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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620969
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k8affects response to substanceISOMap3k8 (Mus musculus)6480464CTDMAP3K8 protein affects the susceptibility to LipopolysaccharidesPMID:11163183
Map3k8increases expressionISOMAP3K8 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of MAP3K8 mRNAPMID:35811015
Map3k8increases expressionISOMap3k8 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of MAP3K8 mRNAPMID:22169119 PMID:22687549
Map3k8multiple interactionsISOMAP3K8 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of MAP3K8 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of MAP3K8 mRNAPMID:35811015
Map3k8multiple interactionsISOMap3k8 (Mus musculus)6480464CTD[Eicosapentaenoic Acid co-treated with procyanidin B3] inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; Eicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 protein; Lithium promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP3K8 protein]; MAP3K8 protein affects the reaction [Lipopolysaccharides affects the transport of and affects the localization of TNF mRNA]; MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAP3K8 protein affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K8 mRNA]PMID:11163183 PMID:19159680 PMID:22169119 PMID:22687549
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