Sipa1l1 (signal-induced proliferation-associated 1 like 1) - Rat Genome Database

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Gene: Sipa1l1 (signal-induced proliferation-associated 1 like 1) Rattus norvegicus
Analyze
Symbol: Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
RGD ID: 708497
Description: Enables actin filament binding activity; protein kinase binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of dendrite morphogenesis; and regulation of postsynapse organization. Located in dendritic spine; neuronal cell body; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; Spa-1; SPA-1 like protein; SPA-1 like protein p1294; SPA-1-like protein p1294; Spa1; SPAL; Spar; spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86107,570,569 - 107,849,613 (+)NCBIGRCr8
mRatBN7.26101,839,351 - 102,118,408 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6101,839,404 - 102,116,950 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6101,994,376 - 102,272,374 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06102,293,579 - 102,571,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06101,662,460 - 101,940,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06106,052,212 - 106,163,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6106,039,991 - 106,163,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,193,905 - 114,304,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46106,171,896 - 106,283,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16106,175,351 - 106,286,464 (+)NCBI
Celera699,843,230 - 99,954,347 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons. Ang XL, etal., J Biol Chem. 2008 Oct 24;283(43):29424-32. doi: 10.1074/jbc.M802475200. Epub 2008 Aug 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage. Herrick S, etal., Mol Cell Neurosci. 2010 Feb;43(2):188-200. doi: 10.1016/j.mcn.2009.10.009. Epub 2009 Nov 10.
4. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
5. Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity. Maruoka H, etal., J Neurosci. 2005 Feb 9;25(6):1421-30.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
8. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Pak DT and Sheng M, Science 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.
9. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Pak DT, etal., Neuron. 2001 Aug 2;31(2):289-303.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus. Roy BC, etal., Genes Cells 2002 Jun;7(6):607-17.
14. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Seeburg DP, etal., Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.
15. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. Wendholt D, etal., J Biol Chem. 2006 May 12;281(19):13805-16. Epub 2006 Mar 7.
Additional References at PubMed
PMID:9756850   PMID:15196935   PMID:15458844   PMID:17785183   PMID:18094260   PMID:18678258   PMID:20146300   PMID:21987493   PMID:23850969   PMID:25931508   PMID:29180226  


Genomics

Comparative Map Data
Sipa1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86107,570,569 - 107,849,613 (+)NCBIGRCr8
mRatBN7.26101,839,351 - 102,118,408 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6101,839,404 - 102,116,950 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6101,994,376 - 102,272,374 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06102,293,579 - 102,571,594 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06101,662,460 - 101,940,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06106,052,212 - 106,163,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6106,039,991 - 106,163,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06114,193,905 - 114,304,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46106,171,896 - 106,283,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16106,175,351 - 106,286,464 (+)NCBI
Celera699,843,230 - 99,954,347 (+)NCBICelera
Cytogenetic Map6q24NCBI
SIPA1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381471,320,476 - 71,741,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1471,320,449 - 71,741,229 (+)EnsemblGRCh38hg38GRCh38
GRCh371471,787,193 - 72,207,926 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361471,065,795 - 71,275,875 (+)NCBINCBI36Build 36hg18NCBI36
Build 341471,065,794 - 71,275,871NCBI
Celera1452,059,323 - 52,269,351 (+)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1452,162,703 - 52,372,954 (+)NCBIHuRef
CHM1_11471,934,305 - 72,144,298 (+)NCBICHM1_1
T2T-CHM13v2.01465,525,922 - 65,946,692 (+)NCBIT2T-CHM13v2.0
Sipa1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391282,216,138 - 82,498,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1282,216,094 - 82,498,560 (+)EnsemblGRCm39 Ensembl
GRCm381282,169,377 - 82,451,786 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1282,169,320 - 82,451,786 (+)EnsemblGRCm38mm10GRCm38
MGSCv371283,271,003 - 83,552,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361283,230,197 - 83,369,119 (+)NCBIMGSCv36mm8
Celera1283,693,171 - 83,908,580 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1238.14NCBI
Sipa1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555233,545,708 - 3,797,572 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555233,545,807 - 3,908,329 (-)NCBIChiLan1.0ChiLan1.0
SIPA1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21572,439,880 - 72,859,090 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11471,656,390 - 72,075,603 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,909,444 - 52,328,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11470,776,089 - 71,192,916 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1471,038,600 - 71,192,916 (+)Ensemblpanpan1.1panPan2
SIPA1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1844,916,309 - 45,260,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl844,990,495 - 45,258,614 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha844,543,228 - 44,922,482 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0845,102,510 - 45,476,140 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl845,102,544 - 45,474,511 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1844,762,748 - 45,148,005 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0844,801,685 - 45,176,501 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0845,162,889 - 45,538,133 (+)NCBIUU_Cfam_GSD_1.0
Sipa1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864030,893,917 - 31,249,447 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936488860,129 - 1,175,051 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936488819,503 - 1,175,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIPA1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl795,022,924 - 95,167,107 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1794,789,794 - 95,168,728 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27101,036,283 - 101,416,110 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIPA1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12448,542,976 - 48,965,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2448,636,323 - 48,965,371 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605336,766,457 - 37,176,731 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sipa1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473429,611,978 - 29,914,317 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473429,612,867 - 29,998,602 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sipa1l1
1140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:116
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000058195
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat

Markers in Region
BE116899  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,116,661 - 102,116,836 (+)MAPPERmRatBN7.2
Rnor_6.06106,163,007 - 106,163,181NCBIRnor6.0
Rnor_5.06114,304,346 - 114,304,520UniSTSRnor5.0
RGSC_v3.46106,282,766 - 106,282,940UniSTSRGSC3.4
Celera699,954,105 - 99,954,279UniSTS
RH 3.4 Map6732.0UniSTS
Cytogenetic Map6q24UniSTS
RH138739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,105,871 - 102,106,184 (+)MAPPERmRatBN7.2
Rnor_6.06106,152,216 - 106,152,528NCBIRnor6.0
Rnor_5.06114,293,555 - 114,293,867UniSTSRnor5.0
RGSC_v3.46106,271,976 - 106,272,288UniSTSRGSC3.4
Celera699,943,315 - 99,943,627UniSTS
RH 3.4 Map6733.0UniSTS
Cytogenetic Map6q24UniSTS
ksks223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,008,403 - 102,008,703 (+)MAPPERmRatBN7.2
Rnor_6.06106,054,436 - 106,054,735NCBIRnor6.0
Rnor_5.06114,196,129 - 114,196,428UniSTSRnor5.0
RGSC_v3.46106,174,120 - 106,174,419UniSTSRGSC3.4
Celera699,845,454 - 99,845,753UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 20 4 19 4 74 35 40 11
Low 23 37 37 37 8 11 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001389245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF026504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY043226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000010626   ⟹   ENSRNOP00000010626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6106,052,212 - 106,072,703 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000058195   ⟹   ENSRNOP00000054996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6101,839,404 - 102,116,950 (+)Ensembl
Rnor_6.0 Ensembl6106,084,815 - 106,163,249 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088917   ⟹   ENSRNOP00000075549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6101,839,404 - 102,116,950 (+)Ensembl
Rnor_6.0 Ensembl6106,039,991 - 106,163,302 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092065   ⟹   ENSRNOP00000072447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6106,153,045 - 106,163,295 (+)Ensembl
RefSeq Acc Id: NM_001389245   ⟹   NP_001376174
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,570,638 - 107,848,160 (+)NCBI
mRatBN7.26101,839,420 - 102,116,950 (+)NCBI
RefSeq Acc Id: NM_139330   ⟹   NP_647546
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,737,392 - 107,848,160 (+)NCBI
mRatBN7.26102,006,180 - 102,116,950 (+)NCBI
Rnor_6.06106,052,212 - 106,163,249 (+)NCBI
Rnor_5.06114,193,905 - 114,304,588 (+)NCBI
RGSC_v3.46106,171,896 - 106,283,008 (+)RGD
Celera699,843,230 - 99,954,347 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111776   ⟹   XP_038967704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,725,151 - 107,849,613 (+)NCBI
mRatBN7.26101,993,927 - 102,118,408 (+)NCBI
RefSeq Acc Id: XM_039111778   ⟹   XP_038967706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,571,374 - 107,849,613 (+)NCBI
mRatBN7.26101,840,141 - 102,118,408 (+)NCBI
RefSeq Acc Id: XM_039111779   ⟹   XP_038967707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,570,569 - 107,849,613 (+)NCBI
mRatBN7.26101,839,352 - 102,118,408 (+)NCBI
RefSeq Acc Id: XM_039111780   ⟹   XP_038967708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,617,261 - 107,849,613 (+)NCBI
mRatBN7.26101,886,047 - 102,118,408 (+)NCBI
RefSeq Acc Id: XM_039111781   ⟹   XP_038967709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,737,100 - 107,849,613 (+)NCBI
mRatBN7.26102,005,850 - 102,118,408 (+)NCBI
RefSeq Acc Id: XM_063261545   ⟹   XP_063117615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,570,746 - 107,849,613 (+)NCBI
RefSeq Acc Id: XM_063261546   ⟹   XP_063117616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,616,828 - 107,849,613 (+)NCBI
RefSeq Acc Id: XM_063261547   ⟹   XP_063117617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,725,175 - 107,849,613 (+)NCBI
RefSeq Acc Id: XM_063261548   ⟹   XP_063117618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,725,175 - 107,849,613 (+)NCBI
RefSeq Acc Id: XM_063261549   ⟹   XP_063117619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,725,175 - 107,849,613 (+)NCBI
RefSeq Acc Id: XM_063261550   ⟹   XP_063117620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,725,143 - 107,814,537 (+)NCBI
RefSeq Acc Id: NP_647546   ⟸   NM_139330
- Peptide Label: isoform 1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072447   ⟸   ENSRNOT00000092065
RefSeq Acc Id: ENSRNOP00000054996   ⟸   ENSRNOT00000058195
RefSeq Acc Id: ENSRNOP00000010626   ⟸   ENSRNOT00000010626
RefSeq Acc Id: ENSRNOP00000075549   ⟸   ENSRNOT00000088917
RefSeq Acc Id: XP_038967707   ⟸   XM_039111779
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001376174   ⟸   NM_001389245
- Peptide Label: isoform 2
- UniProtKB: A6JDP1 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967706   ⟸   XM_039111778
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967708   ⟸   XM_039111780
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967704   ⟸   XM_039111776
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967709   ⟸   XM_039111781
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAW2 (UniProtKB/TrEMBL),   F1LS65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117615   ⟸   XM_063261545
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117616   ⟸   XM_063261546
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117620   ⟸   XM_063261550
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063117617   ⟸   XM_063261547
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117618   ⟸   XM_063261548
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063117619   ⟸   XM_063261549
- Peptide Label: isoform X4
Protein Domains
PDZ   Rap-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35412-F1-model_v2 AlphaFold O35412 1-1822 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708497 AgrOrtholog
BioCyc Gene G2FUF-36872 BioCyc
Ensembl Genes ENSRNOG00000007646 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058195 ENTREZGENE
  ENSRNOT00000058195.5 UniProtKB/TrEMBL
  ENSRNOT00000088917.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1120.160 UniProtKB/Swiss-Prot
  3.40.50.11210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.210 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap_GAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIPA1L_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246212 UniProtKB/Swiss-Prot
NCBI Gene 246212 ENTREZGENE
PANTHER PTHR15711:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAP GTPASE-ACTIVATING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap-GAP_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rap_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPAR_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sipa1l1 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAPGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007646 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111347 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAW2 ENTREZGENE, UniProtKB/TrEMBL
  A6JDP1 ENTREZGENE, UniProtKB/TrEMBL
  A6JDP2_RAT UniProtKB/TrEMBL
  F1LS65 ENTREZGENE, UniProtKB/TrEMBL
  O35412 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Sipa1l1  signal-induced proliferation-associated 1 like 1  Spa1  SPA-1 like protein p1294  Symbol and Name updated 1299863 APPROVED