Cdk6 (cyclin-dependent kinase 6) - Rat Genome Database

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Gene: Cdk6 (cyclin-dependent kinase 6) Rattus norvegicus
Analyze
Symbol: Cdk6
Name: cyclin-dependent kinase 6
RGD ID: 621121
Description: Enables cyclin binding activity. Involved in DNA damage response. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D2-CDK6 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; ceramide signaling pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell division protein kinase 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,592,384 - 31,784,732 (-)NCBIGRCr8
mRatBN7.2430,637,650 - 30,829,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,646,460 - 30,829,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,619,211 - 35,799,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,545,296 - 31,725,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,941,333 - 30,121,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,781,728 - 27,969,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,785,647 - 27,966,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,685,042 - 27,872,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4427,362,656 - 27,618,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1427,471,179 - 27,635,330 (-)NCBI
Celera426,070,823 - 26,248,747 (-)NCBICelera
Cytogenetic Map4q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (ISO)
2-methylcholine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acteoside  (ISO)
adefovir pivoxil  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BMS-754807  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (EXP)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
columbamine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coptisine  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
diclofenac  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dioscin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
embelin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furazolidone  (ISO)
galangin  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
glyphosate  (ISO)
hesperidin  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
quizartinib  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
ritonavir  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
seliciclib  (EXP)
silibinin  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetracaine  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
venetoclax  (ISO)
vinclozolin  (EXP,ISO)
vismodegib  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
2. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Costello JF, etal., Cancer Res. 1997 Apr 1;57(7):1250-4.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. Huang M, etal., Cancer Lett. 2014 Oct 10;353(1):32-40. doi: 10.1016/j.canlet.2014.06.021. Epub 2014 Jul 19.
6. Activation of cyclin D1-related kinase in human lung adenocarcinoma. Igarashi K, etal., Br J Cancer. 1999 Oct;81(4):705-11. doi: 10.1038/sj.bjc.6690752.
7. Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype. Keutgen XM, etal., Cancer. 2018 Feb 1;124(3):636-647. doi: 10.1002/cncr.31057. Epub 2017 Nov 17.
8. Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme. Lam PY, etal., Br J Neurosurg. 2000 Feb;14(1):28-32.
9. Knockdown of CDK6 enhances glioma sensitivity to chemotherapy. Li B, etal., Oncol Rep. 2012 Sep;28(3):909-14. doi: 10.3892/or.2012.1884. Epub 2012 Jun 25.
10. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
11. Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment. Marsh JL, etal., Front Biosci (Landmark Ed). 2014 Jan 1;19:113-25.
12. Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma. Mendrzyk F, etal., J Clin Oncol. 2005 Dec 1;23(34):8853-62. doi: 10.1200/JCO.2005.02.8589.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 to Facilitate the Activation of Cdk4/6 and Early G1 Phase Progression. Obaya AJ, etal., J Biol Chem 2002 Aug 23;277(34):31263-9.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
21. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, etal., Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18.
22. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
23. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
24. Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer. Wu Y, etal., Mol Ther Nucleic Acids. 2013 Apr 16;2:e84. doi: 10.1038/mtna.2013.14.
25. miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6. Zhang J, etal., Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4494-4499.
Additional References at PubMed
PMID:7739547   PMID:8114739   PMID:9751050   PMID:10205165   PMID:12833137   PMID:12861051   PMID:14985467   PMID:15254224   PMID:15315761   PMID:16548883   PMID:17420273   PMID:17431401  
PMID:18495667   PMID:18504428   PMID:18700867   PMID:20466002   PMID:20501390   PMID:20668294   PMID:21508411   PMID:22893700   PMID:23918663   PMID:25342715   PMID:26542173   PMID:26699910  
PMID:26707878   PMID:30701428  


Genomics

Comparative Map Data
Cdk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,592,384 - 31,784,732 (-)NCBIGRCr8
mRatBN7.2430,637,650 - 30,829,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,646,460 - 30,829,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,619,211 - 35,799,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,545,296 - 31,725,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,941,333 - 30,121,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,781,728 - 27,969,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,785,647 - 27,966,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,685,042 - 27,872,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4427,362,656 - 27,618,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1427,471,179 - 27,635,330 (-)NCBI
Celera426,070,823 - 26,248,747 (-)NCBICelera
Cytogenetic Map4q13NCBI
CDK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,604,921 - 92,836,573 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,604,921 - 92,836,573 (-)EnsemblGRCh38hg38GRCh38
GRCh37792,234,235 - 92,465,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,072,171 - 92,301,148 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,878,887 - 92,107,863NCBI
Celera786,938,762 - 87,170,471 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,843,599 - 87,075,188 (-)NCBIHuRef
CHM1_1792,164,273 - 92,395,977 (-)NCBICHM1_1
T2T-CHM13v2.0793,846,868 - 94,078,562 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,563,451 - 91,795,159 (-)NCBI
Cdk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,391,004 - 3,581,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,391,485 - 3,581,008 (+)EnsemblGRCm39 Ensembl
GRCm3853,341,004 - 3,531,008 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,341,485 - 3,531,008 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,344,312 - 3,522,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,350,318 - 3,528,231 (+)NCBIMGSCv36mm8
Celera53,279,311 - 3,457,786 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.04NCBI
Cdk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,521,794 - 9,726,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,521,794 - 9,727,772 (-)NCBIChiLan1.0ChiLan1.0
CDK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26110,490,882 - 110,725,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,755,524 - 158,990,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,603,419 - 84,835,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1798,198,740 - 98,430,305 (-)NCBIpanpan1.1PanPan1.1panPan2
CDK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,178,352 - 18,413,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,188,429 - 18,419,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,739,051 - 17,984,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,990,661 - 18,231,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,991,832 - 18,228,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11418,145,467 - 18,391,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,862,908 - 18,101,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,137,407 - 18,377,659 (-)NCBIUU_Cfam_GSD_1.0
Cdk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,562,931 - 31,777,533 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368031,024,779 - 1,227,516 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368031,025,047 - 1,229,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,518,101 - 72,764,129 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,510,858 - 72,765,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2979,239,881 - 79,316,977 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,167,731 - 56,403,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,170,450 - 56,393,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,876,694 - 48,113,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624809349,404 - 579,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624809349,453 - 588,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdk6
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:49
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000012597
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 18 26 16 17 16 31 29 39 11
Low 2 25 31 25 2 25 8 9 43 6 2 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012597   ⟹   ENSRNOP00000012597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,646,460 - 30,828,229 (-)Ensembl
Rnor_6.0 Ensembl427,785,647 - 27,966,398 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104799   ⟹   ENSRNOP00000087481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl430,648,341 - 30,829,634 (-)Ensembl
RefSeq Acc Id: NM_001191861   ⟹   NP_001178790
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,601,192 - 31,781,502 (-)NCBI
mRatBN7.2430,646,460 - 30,826,780 (-)NCBI
Rnor_6.0427,785,640 - 27,966,398 (-)NCBI
Rnor_5.0427,685,042 - 27,872,388 (-)NCBI
Celera426,070,823 - 26,248,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236019   ⟹   XP_006236081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,592,384 - 31,782,981 (-)NCBI
mRatBN7.2430,637,650 - 30,828,148 (-)NCBI
Rnor_6.0427,781,728 - 27,967,870 (-)NCBI
Rnor_5.0427,685,042 - 27,872,388 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236020   ⟹   XP_006236082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,592,384 - 31,782,980 (-)NCBI
mRatBN7.2430,637,650 - 30,828,005 (-)NCBI
Rnor_6.0427,781,728 - 27,967,870 (-)NCBI
Rnor_5.0427,685,042 - 27,872,388 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236021   ⟹   XP_006236083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,592,384 - 31,784,690 (-)NCBI
mRatBN7.2430,637,650 - 30,829,688 (-)NCBI
Rnor_6.0427,781,728 - 27,969,653 (-)NCBI
Rnor_5.0427,685,042 - 27,872,388 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039106910   ⟹   XP_038962838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,687,670 - 31,784,720 (-)NCBI
mRatBN7.2430,732,962 - 30,829,688 (-)NCBI
RefSeq Acc Id: XM_063285393   ⟹   XP_063141463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,592,384 - 31,782,980 (-)NCBI
RefSeq Acc Id: XM_063285394   ⟹   XP_063141464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8431,603,157 - 31,784,732 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178790   ⟸   NM_001191861
- UniProtKB: F1MA87 (UniProtKB/TrEMBL),   A6K295 (UniProtKB/TrEMBL),   A0A8I6A5X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236083   ⟸   XM_006236021
- Peptide Label: isoform X1
- UniProtKB: F1MA87 (UniProtKB/TrEMBL),   A6K295 (UniProtKB/TrEMBL),   A0A8I6A5X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236081   ⟸   XM_006236019
- Peptide Label: isoform X1
- UniProtKB: F1MA87 (UniProtKB/TrEMBL),   A6K295 (UniProtKB/TrEMBL),   A0A8I6A5X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236082   ⟸   XM_006236020
- Peptide Label: isoform X1
- UniProtKB: F1MA87 (UniProtKB/TrEMBL),   A6K295 (UniProtKB/TrEMBL),   A0A8I6A5X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012597   ⟸   ENSRNOT00000012597
RefSeq Acc Id: XP_038962838   ⟸   XM_039106910
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000087481   ⟸   ENSRNOT00000104799
RefSeq Acc Id: XP_063141463   ⟸   XM_063285393
- Peptide Label: isoform X1
- UniProtKB: A6K295 (UniProtKB/TrEMBL),   F1MA87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141464   ⟸   XM_063285394
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MA87-F1-model_v2 AlphaFold F1MA87 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621121 AgrOrtholog
BioCyc Gene G2FUF-45759 BioCyc
Ensembl Genes ENSRNOG00000009258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012597 ENTREZGENE
  ENSRNOT00000012597.7 UniProtKB/TrEMBL
  ENSRNOT00000104799.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK6 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:114483 UniProtKB/TrEMBL
NCBI Gene 114483 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 6 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Cdk6 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009258 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6A5X3 ENTREZGENE, UniProtKB/TrEMBL
  A6K295 ENTREZGENE, UniProtKB/TrEMBL
  F1MA87 ENTREZGENE, UniProtKB/TrEMBL
  Q99MD0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cdk6  cyclin-dependent kinase 6      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Cdk6        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in hormone-dependent endometrial cancers 70348
gene_disease upregulated in hormone-dependent endometrial cancers 70557
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557