Csf1 (colony stimulating factor 1) - Rat Genome Database

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Gene: Csf1 (colony stimulating factor 1) Rattus norvegicus
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Symbol: Csf1
Name: colony stimulating factor 1
RGD ID: 621063
Description: Enables identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; myeloid leukocyte differentiation; and positive regulation of macrophage proliferation. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1); PARTICIPATES IN cytokine mediated signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: colony stimulating factor 1 (macrophage); colony stimulating factor 1(macrophage); CSF-1; macrophage colony-stimulating factor 1; MCSF; PG-M-CSF; proteoglycan macrophage colony-stimulating factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Csf1tl
Genetic Models: F344tl
Is Marker For: Strains:   LEW-tl ; LEW-tl.BN-(D2Arb16-D2Wox8)
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,065,400 - 198,084,774 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2198,065,405 - 198,084,468 (-)EnsemblGRCr8
mRatBN7.22195,377,215 - 195,396,608 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,377,215 - 195,411,704 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2203,018,890 - 203,037,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,901,047 - 200,920,075 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,717,984 - 195,737,022 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,522,370 - 210,550,546 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,522,375 - 210,550,560 (-)Ensemblrn6Rnor6.0
Rnor_5.02229,989,430 - 230,017,945 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42203,292,765 - 203,307,968 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2188,024,644 - 188,043,645 (-)NCBICelera
RGSC_v3.12203,255,518 - 203,270,701 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspartame  (ISO)
atazanavir sulfate  (ISO)
Azoxymethane  (ISO)
benzalkonium chloride  (ISO)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DAPT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EGTA acetoxymethyl ester  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamidone  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
graphite  (EXP)
GTP  (ISO)
GW 4064  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nitric oxide  (ISO)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
pexidartinib  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Risedronate sodium  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulindac  (EXP)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
terameprocol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymidine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in mammary gland duct morphogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA,ISO)
cellular response to parathyroid hormone stimulus  (IEP)
developmental process involved in reproduction  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
macrophage colony-stimulating factor signaling pathway  (ISO)
macrophage differentiation  (IDA,IEA,IEP)
mammary duct terminal end bud growth  (ISO)
mammary gland fat development  (ISO)
microglial cell proliferation  (ISO)
ossification  (IMP)
osteoclast differentiation  (IBA,IEA,IMP,ISO)
osteoclast proliferation  (ISO)
positive regulation of cell migration  (IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of leukocyte migration  (IEA)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage colony-stimulating factor signaling pathway  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of macrophage differentiation  (IBA,IEA,ISO)
positive regulation of macrophage migration  (IEA,ISO)
positive regulation of macrophage proliferation  (IMP)
positive regulation of microglial cell migration  (IEA,ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of mononuclear cell migration  (IMP)
positive regulation of mononuclear cell proliferation  (IEA,ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of odontogenesis of dentin-containing tooth  (ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of Ras protein signal transduction  (ISO)
regulation of ossification  (ISO)
response to ischemia  (IEA,ISO)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Isolation and characterization of a cDNA clone encoding for rat CSF-1 gene. Post-transcriptional repression occurs in myogenic differentiation. Borycki A, etal., Biochim Biophys Acta 1993 Aug 19;1174(2):143-52.
2. Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis. Budrys NM, etal., Fertil Steril. 2012 May;97(5):1129-35.e1. doi: 10.1016/j.fertnstert.2012.02.007. Epub 2012 Feb 24.
3. Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens. Corcoran AT, etal., World J Urol. 2013 Feb;31(1):241-6. doi: 10.1007/s00345-012-0852-y. Epub 2012 Mar 24.
4. Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat. Dobbins DE, etal., Biochem Biophys Res Commun 2002 Jun 28;294(5):1114-20.
5. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis. Gerdprasert O, etal., Mol Hum Reprod 2002 Jun;8(6):518-24.
8. Serum level of macrophage colony-stimulating factor and atherosclerosis in hemodialysis patients. Haraguchi K, etal., Nephron Clin Pract. 2006;102(1):c14-20. Epub 2005 Sep 13.
9. Macrophage colony-stimulating factor induces prolactin expression in rat pituitary gland. Hoshino S, etal., Zoolog Sci. 2014 Jun;31(6):390-7. doi: 10.2108/zs130226.
10. Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis. Isbel NM, etal., Nephrol Dial Transplant. 2001 Aug;16(8):1638-47.
11. Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. Iyoda M, etal., Kidney Int. 2009 May;75(10):1060-70. doi: 10.1038/ki.2009.43. Epub 2009 Feb 25.
12. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. Jang MH, etal., J Immunol. 2006 Sep 15;177(6):4055-63.
13. Antiangiogenic drugs synergize with a membrane macrophage colony-stimulating factor-based tumor vaccine to therapeutically treat rats with an established malignant intracranial glioma. Jeffes EW, etal., J Immunol. 2005 Mar 1;174(5):2533-43.
14. Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model. Jin Y, etal., Lab Invest. 2013 Jul;93(7):801-11. doi: 10.1038/labinvest.2013.64. Epub 2013 Apr 29.
15. Immunophenotypical characterization of macrophages in rat bleomycin-induced scleroderma. Juniantito V, etal., Vet Pathol. 2013 Jan;50(1):76-85. doi: 10.1177/0300985812450718. Epub 2012 Jun 13.
16. Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation. Kirma N, etal., Cancer Res. 2004 Jun 15;64(12):4162-70.
17. Macrophage colony-stimulating factor expression and macrophage accumulation in renal allograft rejection. Le Meur Y, etal., Transplantation. 2002 Apr 27;73(8):1318-24.
18. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. Lenda DM, etal., J Immunol. 2004 Oct 1;173(7):4744-54.
19. Fcγ Receptor I-Coupled Signaling in Peripheral Nociceptors Mediates Joint Pain in a Rat Model of Rheumatoid Arthritis. Liu F, etal., Arthritis Rheumatol. 2020 Oct;72(10):1668-1678. doi: 10.1002/art.41386. Epub 2020 Sep 6.
20. Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic rats. Liu W, etal., Curr Eye Res. 2009 Feb;34(2):123-33. doi: 10.1080/02713680802650369.
21. Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Menke J, etal., Cancer Res. 2012 Jan 1;72(1):187-200. doi: 10.1158/0008-5472.CAN-11-1232. Epub 2011 Nov 3.
22. Distinct roles of CSF-1 isoforms in lupus nephritis. Menke J, etal., J Am Soc Nephrol. 2011 Oct;22(10):1821-33. doi: 10.1681/ASN.2011010038. Epub 2011 Sep 1.
23. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. Menke J, etal., J Immunol. 2008 Nov 15;181(10):7367-79.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Miyazaki K, etal., Clin Exp Immunol. 1997 May;108(2):318-23.
26. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Nakajima K, etal., J Neurosci Res. 2006 Aug 1;84(2):348-59. doi: 10.1002/jnr.20882.
27. Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force. Nakano Y, etal., Eur J Orthod. 2011 Aug;33(4):335-43. doi: 10.1093/ejo/cjq068. Epub 2010 Sep 10.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts. Paulus P, etal., Cancer Res. 2006 Apr 15;66(8):4349-56.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. Rajavashisth T, etal., J Clin Invest 1998 Jun 15;101(12):2702-10.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma. Richardsen E, etal., Histopathology. 2008 May 28;.
36. Nitric oxide, enhanced by macrophage-colony stimulating factor, mediates renal damage in reflux nephropathy. Rolle U, etal., Kidney Int. 2002 Aug;62(2):507-13.
37. [Mediators of amyloidogenesis and cytokines in dialysis-related amyloidosis]. Rysava R, etal., Cas Lek Cesk. 2002 Apr 26;141(8):244-7.
38. Expansion of CD4+CD16+ blood monocytes in patients with chronic renal failure undergoing dialysis: possible involvement of macrophage colony-stimulating factor. Saionji K and Ohsaka A, Acta Haematol. 2001;105(1):21-6.
39. A temporal evaluation of cytokines in rats after blast exposure. Sajja VS, etal., Biomed Sci Instrum. 2012;48:374-9.
40. Renal epithelial cell-derived monocyte colony stimulating factor as a local informant of renal injury and means of monocyte activation. Singh KA, etal., Transpl Int. 2009 Jul;22(7):730-7. doi: 10.1111/j.1432-2277.2009.00840.x. Epub 2009 Jan 29.
41. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
42. Circulating colony stimulating factor-1 and breast cancer risk. Tamimi RM, etal., Cancer Res. 2008 Jan 1;68(1):18-21.
43. Urinary levels of RANTES and M-CSF are predictors of lupus nephritis flare. Tian S, etal., Inflamm Res. 2007 Jul;56(7):304-10.
44. The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy. Utsunomiya K, etal., J Diabetes Complications. 1995 Oct-Dec;9(4):292-5.
45. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Van Wesenbeeck L, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14303-8.
46. Macrophage colony-stimulating factor release and receptor expression in bone cells. Weir EC, etal., J Bone Miner Res. 1993 Dec;8(12):1507-18. doi: 10.1002/jbmr.5650081214.
47. Macrophage-colony stimulating factor as an inducer of microglial proliferation in axotomized rat facial nucleus. Yamamoto S, etal., J Neurochem. 2010 Nov;115(4):1057-67. doi: 10.1111/j.1471-4159.2010.06996.x. Epub 2010 Oct 12.
48. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
49. CSF-1 signaling mediates recovery from acute kidney injury. Zhang MZ, etal., J Clin Invest. 2012 Dec 3;122(12):4519-32. doi: 10.1172/JCI60363. Epub 2012 Nov 12.
50. [Macrophage colony-stimulating factor production and c-fms expression in cultured rat aortic vascular smooth muscle cells]. Zhu DL, etal., Sheng Li Xue Bao. 1999 Apr;51(2):181-6.
51. Technical Advance: The rat aorta contains resident mononuclear phagocytes with proliferative capacity and proangiogenic properties. Zorzi P, etal., J Leukoc Biol. 2010 Nov;88(5):1051-9. Epub 2010 Jul 13.
Additional References at PubMed
PMID:1739124   PMID:2408759   PMID:2460758   PMID:3264878   PMID:8922060   PMID:9215625   PMID:10652277   PMID:10666185   PMID:10804170   PMID:12865350   PMID:14696961   PMID:15203935  
PMID:15304486   PMID:15657444   PMID:16237150   PMID:16304045   PMID:16883060   PMID:17053831   PMID:17068143   PMID:17244792   PMID:17442941   PMID:18606301   PMID:19017797   PMID:19100238  
PMID:19893052   PMID:21048959   PMID:21176538   PMID:22153499   PMID:22451653   PMID:22902366   PMID:23376485   PMID:23392676   PMID:23443487   PMID:23711477   PMID:24006456   PMID:30687013  


Genomics

Comparative Map Data
Csf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,065,400 - 198,084,774 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2198,065,405 - 198,084,468 (-)EnsemblGRCr8
mRatBN7.22195,377,215 - 195,396,608 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,377,215 - 195,411,704 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2203,018,890 - 203,037,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,901,047 - 200,920,075 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,717,984 - 195,737,022 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,522,370 - 210,550,546 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,522,375 - 210,550,560 (-)Ensemblrn6Rnor6.0
Rnor_5.02229,989,430 - 230,017,945 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42203,292,765 - 203,307,968 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2188,024,644 - 188,043,645 (-)NCBICelera
RGSC_v3.12203,255,518 - 203,270,701 (-)NCBI
Cytogenetic Map2q34NCBI
CSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,910,506 - 109,930,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,910,242 - 109,930,993 (+)Ensemblhg38GRCh38
GRCh371110,453,471 - 110,473,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,254,980 - 110,273,878 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341110,165,498 - 110,184,397NCBI
Celera1108,699,836 - 108,719,046 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,322,980 - 108,343,084 (+)NCBIHuRef
CHM1_11110,568,036 - 110,588,399 (+)NCBICHM1_1
T2T-CHM13v2.01109,920,642 - 109,941,109 (+)NCBIT2T-CHM13v2.0
Csf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,648,364 - 107,668,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383107,741,048 - 107,760,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)Ensemblmm10GRCm38
MGSCv373107,543,966 - 107,563,387 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363107,869,116 - 107,888,525 (-)NCBIMGSCv36mm8
Celera3110,073,392 - 110,092,813 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Csf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,404,508 - 13,424,247 (+)Ensembl
ChiLan1.0NW_00495543513,404,236 - 13,423,059 (+)NCBIChiLan1.0ChiLan1.0
CSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,113,655 - 117,134,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,261,714 - 116,282,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,764,916 - 127,864,188 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,764,916 - 127,781,943 (-)EnsemblpanPan2panpan1.1
CSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,028,454 - 42,047,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,034,149 - 42,049,371 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha644,804,295 - 44,823,439 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0642,360,013 - 42,379,162 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,360,330 - 42,379,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,092,785 - 42,111,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,050,361 - 42,070,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,485,555 - 42,505,704 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,720,989 - 18,742,009 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,378,103 - 1,393,542 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,372,137 - 1,393,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14110,178,466 - 110,198,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,592,959 - 120,605,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,615,107 - 23,635,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603834,824,127 - 34,844,440 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,663,070 - 5,707,753 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247725,663,374 - 5,705,965 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Csf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1350,506,454 - 50,525,680 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csf1
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:558
Count of miRNA genes:248
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000025222
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
D3Mit104.1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82198,084,640 - 198,084,895 (+)Marker Load Pipeline
Celera2188,043,818 - 188,044,071UniSTS
Cytogenetic Map2q34UniSTS
AI547928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,378,243 - 195,378,453 (+)MAPPERmRatBN7.2
Rnor_6.02210,537,681 - 210,537,890NCBIRnor6.0
Rnor_6.02210,523,399 - 210,523,608NCBIRnor6.0
Rnor_5.02230,004,741 - 230,004,950UniSTSRnor5.0
Rnor_5.02229,990,459 - 229,990,668UniSTSRnor5.0
RGSC_v3.42203,293,789 - 203,293,998UniSTSRGSC3.4
Celera2188,025,668 - 188,025,877UniSTS
RH 3.4 Map21387.9UniSTS
Cytogenetic Map2q34UniSTS
CSF1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,384,314 - 195,384,469 (+)MAPPERmRatBN7.2
mRatBN7.22195,384,314 - 195,384,547 (+)MAPPERmRatBN7.2
Rnor_6.02210,529,458 - 210,529,690NCBIRnor6.0
Rnor_6.02210,529,458 - 210,529,612NCBIRnor6.0
Rnor_5.02229,996,518 - 229,996,750UniSTSRnor5.0
Rnor_5.02229,996,518 - 229,996,672UniSTSRnor5.0
RGSC_v3.42203,299,856 - 203,300,010UniSTSRGSC3.4
RGSC_v3.42203,299,856 - 203,300,088UniSTSRGSC3.4
Celera2188,031,723 - 188,031,955UniSTS
Celera2188,031,723 - 188,031,877UniSTS
Cytogenetic Map2q34UniSTS
AI176011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,377,718 - 195,377,873 (+)MAPPERmRatBN7.2
Rnor_6.02210,522,874 - 210,523,028NCBIRnor6.0
Rnor_5.02229,989,934 - 229,990,088UniSTSRnor5.0
RGSC_v3.42203,293,264 - 203,293,418UniSTSRGSC3.4
Celera2188,025,143 - 188,025,297UniSTS
RH 3.4 Map21388.4UniSTS
Cytogenetic Map2q34UniSTS
PMC101742P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,384,882 - 195,385,229 (+)MAPPERmRatBN7.2
Rnor_6.02210,530,026 - 210,530,372NCBIRnor6.0
Rnor_5.02229,997,086 - 229,997,432UniSTSRnor5.0
RGSC_v3.42203,300,424 - 203,300,770UniSTSRGSC3.4
Celera2188,032,291 - 188,032,637UniSTS
Cytogenetic Map2q34UniSTS
PMC137879P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2188,043,448 - 188,043,639UniSTS
Cytogenetic Map2q34UniSTS


Related Rat Strains
The following Strains have been annotated to Csf1
LEW-tl     LEW-tl.BN-(D2Arb16-D2Wox8)    


Genetic Models
This gene Csf1 is modified in the following models/strains:
F344tl    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF514355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF514356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF514357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF515736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000025222   ⟹   ENSRNOP00000025221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,065,405 - 198,084,468 (-)Ensembl
mRatBN7.2 Ensembl2195,377,215 - 195,396,310 (-)Ensembl
Rnor_6.0 Ensembl2210,522,375 - 210,550,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081835   ⟹   ENSRNOP00000073134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,072,402 - 198,082,040 (-)Ensembl
mRatBN7.2 Ensembl2195,384,221 - 195,393,859 (-)Ensembl
Rnor_6.0 Ensembl2210,528,025 - 210,550,490 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086403   ⟹   ENSRNOP00000072096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2210,547,076 - 210,550,560 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111860   ⟹   ENSRNOP00000097151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2198,065,405 - 198,084,468 (-)Ensembl
mRatBN7.2 Ensembl2195,377,217 - 195,411,704 (-)Ensembl
RefSeq Acc Id: NM_023981   ⟹   NP_076471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,065,405 - 198,084,468 (-)NCBI
mRatBN7.22195,377,220 - 195,396,291 (-)NCBI
Rnor_6.02210,522,375 - 210,550,546 (-)NCBI
Rnor_5.02229,989,430 - 230,017,945 (-)NCBI
RGSC_v3.42203,292,765 - 203,307,968 (-)RGD
Celera2188,024,644 - 188,043,645 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233187   ⟹   XP_006233249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,069,894 - 198,084,745 (-)NCBI
mRatBN7.22195,381,709 - 195,396,573 (-)NCBI
Rnor_6.02210,525,874 - 210,550,416 (-)NCBI
Rnor_5.02229,989,430 - 230,017,945 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761426   ⟹   XP_008759648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,065,400 - 198,084,749 (-)NCBI
mRatBN7.22195,377,215 - 195,396,585 (-)NCBI
Rnor_6.02210,522,370 - 210,550,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761428   ⟹   XP_008759650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,065,400 - 198,084,744 (-)NCBI
mRatBN7.22195,377,215 - 195,396,572 (-)NCBI
Rnor_6.02210,522,370 - 210,550,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761429   ⟹   XP_008759651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,069,894 - 198,084,753 (-)NCBI
mRatBN7.22195,381,709 - 195,396,592 (-)NCBI
Rnor_6.02210,525,874 - 210,550,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591125   ⟹   XP_017446614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,067,344 - 198,084,744 (-)NCBI
mRatBN7.22195,377,215 - 195,396,571 (-)NCBI
Rnor_6.02210,524,370 - 210,550,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103173   ⟹   XP_038959101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,065,400 - 198,084,774 (-)NCBI
mRatBN7.22195,377,215 - 195,396,608 (-)NCBI
RefSeq Acc Id: XM_039103174   ⟹   XP_038959102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,067,344 - 198,084,771 (-)NCBI
mRatBN7.22195,379,164 - 195,396,598 (-)NCBI
RefSeq Acc Id: XM_063282597   ⟹   XP_063138667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,065,400 - 198,084,754 (-)NCBI
RefSeq Acc Id: NP_076471   ⟸   NM_023981
- Peptide Label: precursor
- UniProtKB: Q8JZQ0 (UniProtKB/Swiss-Prot),   Q6GMN4 (UniProtKB/TrEMBL),   A6HUV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233249   ⟸   XM_006233187
- Peptide Label: isoform X4
- UniProtKB: Q8JZQ0 (UniProtKB/Swiss-Prot),   A0A8L2QDI9 (UniProtKB/TrEMBL),   A6HUV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759650   ⟸   XM_008761428
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K4Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759648   ⟸   XM_008761426
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008759651   ⟸   XM_008761429
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K4Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446614   ⟸   XM_017591125
- Peptide Label: isoform X4
- UniProtKB: Q8JZQ0 (UniProtKB/Swiss-Prot),   A0A8L2QDI9 (UniProtKB/TrEMBL),   A6HUV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073134   ⟸   ENSRNOT00000081835
Ensembl Acc Id: ENSRNOP00000072096   ⟸   ENSRNOT00000086403
Ensembl Acc Id: ENSRNOP00000025221   ⟸   ENSRNOT00000025222
RefSeq Acc Id: XP_038959101   ⟸   XM_039103173
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038959102   ⟸   XM_039103174
- Peptide Label: isoform X7
- UniProtKB: A6HUV3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097151   ⟸   ENSRNOT00000111860
RefSeq Acc Id: XP_063138667   ⟸   XM_063282597
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8JZQ0-F1-model_v2 AlphaFold Q8JZQ0 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691672
Promoter ID:EPDNEW_R2187
Type:single initiation site
Name:Csf1_1
Description:colony stimulating factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,550,565 - 210,550,625EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621063 AgrOrtholog
BioCyc Gene G2FUF-51663 BioCyc
Ensembl Genes ENSRNOG00000018659 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025222 ENTREZGENE
  ENSRNOT00000111860 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099454 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  MCSF-1 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91410 IMAGE-MGC_LOAD
NCBI Gene 78965 ENTREZGENE
PANTHER MACROPHAGE COLONY-STIMULATING FACTOR 1 UniProtKB/Swiss-Prot
  PTHR10058 UniProtKB/Swiss-Prot
Pfam CSF-1 UniProtKB/Swiss-Prot
PhenoGen Csf1 PhenoGen
PIRSF MCSF-1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018659 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A0G2K4Q6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN73_RAT UniProtKB/TrEMBL
  A0A8L2QDI9 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV0_RAT UniProtKB/TrEMBL
  A6HUV1 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV3 ENTREZGENE, UniProtKB/TrEMBL
  CSF1_RAT UniProtKB/Swiss-Prot
  Q6GMN4 ENTREZGENE, UniProtKB/TrEMBL
  Q8JZQ0 ENTREZGENE
  Q8K408_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Csf1  colony stimulating factor 1  Csf1  colony stimulating factor 1 (macrophage)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Csf1  colony stimulating factor 1 (macrophage)    colony stimulating factor 1(macrophage)  Name updated 1299863 APPROVED
2002-08-07 Csf1  colony stimulating factor 1(macrophage)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the gene causes the toothless (tl) rat mutant, which has severe osteopetrosis 628338
gene_mutations_overexpression loss-of-function frameshift mutation results in toothless (tl) mutation in the rat 628338
gene_transcript 15 kilobases in size 628338
gene_transcript consists of 8 exons split by 7 introns stop signal (TAG) is in exon 8 628338