Ppargc1a (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (PPARG coactivator 1 alpha) Rattus norvegicus
Analyze
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
RGD ID: 620925
Description: Enables several functions, including alpha-tubulin binding activity; nuclear estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; regulation of primary metabolic process; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); sciatic neuropathy; and steatotic liver disease (multiple). Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); liver disease (multiple); placental insufficiency; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-schisandrin B; (+)-taxifolin; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LRPGC1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1-alpha; PGC-1alpha; PGC-1v; PGCvf; PGCvf-1; PGCvf1; PPAR gamma coactivator 1alpha variant form-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1; Ppargc1a-vf1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Ppargc1aRatabdominal obesity-metabolic syndrome  IEP 7241841mRNA:increased expression:gastrocnemius muscle (rat)RGD 
Ppargc1aRatacute kidney failure  ISOPpargc1a (Mus musculus)7242026associated with Endotoxemia and mRNA:decreased expression:kidney (mouse)RGD 
Ppargc1aRatAlbuminuria  ISOPPARGC1A (Homo sapiens)7242025associated with Diabetes Mellitus more ...RGD 
Ppargc1aRatAlzheimer's disease  IDA 7242180 RGD 
Ppargc1aRatAlzheimer's disease  ISOPpargc1a (Mus musculus)6484260 RGD 
Ppargc1aRatAlzheimer's disease disease_progressionISOPPARGC1A (Homo sapiens)7242017mRNA and protein:decreased expression:hippocampal formation (human)RGD 
Ppargc1aRatamblyopia  IEP 10059668protein:decreased expression:visual cortex (rat)RGD 
Ppargc1aRatamnestic disorder  IEP 407571681associated with morphine withdrawal syndrome and mRNA:increased expression:hippocamous (rat)RGD 
Ppargc1aRatamyotrophic lateral sclerosis  ISOPpargc1a (Mus musculus)7242019mRNA:decreased expression:spinal cord and gastrocnemius muscle (mouse)RGD 
Ppargc1aRatamyotrophic lateral sclerosis  ISOPPARGC1A (Homo sapiens)6484265human gene in mouse modelRGD 
Ppargc1aRatamyotrophic lateral sclerosis  ISOPPARGC1A (Homo sapiens)7242019mRNA:decreased expression:motor cortex and muscle (human)RGD 
Ppargc1aRatBrain Injuries treatmentIEP 10059630protein:decreased expression:frontal cortex (rat)RGD 
Ppargc1aRatBrain Injuries  ISOPpargc1a (Mus musculus)6484257 RGD 
Ppargc1aRatCardiomegaly  IEP 7242192protein:increased expression:myocardium of left ventricle (rat)RGD 
Ppargc1aRatCardiomegaly  ISOPpargc1a (Mus musculus)10053662 RGD 
Ppargc1aRatcardiovascular system disease susceptibilityISOPPARGC1A (Homo sapiens)7242032DNA:snps:cds more ...RGD 
Ppargc1aRatCarotid Artery Injuries  IDA 7242065 RGD 
Ppargc1aRatCarotid Artery Injuries treatmentISOPpargc1a (Mus musculus)2311405mouse gene in a rat modelRGD 
Ppargc1aRatchronic kidney disease  ISOPpargc1a (Mus musculus)7242023 RGD 
Ppargc1aRatchronic obstructive pulmonary disease  ISOPPARGC1A (Homo sapiens)6484530 RGD 
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Ppargc1aRat(+)-artemisinin multiple interactionsISOPPARGC1A (Homo sapiens)6480464artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]CTDPMID:30818834
Ppargc1aRat(+)-catechin affects expressionISOPpargc1a (Mus musculus)6480464Catechin affects the expression of PPARGC1A mRNACTDPMID:26363153
Ppargc1aRat(+)-catechin multiple interactionsISOPpargc1a (Mus musculus)6480464Quercetin affects the reaction [Catechin affects the expression of PPARGC1A mRNA]CTDPMID:26363153
Ppargc1aRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A mRNA]CTDPMID:31150632
Ppargc1aRat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]CTDPMID:32525071
Ppargc1aRat(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A mRNA and [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A proteinCTDPMID:22742579
Ppargc1aRat(-)-epigallocatechin 3-gallate decreases expressionISOPpargc1a (Mus musculus)6480464epigallocatechin gallate results in decreased expression of PPARGC1A proteinCTDPMID:29175576
Ppargc1aRat(1->4)-beta-D-glucan multiple interactionsISOPpargc1a (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPARGC1A mRNACTDPMID:36331819
Ppargc1aRat(20S)-ginsenoside Rg3 increases expressionEXP 6480464ginsenoside Rg3 results in increased expression of PPARGC1A mRNACTDPMID:30144466
Ppargc1aRat(R)-adrenaline increases expressionEXP 6480464Epinephrine results in increased expression of PPARGC1A mRNACTDPMID:22496244
Ppargc1aRat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [Methotrexate results in decreased expression of PPARGC1A protein]CTDPMID:37312617
Ppargc1aRat(R)-lipoic acid multiple interactionsISOPPARGC1A (Homo sapiens)6480464[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A proteinCTDPMID:20414966
Ppargc1aRat(R)-lipoic acid decreases expressionISOPpargc1a (Mus musculus)6480464Thioctic Acid results in decreased expression of PPARGC1A proteinCTDPMID:37739047
Ppargc1aRat(R)-lipoic acid multiple interactionsISOPpargc1a (Mus musculus)6480464[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein and Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]CTDPMID:34252510 and PMID:37739047
Ppargc1aRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]CTDPMID:22464149
Ppargc1aRat(R)-lipoic acid increases expressionISOPPARGC1A (Homo sapiens)6480464Thioctic Acid results in increased expression of PPARGC1A proteinCTDPMID:20414966
Ppargc1aRat(R)-noradrenaline multiple interactionsISOPpargc1a (Mus musculus)6480464[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA] and N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]CTDPMID:16513826
Ppargc1aRat(R)-noradrenaline multiple interactionsEXP 6480464Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]CTDPMID:16954335
Ppargc1aRat(R)-noradrenaline increases expressionISOPpargc1a (Mus musculus)6480464Norepinephrine results in increased expression of PPARGC1A mRNACTDPMID:16513826
Ppargc1aRat(S)-nicotine multiple interactionsISOPpargc1a (Mus musculus)6480464[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA and [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A proteinCTDPMID:33091441

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Biological Process
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Original Reference(s)
Ppargc1aRatadaptive thermogenesis  IEP 10401808 RGD 
Ppargc1aRatadipose tissue development involved_inISOPpargc1a (Mus musculus)1624291 PMID:22237023RGDPMID:22237023
Ppargc1aRatandrogen metabolic process  IEP 7241839nandroloneRGD 
Ppargc1aRatautophagy of mitochondrion  IEP 10059673 RGD 
Ppargc1aRatcellular response to caffeine  IEP 10059651 RGD 
Ppargc1aRatcellular response to estradiol stimulus  IEP 10059654 RGD 
Ppargc1aRatcellular response to fatty acid  IEP 7242169 RGD 
Ppargc1aRatcellular response to follicle-stimulating hormone stimulus  IDA 4781450 RGD 
Ppargc1aRatcellular response to fructose stimulus  IEP 9585757 RGD 
Ppargc1aRatcellular response to glucose stimulus  IEP 10059632 RGD 
Ppargc1aRatcellular response to hypoxia  IEP 7242177 RGD 
Ppargc1aRatcellular response to interleukin-6  IEP 10059632 RGD 
Ppargc1aRatcellular response to ionomycin  IEP 10059651 RGD 
Ppargc1aRatcellular response to lipopolysaccharide  IEP 10059687 RGD 
Ppargc1aRatcellular response to nitrite  IEP 7242065 RGD 
Ppargc1aRatcellular response to oxidative stress involved_inISSUniProtKB:O703431600115GO_REF:0000024UniProtGO_REF:0000024
Ppargc1aRatcellular response to oxidative stress acts_upstream_of_or_withinISOPpargc1a (Mus musculus)1624291 PMID:20566846RGDPMID:20566846
Ppargc1aRatcellular response to potassium ion  IEP 10059655 RGD 
Ppargc1aRatcellular response to resveratrol  IEP 10059668 RGD 
Ppargc1aRatcellular response to thyroid hormone stimulus  IEP 7242010 RGD 
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Cellular Component
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Ppargc1aRatapical dendrite  IDA 10059646 RGD 
Ppargc1aRatcytosol located_inISOPPARGC1A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Ppargc1aRatcytosolic ribosome  IDA 10059655 RGD 
Ppargc1aRateuchromatin  IDA 10059655 RGD 
Ppargc1aRatneuronal cell body  IDA 10059646 RGD 
Ppargc1aRatnucleoplasm located_inISOPPARGC1A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Ppargc1aRatnucleus is_active_inISOPPARGC1A (Homo sapiens)1624291 PMID:10713165RGDPMID:10713165
Ppargc1aRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Ppargc1aRatnucleus located_inISOPpargc1a (Mus musculus)1624291 PMID:17952069RGDPMID:17952069
Ppargc1aRatnucleus is_active_inIBAFB:FBgn0037248 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppargc1aRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Ppargc1aRatnucleus located_inISOPPARGC1A (Homo sapiens)1624291 PMID:23836911RGDPMID:23836911
Ppargc1aRatPML body located_inIEAUniProtKB-SubCell:SL-04651600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
Ppargc1aRatalpha-tubulin binding  IDA 10059660 RGD 
Ppargc1aRatchromatin binding  IDA 7242168 RGD 
Ppargc1aRatchromatin DNA binding enablesISSUniProtKB:O703431600115GO_REF:0000024UniProtGO_REF:0000024
Ppargc1aRatchromatin DNA binding enablesISOPpargc1a (Mus musculus)1624291 PMID:17952069RGDPMID:17952069
Ppargc1aRatDNA binding enablesISSUniProtKB:O703431600115GO_REF:0000024UniProtGO_REF:0000024
Ppargc1aRatDNA binding enablesISOPpargc1a (Mus musculus)1624291 PMID:15681609RGDPMID:15681609
Ppargc1aRatlncRNA binding enablesISOPpargc1a (Mus musculus)1624291MGI:2144114 PMID:27760051RGDPMID:27760051
Ppargc1aRatnuclear estrogen receptor binding  IPIEsr1 (Rattus norvegicus)4781450 RGD 
Ppargc1aRatnuclear receptor binding enablesISOPPARGC1A (Homo sapiens)1624291UniProtKB:P24468 and PMID:18798693RGDPMID:18798693
Ppargc1aRatnucleic acid binding enablesIEAInterPro:IPR0359791600115GO_REF:0000002InterProGO_REF:0000002
Ppargc1aRatperoxisome proliferator activated receptor binding  IPIPpara (Rattus norvegicus)10059644 RGD 
Ppargc1aRatpromoter-specific chromatin binding  IDA 10059643 RGD 
Ppargc1aRatprotein binding  IPIKat2a (Rattus norvegicus)8693747 RGD 
Ppargc1aRatprotein binding enablesISOPPARGC1A (Homo sapiens)1624291UniProtKB:P10826-2 more ...RGDPMID:12522104 more ...
Ppargc1aRatprotein binding enablesISOPpargc1a (Mus musculus) and PR:O70343-11624291UniProtKB:Q60641-1 more ...RGDPMID:14729567
Ppargc1aRatprotein binding enablesISOPpargc1a (Mus musculus)1624291PR:P23204 more ...RGDPMID:14744933 more ...
Ppargc1aRatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Ppargc1aRatRNA binding enablesIEAInterPro:IPR0005041600115GO_REF:0000002InterProGO_REF:0000002
Ppargc1aRatRNA binding enablesIEAUniRule:UR0004146191600115GO_REF:0000104UniProtGO_REF:0000104
Ppargc1aRatRNA polymerase II-specific DNA-binding transcription factor binding enablesISOPpargc1a (Mus musculus)1624291UniProtKB:P26687 and PMID:19345188RGDPMID:19345188
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Ppargc1aRataldosterone signaling pathway   ISOPPARGC1A (Homo sapiens)7421504 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Ppargc1aRatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Ppargc1aRatinsulin signaling pathway   IEA 6907045 KEGGrno:04910

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Ppargc1aRatmTOR signaling pathway   ISOPPARGC1A (Homo sapiens)6484113 PIDPID:200096

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Reference Title
Reference Citation
1. Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-gamma coactivator-1alpha of fibres in the soleus muscle of Zucker diabetic fatty rats. Adachi T, etal., Exp Physiol. 2007 Mar;92(2):449-55. Epub 2006 Dec 7.
2. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Agrawal R, etal., Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. Epub 2013 Dec 15.
3. Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet. Alberdi G, etal., Nutrition. 2013 Mar;29(3):562-7. doi: 10.1016/j.nut.2012.09.011. Epub 2012 Dec 28.
4. Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity. Amengual-Cladera E, etal., Metabolism. 2012 Aug;61(8):1108-17. doi: 10.1016/j.metabol.2011.12.016. Epub 2012 Mar 7.
5. Role of neuropeptide Y and peroxisome proliferator-activated receptor gamma coactivator-1alpha in stress cardiomyopathy. Ananda S, etal., J Huazhong Univ Sci Technolog Med Sci. 2012 Dec;32(6):823-8. doi: 10.1007/s11596-012-1041-3. Epub 2012 Dec 28.
6. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Arduini A, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G119-27. Epub 2011 Mar 17.
7. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1alpha levels in Abeta-injected rats. Ashabi G, etal., Behav Brain Res. 2012 Jun 15;232(1):165-73. doi: 10.1016/j.bbr.2012.04.006. Epub 2012 Apr 9.
8. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. Atherton PJ, etal., FASEB J. 2005 May;19(7):786-8. Epub 2005 Feb 16.
9. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha). Attia RR, etal., J Biol Chem. 2010 Jan 22;285(4):2375-85. doi: 10.1074/jbc.M109.039081. Epub 2009 Nov 30.
10. Differential effects of thyroid hormones on energy metabolism of rat slow- and fast-twitch muscles. Bahi L, etal., J Cell Physiol. 2005 Jun;203(3):589-98.
11. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity. Baker DJ, etal., J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):675-84.
12. Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. Branvold DJ, etal., J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.
13. Fatty acids-stress attenuates gluconeogenesis induction and glucose production in primary hepatocytes. Budick-Harmelin N, etal., Lipids Health Dis. 2012 Jul 9;11:66. doi: 10.1186/1476-511X-11-66.
14. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Bugger H, etal., Diabetes. 2009 Sep;58(9):1986-97. doi: 10.2337/db09-0259. Epub 2009 Jun 19.
15. Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. Buler M, etal., J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.
16. Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A. Burgueno AL, etal., J Nutr Biochem. 2013 Jan;24(1):6-13. doi: 10.1016/j.jnutbio.2011.12.008. Epub 2012 May 30.
17. Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance. Cao L, etal., Oxid Med Cell Longev. 2012;2012:374346. doi: 10.1155/2012/374346. Epub 2012 Dec 25.
18. Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. Cao S, etal., PLoS One. 2012;7(12):e51709. doi: 10.1371/journal.pone.0051709. Epub 2012 Dec 13.
19. Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism. Caton PW, etal., J Endocrinol. 2011 Mar;208(3):273-83. doi: 10.1530/JOE-10-0190. Epub 2011 Jan 6.
20. Localization of sequence variations in PGC-1alpha influence their modifying effect in Huntington disease. Che HV, etal., Mol Neurodegener. 2011 Jan 6;6(1):1. doi: 10.1186/1750-1326-6-1.
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PMID:10913342   PMID:12531492   PMID:12734114   PMID:12821652   PMID:14570700   PMID:14576981   PMID:14744933   PMID:15044597   PMID:15165993   PMID:15199055   PMID:15681609   PMID:15716268  
PMID:15733855   PMID:15967803   PMID:16014350   PMID:16271724   PMID:16352671   PMID:16488887   PMID:16720625   PMID:17239528   PMID:17273866   PMID:17284668   PMID:17476214   PMID:17488713  
PMID:17640976   PMID:17952069   PMID:18555842   PMID:18789599   PMID:18798693   PMID:18972406   PMID:18993053   PMID:19082571   PMID:19179292   PMID:19345188   PMID:19389810   PMID:19542216  
PMID:19651776   PMID:19686839   PMID:19698760   PMID:19766270   PMID:19773550   PMID:19774670   PMID:19774674   PMID:20086200   PMID:20143420   PMID:20359506   PMID:20385772   PMID:20457122  
PMID:20566846   PMID:20661474   PMID:20799369   PMID:20849372   PMID:21106753   PMID:21162799   PMID:21307617   PMID:21536107   PMID:21590341   PMID:21789886   PMID:21972093   PMID:21994947  
PMID:22064484   PMID:22234788   PMID:22237023   PMID:22342160   PMID:22354784   PMID:22461724   PMID:22533417   PMID:22738191   PMID:22899824   PMID:23117952   PMID:23139024   PMID:23212379  
PMID:23292098   PMID:23505321   PMID:23515531   PMID:23525105   PMID:23525500   PMID:23602251   PMID:23635713   PMID:23836911   PMID:23880578   PMID:23948478   PMID:23994518   PMID:24005768  
PMID:24084166   PMID:24096033   PMID:24562467   PMID:24726645   PMID:24898700   PMID:25118933   PMID:25333348   PMID:25402826   PMID:25572651   PMID:25675425   PMID:25824459   PMID:25853493  
PMID:25972379   PMID:26020641   PMID:26054747   PMID:26102301   PMID:26118953   PMID:26287659   PMID:26310573   PMID:26844631   PMID:27076782   PMID:27132229   PMID:27174562   PMID:27178364  
PMID:27302464   PMID:27453548   PMID:27526155   PMID:27793739   PMID:28467933   PMID:28482939   PMID:29383690   PMID:29543139   PMID:29604268   PMID:29901150   PMID:29913155   PMID:30221360  
1 to 10 of 14 rows



Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ppargc1a
2507 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
14 63151271 63151272 A C snv F344/NCrl (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:28
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006071
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat

1 to 10 of 21 rows
MARC_49176-49177:1118326844:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21459,495,697 - 59,496,182 (+)MAPPERmRatBN7.2
Rnor_6.01463,169,863 - 63,170,347NCBIRnor6.0
Rnor_5.01463,269,140 - 63,269,624UniSTSRnor5.0
RGSC_v3.41464,352,392 - 64,352,876UniSTSRGSC3.4
Celera1458,590,965 - 58,591,449UniSTS
Cytogenetic Map14q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_031347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY237127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY382577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC227803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000006071   ⟹   ENSRNOP00000006071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,421,542 - 59,512,656 (+)Ensembl
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105198   ⟹   ENSRNOP00000076568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,426,456 - 59,512,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108897   ⟹   ENSRNOP00000086053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1459,421,606 - 59,512,619 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116869   ⟹   ENSRNOP00000093101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)Ensembl
RefSeq Acc Id: NM_031347   ⟹   NP_112637
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,308 - 63,725,344 (+)NCBI
mRatBN7.21459,421,606 - 59,512,656 (+)NCBI
Rnor_6.01463,095,827 - 63,186,819 (+)NCBI
Rnor_5.01463,182,479 - 63,286,252 (+)NCBI
RGSC_v3.41464,278,115 - 64,370,912 (+)RGD
Celera1458,516,257 - 58,607,916 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092489   ⟹   XP_038948417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,129 - 63,729,215 (+)NCBI
mRatBN7.21459,421,414 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092490   ⟹   XP_038948418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,620,036 - 63,729,215 (+)NCBI
mRatBN7.21459,407,506 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092491   ⟹   XP_038948419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,073,505 - 63,729,215 (+)NCBI
mRatBN7.21458,860,752 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_039092492   ⟹   XP_038948420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,131 - 63,729,215 (+)NCBI
mRatBN7.21459,421,852 - 59,516,525 (+)NCBI
RefSeq Acc Id: XM_063273669   ⟹   XP_063129739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,620,036 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273670   ⟹   XP_063129740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,073,505 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273671   ⟹   XP_063129741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,125 - 63,725,858 (+)NCBI
RefSeq Acc Id: XM_063273672   ⟹   XP_063129742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,127 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273673   ⟹   XP_063129743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,634,131 - 63,729,215 (+)NCBI
RefSeq Acc Id: XM_063273674   ⟹   XP_063129744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81463,635,467 - 63,729,215 (+)NCBI
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_112637   ⟸   NM_031347
- UniProtKB: Q9QYK2 (UniProtKB/Swiss-Prot),   A6IJI5 (UniProtKB/TrEMBL),   A0A8I5Y905 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006071   ⟸   ENSRNOT00000006071
RefSeq Acc Id: XP_038948419   ⟸   XM_039092491
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948418   ⟸   XM_039092490
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948417   ⟸   XM_039092489
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y905 (UniProtKB/TrEMBL)
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYK2-F1-model_v2 AlphaFold Q9QYK2 1-796 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699342
Promoter ID:EPDNEW_R9866
Type:multiple initiation site
Name:Ppargc1a_1
Description:PPARG coactivator 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01463,095,778 - 63,095,838EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-15584 BioCyc
Ensembl Genes ENSRNOG00000004473 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000108897 ENTREZGENE
  ENSRNOT00000116869 ENTREZGENE
  ENSRNOT00000133457 ENTREZGENE
  ENSRNOT00000145100 ENTREZGENE
  ENSRNOT00000170033 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PGC-1 UniProtKB/Swiss-Prot
  PPARGC1A_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:83516 UniProtKB/Swiss-Prot
NCBI Gene 83516 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot
  PTHR15528:SF10 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Ppargc1a PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004473 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I5Y905 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A531 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q1Y2 ENTREZGENE, UniProtKB/TrEMBL
  A6IJI5 ENTREZGENE, UniProtKB/TrEMBL
  A6IJI6_RAT UniProtKB/TrEMBL
  A6IJI7_RAT UniProtKB/TrEMBL
  PRGC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ppargc1a  PPARG coactivator 1 alpha  Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppargc1a  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Ppargc1a  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha  Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ppargc1  peroxisome proliferative activated receptor, gamma, coactivator 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_process regulates gluconeogenic genes by cAMP and glucocorticoids; induces liver carnitine palmitoyltransferase I gene expression by cAMP 633650