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Strain Registration

Strain: LEW-tl.BN-(D2Arb16-D2Wox8)

Symbol: LEW-tl.BN-(D2Arb16-D2Wox8)
Strain: LEW-tl.BN-(D2Arb16-D2Wox8)
RGD ID: 629506
Citation ID: RRID:RGD_629506
Ontology ID: RS:0000499
Alleles: Csf1
Also Known As: LEW.tl-(D2Arb16-D2Wox8); LEW-tl-(D2Arb16-D2Wox8); LEW-tl.BN-(D2Arb16-D2Wox8)
Type: congenic
Available Source: Not Available
Origination: Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Description: LEW.tl carrier females were mated with BN/SsNHsd males to develop these congenic animals which has a 2.5 cM region of chr 2.
Inbred Generations: F14
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22190,602,746 - 204,499,414RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02205,572,952 - 219,581,453RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02225,003,539 - 237,636,701RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42198,312,439 - 212,776,982RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Application of interval haplotype analysis facilitates efficient mapping of the mutation causing osteopetrosis in tl rats. Remmers EF, etal., Mamm Genome 2002 Jun;13(6):299-301.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D2Arb16)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22190,602,746 - 190,602,963 (+)MAPPER
Rnor_6.02205,572,952 - 205,573,168NCBI
Rnor_5.02225,003,539 - 225,003,755UniSTS
RGSC_v3.42198,312,439 - 198,312,656RGD
RGSC_v3.42198,312,440 - 198,312,656UniSTS
RGSC_v3.12198,275,193 - 198,275,410RGD
Celera2183,076,093 - 183,076,309UniSTS
SHRSP x BN Map272.7698UniSTS
SHRSP x BN Map272.7698RGD
Cytogenetic Map2q34UniSTS

Flank 2 / 1 (D2Wox8)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22204,499,123 - 204,499,414 (+)MAPPER
Rnor_6.02219,581,163 - 219,581,453NCBI
Rnor_5.02237,636,409 - 237,636,701UniSTS
RGSC_v3.42212,776,691 - 212,776,982RGD
RGSC_v3.42212,776,692 - 212,776,982UniSTS
RGSC_v3.12212,739,445 - 212,739,736RGD
Celera2196,991,794 - 196,992,084UniSTS
RH 3.4 Map21480.5UniSTS
RH 3.4 Map21480.5RGD
RH 2.0 Map21055.8RGD
Cytogenetic Map2q41UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Osteopetrotic tl/tl rats do not survive to breed so this has been transferred to LEW by a series of backcrosses. In each generation the offsprings are identified for tl mutation. 619693
strain_life_disease rat model for osteopetrosis 619693

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-13 LEW-tl.BN-(D2Arb16-D2Wox8)    LEW.tl.BN-(D2Arb16-D2Wox8)    Symbol updated 68687 APPROVED
2012-09-13 LEW-tl.BN-(D2Arb16-D2Wox8)    LEW.tl.BN-(D2Arb16-D2Wox8)    Name updated 68913 APPROVED
2012-09-13 LEW-tl.BN-(D2Arb16-D2Wox8)    LEW.tl.BN-(D2Arb16-D2Wox8)    Symbol updated 68687 APPROVED
2012-09-13 LEW-tl.BN-(D2Arb16-D2Wox8)    LEW.tl.BN-(D2Arb16-D2Wox8)    Name updated 68913 APPROVED