Gene:	Map3k8 ( Rattus norvegicus ) mitogen-activated protein kinase kinase kinase 8
Description:	kinase; involved in signaling pathways for cell proliferation/differentiation and stress responses
Synonyms:	Tpl-2; D17TPL2; tumor progression locus 2; Tpl2;
ArrayIDs:	6702543; 1369393_at; 6421956; 6161971; A_43_P15587; 6362978; 6244066; 6145327; 6115991; 5924617; 6389084; GE21870; M94454_at; 5725311; 5960425;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: MAP3K8     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Map3k8     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Map3k8 genome assembly 3.1 17 61921011 - 61941292     Rat Celera Assembly 17 49376490 - 49396770     RGSC genome assembly v3.4 17 61910179 - 61930459     Cytogenetic 17 q12 Mus musculus Map3k8 Mouse genome assembly build 36.1 18 4331325 - 4352951     Cytogenetic 18 18 A1 Homo sapiens MAP3K8 human genome assembly 10 30762871 - 30790767     Human genome assembly build 36.2 10 30762872 - 30790767     Cytogenetic 10 p11.23   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  nucleotide binding,  MAP kinase kinase kinase activity ...  (details...)
Biological Process	Gene Ontology protein amino acid phosphorylation,  signal transduction,  cell cycle (details...)
Cellular Component	Gene Ontology cytoplasm,  cytosol (details...)
Expression	Note Reference expressed in most tissues 70317 expression increases after birth 70317
Protein	Note Reference expression is up-regulated during postnatal development 70317
External Links
Databases	DATABASE ID SOURCE PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI000012EAD8 IPI KEGG Report: rno:116596 ENTREZGENE HomoloGene Group ID: 3812 ENTREZGENE Germonline: 620969 Pfam: Pkinase IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE InterPro: MAPKKK8. IPI InterPro: Kinase-like_dom. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI IPI: IPI00210121 IPI Ensembl Protein: ENSRNOP00000022190 IPI PIRSF: MAPKKK8 IPI Entrez Gene: Map3k8 ENTREZGENE UniProt: M3K8_RAT IPI Ensembl Genes: ENSRNOG00000016378 IPI RatMap: 34509 ENTREZGENE Superfamily-SCOP: Kinase_like IPI
Sequences	Nucleotide: CH474030 Get FASTA Search GEO Profiles Nucleotide: L15357 Get FASTA Search GEO Profiles Nucleotide: NM_053847 Get FASTA Search GEO Profiles Nucleotide: M94454 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: AAA42185 Get FASTA Protein: NP_446299 Get FASTA Protein: EDL87455 Get FASTA Protein: EDL87456 Get FASTA Protein: Q63562 Get FASTA (View all 5 Protein Accessions)
Clusters	UniGene: 9939
References
Curated References	6 references in RGD related to Map3k8
Other References	5 other references at PubMed related to Map3k8
Database Information
RGD ID	620969
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-APR-03: Map3k8 mitogen-activated protein kinase kinase kinase 8 APPROVED Symbol and Name updated 629477 12-MAR-03: Map3k8 mitogen-activated protein kinase kinase kinase 8 Tpl2 tumor progression locus 2 PROVISIONAL Data Merged 628472 07-AUG-02: Map3k8 itogen-activated protein kinase kinase kinase 8 PROVISIONAL Symbol and Name status set to provisional 70820 10-JUN-02: Tpl2 tumor progression locus 2 APPROVED Symbol and Name status set to approved 70586