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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620562
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12A
Acc ID: CHEBI:36706
Term: resiquimod
Definition: An imidazoquinoline that has formula C17H22N4O2.
Chemical ID: MESH:C402365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12amultiple interactionsISOIL12A (Homo sapiens)6480464CTD[Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [beta-Glucans co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [beta-Glucans co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; [Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]; IFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]PMID:18490488
Il12amultiple interactionsISOIl12a (Mus musculus)6480464CTD[resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]PMID:15851485
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