Plk2 (polo-like kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Plk2 (polo-like kinase 2) Rattus norvegicus
Analyze
Symbol: Plk2
Name: polo-like kinase 2
RGD ID: 620760
Description: Enables clathrin heavy chain binding activity; enzyme binding activity; and protein serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein localization to cell surface; and small GTPase-mediated signal transduction. Located in dendrite. Is active in postsynapse. Orthologous to human PLK2 (polo like kinase 2); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PLK-2; polo-like kinase 1; polo-like kinase 2 (Drosophila); serine/threonine-protein kinase PLK2; serine/threonine-protein kinase SNK; serum-inducible kinase; Snk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8243,702,536 - 43,708,305 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl243,701,865 - 43,708,296 (+)EnsemblGRCr8
mRatBN7.2241,969,176 - 41,974,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx249,090,164 - 49,095,930 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0247,148,897 - 47,154,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0242,001,899 - 42,007,665 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0241,911,143 - 41,916,901 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)Ensemblrn6Rnor6.0
Rnor_5.0260,970,300 - 60,976,058 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4241,800,745 - 41,806,503 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera237,785,007 - 37,790,765 (+)NCBICelera
RGSC_v3.1241,721,113 - 41,726,872 (+)NCBI
Cytogenetic Map2q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
7,12-dimethyltetraphene  (EXP,IEP,ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
fluoranthene  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
heme b  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
L-ascorbic acid  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,IEP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
riddelliine  (ISO)
Rutecarpine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
DNA damage response  (IEA)
G1/S transition of mitotic cell cycle  (IBA,IEA,ISO,ISS)
long-term synaptic depression  (IDA)
long-term synaptic potentiation  (IDA)
memory  (IEA,ISO,ISS)
mitotic cell cycle  (ISO)
mitotic spindle organization  (IBA,IEA,ISO,ISS)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of apoptotic process in bone marrow cell  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of dendritic spine development  (IMP)
negative regulation of excitatory postsynaptic potential  (IMP)
negative regulation of protein binding  (IMP)
negative regulation of protein localization to cell surface  (IMP)
positive regulation of autophagy  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IMP)
positive regulation of protein binding  (IDA)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of receptor internalization  (IMP)
protein phosphorylation  (IDA,ISO)
Rap protein signal transduction  (IDA)
Ras protein signal transduction  (IDA)
regulation of cell communication  (IEA)
regulation of centriole replication  (IEA,ISO,ISS)
regulation of signaling  (IEA)
regulation of synaptic plasticity  (IBA,IDA,IEA,IMP,ISO,TAS)
regulation protein catabolic process at postsynapse  (IDA,IEP,IMP)

Cellular Component
centriole  (IBA,IEA,ISO,ISS)
centrosome  (IBA,IEA,ISO,ISS)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
dendrite  (IDA,IEA)
Golgi apparatus  (IEA)
kinetochore  (IBA)
nucleolus  (IEA)
nucleus  (IBA)
postsynapse  (IDA,IEP,IMP)
spindle pole  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons. Ang XL, etal., J Biol Chem. 2008 Oct 24;283(43):29424-32. doi: 10.1074/jbc.M802475200. Epub 2008 Aug 22.
2. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. Kauselmann G, etal., EMBO J 1999 Oct 15;18(20):5528-39.
6. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Pak DT and Sheng M, Science 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Seeburg DP, etal., Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.
14. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12761501   PMID:12897130   PMID:12972611   PMID:15242618   PMID:15489334   PMID:16203730   PMID:18579731   PMID:19001868   PMID:20146300   PMID:20352051   PMID:20531387   PMID:21691298  
PMID:22854038   PMID:22870256   PMID:23466428   PMID:23479645   PMID:23850969   PMID:23983262   PMID:26934179   PMID:27579920   PMID:27908889   PMID:29066438   PMID:31134620   PMID:34047419  
PMID:37654026  


Genomics

Comparative Map Data
Plk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8243,702,536 - 43,708,305 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl243,701,865 - 43,708,296 (+)EnsemblGRCr8
mRatBN7.2241,969,176 - 41,974,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx249,090,164 - 49,095,930 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0247,148,897 - 47,154,663 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0242,001,899 - 42,007,665 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0241,911,143 - 41,916,901 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)Ensemblrn6Rnor6.0
Rnor_5.0260,970,300 - 60,976,058 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4241,800,745 - 41,806,503 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera237,785,007 - 37,790,765 (+)NCBICelera
RGSC_v3.1241,721,113 - 41,726,872 (+)NCBI
Cytogenetic Map2q14NCBI
PLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38558,453,982 - 58,460,086 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl558,453,982 - 58,460,139 (-)Ensemblhg38GRCh38
GRCh37557,749,809 - 57,755,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36557,785,566 - 57,791,670 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34557,785,569 - 57,791,844NCBI
Celera554,688,300 - 54,694,404 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef554,706,921 - 54,713,078 (-)NCBIHuRef
CHM1_1557,749,420 - 57,755,577 (-)NCBICHM1_1
T2T-CHM13v2.0559,272,431 - 59,278,533 (-)NCBIT2T-CHM13v2.0
Plk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913110,531,578 - 110,537,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13110,531,580 - 110,537,378 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3813110,395,044 - 110,400,844 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13110,395,046 - 110,400,844 (+)Ensemblmm10GRCm38
MGSCv3713111,185,252 - 111,191,052 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613111,515,940 - 111,521,722 (+)NCBIMGSCv36mm8
Celera13114,729,888 - 114,735,651 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1361.97NCBI
Plk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554469,671,090 - 9,677,188 (+)Ensembl
ChiLan1.0NW_0049554469,671,090 - 9,676,956 (+)NCBIChiLan1.0ChiLan1.0
PLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2455,454,341 - 55,461,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1553,607,973 - 53,614,939 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0555,543,828 - 55,550,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1557,178,503 - 57,184,793 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl557,177,836 - 57,184,793 (+)EnsemblpanPan2panpan1.1
PLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,359,865 - 45,365,496 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,360,374 - 45,367,441 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha242,431,127 - 42,436,818 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0245,844,932 - 45,850,642 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,844,939 - 45,850,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,914,745 - 42,920,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,720,594 - 43,726,300 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0244,541,169 - 44,546,873 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213200,743,971 - 200,750,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364809,680,449 - 9,686,595 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364809,680,461 - 9,686,593 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1637,299,119 - 37,305,114 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11637,299,116 - 37,305,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21640,067,358 - 40,073,357 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1454,629,868 - 54,636,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl454,629,194 - 54,636,032 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660493,546,484 - 3,552,760 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624759811,316 - 817,474 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624759811,320 - 817,401 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Plk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13186,628,043 - 186,633,827 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plk2
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:252
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000016768
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
IB1671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2241,974,662 - 41,974,824 (+)MAPPERmRatBN7.2
Rnor_6.0241,916,622 - 41,916,783NCBIRnor6.0
Rnor_5.0260,975,779 - 60,975,940UniSTSRnor5.0
RGSC_v3.4241,806,224 - 41,806,385UniSTSRGSC3.4
Celera237,790,486 - 37,790,647UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 89 59 6 353 189 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016768   ⟹   ENSRNOP00000016768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl243,701,865 - 43,708,296 (+)Ensembl
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)Ensembl
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111192   ⟹   ENSRNOP00000092527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl243,701,865 - 43,708,296 (+)Ensembl
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)Ensembl
RefSeq Acc Id: NM_031821   ⟹   NP_114009
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8243,702,536 - 43,708,305 (+)NCBI
mRatBN7.2241,969,176 - 41,974,945 (+)NCBI
Rnor_6.0241,911,143 - 41,916,901 (+)NCBI
Rnor_5.0260,970,300 - 60,976,058 (+)NCBI
RGSC_v3.4241,800,745 - 41,806,503 (+)RGD
Celera237,785,007 - 37,790,765 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114009 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF08366 (Get FASTA)   NCBI Sequence Viewer  
  AAH70878 (Get FASTA)   NCBI Sequence Viewer  
  EDM10332 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016768
  ENSRNOP00000016768.3
GenBank Protein Q9R012 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114009   ⟸   NM_031821
- UniProtKB: Q9R012 (UniProtKB/Swiss-Prot),   A6I5M4 (UniProtKB/TrEMBL),   A0A8I6ADU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016768   ⟸   ENSRNOT00000016768
Ensembl Acc Id: ENSRNOP00000092527   ⟸   ENSRNOT00000111192
Protein Domains
POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R012-F1-model_v2 AlphaFold Q9R012 1-682 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691133
Promoter ID:EPDNEW_R1657
Type:single initiation site
Name:Plk2_1
Description:polo-like kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0241,911,135 - 41,911,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620760 AgrOrtholog
BioCyc Gene G2FUF-54435 BioCyc
Ensembl Genes ENSRNOG00000011951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016768 ENTREZGENE
  ENSRNOT00000016768.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096750 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PLK2_STKc UniProtKB/Swiss-Prot
  POLO_box_1 UniProtKB/Swiss-Prot
  POLO_box_2 UniProtKB/Swiss-Prot
  POLO_box_dom UniProtKB/Swiss-Prot
  POLO_box_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:83722 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91616 IMAGE-MGC_LOAD
NCBI Gene 83722 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE PLK2 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  POLO_box UniProtKB/Swiss-Prot
PhenoGen Plk2 PhenoGen
PROSITE POLO_BOX UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011951 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ADU0 ENTREZGENE, UniProtKB/TrEMBL
  A6I5M4 ENTREZGENE, UniProtKB/TrEMBL
  PLK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk2  polo-like kinase 2  Plk2  polo-like kinase 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Plk2  polo-like kinase 2 (Drosophila)  Snk  serum-inducible kinase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Snk  serum-inducible kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced by neuronal activity 61555
gene_product member of the polo family of cell cycle associated kinases 61555