CSF1 (colony stimulating factor 1) - Rat Genome Database

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Gene: CSF1 (colony stimulating factor 1) Pan paniscus
Analyze
Symbol: CSF1
Name: colony stimulating factor 1
RGD ID: 11941382
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: macrophage colony-stimulating factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,113,655 - 117,134,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,261,714 - 116,282,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,764,916 - 127,864,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,764,916 - 127,781,943 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in mammary gland duct morphogenesis  (IEA,ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to parathyroid hormone stimulus  (ISO)
developmental process involved in reproduction  (IEA)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
macrophage differentiation  (IEA,ISO)
macrophage homeostasis  (IEA,ISO)
mammary duct terminal end bud growth  (IEA,ISO)
mammary gland fat development  (IEA,ISO)
microglial cell proliferation  (IEA)
monocyte differentiation  (IEA,ISO)
monocyte homeostasis  (IEA,ISO)
myeloid leukocyte migration  (IEA,ISO)
neutrophil homeostasis  (IEA,ISO)
ossification  (ISO)
osteoclast differentiation  (IEA,ISO)
osteoclast proliferation  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage colony-stimulating factor signaling pathway  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of macrophage migration  (IEA)
positive regulation of macrophage proliferation  (ISO)
positive regulation of microglial cell migration  (IEA)
positive regulation of monocyte differentiation  (IEA,ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of mononuclear cell proliferation  (IEA)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of Ras protein signal transduction  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of ossification  (IEA,ISO)
response to ischemia  (IEA)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,113,655 - 117,134,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,261,714 - 116,282,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,764,916 - 127,864,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,764,916 - 127,781,943 (-)Ensemblpanpan1.1panPan2
CSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,910,506 - 109,930,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,910,242 - 109,930,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,453,471 - 110,473,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,254,980 - 110,273,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,165,498 - 110,184,397NCBI
Celera1108,699,836 - 108,719,046 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,322,980 - 108,343,084 (+)NCBIHuRef
CHM1_11110,568,036 - 110,588,399 (+)NCBICHM1_1
T2T-CHM13v2.01109,920,642 - 109,941,109 (+)NCBIT2T-CHM13v2.0
Csf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,648,364 - 107,668,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)EnsemblGRCm39 Ensembl
GRCm383107,741,048 - 107,760,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,543,966 - 107,563,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,869,116 - 107,888,525 (-)NCBIMGSCv36mm8
Celera3110,073,392 - 110,092,813 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Csf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,065,400 - 198,084,774 (-)NCBIGRCr8
mRatBN7.22195,377,215 - 195,396,608 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,377,215 - 195,411,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,018,890 - 203,037,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,901,047 - 200,920,075 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,717,984 - 195,737,022 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,522,370 - 210,550,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,522,375 - 210,550,560 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,989,430 - 230,017,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,292,765 - 203,307,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,255,518 - 203,270,701 (-)NCBI
Celera2188,024,644 - 188,043,645 (-)NCBICelera
Cytogenetic Map2q34NCBI
Csf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,404,508 - 13,424,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,404,236 - 13,423,059 (+)NCBIChiLan1.0ChiLan1.0
CSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,028,454 - 42,047,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,034,149 - 42,049,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,804,295 - 44,823,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,360,013 - 42,379,162 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,360,330 - 42,379,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,092,785 - 42,111,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,050,361 - 42,070,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,485,555 - 42,505,704 (-)NCBIUU_Cfam_GSD_1.0
Csf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,720,989 - 18,742,009 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,378,103 - 1,393,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,372,137 - 1,393,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,178,466 - 110,198,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,592,959 - 120,605,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,615,107 - 23,635,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603834,824,127 - 34,844,440 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,663,070 - 5,707,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,663,374 - 5,705,965 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063124   ⟹   ENSPPAP00000040209
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,764,916 - 127,781,653 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063129   ⟹   ENSPPAP00000040214
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,770,717 - 127,781,943 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063135   ⟹   ENSPPAP00000040220
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,770,730 - 127,781,707 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063140   ⟹   ENSPPAP00000040225
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,770,730 - 127,781,650 (-)Ensembl
RefSeq Acc Id: XM_034933157   ⟹   XP_034789048
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21117,113,655 - 117,134,103 (-)NCBI
NHGRI_mPanPan11116,261,714 - 116,282,021 (-)NCBI
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBI
RefSeq Acc Id: XM_034933162   ⟹   XP_034789053
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21117,117,721 - 117,133,964 (-)NCBI
NHGRI_mPanPan11116,263,865 - 116,282,022 (-)NCBI
Mhudiblu_PPA_v01112,555,763 - 112,571,828 (+)NCBI
RefSeq Acc Id: XM_034933164   ⟹   XP_034789055
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21117,113,655 - 117,134,004 (-)NCBI
NHGRI_mPanPan11116,261,714 - 116,282,024 (-)NCBI
Mhudiblu_PPA_v01112,555,769 - 112,575,894 (+)NCBI
RefSeq Acc Id: XM_063599449   ⟹   XP_063455519
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21117,113,655 - 117,133,434 (-)NCBI
RefSeq Acc Id: XM_063599461   ⟹   XP_063455531
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21117,117,721 - 117,133,817 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_034789048   ⟸   XM_034933157
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034789053   ⟸   XM_034933162
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034789055   ⟸   XM_034933164
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000040214   ⟸   ENSPPAT00000063129
RefSeq Acc Id: ENSPPAP00000040209   ⟸   ENSPPAT00000063124
RefSeq Acc Id: ENSPPAP00000040225   ⟸   ENSPPAT00000063140
RefSeq Acc Id: ENSPPAP00000040220   ⟸   ENSPPAT00000063135
RefSeq Acc Id: XP_063455519   ⟸   XM_063599449
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063455531   ⟸   XM_063599461
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042763 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063124.1 UniProtKB/TrEMBL
  ENSPPAT00000063129.1 UniProtKB/TrEMBL
  ENSPPAT00000063135.1 UniProtKB/TrEMBL
  ENSPPAT00000063140.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  MCSF-1 UniProtKB/TrEMBL
NCBI Gene CSF1 ENTREZGENE
PANTHER MACROPHAGE COLONY-STIMULATING FACTOR 1 UniProtKB/TrEMBL
  PTHR10058 UniProtKB/TrEMBL
Pfam CSF-1 UniProtKB/TrEMBL
PIRSF MCSF-1 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R9CE58_PANPA UniProtKB/TrEMBL
  A0A2R9CE62_PANPA UniProtKB/TrEMBL
  A0A2R9CE96_PANPA UniProtKB/TrEMBL
  A0A2R9CEA1_PANPA UniProtKB/TrEMBL