Il12a (interleukin 12A) - Rat Genome Database

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Gene: Il12a (interleukin 12A) Rattus norvegicus
Analyze
Symbol: Il12a
Name: interleukin 12A
RGD ID: 620562
Description: Predicted to enable cytokine binding activity; interleukin-12 receptor binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface and cytoplasm. Predicted to be part of interleukin-12 complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-27 signaling pathway; allograft rejection pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CLMF p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; interleukin 12 p35 subunit; interleukin-12 subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm54
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,275,734 - 155,282,997 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2155,275,625 - 155,282,997 (+)EnsemblGRCr8
mRatBN7.22152,965,769 - 152,973,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2160,091,860 - 160,098,803 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,142,380 - 158,149,321 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02152,775,143 - 152,782,090 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,076,945 - 165,083,996 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)Ensemblrn6Rnor6.0
Rnor_5.02184,430,744 - 184,437,696 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42158,710,261 - 158,717,689 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2147,317,946 - 147,324,898 (+)NCBICelera
RGSC_v3.12158,660,223 - 158,667,652 (+)NCBI
Cytogenetic Map2q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-deoxy-D-glucose  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Alpinetin  (ISO)
ammonium chloride  (EXP)
anthranilic acid  (ISO)
antimony(0)  (ISO)
apilimod  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucan  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
CGS-21680  (ISO)
chlorophyllin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dichlorine  (ISO)
diltiazem  (ISO)
Dimaprit  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
esketamine  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
famotidine  (ISO)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
Ganoderic acid C2  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucuronoxylomannan  (ISO)
glycyrrhizinic acid  (ISO)
helenalin  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
Ibudilast  (ISO)
imiquimod  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isocyanates  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene D4  (ISO)
lipid As  (ISO)
lipopolysaccharide  (ISO)
lupane  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
mechlorethamine  (EXP)
melphalan  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methotrexate  (ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isothiocyanate  (ISO)
methyl methanesulfonate  (ISO)
Mitoquinone  (ISO)
MK-2206  (ISO)
montelukast  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neocuproine  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nonanoic acid  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisone  (ISO)
pristane  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
protosappanin A  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
Ro 41-5253  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
stattic  (ISO)
sulfasalazine  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
warfarin  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
defense response to protozoan  (ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
immune response  (IEA)
interleukin-12-mediated signaling pathway  (IBA,IEA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of protein secretion  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of dendritic cell chemotaxis  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of mononuclear cell proliferation  (IEA,ISO)
positive regulation of natural killer cell activation  (IEA,ISO)
positive regulation of natural killer cell mediated cytotoxicity  (IEA,ISO)
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IEA,ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of NK T cell activation  (IEA,ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to granulocyte colony-stimulating factor  (IEP)
response to lipopolysaccharide  (IEA,ISO)
response to UV-B  (IEA,ISO)
response to virus  (IEA,ISO)
T-helper 1 cell activation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Calcineurin inhibitors and the IL12A locus influence risk of recurrent primary biliary cirrhosis after liver transplantation. Carbone M, etal., Am J Transplant. 2013 Apr;13(4):1110-1111. doi: 10.1111/ajt.12132. Epub 2013 Feb 22.
2. IL12 Gene Polymorphism in Association with Hepatocellular Carcinoma in HCV-infected Egyptian Patients. Elsayed HM, etal., Immunol Invest. 2017 Feb;46(2):123-133. doi: 10.1080/08820139.2016.1229789. Epub 2016 Nov 7.
3. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. Gran B, etal., J Immunol 2002 Dec 15;169(12):7104-10.
4. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. Hirschfield GM, etal., N Engl J Med. 2009 Jun 11;360(24):2544-55. doi: 10.1056/NEJMoa0810440. Epub 2009 May 20.
5. Serum levels of Interleukins 1-Alpha & 12 as Predictors of Disease Progression in Hepatitis C Diabetic Patients. Khalil M, etal., Egypt J Immunol. 2018 Jan;25(1):181-190.
6. Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population. Li P, etal., Medicine (Baltimore). 2016 May;95(19):e3665. doi: 10.1097/MD.0000000000003665.
7. IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population. Liu L, etal., Int J Cancer. 2011 Apr 1;128(7):1692-6. doi: 10.1002/ijc.25488. Epub 2010 Jun 2.
8. IL-12 contributes to allergen-induced airway inflammation in experimental asthma. Meyts I, etal., J Immunol. 2006 Nov 1;177(9):6460-70.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte colony-stimulating factor-treated donors. Ohmori I, etal., Cytokine. 2003 Jan 7;21(1):27-31. doi: 10.1016/s1043-4666(02)00492-1.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. Sel S, etal., J Immunol. 2007 Jun 15;178(12):7805-13.
17. Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population. Tan A, etal., Tumour Biol. 2016 May;37(5):6343-8. doi: 10.1007/s13277-015-4520-x. Epub 2015 Dec 2.
18. Intracellular localization of the p35 subunit of murine IL-12. Vaidyanathan H, etal., Cytokine 2003 Feb 7;21(3):120-8.
19. Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway. Wang HW, etal., Mol Cell Biochem. 2015 Sep;407(1-2):135-42. doi: 10.1007/s11010-015-2463-6. Epub 2015 Jun 11.
Additional References at PubMed
PMID:1357073   PMID:1674604   PMID:2204066   PMID:7605994   PMID:7690439   PMID:7903063   PMID:8557999   PMID:8992506   PMID:9342359   PMID:9348310   PMID:11023671   PMID:11057672  
PMID:11114383   PMID:11737071   PMID:12372421   PMID:14681019   PMID:15220916   PMID:15843532   PMID:16456693   PMID:16482511   PMID:16548883   PMID:16942485   PMID:19047410   PMID:19050265  
PMID:19088061   PMID:20818394   PMID:21444916   PMID:22851706   PMID:22968459   PMID:25754930   PMID:26994309   PMID:30106099  


Genomics

Comparative Map Data
Il12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,275,734 - 155,282,997 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2155,275,625 - 155,282,997 (+)EnsemblGRCr8
mRatBN7.22152,965,769 - 152,973,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2160,091,860 - 160,098,803 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,142,380 - 158,149,321 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02152,775,143 - 152,782,090 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,076,945 - 165,083,996 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)Ensemblrn6Rnor6.0
Rnor_5.02184,430,744 - 184,437,696 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42158,710,261 - 158,717,689 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2147,317,946 - 147,324,898 (+)NCBICelera
RGSC_v3.12158,660,223 - 158,667,652 (+)NCBI
Cytogenetic Map2q32NCBI
IL12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383159,988,835 - 159,996,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3159,988,835 - 159,996,019 (+)Ensemblhg38GRCh38
GRCh373159,706,622 - 159,713,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,189,323 - 161,196,500 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343161,189,330 - 161,196,507NCBI
Celera3158,128,398 - 158,135,579 (+)NCBICelera
Cytogenetic Map3q25.33NCBI
HuRef3157,102,994 - 157,110,193 (+)NCBIHuRef
CHM1_13159,669,641 - 159,676,836 (+)NCBICHM1_1
T2T-CHM13v2.03162,763,550 - 162,770,734 (+)NCBIT2T-CHM13v2.0
Il12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,597,977 - 68,605,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl368,597,977 - 68,605,880 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38368,690,644 - 68,698,550 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl368,690,644 - 68,698,547 (+)Ensemblmm10GRCm38
MGSCv37368,494,566 - 68,502,469 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36368,778,573 - 68,786,454 (+)NCBIMGSCv36mm8
Celera368,820,603 - 68,828,506 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map331.92NCBI
Il12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544810,610,629 - 10,618,003 (+)Ensembl
ChiLan1.0NW_00495544810,611,131 - 10,617,911 (+)NCBIChiLan1.0ChiLan1.0
IL12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22157,926,204 - 157,935,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13157,930,880 - 157,942,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,011,675 - 157,019,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,061,505 - 165,068,666 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,061,505 - 165,068,666 (+)EnsemblpanPan2panpan1.1
IL12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,125,529 - 26,133,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,124,770 - 26,133,550 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3430,167,784 - 30,175,056 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03426,181,526 - 26,189,271 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,180,963 - 26,189,280 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,112,551 - 26,119,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,072,972 - 26,080,252 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,312,100 - 26,319,473 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560283,553,229 - 83,559,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,175,261 - 6,180,396 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,166,060 - 6,180,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1399,733,394 - 99,741,078 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11399,733,394 - 99,741,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,066,792 - 108,074,477 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11530,887,048 - 30,896,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1530,887,897 - 30,894,550 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660413,416,998 - 3,424,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473037,787,909 - 37,794,940 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473037,787,772 - 37,794,871 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Il12a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1386,584,398 - 86,591,333 (-)NCBIRrattus_CSIRO_v1

Variants

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Variants in Il12a
141 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000012831
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 63 163 86 85 54 74 54 6 317 169 11 138 71 87 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012831   ⟹   ENSRNOP00000012832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2155,275,625 - 155,282,997 (+)Ensembl
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)Ensembl
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100522   ⟹   ENSRNOP00000080028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2152,966,164 - 152,972,734 (+)Ensembl
RefSeq Acc Id: NM_053390   ⟹   NP_445842
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,275,734 - 155,282,696 (+)NCBI
mRatBN7.22152,965,769 - 152,972,734 (+)NCBI
Rnor_6.02165,076,945 - 165,083,996 (+)NCBI
Rnor_5.02184,430,744 - 184,437,696 (+)NCBI
RGSC_v3.42158,710,261 - 158,717,689 (+)RGD
Celera2147,317,946 - 147,324,898 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103267   ⟹   XP_038959195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,276,408 - 155,282,997 (+)NCBI
mRatBN7.22152,967,047 - 152,973,035 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445842 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD51364 (Get FASTA)   NCBI Sequence Viewer  
  EDM00915 (Get FASTA)   NCBI Sequence Viewer  
  EDM00916 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012832
GenBank Protein Q9R103 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445842   ⟸   NM_053390
- Peptide Label: precursor
- UniProtKB: Q9R103 (UniProtKB/Swiss-Prot),   A6J5M3 (UniProtKB/TrEMBL),   G3V780 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012832   ⟸   ENSRNOT00000012831
RefSeq Acc Id: XP_038959195   ⟸   XM_039103267
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080028   ⟸   ENSRNOT00000100522

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R103-F1-model_v2 AlphaFold Q9R103 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620562 AgrOrtholog
BioCyc Gene G2FUF-52848 BioCyc
Ensembl Genes ENSRNOG00000009468 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012831 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-12_alpha UniProtKB/Swiss-Prot
  IL-12_family_cytokines UniProtKB/Swiss-Prot
KEGG Report rno:84405 UniProtKB/Swiss-Prot
NCBI Gene 84405 ENTREZGENE
PANTHER INTERLEUKIN-12 SUBUNIT ALPHA UniProtKB/Swiss-Prot
  INTERLEUKIN-12 SUBUNIT BETA-RELATED UniProtKB/Swiss-Prot
Pfam IL12 UniProtKB/Swiss-Prot
PhenoGen Il12a PhenoGen
RatGTEx ENSRNOG00000009468 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6J5M3 ENTREZGENE, UniProtKB/TrEMBL
  G3V780 ENTREZGENE, UniProtKB/TrEMBL
  IL12A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-29 Il12a  interleukin 12A  Il12a  interleukin 12a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Il12a  interleukin 12a    interleukin 12 p35 subunit  Name updated 1299863 APPROVED
2002-08-07 Il12a  interleukin 12 p35 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL