Hcn2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) - Rat Genome Database

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Gene: Hcn2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2) Rattus norvegicus
Analyze
Symbol: Hcn2
Name: hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
RGD ID: 620689
Description: Enables PDZ domain binding activity and molecular adaptor activity. Involved in cellular response to aldosterone; inorganic cation transmembrane transport; and response to xenobiotic stimulus. Located in axon; dendrite; and neuronal cell body. Biomarker of dermatitis and meningitis. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,620,422 - 10,639,457 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,620,422 - 10,639,457 (-)EnsemblGRCr8
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,143,888 - 8,161,946 (-)NCBICelera
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression. Acosta C, etal., PLoS One. 2012;7(12):e50442. doi: 10.1371/journal.pone.0050442. Epub 2012 Dec 7.
2. Functional presynaptic HCN channels in the rat globus pallidus. Boyes J, etal., Eur J Neurosci. 2007 Apr;25(7):2081-92.
3. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Brewster AL, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):200-7.
4. Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Budde T, etal., Pflugers Arch. 2008 Sep;456(6):1061-73. Epub 2008 May 14.
5. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. Buniel M, etal., J Comp Neurol. 2008 Oct 1;510(4):367-77.
6. The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron. Carrisoza-Gaytán R, etal., Kidney Int. 2011 Oct;80(8):832-40. doi: 10.1038/ki.2011.230. Epub 2011 Jul 27.
7. Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Cho HJ, etal., Neuroscience. 2009 Aug 18;162(2):453-61. Epub 2009 May 3.
8. Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. Dougherty KA, etal., J Neurophysiol. 2013 Apr;109(7):1940-53. doi: 10.1152/jn.00010.2013. Epub 2013 Jan 16.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Age-related down-regulation of HCN channels in rat sinoatrial node. Huang X, etal., Basic Res Cardiol. 2007 Sep;102(5):429-35. Epub 2007 Jun 18.
12. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. Kanyshkova T, etal., J Neurosci. 2009 Jul 8;29(27):8847-57.
13. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction. Kimura K, etal., Genes Cells. 2004 Jul;9(7):631-40.
14. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Li CJ, etal., Mol Neurobiol. 2014 Oct;50(2):704-20. doi: 10.1007/s12035-014-8736-3. Epub 2014 May 18.
15. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes. Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
18. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
19. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Muto T, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2710-8. Epub 2007 Jul 20.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Pachucki J, etal., Circ Res. 1999 Sep 17;85(6):498-503.
22. HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. Ramakrishnan NA, etal., J Biol Chem. 2012 Nov 2;287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
26. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6.
27. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth. Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23.
28. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Whitaker GM, etal., J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.
29. Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Xiao J, etal., J Cell Physiol. 2007 Aug;212(2):285-92.
30. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
31. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. Zha Q, etal., J Neurochem. 2008 Apr;105(1):68-77. Epub 2007 Nov 5.
Additional References at PubMed
PMID:10228147   PMID:14991560   PMID:15016091   PMID:15056713   PMID:15245481   PMID:15292247   PMID:15525777   PMID:15564593   PMID:15958747   PMID:16175581   PMID:16395601   PMID:16648453  
PMID:16760342   PMID:16979600   PMID:17065201   PMID:17311321   PMID:18255311   PMID:18326556   PMID:18397293   PMID:18450385   PMID:18524809   PMID:18614814   PMID:18768480   PMID:19236845  
PMID:19500574   PMID:20220080   PMID:20726890   PMID:21753027   PMID:21798320   PMID:22006928   PMID:22377439   PMID:22748890   PMID:22871113   PMID:23620341   PMID:24460767   PMID:24592881  
PMID:25290015   PMID:25659346   PMID:25813712   PMID:25998542   PMID:26021557   PMID:26065643   PMID:26341471   PMID:27496876   PMID:27542339   PMID:27569278   PMID:29806529   PMID:31432175  
PMID:32165274   PMID:32454040   PMID:33653265   PMID:34875252   PMID:35008085   PMID:36336089   PMID:37085778  


Genomics

Comparative Map Data
Hcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,620,422 - 10,639,457 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,620,422 - 10,639,457 (-)EnsemblGRCr8
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,143,888 - 8,161,946 (-)NCBICelera
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Cytogenetic Map7q11NCBI
HCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819589,881 - 617,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19589,881 - 617,159 (+)Ensemblhg38GRCh38
GRCh3719589,881 - 617,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619540,893 - 568,159 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3419540,892 - 568,157NCBI
Celera19200,463 - 228,092 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19373,968 - 384,301 (+)NCBIHuRef
CHM1_119589,749 - 616,575 (+)NCBICHM1_1
T2T-CHM13v2.019543,772 - 571,465 (+)NCBIT2T-CHM13v2.0
Hcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)Ensemblmm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBIMGSCv36mm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Hcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,124,640 - 7,194,223 (-)Ensembl
ChiLan1.0NW_0049554957,124,060 - 7,143,730 (-)NCBIChiLan1.0ChiLan1.0
HCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,914,303 - 4,942,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,153,083 - 4,180,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019521,348 - 528,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119559,108 - 584,128 (+)NCBIPanPan1.1PanPan1.1panPan2
HCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,920,089 - 57,941,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,920,740 - 57,938,374 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2057,722,746 - 57,741,278 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,663,358 - 58,681,919 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,663,358 - 58,681,919 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,717,402 - 57,735,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,196,864 - 58,215,545 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,400,096 - 58,421,283 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,625,528 - 217,639,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588142,786 - 208,606 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588202,101 - 209,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,708,162 - 77,730,881 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,708,159 - 77,730,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6324,517 - 358,119 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,889,025 - 7,908,639 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248287,889,616 - 7,908,855 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hcn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,138,074 - 155,156,965 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hcn2
235 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI18458081
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000011837
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 162 90 89 58 88 58 6 350 187 9 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011837   ⟹   ENSRNOP00000011837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,620,422 - 10,639,457 (-)Ensembl
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)Ensembl
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)Ensembl
RefSeq Acc Id: NM_053684   ⟹   NP_446136
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,620,422 - 10,639,457 (-)NCBI
mRatBN7.279,969,802 - 9,988,839 (-)NCBI
Rnor_6.0712,851,730 - 12,870,087 (-)NCBI
Rnor_5.0713,021,934 - 13,051,802 (-)NCBI
RGSC_v3.4711,485,257 - 11,503,614 (-)RGD
Celera78,143,888 - 8,161,946 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078239   ⟹   XP_038934167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,620,422 - 10,628,909 (-)NCBI
mRatBN7.279,969,801 - 9,978,022 (-)NCBI
RefSeq Acc Id: NP_446136   ⟸   NM_053684
- UniProtKB: Q9QZW6 (UniProtKB/Swiss-Prot),   Q6BCT5 (UniProtKB/Swiss-Prot),   Q9JKA9 (UniProtKB/Swiss-Prot),   F1LRY7 (UniProtKB/TrEMBL),   A6K8Y2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011837   ⟸   ENSRNOT00000011837
RefSeq Acc Id: XP_038934167   ⟸   XM_039078239
- Peptide Label: isoform X1
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKA9-F1-model_v2 AlphaFold Q9JKA9 1-863 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620689 AgrOrtholog
BioCyc Gene G2FUF-34884 BioCyc
Ensembl Genes ENSRNOG00000008831 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055031041 UniProtKB/Swiss-Prot
  ENSRNOG00060027027 UniProtKB/Swiss-Prot
  ENSRNOG00065020456 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011837 ENTREZGENE
  ENSRNOT00000011837.7 UniProtKB/Swiss-Prot
  ENSRNOT00055053819 UniProtKB/Swiss-Prot
  ENSRNOT00060046853 UniProtKB/Swiss-Prot
  ENSRNOT00065034581 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  Ion_trans_N UniProtKB/Swiss-Prot
  K/Na_HCN_channel UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:114244 UniProtKB/Swiss-Prot
NCBI Gene 114244 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/Swiss-Prot
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2 UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  Ion_trans_N UniProtKB/Swiss-Prot
PharmGKB HCN2 RGD
PhenoGen Hcn2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008831 RatGTEx
  ENSRNOG00055031041 RatGTEx
  ENSRNOG00060027027 RatGTEx
  ENSRNOG00065020456 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6K8Y2 ENTREZGENE, UniProtKB/TrEMBL
  F1LRY7 ENTREZGENE
  HCN2_RAT UniProtKB/Swiss-Prot
  Q6BCT5 ENTREZGENE
  Q9JKA9 ENTREZGENE
  Q9QZW6 ENTREZGENE
UniProt Secondary F1LRY7 UniProtKB/Swiss-Prot
  Q6BCT5 UniProtKB/Swiss-Prot
  Q9QZW6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Hcn2  hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2  Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hcn2  hyperpolarization activated cyclic nucleotide-gated potassium channel 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neonatal and adult cardiac ventricle  
gene_product member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides 70760