Aoc3 (amine oxidase, copper containing 3) - Rat Genome Database

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Gene: Aoc3 (amine oxidase, copper containing 3) Rattus norvegicus
Analyze
Symbol: Aoc3
Name: amine oxidase, copper containing 3
RGD ID: 62058
Description: Enables identical protein binding activity and primary methylamine oxidase activity. Involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of D-glucose transmembrane transport. Located in extracellular space. Used to study aortic aneurysm; obesity; type 2 diabetes mellitus; and uveitis. Biomarker of intracranial aneurysm. Orthologous to human AOC3 (amine oxidase copper containing 3); PARTICIPATES IN beta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amine oxidase [copper-containing] 3; amine oxidase, copper containing 3 (vascular adhesion protein 1); copper amine oxidase; membrane primary amine oxidase; semicarbazide-sensitive amine oxidase; SSAO; VAP-1; vascular adhesion protein 1; VP97
RGD Orthologs
Human
Mouse
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,773,018 - 86,780,961 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21086,272,757 - 86,280,702 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1091,310,347 - 91,318,078 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,785,046 - 90,792,989 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,178,338 - 86,186,282 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,251,370 - 89,259,313 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)Ensemblrn6Rnor6.0
Rnor_5.01089,049,333 - 89,057,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,357,094 - 90,365,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,990,891 - 84,998,741 (+)NCBICelera
RGSC_v3.11090,371,458 - 90,372,508 (+)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Allylamine  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonia  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
drometrizole  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
lidocaine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylamine  (ISO)
mifepristone  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
PhIP  (EXP)
pioglitazone  (ISO)
procarbazine  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
semicarbazide  (EXP,ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO,ISS)
cytoplasm  (ISO)
early endosome  (IBA,ISO)
endoplasmic reticulum  (IBA,ISO)
extracellular space  (IDA)
Golgi apparatus  (IBA,ISO)
membrane  (ISO,ISS)
microvillus  (ISO)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Abella A, etal., Diabetes. 2003 Apr;52(4):1004-13.
2. Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats. Abella A, etal., J Physiol Biochem. 2003 Sep;59(3):153-60.
3. Plasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure. Boomsma F, etal., Eur Heart J. 2000 Nov;21(22):1859-63.
4. Age-related changes in the activities of the amine metabolizing enzymes of rat eye. Cao Danh H, etal., J Pharm Pharmacol. 1985 May;37(5):357-61.
5. Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Carpene C, etal., Pharmacol Res. 2007 Dec;56(6):522-30. Epub 2007 Sep 26.
6. Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Conklin DJ, etal., Toxicol Sci. 1998 Dec;46(2):386-92.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Gong B, etal., Birth Defects Res A Clin Mol Teratol. 2006 Jan;76(1):29-38.
10. Follow-up of plasma semicarbazide-sensitive amine oxidase activity and retinopathy in Type 2 diabetes mellitus. Gronvall-Nordquist JL, etal., J Diabetes Complications. 2001 Sep-Oct;15(5):250-6.
11. Semicarbazide-sensitive amine oxidase activity in streptozotocin diabetic rats. Hayes BE and Clarke DE, Res Commun Chem Pathol Pharmacol. 1990 Jul;69(1):71-83.
12. Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. Li HY, etal., Clin Chim Acta. 2009 Jun 27;404(2):149-53. Epub 2009 Mar 29.
13. Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo. Marttila-Ichihara F, etal., Arthritis Rheum. 2006 Sep;54(9):2852-62.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. Morris NJ, etal., J Biol Chem 1997 Apr 4;272(14):9388-92.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes. Noda K, etal., Exp Eye Res. 2009 Nov;89(5):774-81. Epub 2009 Jul 25.
18. Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis. Noda K, etal., FASEB J. 2008 Apr;22(4):1094-103. Epub 2007 Nov 21.
19. Vascular adhesion protein-1 blockade suppresses choroidal neovascularization. Noda K, etal., FASEB J. 2008 Aug;22(8):2928-35. Epub 2008 Apr 24.
20. Semicarbazide-sensitive amine oxidase (SSAO) gene expression in alloxan-induced diabetes in mice. Nordquist JE, etal., Mol Med. 2002 Dec;8(12):824-9.
21. Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. O'Rourke AM, etal., J Pharmacol Exp Ther. 2008 Feb;324(2):867-75. Epub 2007 Nov 9.
22. Evidence for existence of immobilization stress-inducible semicarbazide-sensitive amine oxidase inhibitor in rat brain cytosol. Obata T and Yamanaka Y, Neurosci Lett. 2000 Dec 15;296(1):58-60.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes. Salmi M, etal., Am J Pathol. 2002 Dec;161(6):2255-62.
28. Association between semicarbazide-sensitive amine oxidase, a regulator of the glucose transporter, and elastic lamellae thinning during experimental cerebral aneurysm development: laboratory investigation. Sibon I, etal., J Neurosurg. 2008 Mar;108(3):558-66.
29. Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. Smith DJ, etal., J Exp Med. 1998 Jul 6;188(1):17-27.
30. Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease. Unzeta M, etal., J Neural Transm. 2007;114(6):857-62. Epub 2007 Mar 29.
31. Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. Vidrio H and Medina M, J Neural Transm. 2007;114(6):863-5. Epub 2007 Mar 26.
32. Vascular adhesion protein-1 plays an important role in postischemic inflammation and neuropathology in diabetic, estrogen-treated ovariectomized female rats subjected to transient forebrain ischemia. Xu HL, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):19-29. Epub 2005 Dec 8.
33. Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice. Yu PH, etal., Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E634-41. Epub 2003 Dec 2.
Additional References at PubMed
PMID:8520629   PMID:12477932   PMID:15489334   PMID:15744061   PMID:16046623   PMID:16524643   PMID:17431735   PMID:19764817   PMID:20686801   PMID:23349812   PMID:23474851   PMID:26886786  
PMID:28318627   PMID:28910971   PMID:29600311   PMID:32410850   PMID:36835077  


Genomics

Comparative Map Data
Aoc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,773,018 - 86,780,961 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21086,272,757 - 86,280,702 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1091,310,347 - 91,318,078 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,785,046 - 90,792,989 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,178,338 - 86,186,282 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,251,370 - 89,259,313 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)Ensemblrn6Rnor6.0
Rnor_5.01089,049,333 - 89,057,276 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,357,094 - 90,365,040 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,990,891 - 84,998,741 (+)NCBICelera
RGSC_v3.11090,371,458 - 90,372,508 (+)NCBI
Cytogenetic Map10q31NCBI
AOC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,851,199 - 42,858,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,851,184 - 42,858,130 (+)Ensemblhg38GRCh38
GRCh371741,003,216 - 41,010,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,256,727 - 38,263,667 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341738,256,726 - 38,263,664NCBI
Celera1737,659,256 - 37,666,196 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,767,841 - 36,774,787 (+)NCBIHuRef
CHM1_11741,238,814 - 41,245,760 (+)NCBICHM1_1
T2T-CHM13v2.01743,708,339 - 43,715,264 (+)NCBIT2T-CHM13v2.0
Aoc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,221,432 - 101,230,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,221,431 - 101,232,764 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,330,606 - 101,339,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,330,605 - 101,341,938 (+)Ensemblmm10GRCm38
MGSCv3711101,191,920 - 101,200,744 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611102,109,647 - 102,118,471 (+)NCBIMGSCv36mm8
MGSCv3611101,146,696 - 101,155,514 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.72NCBI
AOC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,158,581 - 20,179,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,157,410 - 20,241,376 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha919,619,309 - 19,641,100 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0920,876,395 - 20,898,170 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,877,411 - 20,897,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,661,243 - 19,683,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,927,536 - 19,949,304 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,044,945 - 20,051,732 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
UU_Cfam_GSD_1.0920,030,195 - 20,037,021 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101973421
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,511,803 - 19,525,647 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,549,436 - 17,564,878 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,549,836 - 17,564,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110256000
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11219,996,324 - 20,007,006 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AOC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,435,494 - 63,442,790 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,437,067 - 63,442,256 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607734,225,706 - 34,232,618 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aoc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,633,507 - 60,640,897 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aoc3
84 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 156 91 90 59 86 59 6 347 186 11 135 79 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000076820   ⟹   ENSRNOP00000068449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)Ensembl
RefSeq Acc Id: NM_031582   ⟹   NP_113770
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,773,018 - 86,780,961 (+)NCBI
mRatBN7.21086,272,757 - 86,280,702 (+)NCBI
Rnor_6.01089,251,370 - 89,259,313 (+)NCBI
Rnor_5.01089,049,333 - 89,057,276 (+)NCBI
RGSC_v3.41090,357,094 - 90,365,040 (+)RGD
Celera1084,990,891 - 84,998,741 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113770 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53189 (Get FASTA)   NCBI Sequence Viewer  
  AAI00614 (Get FASTA)   NCBI Sequence Viewer  
  BAD74047 (Get FASTA)   NCBI Sequence Viewer  
  EDM06115 (Get FASTA)   NCBI Sequence Viewer  
  O08590 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113770   ⟸   NM_031582
- UniProtKB: Q497D2 (UniProtKB/Swiss-Prot),   Q5R1T5 (UniProtKB/Swiss-Prot),   O08590 (UniProtKB/Swiss-Prot),   A6HJB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068449   ⟸   ENSRNOT00000076820
Protein Domains
Copper amine oxidase catalytic   Copper amine oxidase N3-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08590-F1-model_v2 AlphaFold O08590 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697755
Promoter ID:EPDNEW_R8280
Type:multiple initiation site
Name:Aoc3_1
Description:amine oxidase, copper containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,251,363 - 89,251,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62058 AgrOrtholog
BioCyc Gene G2FUF-23179 BioCyc
BioCyc Pathway 2PHENDEG-PWY [phenylethylamine degradation I] BioCyc
BioCyc Pathway Image 2PHENDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000051307 Ensembl
Gene3D-CATH 2.70.98.20 UniProtKB/Swiss-Prot
  3.10.450.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598211 IMAGE-MGC_LOAD
InterPro Cu_Am_Ox_Cu-bd UniProtKB/Swiss-Prot
  Cu_Am_ox_TPQ-bd UniProtKB/Swiss-Prot
  Cu_amine_oxidase UniProtKB/Swiss-Prot
  Cu_amine_oxidase_C UniProtKB/Swiss-Prot
  Cu_amine_oxidase_C_sf UniProtKB/Swiss-Prot
  Cu_amine_oxidase_N-reg UniProtKB/Swiss-Prot
  Cu_amine_oxidase_N2 UniProtKB/Swiss-Prot
  Cu_amine_oxidase_N3 UniProtKB/Swiss-Prot
KEGG Report rno:29473 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124520 IMAGE-MGC_LOAD
NCBI Gene 29473 ENTREZGENE
PANTHER MEMBRANE PRIMARY AMINE OXIDASE UniProtKB/Swiss-Prot
  PTHR10638 UniProtKB/Swiss-Prot
Pfam Cu_amine_oxid UniProtKB/Swiss-Prot
  Cu_amine_oxidN2 UniProtKB/Swiss-Prot
  Cu_amine_oxidN3 UniProtKB/Swiss-Prot
PhenoGen Aoc3 PhenoGen
PRINTS CUDAOXIDASE UniProtKB/Swiss-Prot
PROSITE COPPER_AMINE_OXID_1 UniProtKB/Swiss-Prot
  COPPER_AMINE_OXID_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051307 RatGTEx
Superfamily-SCOP SSF49998 UniProtKB/Swiss-Prot
  SSF54416 UniProtKB/Swiss-Prot
UniProt A6HJB0 ENTREZGENE, UniProtKB/TrEMBL
  AOC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q497D2 ENTREZGENE
  Q5R1T5 ENTREZGENE
UniProt Secondary Q497D2 UniProtKB/Swiss-Prot
  Q5R1T5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-15 Aoc3  amine oxidase, copper containing 3  Aoc3  amine oxidase, copper containing 3 (vascular adhesion protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aoc3  amine oxidase, copper containing 3 (vascular adhesion protein 1)  Aoc3  amine oxidase, copper containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aoc3  amine oxidase, copper containing 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 97 kDa 61537