Vegfd (vascular endothelial growth factor D) - Rat Genome Database

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Gene: Vegfd (vascular endothelial growth factor D) Rattus norvegicus
Analyze
Symbol: Vegfd
Name: vascular endothelial growth factor D
RGD ID: 620695
Description: Enables vascular endothelial growth factor receptor binding activity. Involved in several processes, including positive regulation of interleukin-6 production; regulation of vascular endothelial growth factor receptor signaling pathway; and response to interleukin-1. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human VEGFD (vascular endothelial growth factor D); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ceramide signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-fos induced growth factor; c-fos induced growth factor (vascular endothelial growth factor D); c-fos-induced growth factor; Figf; Vegf-d
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,704,582 - 33,740,305 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX33,706,055 - 33,740,167 (-)EnsemblGRCr8
mRatBN7.2X30,073,122 - 30,108,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,074,163 - 30,108,295 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,113,543 - 31,147,406 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,544,052 - 34,577,893 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,738,361 - 30,772,226 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,816,480 - 31,852,239 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,816,436 - 31,851,715 (-)Ensemblrn6Rnor6.0
Rnor_5.0X32,190,233 - 32,225,843 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X50,830,612 - 50,864,445 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,420,833 - 30,454,666 (-)NCBICelera
RGSC_v3.1X50,884,080 - 50,917,914 (-)NCBI
Cytogenetic MapXq14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
furan  (EXP)
glucose  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
isobutyl nitrite  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
minocycline  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methylformamide  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
PCB138  (ISO)
permethrin  (ISO)
picoxystrobin  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
tebufenpyrad  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IEA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma. Bolat F, etal., Pathol Res Pract. 2008;204(6):379-87. Epub 2008 Mar 17.
2. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Byzova TV, etal., Blood 2002 Jun 15;99(12):4434-42.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. VEGF-C, VEGF-D and Flt-4 in transitional bladder cancer: relationships to clinicopathological parameters and long-term survival. Herrmann E, etal., Anticancer Res. 2007 Sep-Oct;27(5A):3127-33.
6. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin V, etal., Eur J Biochem 2001 Nov;268(21):5530-40.
7. Role of vascular endothelial growth factor-D (VEGF-D) on IL-6 expression in cerulein-stimulated pancreatic acinar cells. Lee J, etal., Ann N Y Acad Sci. 2007 Jan;1095:129-33.
8. Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1. Mountain DJ, etal., J Cell Physiol. 2008 May;215(2):337-43.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells. Ohnishi S, etal., Stem Cells. 2007 May;25(5):1166-77. Epub 2007 Feb 8.
13. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
14. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
15. Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study. Pezzilli R, etal., Clin Chem Lab Med. 2011 Jun;49(6):1047-51. doi: 10.1515/CCLM.2011.159. Epub 2011 Mar 17.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast cancer. van Iterson V, etal., Am J Clin Pathol. 2007 Nov;128(5):759-66.
21. Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. Yamada Y, etal., Genomics 1997 Jun 15;42(3):483-8.
22. The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma. Yu H, etal., J Exp Clin Cancer Res. 2009 Jul 9;28:98.
Additional References at PubMed
PMID:8876195   PMID:9435229   PMID:11136737   PMID:11279005   PMID:11574540   PMID:11606379   PMID:16533777   PMID:19275959   PMID:22535492   PMID:22818386   PMID:23012479   PMID:24006456  


Genomics

Comparative Map Data
Vegfd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,704,582 - 33,740,305 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX33,706,055 - 33,740,167 (-)EnsemblGRCr8
mRatBN7.2X30,073,122 - 30,108,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,074,163 - 30,108,295 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX31,113,543 - 31,147,406 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,544,052 - 34,577,893 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,738,361 - 30,772,226 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,816,480 - 31,852,239 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,816,436 - 31,851,715 (-)Ensemblrn6Rnor6.0
Rnor_5.0X32,190,233 - 32,225,843 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X50,830,612 - 50,864,445 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX30,420,833 - 30,454,666 (-)NCBICelera
RGSC_v3.1X50,884,080 - 50,917,914 (-)NCBI
Cytogenetic MapXq14NCBI
VEGFD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,345,596 - 15,384,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,345,594 - 15,384,509 (-)Ensemblhg38GRCh38
GRCh37X15,363,718 - 15,402,535 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,273,639 - 15,312,498 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X15,123,375 - 15,162,234NCBI
CeleraX19,479,224 - 19,518,092 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,122,815 - 13,159,253 (-)NCBIHuRef
CHM1_1X15,394,667 - 15,433,457 (-)NCBICHM1_1
T2T-CHM13v2.0X14,928,484 - 14,967,347 (-)NCBIT2T-CHM13v2.0
Vegfd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,156,282 - 163,185,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,156,374 - 163,185,646 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X164,373,522 - 164,402,650 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,373,378 - 164,402,650 (+)Ensemblmm10GRCm38
MGSCv37X160,811,480 - 160,840,579 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X159,717,653 - 159,746,752 (+)NCBIMGSCv36mm8
CeleraX147,588,947 - 147,618,041 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.35NCBI
Vegfd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,813,438 - 2,845,915 (+)Ensembl
ChiLan1.0NW_0049555192,813,475 - 2,845,856 (+)NCBIChiLan1.0ChiLan1.0
VEGFD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,144,870 - 17,183,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,147,684 - 17,187,404 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,972,227 - 8,011,263 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,254,945 - 15,293,704 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,254,945 - 15,293,704 (-)EnsemblpanPan2panpan1.1
VEGFD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,590,097 - 11,627,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,590,089 - 11,626,486 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX11,497,333 - 11,534,670 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,552,176 - 11,589,521 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,552,198 - 11,588,820 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,615,093 - 11,652,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,606,440 - 11,643,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,634,519 - 11,671,865 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vegfd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,761,827 - 4,794,675 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,762,332 - 4,793,938 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,761,827 - 4,794,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,893,259 - 11,933,809 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X11,893,254 - 11,933,923 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,853,823 - 12,894,483 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,813,472 - 13,854,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,813,403 - 13,854,057 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605615,650,140 - 15,689,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vegfd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829148,317 - 181,098 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624829148,371 - 181,742 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vegfd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X24,950,402 - 24,979,727 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vegfd
137 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000068601
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
MARC_21748-21749:1023808694:5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,103,977 - 30,104,243 (+)MAPPERmRatBN7.2
Rnor_6.0X31,847,764 - 31,848,029NCBIRnor6.0
Rnor_5.0X32,221,515 - 32,221,780UniSTSRnor5.0
RGSC_v3.4X50,860,423 - 50,860,688UniSTSRGSC3.4
CeleraX30,450,644 - 30,450,909UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 65 122 91 90 59 28 59 6 270 125 9 99 64 92 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000068601   ⟹   ENSRNOP00000058883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX33,706,055 - 33,739,892 (-)Ensembl
mRatBN7.2 EnsemblX30,074,163 - 30,108,295 (-)Ensembl
Rnor_6.0 EnsemblX31,816,436 - 31,851,715 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152015   ⟹   ENSRNOP00000104705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX33,706,055 - 33,740,167 (-)Ensembl
RefSeq Acc Id: NM_031761   ⟹   NP_113949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,706,055 - 33,739,892 (-)NCBI
mRatBN7.2X30,074,163 - 30,108,000 (-)NCBI
Rnor_6.0X31,817,953 - 31,851,786 (-)NCBI
Rnor_5.0X32,190,233 - 32,225,843 (-)NCBI
RGSC_v3.4X50,830,612 - 50,864,445 (-)RGD
CeleraX30,420,833 - 30,454,666 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256863   ⟹   XP_006256925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,704,582 - 33,740,279 (-)NCBI
mRatBN7.2X30,073,122 - 30,108,413 (-)NCBI
Rnor_6.0X31,816,480 - 31,852,239 (-)NCBI
Rnor_5.0X32,190,233 - 32,225,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280111   ⟹   XP_063136181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,704,582 - 33,740,305 (-)NCBI
RefSeq Acc Id: XM_063280112   ⟹   XP_063136182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,704,582 - 33,740,305 (-)NCBI
RefSeq Acc Id: XR_005498006
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,706,501 - 33,740,305 (-)NCBI
mRatBN7.2X30,074,604 - 30,108,413 (-)NCBI
RefSeq Acc Id: NP_113949   ⟸   NM_031761
- Peptide Label: precursor
- UniProtKB: Q91ZE4 (UniProtKB/Swiss-Prot),   O35251 (UniProtKB/Swiss-Prot),   A6K2L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256925   ⟸   XM_006256863
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000058883   ⟸   ENSRNOT00000068601
RefSeq Acc Id: XP_063136181   ⟸   XM_063280111
- Peptide Label: isoform X2
- UniProtKB: Q91ZE4 (UniProtKB/Swiss-Prot),   O35251 (UniProtKB/Swiss-Prot),   G3V9S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136182   ⟸   XM_063280112
- Peptide Label: isoform X3
- UniProtKB: Q91ZE4 (UniProtKB/Swiss-Prot),   O35251 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000104705   ⟸   ENSRNOT00000152015
Protein Domains
Platelet-derived growth factor (PDGF) family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35251-F1-model_v2 AlphaFold O35251 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620695 AgrOrtholog
BioCyc Gene G2FUF-2593 BioCyc
Ensembl Genes ENSRNOG00000003587 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000068601 ENTREZGENE
  ENSRNOT00000152015 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro CXCXC_repeat UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report rno:360457 UniProtKB/Swiss-Prot
NCBI Gene Vegfd ENTREZGENE
PANTHER VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR D UniProtKB/Swiss-Prot
Pfam CXCXC UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Vegfd PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003587 RatGTEx
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0ABK0LTD5_RAT UniProtKB/TrEMBL
  A6K2L1 ENTREZGENE, UniProtKB/TrEMBL
  G3V9S8 ENTREZGENE, UniProtKB/TrEMBL
  O35251 ENTREZGENE
  Q91ZE4 ENTREZGENE
  VEGFD_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91ZE4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Vegfd  vascular endothelial growth factor D  Figf  c-fos induced growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Figf  c-fos induced growth factor    c-fos induced growth factor (vascular endothelial growth factor D)  Name updated 1299863 APPROVED
2002-08-07 Figf  c-fos induced growth factor (vascular endothelial growth factor D)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation VEGF-D induction of VEGFR-3 kinase activity is inhibited by some indolinones 727326