Il12a (interleukin 12A) - Rat Genome Database

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Gene: Il12a (interleukin 12A) Rattus norvegicus
Analyze
Symbol: Il12a
Name: interleukin 12A
RGD ID: 620562
Description: Predicted to enable interleukin-12 beta subunit binding activity; interleukin-27 binding activity; and protein heterodimerization activity. Predicted to contribute to cytokine activity and growth factor activity. Involved in response to granulocyte colony-stimulating factor. Predicted to be located in cell surface and cytoplasm. Predicted to be part of interleukin-12 complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-27 signaling pathway; allograft rejection pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CLMF p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; interleukin 12 p35 subunit; interleukin-12 subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm54
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,275,734 - 155,282,997 (+)NCBIGRCr8
mRatBN7.22152,965,769 - 152,973,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,091,860 - 160,098,803 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,142,380 - 158,149,321 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02152,775,143 - 152,782,090 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,076,945 - 165,083,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02184,430,744 - 184,437,696 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42158,710,261 - 158,717,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12158,660,223 - 158,667,652 (+)NCBI
Celera2147,317,946 - 147,324,898 (+)NCBICelera
Cytogenetic Map2q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthranilic acid  (ISO)
antimony(0)  (ISO)
apilimod  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucan  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
CGS-21680  (ISO)
chlorophyllin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
dichlorine  (ISO)
diltiazem  (ISO)
Dimaprit  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
esketamine  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
famotidine  (ISO)
fumigaclavine C  (ISO)
fumonisin B1  (ISO)
Ganoderic acid C2  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucuronoxylomannan  (ISO)
glycyrrhizinic acid  (ISO)
helenalin  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
Ibudilast  (ISO)
imiquimod  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isocyanates  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
kainic acid  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene D4  (ISO)
lipid As  (ISO)
lipopolysaccharide  (ISO)
lupane  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
mechlorethamine  (EXP)
melphalan  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methotrexate  (ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isothiocyanate  (ISO)
methyl methanesulfonate  (ISO)
MK-2206  (ISO)
montelukast  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neocuproine  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nonanoic acid  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisone  (ISO)
pristane  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
Ro 41-5253  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
stattic  (ISO)
sulfasalazine  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
warfarin  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (IEA)
defense response to Gram-positive bacterium  (IEA,ISO)
defense response to protozoan  (ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
immune response  (IEA)
interleukin-12-mediated signaling pathway  (IEA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of dendritic cell chemotaxis  (IEA,ISO)
positive regulation of lymphocyte proliferation  (IEA,ISO)
positive regulation of mononuclear cell proliferation  (ISO)
positive regulation of natural killer cell activation  (IEA,ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IEA,ISO)
positive regulation of NK T cell activation  (IEA,ISO)
positive regulation of smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to granulocyte colony-stimulating factor  (IEP)
response to lipopolysaccharide  (IEA,ISO)
response to UV-B  (IEA,ISO)
response to virus  (ISO)
signal transduction  (IEA)
T cell proliferation  (ISO)
T-helper 1 cell activation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Calcineurin inhibitors and the IL12A locus influence risk of recurrent primary biliary cirrhosis after liver transplantation. Carbone M, etal., Am J Transplant. 2013 Apr;13(4):1110-1111. doi: 10.1111/ajt.12132. Epub 2013 Feb 22.
2. IL12 Gene Polymorphism in Association with Hepatocellular Carcinoma in HCV-infected Egyptian Patients. Elsayed HM, etal., Immunol Invest. 2017 Feb;46(2):123-133. doi: 10.1080/08820139.2016.1229789. Epub 2016 Nov 7.
3. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. Gran B, etal., J Immunol 2002 Dec 15;169(12):7104-10.
4. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. Hirschfield GM, etal., N Engl J Med. 2009 Jun 11;360(24):2544-55. doi: 10.1056/NEJMoa0810440. Epub 2009 May 20.
5. Serum levels of Interleukins 1-Alpha & 12 as Predictors of Disease Progression in Hepatitis C Diabetic Patients. Khalil M, etal., Egypt J Immunol. 2018 Jan;25(1):181-190.
6. Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population. Li P, etal., Medicine (Baltimore). 2016 May;95(19):e3665. doi: 10.1097/MD.0000000000003665.
7. IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population. Liu L, etal., Int J Cancer. 2011 Apr 1;128(7):1692-6. doi: 10.1002/ijc.25488. Epub 2010 Jun 2.
8. IL-12 contributes to allergen-induced airway inflammation in experimental asthma. Meyts I, etal., J Immunol. 2006 Nov 1;177(9):6460-70.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte colony-stimulating factor-treated donors. Ohmori I, etal., Cytokine. 2003 Jan 7;21(1):27-31. doi: 10.1016/s1043-4666(02)00492-1.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10. Sel S, etal., J Immunol. 2007 Jun 15;178(12):7805-13.
17. Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population. Tan A, etal., Tumour Biol. 2016 May;37(5):6343-8. doi: 10.1007/s13277-015-4520-x. Epub 2015 Dec 2.
18. Intracellular localization of the p35 subunit of murine IL-12. Vaidyanathan H, etal., Cytokine 2003 Feb 7;21(3):120-8.
19. Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway. Wang HW, etal., Mol Cell Biochem. 2015 Sep;407(1-2):135-42. doi: 10.1007/s11010-015-2463-6. Epub 2015 Jun 11.
Additional References at PubMed
PMID:1357073   PMID:1674604   PMID:2204066   PMID:7605994   PMID:7690439   PMID:7903063   PMID:8557999   PMID:8992506   PMID:9342359   PMID:9348310   PMID:11023671   PMID:11057672  
PMID:11114383   PMID:11737071   PMID:12372421   PMID:14681019   PMID:15220916   PMID:15843532   PMID:16456693   PMID:16482511   PMID:16548883   PMID:16942485   PMID:19047410   PMID:19050265  
PMID:19088061   PMID:20818394   PMID:21444916   PMID:22851706   PMID:22968459   PMID:25754930   PMID:26994309   PMID:30106099  


Genomics

Comparative Map Data
Il12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,275,734 - 155,282,997 (+)NCBIGRCr8
mRatBN7.22152,965,769 - 152,973,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,091,860 - 160,098,803 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,142,380 - 158,149,321 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02152,775,143 - 152,782,090 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,076,945 - 165,083,996 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02184,430,744 - 184,437,696 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42158,710,261 - 158,717,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12158,660,223 - 158,667,652 (+)NCBI
Celera2147,317,946 - 147,324,898 (+)NCBICelera
Cytogenetic Map2q32NCBI
IL12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383159,988,835 - 159,996,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3159,988,835 - 159,996,019 (+)EnsemblGRCh38hg38GRCh38
GRCh373159,706,622 - 159,713,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,189,323 - 161,196,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 343161,189,330 - 161,196,507NCBI
Celera3158,128,398 - 158,135,579 (+)NCBICelera
Cytogenetic Map3q25.33NCBI
HuRef3157,102,994 - 157,110,193 (+)NCBIHuRef
CHM1_13159,669,641 - 159,676,836 (+)NCBICHM1_1
T2T-CHM13v2.03162,763,550 - 162,770,734 (+)NCBIT2T-CHM13v2.0
Il12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39368,597,977 - 68,605,881 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl368,597,977 - 68,605,880 (+)EnsemblGRCm39 Ensembl
GRCm38368,690,644 - 68,698,550 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl368,690,644 - 68,698,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37368,494,566 - 68,502,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36368,778,573 - 68,786,454 (+)NCBIMGSCv36mm8
Celera368,820,603 - 68,828,506 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map331.92NCBI
Il12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544810,611,131 - 10,617,911 (+)NCBIChiLan1.0ChiLan1.0
IL12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22157,926,204 - 157,935,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13157,930,880 - 157,942,229 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,011,675 - 157,019,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,061,505 - 165,068,666 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,061,505 - 165,068,666 (+)Ensemblpanpan1.1panPan2
IL12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,125,529 - 26,133,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,124,770 - 26,133,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,167,784 - 30,175,056 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,181,526 - 26,189,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,180,963 - 26,189,280 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,112,551 - 26,119,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,072,972 - 26,080,252 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,312,100 - 26,319,473 (+)NCBIUU_Cfam_GSD_1.0
Il12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560283,553,229 - 83,559,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,175,261 - 6,180,396 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,166,060 - 6,180,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1399,733,394 - 99,741,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11399,733,394 - 99,741,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,066,792 - 108,074,477 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11530,887,048 - 30,896,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1530,887,897 - 30,894,550 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660413,416,998 - 3,424,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473037,787,909 - 37,794,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473037,787,772 - 37,794,871 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il12a
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000012831
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 47 111 86 85 54 25 54 6 210 94 91 45 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000012831   ⟹   ENSRNOP00000012832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2152,965,769 - 152,972,734 (+)Ensembl
Rnor_6.0 Ensembl2165,076,607 - 165,084,318 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100522   ⟹   ENSRNOP00000080028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2152,966,164 - 152,972,734 (+)Ensembl
RefSeq Acc Id: NM_053390   ⟹   NP_445842
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,275,734 - 155,282,696 (+)NCBI
mRatBN7.22152,965,769 - 152,972,734 (+)NCBI
Rnor_6.02165,076,945 - 165,083,996 (+)NCBI
Rnor_5.02184,430,744 - 184,437,696 (+)NCBI
RGSC_v3.42158,710,261 - 158,717,689 (+)RGD
Celera2147,317,946 - 147,324,898 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103267   ⟹   XP_038959195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82155,276,408 - 155,282,997 (+)NCBI
mRatBN7.22152,967,047 - 152,973,035 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445842 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD51364 (Get FASTA)   NCBI Sequence Viewer  
  EDM00915 (Get FASTA)   NCBI Sequence Viewer  
  EDM00916 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012832.1
  ENSRNOP00000080028.1
GenBank Protein Q9R103 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445842   ⟸   NM_053390
- Peptide Label: precursor
- UniProtKB: Q9R103 (UniProtKB/Swiss-Prot),   A6J5M3 (UniProtKB/TrEMBL),   G3V780 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012832   ⟸   ENSRNOT00000012831
RefSeq Acc Id: XP_038959195   ⟸   XM_039103267
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080028   ⟸   ENSRNOT00000100522

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R103-F1-model_v2 AlphaFold Q9R103 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620562 AgrOrtholog
BioCyc Gene G2FUF-52848 BioCyc
Ensembl Genes ENSRNOG00000009468 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012831.4 UniProtKB/TrEMBL
  ENSRNOT00000100522.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-12_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-12_family_cytokines UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84405 UniProtKB/Swiss-Prot
NCBI Gene 84405 ENTREZGENE
PANTHER INTERLEUKIN-12 SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-12 SUBUNIT BETA-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il12a PhenoGen
RatGTEx ENSRNOG00000009468 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPS7_RAT UniProtKB/TrEMBL
  A6J5M3 ENTREZGENE, UniProtKB/TrEMBL
  G3V780 ENTREZGENE, UniProtKB/TrEMBL
  IL12A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-29 Il12a  interleukin 12A  Il12a  interleukin 12a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Il12a  interleukin 12a    interleukin 12 p35 subunit  Name updated 1299863 APPROVED
2002-08-07 Il12a  interleukin 12 p35 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL