Rap1b (RAP1B, member of RAS oncogene family) - Rat Genome Database

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Gene: Rap1b (RAP1B, member of RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rap1b
Name: RAP1B, member of RAS oncogene family
RGD ID: 620577
Description: Predicted to enable G protein activity; GDP binding activity; and GTP binding activity. Involved in cellular response to forskolin; cellular response to gonadotropin-releasing hormone; and response to carbohydrate. Predicted to be located in cell-cell junction; cytosol; and lipid droplet. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding protein smg p21B; MGC93206; RAS related protein 1b; ras-related protein Rap-1b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,308,922 - 55,342,217 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl755,308,922 - 55,342,217 (-)EnsemblGRCr8
mRatBN7.2753,423,039 - 53,456,349 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,423,130 - 53,456,370 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx755,333,280 - 55,340,337 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,536,389 - 57,543,446 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,314,247 - 57,321,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,850,406 - 60,878,226 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)Ensemblrn6Rnor6.0
Rnor_5.0760,850,369 - 60,879,083 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4757,132,750 - 57,139,811 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera750,197,811 - 50,204,871 (-)NCBICelera
RGSC_v3.1757,150,631 - 57,182,957 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
8-Br-cAMP  (EXP)
acrolein  (ISO)
alpha-pinene  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
GTP  (EXP,ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel subsulfide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paraquat  (ISO)
Pentoxifylline  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rolipram  (EXP)
rotenone  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway. Lin S, etal., J Biol Chem. 2002 Nov 1;277(44):41725-35. Epub 2002 Aug 23.
3. cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. Lou L, etal., J Biol Chem 2002 Sep 6;277(36):32799-806.
4. Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. McPhee I, etal., FEBS Lett. 2000 Jul 21;477(3):213-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Ribeiro-Neto F, etal., Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5418-23.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation. Urayama O, etal., Brain Res Mol Brain Res 1997 May;45(2):331-4.
14. Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Yuen T, etal., Mol Cell Endocrinol. 2012 Mar 5;350(1):10-9. doi: 10.1016/j.mce.2011.11.017. Epub 2011 Nov 25.
Additional References at PubMed
PMID:14712229   PMID:14741744   PMID:15489334   PMID:18309292   PMID:18504258   PMID:18550542   PMID:18582561   PMID:18842593   PMID:19199708   PMID:19461049   PMID:20332120   PMID:20458337  
PMID:21700703   PMID:21840392   PMID:22797597   PMID:23209302   PMID:23376485   PMID:23616533   PMID:24165023   PMID:25935485  


Genomics

Comparative Map Data
Rap1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8755,308,922 - 55,342,217 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl755,308,922 - 55,342,217 (-)EnsemblGRCr8
mRatBN7.2753,423,039 - 53,456,349 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl753,423,130 - 53,456,370 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx755,333,280 - 55,340,337 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,536,389 - 57,543,446 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0757,314,247 - 57,321,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,850,406 - 60,878,226 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)Ensemblrn6Rnor6.0
Rnor_5.0760,850,369 - 60,879,083 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4757,132,750 - 57,139,811 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera750,197,811 - 50,204,871 (-)NCBICelera
RGSC_v3.1757,150,631 - 57,182,957 (-)NCBI
Cytogenetic Map7q22NCBI
RAP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381268,610,899 - 68,671,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1268,610,410 - 68,671,901 (+)Ensemblhg38GRCh38
GRCh371269,004,679 - 69,065,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361267,290,919 - 67,340,641 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341267,290,918 - 67,340,644NCBI
Celera1268,668,392 - 68,717,826 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,093,121 - 66,105,030 (+)NCBIHuRef
CHM1_11268,972,799 - 69,022,538 (+)NCBICHM1_1
T2T-CHM13v2.01268,590,436 - 68,651,443 (+)NCBIT2T-CHM13v2.0
Rap1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,650,502 - 117,681,879 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,649,776 - 117,681,940 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810117,814,597 - 117,845,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,813,871 - 117,846,035 (-)Ensemblmm10GRCm38
MGSCv3710117,251,653 - 117,283,030 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610117,217,590 - 117,248,967 (-)NCBIMGSCv36mm8
Celera10119,752,445 - 119,762,526 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.32NCBI
Rap1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545815,080,778 - 15,123,203 (+)Ensembl
ChiLan1.0NW_00495545815,110,709 - 15,121,868 (+)NCBIChiLan1.0ChiLan1.0
RAP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21076,628,927 - 76,679,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11276,625,344 - 76,675,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,122,212 - 66,172,450 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11268,919,369 - 68,955,650 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1268,942,053 - 68,955,649 (+)EnsemblpanPan2panpan1.1
RAP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11010,805,359 - 10,816,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1010,805,357 - 10,815,575 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1010,700,667 - 10,750,121 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01010,891,820 - 10,941,270 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,891,815 - 10,941,253 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11010,759,466 - 10,808,891 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,005,977 - 11,055,507 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,128,484 - 11,177,911 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rap1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494547,531,710 - 47,542,147 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365456,568,577 - 6,574,595 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365456,567,873 - 6,578,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,910,259 - 32,964,870 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1532,910,181 - 32,961,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2535,681,835 - 35,733,656 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,240,501 - 64,290,515 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl827,134,293 - 27,134,847 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl1164,240,651 - 64,286,727 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037181,414,337 - 181,465,079 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rap1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624948623,527 - 664,000 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624948623,527 - 664,044 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rap1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11195,922,653 - 195,955,305 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rap1b
201 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:581
Count of miRNA genes:259
Interacting mature miRNAs:308
Transcripts:ENSRNOT00000009511
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
BF386582  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,425,770 - 53,425,957 (+)MAPPERmRatBN7.2
Rnor_6.0760,853,138 - 60,853,324NCBIRnor6.0
Rnor_5.0760,853,101 - 60,853,287UniSTSRnor5.0
RGSC_v3.4757,131,958 - 57,132,144UniSTSRGSC3.4
Celera750,197,019 - 50,197,205UniSTS
RH 3.4 Map7489.1UniSTS
Cytogenetic Map7q22UniSTS
BF401892  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2753,456,892 - 53,456,983 (+)MAPPERmRatBN7.2
Rnor_6.0760,891,298 - 60,891,388NCBIRnor6.0
Rnor_5.0760,891,554 - 60,891,644UniSTSRnor5.0
RGSC_v3.4757,162,810 - 57,162,900UniSTSRGSC3.4
Celera750,227,774 - 50,227,864UniSTS
RH 3.4 Map7486.2UniSTS
Cytogenetic Map7q22UniSTS
MARC_2660-2661:991933047:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21217,733,490 - 17,733,786 (+)MAPPERmRatBN7.2
mRatBN7.21217,756,893 - 17,757,189 (+)MAPPERmRatBN7.2
mRatBN7.21218,838,325 - 18,838,621 (+)MAPPERmRatBN7.2
mRatBN7.21218,821,229 - 18,821,524 (+)MAPPERmRatBN7.2
Rnor_6.01221,894,096 - 21,894,391NCBIRnor6.0
Rnor_5.01223,911,144 - 23,911,439UniSTSRnor5.0
RGSC_v3.41220,568,395 - 20,568,690UniSTSRGSC3.4
Celera1220,639,611 - 20,639,906UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY607847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009511   ⟹   ENSRNOP00000009511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl753,427,389 - 53,456,370 (-)Ensembl
Rnor_6.0 Ensembl760,853,930 - 60,860,990 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113270   ⟹   ENSRNOP00000078778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl755,308,922 - 55,342,217 (-)Ensembl
mRatBN7.2 Ensembl753,423,130 - 53,456,295 (-)Ensembl
RefSeq Acc Id: NM_001412600   ⟹   NP_001399529
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,308,922 - 55,342,217 (-)NCBI
mRatBN7.2753,423,039 - 53,456,337 (-)NCBI
RefSeq Acc Id: NM_134346   ⟹   NP_599173
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,308,922 - 55,342,217 (-)NCBI
mRatBN7.2753,423,039 - 53,456,337 (-)NCBI
Rnor_6.0760,853,930 - 60,860,990 (-)NCBI
Rnor_5.0760,850,369 - 60,879,083 (-)NCBI
RGSC_v3.4757,132,750 - 57,139,811 (-)RGD
Celera750,197,811 - 50,204,871 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078357   ⟹   XP_038934285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,309,516 - 55,342,209 (-)NCBI
mRatBN7.2753,423,039 - 53,456,329 (-)NCBI
RefSeq Acc Id: XR_010052940
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8755,309,516 - 55,342,209 (-)NCBI
RefSeq Acc Id: NP_599173   ⟸   NM_134346
- Peptide Label: precursor
- UniProtKB: Q6J167 (UniProtKB/Swiss-Prot),   Q62636 (UniProtKB/Swiss-Prot),   A6IGU3 (UniProtKB/TrEMBL),   A0A8L2UI57 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009511   ⟸   ENSRNOT00000009511
RefSeq Acc Id: XP_038934285   ⟸   XM_039078357
- Peptide Label: isoform X1
- UniProtKB: Q62636 (UniProtKB/Swiss-Prot),   Q6J167 (UniProtKB/Swiss-Prot),   A6IGU3 (UniProtKB/TrEMBL),   A0A8L2UI57 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078778   ⟸   ENSRNOT00000113270
RefSeq Acc Id: NP_001399529   ⟸   NM_001412600
- Peptide Label: precursor
- UniProtKB: Q62636 (UniProtKB/Swiss-Prot),   Q6J167 (UniProtKB/Swiss-Prot),   A6IGU3 (UniProtKB/TrEMBL),   A0A8L2UI57 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62636-F1-model_v2 AlphaFold Q62636 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620577 AgrOrtholog
BioCyc Gene G2FUF-33976 BioCyc
Ensembl Genes ENSRNOG00000007048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113270 ENTREZGENE
  ENSRNOT00000113270.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192310 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rap1 UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
KEGG Report rno:171337 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93206 IMAGE-MGC_LOAD
NCBI Gene 171337 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rap1b PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007048 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2UI57 ENTREZGENE
  A6IGU3 ENTREZGENE, UniProtKB/TrEMBL
  Q62636 ENTREZGENE
  Q6J167 ENTREZGENE
  RAP1B_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6J167 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rap1b  RAP1B, member of RAS oncogene family  Rap1b  RAS related protein 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Rap1b  RAS related protein 1b    RAP1B, member of RAS oncogene family  Name updated 1299863 APPROVED
2002-08-07 Rap1b  RAP1B, member of RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation phosphorylated and activated by cAMP 633761