RGD Reference Report - A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort. - Rat Genome Database

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A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.

Authors: Weydt, P  Soyal, SM  Landwehrmeyer, GB  Patsch, W   
Citation: Weydt P, etal., BMC Neurol. 2014 Jan 2;14:1. doi: 10.1186/1471-2377-14-1.
RGD ID: 10053663
Pubmed: PMID:24383721   (View Abstract at PubMed)
PMCID: PMC3880172   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2377-14-1   (Journal Full-text)

BACKGROUND: Genetic modifiers are important clues for the identification of therapeutic targets in neurodegenerative diseases. Huntington disease (HD) is one of the most common autosomal dominant inherited neurodegenerative diseases. The clinical symptoms include motor abnormalities, cognitive decline and behavioral disturbances. Symptom onset is typically between 40 and 50 years of age, but can vary by several decades in extreme cases and this is in part determined by modifying genetic factors. The metabolic master regulator PGC-1alpha, coded by the PPARGC1A gene, coordinates cellular respiration and was shown to play a role in neurodegenerative diseases, including HD. METHODS: Using a candidate gene approach we analyzed a large European cohort (n = 1706) from the REGISTRY study for associations between PPARGC1A genotype and age at onset (AO) in HD. RESULTS: We report that a coding variant (rs3736265) in PPARGC1A is associated with an earlier motor AO in men but not women carrying the HD mutation. CONCLUSIONS: These results further strengthen the evidence for a role of PGC-1alpha in HD and unexpectedly suggest a gender effect.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Huntington's disease onsetIAGP 10053663DNA:missense mutation:cds:pT612M (rs3736265) (human)RGD 
Huntington's disease onsetISOPPARGC1A (Homo sapiens)10053663; 10053663DNA:missense mutation:cds:pT612M (rs3736265) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppargc1a  (PPARG coactivator 1 alpha)

Genes (Mus musculus)
Ppargc1a  (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)

Genes (Homo sapiens)
PPARGC1A  (PPARG coactivator 1 alpha)


Additional Information