) - Rat Genome Database

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Gene: Ezr (ezrin) Rattus norvegicus
Analyze
Symbol: Ezr
Name: ezrin
RGD ID: 621161
Description: Enables protein domain specific binding activity. Involved in epithelial cell differentiation and filopodium assembly. Located in several cellular components, including basolateral plasma membrane; microspike; and microvillus. Orthologous to human EZR (ezrin); PARTICIPATES IN FasL mediated signaling pathway; parathyroid hormone signaling pathway; protein kinase A (PKA) signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytovillin; MGC94076; p81; Vil2; villin 2; villin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,373,033 - 49,416,573 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,373,035 - 49,416,573 (-)EnsemblGRCr8
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)Ensemblrn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,655,531 - 42,699,079 (-)NCBICelera
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
aniline  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
cannabidiol  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclohexanols  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
microcystin-LR  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
neomycin  (EXP)
nicotine  (ISO)
nitrates  (ISO)
nitric oxide  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
Propiverine  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hydroxide  (ISO)
Soman  (EXP)
starch  (EXP)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triton X-100  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
Withanone  (ISO)
Y-27632  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actin filament bundle assembly  (IEA,ISO,ISS)
astral microtubule organization  (IEA,ISO)
cAMP/PKA signal transduction  (IEA,ISO)
cortical microtubule organization  (IEA,ISO)
epithelial cell differentiation  (IEP)
establishment of centrosome localization  (IEA,ISO)
establishment of endothelial barrier  (IEA,ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (IEA,IMP,ISO)
gland morphogenesis  (ISO)
intestinal D-glucose absorption  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA,ISO)
membrane to membrane docking  (IEA,ISO)
microvillus assembly  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of p38MAPK cascade  (IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of early endosome to late endosome transport  (IBA,IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-2-mediated signaling pathway  (ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein localization to early endosome  (IBA,IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
postsynaptic actin cytoskeleton organization  (IEA,ISO)
protein localization to cell cortex  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
protein-containing complex localization  (IEA,ISO)
receptor internalization  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell shape  (IBA,IEA,ISO)
regulation of microvillus length  (IEA,ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of organelle assembly  (IBA,IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
terminal web assembly  (IEA,ISO)

Cellular Component
actin cytoskeleton  (IEA,ISO,ISS)
actin filament  (IEA,ISO,ISS)
adherens junction  (IBA)
apical part of cell  (IBA,IEA,ISO)
apical plasma membrane  (IDA,IEA,ISO)
astrocyte projection  (IDA)
basolateral plasma membrane  (IDA)
brush border  (IEA,ISO)
cell body  (IDA)
cell cortex  (IEA)
cell periphery  (IEA,ISO)
cell projection  (IEA,ISO)
cell tip  (IDA,IEA)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO,TAS)
endosome  (IEA,ISO)
filopodium  (IBA,IDA,IEA,ISO)
focal adhesion  (IEA,ISO)
immunological synapse  (IEA,ISO)
microspike  (IDA)
microvillus  (IBA,IEA,ISO)
microvillus membrane  (IDA,IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
plasma membrane raft  (IEA,ISO)
protein-containing complex  (IEA,ISO)
ruffle  (IEA,ISO)
ruffle membrane  (IEA)
Schwann cell microvillus  (IDA)
T-tubule  (IDA,IEA)
uropod  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. Antoine-Bertrand J, etal., Mol Biol Cell. 2011 Oct;22(19):3734-46. doi: 10.1091/mbc.E10-11-0917. Epub 2011 Aug 17.
2. Transcriptional regulation of the ezrin gene during rat intestinal development and epithelial differentiation. Barila D, etal., Biochim Biophys Acta 1995 Aug 22;1263(2):133-40.
3. Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium. Bonilha VL and Rodriguez-Boulan E, Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3274-82.
4. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
5. ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. Darmellah A, etal., Cardiovasc Res. 2009 Feb 1;81(2):294-300. doi: 10.1093/cvr/cvn320. Epub 2008 Nov 21.
6. Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility. Gatto CL, etal., J Cell Physiol. 2007 Jan;210(1):122-32.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. A functional FERM domain binding motif in neurofascin. Gunn-Moore FJ, etal., Mol Cell Neurosci. 2006 Dec;33(4):441-6. Epub 2006 Oct 12.
10. Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Lavialle M, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12915-9. doi: 10.1073/pnas.1100957108. Epub 2011 Jul 13.
11. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. ERMs colocalize transiently with L1 during neocortical axon outgrowth. Mintz CD, etal., J Comp Neurol 2003 Sep 29;464(4):438-48.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin. Orlando RA, etal., J Am Soc Nephrol. 2001 Aug;12(8):1589-98.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Smith PM, etal., Endocrinology. 2004 Jul;145(7):3075-83. Epub 2004 Mar 24.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
22. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
23. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:7844168   PMID:9472040   PMID:9852149   PMID:9890997   PMID:10793131   PMID:11285285   PMID:11598191   PMID:11728336   PMID:12082081   PMID:14625387   PMID:14996907   PMID:15177033  
PMID:15489334   PMID:15498789   PMID:15797715   PMID:16365167   PMID:16502470   PMID:17065554   PMID:17122142   PMID:17138661   PMID:17292355   PMID:17634366   PMID:17825285   PMID:17911601  
PMID:18321067   PMID:18478542   PMID:19190083   PMID:19783662   PMID:19946888   PMID:20458337   PMID:20551175   PMID:20551903   PMID:21120533   PMID:21134835   PMID:21148287   PMID:21282464  
PMID:21377456   PMID:21423176   PMID:21451047   PMID:21666723   PMID:21988832   PMID:22114352   PMID:22132106   PMID:22206666   PMID:22291017   PMID:22467863   PMID:22658674   PMID:22681889  
PMID:22797597   PMID:22871113   PMID:23106337   PMID:23264465   PMID:23284756   PMID:23376485   PMID:23533145   PMID:23857773   PMID:24091598   PMID:24184478   PMID:24284068   PMID:24385580  
PMID:24726496   PMID:24862762   PMID:25051438   PMID:25097019   PMID:25468996   PMID:25486435   PMID:25554515   PMID:25652626   PMID:25854562   PMID:25889165   PMID:28077322   PMID:29568061  
PMID:30654004   PMID:31931020  


Genomics

Comparative Map Data
Ezr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,373,033 - 49,416,573 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,373,035 - 49,416,573 (-)EnsemblGRCr8
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)Ensemblrn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,655,531 - 42,699,079 (-)NCBICelera
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Cytogenetic Map1q11NCBI
EZR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386158,765,748 - 158,819,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6158,765,741 - 158,819,413 (-)Ensemblhg38GRCh38
GRCh376159,186,780 - 159,240,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,106,764 - 159,159,247 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346159,157,186 - 159,209,668NCBI
Celera6159,834,789 - 159,888,323 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6156,657,307 - 156,711,123 (-)NCBIHuRef
CHM1_16159,449,491 - 159,503,058 (-)NCBICHM1_1
T2T-CHM13v2.06160,010,984 - 160,064,812 (-)NCBIT2T-CHM13v2.0
Ezr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,005,530 - 7,050,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,005,440 - 7,050,183 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38176,738,131 - 6,782,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl176,738,041 - 6,782,784 (-)Ensemblmm10GRCm38
MGSCv37176,942,480 - 6,987,129 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36176,587,789 - 6,632,438 (-)NCBIMGSCv36mm8
Celera1514,687,905 - 14,732,667 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.38NCBI
Ezr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554393,703,013 - 3,740,345 (+)Ensembl
ChiLan1.0NW_0049554393,701,722 - 3,740,345 (+)NCBIChiLan1.0ChiLan1.0
EZR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25178,869,668 - 178,923,683 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16176,774,286 - 176,828,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16161,670,483 - 161,723,102 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)EnsemblpanPan2panpan1.1
EZR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ezr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18,403,453 - 8,452,742 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.118,403,362 - 8,452,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,423,530 - 10,432,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11386,342,954 - 86,399,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,344,051 - 86,370,622 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604058,721,321 - 58,778,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624929826,531 - 873,572 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624929827,275 - 873,743 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ezr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12192,379,000 - 192,422,154 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ezr
314 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:61
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000046746
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
RH127410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,967,667 - 46,967,854 (+)MAPPERmRatBN7.2
Rnor_6.0147,287,579 - 47,287,765NCBIRnor6.0
Rnor_5.0148,590,678 - 48,590,864UniSTSRnor5.0
RGSC_v3.4141,177,902 - 41,178,088UniSTSRGSC3.4
Celera142,655,238 - 42,655,424UniSTS
RH 3.4 Map1541.1UniSTS
Cytogenetic Map1q11UniSTS
RH125205  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,970,865 - 46,971,872 (+)MAPPERmRatBN7.2
Rnor_6.0147,290,777 - 47,291,783NCBIRnor6.0
Rnor_5.0148,593,876 - 48,594,882UniSTSRnor5.0
RGSC_v3.4141,181,100 - 41,182,106UniSTSRGSC3.4
Celera142,658,436 - 42,659,442UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000046746   ⟹   ENSRNOP00000046593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,373,035 - 49,416,573 (-)Ensembl
mRatBN7.2 Ensembl146,967,963 - 47,011,505 (-)Ensembl
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090033   ⟹   ENSRNOP00000074514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,373,035 - 49,393,806 (-)Ensembl
mRatBN7.2 Ensembl146,967,658 - 46,988,735 (-)Ensembl
Rnor_6.0 Ensembl147,288,576 - 47,307,488 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105371   ⟹   ENSRNOP00000076572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,373,035 - 49,393,226 (-)Ensembl
mRatBN7.2 Ensembl146,967,658 - 46,988,155 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112255   ⟹   ENSRNOP00000087725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,967,658 - 47,011,114 (-)Ensembl
RefSeq Acc Id: NM_019357   ⟹   NP_062230
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,373,033 - 49,416,573 (-)NCBI
mRatBN7.2146,967,961 - 47,011,505 (-)NCBI
Rnor_6.0147,287,872 - 47,331,412 (-)NCBI
Rnor_5.0148,590,971 - 48,634,511 (-)NCBI
RGSC_v3.4141,178,195 - 41,221,735 (-)RGD
Celera142,655,531 - 42,699,079 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062230 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81958 (Get FASTA)   NCBI Sequence Viewer  
  AAL47844 (Get FASTA)   NCBI Sequence Viewer  
  AAR91694 (Get FASTA)   NCBI Sequence Viewer  
  CAA48004 (Get FASTA)   NCBI Sequence Viewer  
  EDL83712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046593
  ENSRNOP00000046593.2
GenBank Protein P31977 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062230   ⟸   NM_019357
- UniProtKB: Q66H97 (UniProtKB/Swiss-Prot),   Q5WQV4 (UniProtKB/Swiss-Prot),   Q8VHK3 (UniProtKB/Swiss-Prot),   P31977 (UniProtKB/Swiss-Prot),   A6KP14 (UniProtKB/TrEMBL),   A0A8I5Y4R7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074514   ⟸   ENSRNOT00000090033
Ensembl Acc Id: ENSRNOP00000046593   ⟸   ENSRNOT00000046746
Ensembl Acc Id: ENSRNOP00000076572   ⟸   ENSRNOT00000105371
Ensembl Acc Id: ENSRNOP00000087725   ⟸   ENSRNOT00000112255
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31977-F1-model_v2 AlphaFold P31977 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689609
Promoter ID:EPDNEW_R132
Type:multiple initiation site
Name:Ezr_1
Description:ezrin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,331,024 - 47,331,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621161 AgrOrtholog
BioCyc Gene G2FUF-61612 BioCyc
Ensembl Genes ENSRNOG00000018524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046746 ENTREZGENE
  ENSRNOT00000046746.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.450 UniProtKB/Swiss-Prot
  1.20.80.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  6.10.360.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124292 IMAGE-MGC_LOAD
InterPro Band_41_domain UniProtKB/Swiss-Prot
  ERM UniProtKB/Swiss-Prot
  ERM_C_dom UniProtKB/Swiss-Prot
  ERM_FERM_C UniProtKB/Swiss-Prot
  ERM_helical UniProtKB/Swiss-Prot
  Ez/rad/moesin-like UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_CS UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  FERM_PH-like_C UniProtKB/Swiss-Prot
  Moesin_tail_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:54319 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94076 IMAGE-MGC_LOAD
NCBI Gene 54319 ENTREZGENE
PANTHER PTHR23281 UniProtKB/Swiss-Prot
Pfam ERM_C UniProtKB/Swiss-Prot
  ERM_helical UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
  FERM_M UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
PhenoGen Ezr PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot
PRINTS BAND41 UniProtKB/Swiss-Prot
  ERMFAMILY UniProtKB/Swiss-Prot
PROSITE FERM_1 UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018524 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
  SSF48678 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A0G2K890_RAT UniProtKB/TrEMBL
  A0A8I5Y4R7 ENTREZGENE, UniProtKB/TrEMBL
  A6KP14 ENTREZGENE, UniProtKB/TrEMBL
  EZRI_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5WQV4 ENTREZGENE
  Q66H97 ENTREZGENE
  Q8VHK3 ENTREZGENE
UniProt Secondary Q5WQV4 UniProtKB/Swiss-Prot
  Q66H97 UniProtKB/Swiss-Prot
  Q8VHK3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Ezr  ezrin  Vil2  villin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Vil2  villin 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vil2  villin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may play an important role during development and differentiation of the intestinal epithelium 729995