Chek1 (checkpoint kinase 1) - Rat Genome Database

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Gene: Chek1 (checkpoint kinase 1) Rattus norvegicus
Analyze
Symbol: Chek1
Name: checkpoint kinase 1
RGD ID: 620545
Description: Enables protein kinase activity. Involved in several processes, including cellular response to caffeine; negative regulation of DNA biosynthetic process; and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in centrosome; chromosome; and cytoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1); PARTICIPATES IN G2/M DNA damage checkpoint pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: checkpoint kinase 1 homolog; checkpoint kinase 1 homolog (S. pombe); checkpoint kinase-1; CHK1 checkpoint homolog; CHK1 checkpoint homolog (S. pombe); serine/threonine-protein kinase Chk1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Chek1_v2 ; Chek1_v1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8844,609,417 - 44,629,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl844,609,417 - 44,629,359 (-)EnsemblGRCr8
mRatBN7.2836,420,565 - 36,443,477 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl836,420,569 - 36,441,009 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx840,429,698 - 40,450,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0838,712,754 - 38,733,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0836,575,640 - 36,596,176 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0839,181,162 - 39,201,588 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,181,163 - 39,243,882 (-)Ensemblrn6Rnor6.0
Rnor_5.0839,184,020 - 39,204,446 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4837,954,322 - 37,974,748 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera838,000,251 - 38,020,582 (+)NCBICelera
RGSC_v3.1837,963,088 - 37,983,514 (-)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP,ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methoxy-TEMPO  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthocyanin  (ISO)
anthracene-1,8,9-triol  (ISO)
antimycin A  (ISO)
aphidicolin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
brequinar  (ISO)
Brevetoxin B  (ISO)
busulfan  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
catechol  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (ISO)
ciprofloxacin  (EXP)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coptisine  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
CX-5461  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
desferrioxamine B  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
diethyl sulfate  (ISO)
digitoxin  (ISO)
dioscin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
equol  (ISO)
estragole  (EXP)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
floxuridine  (ISO)
flumequine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
furosemide  (EXP)
genistein  (ISO)
geraniol  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
iron dichloride  (ISO)
iron trichloride  (ISO)
isoflurane  (EXP)
kaempferol  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP)
leptomycin B  (ISO)
lovastatin  (EXP,ISO)
MeIQx  (ISO)
melatonin  (ISO)
melphalan  (ISO)
menadione  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl isocyanate  (ISO)
methylmercury chloride  (ISO)
Mezerein  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nimustine  (ISO)
nocodazole  (ISO)
NORCANTHARIDIN  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
octamethylcyclotetrasiloxane  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oxaliplatin  (EXP,ISO)
oxfendazole  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PF-00477736  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propiconazole  (ISO)
Ptaquiloside  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline yellow  (ISO)
quizartinib  (ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
riddelliine  (ISO)
rimonabant  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
saccharin  (ISO)
selinexor  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium nitrite  (ISO)
stavudine  (ISO)
sterigmatocystin  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
versicolorin A  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Hansel DE, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6152-8.
4. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. Hu B, etal., J Biol Chem. 2001 May 25;276(21):17693-8. Epub 2001 Mar 7.
5. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
6. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. Okazaki T, etal., Clin Cancer Res. 2008 Apr 1;14(7):2042-8.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat. Shann YJ and Hsu MT, J Biol Chem 2001 Dec 28;276(52):48863-70.
16. CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicity. Wang JL, etal., Cell Cycle. 2002 Jul-Aug;1(4):267-72.
Additional References at PubMed
PMID:9382850   PMID:10859163   PMID:10859164   PMID:11555636   PMID:11790307   PMID:12477932   PMID:12529385   PMID:15149599   PMID:15311285   PMID:15364958   PMID:15389625   PMID:15665856  
PMID:16963448   PMID:18243098   PMID:19593445   PMID:19716789   PMID:20495005   PMID:20932473   PMID:21336968   PMID:21737879   PMID:22024163   PMID:23028632   PMID:23432726   PMID:23580065  
PMID:23861943   PMID:24158981   PMID:25880015   PMID:26296656  


Genomics

Comparative Map Data
Chek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8844,609,417 - 44,629,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl844,609,417 - 44,629,359 (-)EnsemblGRCr8
mRatBN7.2836,420,565 - 36,443,477 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl836,420,569 - 36,441,009 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx840,429,698 - 40,450,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0838,712,754 - 38,733,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0836,575,640 - 36,596,176 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0839,181,162 - 39,201,588 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,181,163 - 39,243,882 (-)Ensemblrn6Rnor6.0
Rnor_5.0839,184,020 - 39,204,446 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4837,954,322 - 37,974,748 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera838,000,251 - 38,020,582 (+)NCBICelera
RGSC_v3.1837,963,088 - 37,983,514 (-)NCBI
Cytogenetic Map8q22NCBI
CHEK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,625,136 - 125,681,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11125,625,163 - 125,676,255 (+)Ensemblhg38GRCh38
GRCh3711125,495,031 - 125,546,150 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,001,547 - 125,030,847 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411125,001,546 - 125,030,847NCBI
Celera11122,655,346 - 122,706,400 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11121,436,397 - 121,487,529 (+)NCBIHuRef
CHM1_111125,381,155 - 125,432,283 (+)NCBICHM1_1
T2T-CHM13v2.011125,653,757 - 125,709,785 (+)NCBIT2T-CHM13v2.0
Chek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39936,619,935 - 36,637,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl936,619,778 - 36,638,361 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38936,708,482 - 36,726,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl936,708,482 - 36,727,065 (-)Ensemblmm10GRCm38
MGSCv37936,516,067 - 36,534,243 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36936,458,153 - 36,476,298 (-)NCBIMGSCv36mm8
Celera933,911,337 - 33,929,618 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.67NCBI
Chek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541226,627,606 - 26,650,947 (+)Ensembl
ChiLan1.0NW_00495541226,627,606 - 26,650,554 (+)NCBIChiLan1.0ChiLan1.0
CHEK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29126,315,104 - 126,366,201 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111127,420,236 - 127,470,688 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011120,446,352 - 120,478,207 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111124,359,218 - 124,410,385 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,359,218 - 124,390,981 (+)EnsemblpanPan2panpan1.1
CHEK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,878,511 - 8,910,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,879,147 - 8,907,669 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha58,923,479 - 8,955,720 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.058,821,650 - 8,853,260 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,821,983 - 8,853,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.158,890,756 - 8,922,634 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,860,679 - 8,892,710 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.058,897,288 - 8,929,731 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947107,757,062 - 107,779,783 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367432,005,851 - 2,026,587 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367432,004,535 - 2,027,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHEK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl952,753,528 - 52,790,700 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1952,759,224 - 52,790,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2958,411,395 - 58,444,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHEK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,768,141 - 116,809,557 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,767,944 - 116,801,371 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660439,201,283 - 9,302,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chek1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249271,610,878 - 1,643,409 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249271,609,404 - 1,643,409 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chek1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1832,885,417 - 32,905,845 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chek1
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:96
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000011226
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83910625849610361Rat

Markers in Region
D8Got46  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8844,628,766 - 44,628,920 (+)Marker Load Pipeline
mRatBN7.2836,439,917 - 36,440,070 (+)MAPPERmRatBN7.2
Rnor_6.0839,200,513 - 39,200,665NCBIRnor6.0
Rnor_5.0839,203,371 - 39,203,523UniSTSRnor5.0
RGSC_v3.4837,973,671 - 37,973,825RGDRGSC3.4
RGSC_v3.4837,973,673 - 37,973,825UniSTSRGSC3.4
Celera838,001,174 - 38,001,326UniSTS
RGSC_v3.1837,982,437 - 37,982,591RGD
RH 3.4 Map8315.0UniSTS
RH 3.4 Map8315.0RGD
RH 2.0 Map8237.8RGD
Cytogenetic Map8q21UniSTS
D8Got212  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,439,954 - 36,440,210 (+)MAPPERmRatBN7.2
mRatBN7.2836,439,954 - 36,440,077 (+)MAPPERmRatBN7.2
Rnor_6.0839,200,550 - 39,200,672NCBIRnor6.0
Rnor_6.0839,200,550 - 39,200,805NCBIRnor6.0
Rnor_5.0839,203,408 - 39,203,530UniSTSRnor5.0
Rnor_5.0839,203,408 - 39,203,663UniSTSRnor5.0
RGSC_v3.4837,973,710 - 37,973,965UniSTSRGSC3.4
RGSC_v3.4837,973,709 - 37,973,832RGDRGSC3.4
RGSC_v3.4837,973,710 - 37,973,832UniSTSRGSC3.4
Celera838,001,034 - 38,001,289UniSTS
Celera838,001,167 - 38,001,289UniSTS
RGSC_v3.1837,982,475 - 37,982,598RGD
RH 3.4 Map8320.4RGD
RH 3.4 Map8320.4UniSTS
RH 2.0 Map8250.7RGD
Cytogenetic Map8q21UniSTS
D8Got349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,439,961 - 36,440,080 (+)MAPPERmRatBN7.2
mRatBN7.2836,439,961 - 36,440,213 (+)MAPPERmRatBN7.2
Rnor_6.0839,200,557 - 39,200,808NCBIRnor6.0
Rnor_6.0839,200,557 - 39,200,675NCBIRnor6.0
Rnor_5.0839,203,415 - 39,203,666UniSTSRnor5.0
Rnor_5.0839,203,415 - 39,203,533UniSTSRnor5.0
RGSC_v3.4837,973,717 - 37,973,968UniSTSRGSC3.4
RGSC_v3.4837,973,717 - 37,973,835UniSTSRGSC3.4
Celera838,001,031 - 38,001,282UniSTS
Celera838,001,164 - 38,001,282UniSTS
Cytogenetic Map8q21UniSTS
RH142972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,420,891 - 36,421,014 (+)MAPPERmRatBN7.2
Rnor_6.0839,181,489 - 39,181,611NCBIRnor6.0
Rnor_5.0839,184,347 - 39,184,469UniSTSRnor5.0
RGSC_v3.4837,954,649 - 37,954,771UniSTSRGSC3.4
Celera838,020,133 - 38,020,255UniSTS
RH 3.4 Map8314.2UniSTS
Cytogenetic Map8q21UniSTS
RH136824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,420,835 - 36,420,962 (+)MAPPERmRatBN7.2
Rnor_6.0839,181,433 - 39,181,559NCBIRnor6.0
Rnor_5.0839,184,291 - 39,184,417UniSTSRnor5.0
RGSC_v3.4837,954,593 - 37,954,719UniSTSRGSC3.4
Celera838,020,185 - 38,020,311UniSTS
RH 3.4 Map8309.4UniSTS
Cytogenetic Map8q21UniSTS
AI230581  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,429,656 - 36,429,861 (+)MAPPERmRatBN7.2
Rnor_6.0839,190,254 - 39,190,458NCBIRnor6.0
Rnor_5.0839,193,112 - 39,193,316UniSTSRnor5.0
RGSC_v3.4837,963,414 - 37,963,618UniSTSRGSC3.4
Celera838,011,379 - 38,011,583UniSTS
RH 3.4 Map8314.2UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011226   ⟹   ENSRNOP00000011226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,609,417 - 44,629,109 (-)Ensembl
mRatBN7.2 Ensembl836,420,569 - 36,441,009 (-)Ensembl
Rnor_6.0 Ensembl839,181,163 - 39,201,588 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043518   ⟹   ENSRNOP00000040087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,632,473 - 44,671,990 (-)Ensembl
mRatBN7.2 Ensembl836,447,598 - 36,483,142 (-)Ensembl
Rnor_6.0 Ensembl839,204,218 - 39,243,705 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082086   ⟹   ENSRNOP00000069884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl836,439,847 - 36,483,293 (-)Ensembl
Rnor_6.0 Ensembl839,198,733 - 39,243,882 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090161   ⟹   ENSRNOP00000070708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,609,417 - 44,629,109 (-)Ensembl
mRatBN7.2 Ensembl836,420,569 - 36,441,009 (-)Ensembl
Rnor_6.0 Ensembl839,181,163 - 39,190,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096876   ⟹   ENSRNOP00000097342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,632,473 - 44,672,226 (-)Ensembl
mRatBN7.2 Ensembl836,446,788 - 36,483,293 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096991   ⟹   ENSRNOP00000083121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,610,280 - 44,629,109 (-)Ensembl
mRatBN7.2 Ensembl836,421,428 - 36,441,009 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103971   ⟹   ENSRNOP00000076852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl836,446,788 - 36,475,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112569   ⟹   ENSRNOP00000083682
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,660,013 - 44,669,527 (-)Ensembl
mRatBN7.2 Ensembl836,471,164 - 36,483,142 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146362   ⟹   ENSRNOP00000112791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,609,417 - 44,629,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167475   ⟹   ENSRNOP00000099211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl844,609,417 - 44,629,359 (-)Ensembl
RefSeq Acc Id: NM_080400   ⟹   NP_536325
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,609,417 - 44,629,843 (-)NCBI
mRatBN7.2836,420,565 - 36,440,993 (-)NCBI
Rnor_6.0839,181,162 - 39,201,588 (-)NCBI
Rnor_5.0839,184,020 - 39,204,446 (-)NCBI
RGSC_v3.4837,954,322 - 37,974,748 (-)RGD
Celera838,000,251 - 38,020,582 (+)RGD
Sequence:
RefSeq Acc Id: XM_008766042   ⟹   XP_008764264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,609,417 - 44,629,867 (-)NCBI
mRatBN7.2836,420,565 - 36,441,018 (-)NCBI
Rnor_6.0839,181,162 - 39,201,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766043   ⟹   XP_008764265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,609,417 - 44,629,826 (-)NCBI
mRatBN7.2836,420,565 - 36,440,923 (-)NCBI
Rnor_6.0839,181,162 - 39,201,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080725   ⟹   XP_038936653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,609,417 - 44,627,040 (-)NCBI
mRatBN7.2836,420,565 - 36,440,277 (-)NCBI
RefSeq Acc Id: XM_039080726   ⟹   XP_038936654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,615,401 - 44,629,620 (-)NCBI
mRatBN7.2836,426,394 - 36,442,061 (-)NCBI
RefSeq Acc Id: XM_063264798   ⟹   XP_063120868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,609,417 - 44,626,045 (-)NCBI
RefSeq Acc Id: XM_063264799   ⟹   XP_063120869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8844,615,254 - 44,629,620 (-)NCBI
RefSeq Acc Id: NP_536325   ⟸   NM_080400
- UniProtKB: Q91ZN6 (UniProtKB/Swiss-Prot),   Q91ZN7 (UniProtKB/Swiss-Prot),   A6KRN1 (UniProtKB/TrEMBL),   A0A8L2UQ45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764264   ⟸   XM_008766042
- Peptide Label: isoform X1
- UniProtKB: Q91ZN6 (UniProtKB/Swiss-Prot),   Q91ZN7 (UniProtKB/Swiss-Prot),   A6KRN1 (UniProtKB/TrEMBL),   A0A8L2UQ45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764265   ⟸   XM_008766043
- Peptide Label: isoform X1
- UniProtKB: Q91ZN6 (UniProtKB/Swiss-Prot),   Q91ZN7 (UniProtKB/Swiss-Prot),   A6KRN1 (UniProtKB/TrEMBL),   A0A8L2UQ45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070708   ⟸   ENSRNOT00000090161
Ensembl Acc Id: ENSRNOP00000040087   ⟸   ENSRNOT00000043518
Ensembl Acc Id: ENSRNOP00000069884   ⟸   ENSRNOT00000082086
Ensembl Acc Id: ENSRNOP00000011226   ⟸   ENSRNOT00000011226
RefSeq Acc Id: XP_038936653   ⟸   XM_039080725
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936654   ⟸   XM_039080726
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000083682   ⟸   ENSRNOT00000112569
Ensembl Acc Id: ENSRNOP00000097342   ⟸   ENSRNOT00000096876
Ensembl Acc Id: ENSRNOP00000076852   ⟸   ENSRNOT00000103971
Ensembl Acc Id: ENSRNOP00000083121   ⟸   ENSRNOT00000096991
RefSeq Acc Id: XP_063120868   ⟸   XM_063264798
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120869   ⟸   XM_063264799
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000099211   ⟸   ENSRNOT00000167475
Ensembl Acc Id: ENSRNOP00000112791   ⟸   ENSRNOT00000146362
Protein Domains
AglB-like core   Oligosaccharyl transferase STT3 N-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZN7-F1-model_v2 AlphaFold Q91ZN7 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695853
Promoter ID:EPDNEW_R6378
Type:multiple initiation site
Name:Chek1_2
Description:checkpoint kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6379  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0839,201,600 - 39,201,660EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620545 AgrOrtholog
BioCyc Gene G2FUF-31103 BioCyc
Ensembl Genes ENSRNOG00000031896 Ensembl
  ENSRNOG00000071217 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011226 ENTREZGENE
  ENSRNOT00000011226.6 UniProtKB/Swiss-Prot
Gene3D-CATH Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Chk1_catalytic_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:140583 UniProtKB/Swiss-Prot
NCBI Gene 140583 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot
  SERINE_THREONINE-PROTEIN KINASE CHK1 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB CHEK1 RGD
PhenoGen Chek1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031896 RatGTEx
  ENSRNOG00000071217 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZX38_RAT UniProtKB/TrEMBL
  A0A8I5ZYL4_RAT UniProtKB/TrEMBL
  A0A8I6AND0_RAT UniProtKB/TrEMBL
  A0A8J8YL51_RAT UniProtKB/TrEMBL
  A0A8L2UQ45 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEH2_RAT UniProtKB/TrEMBL
  A0ABK0LP45_RAT UniProtKB/TrEMBL
  A6KRN1 ENTREZGENE, UniProtKB/TrEMBL
  A6KRN2_RAT UniProtKB/TrEMBL
  CHK1_RAT UniProtKB/Swiss-Prot
  Q91ZN6 ENTREZGENE
  Q91ZN7 ENTREZGENE
UniProt Secondary Q91ZN6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-06 Chek1  checkpoint kinase 1  Chek1  CHK1 checkpoint homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chek1  CHK1 checkpoint homolog (S. pombe)  Chek1  checkpoint kinase 1 homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Chek1  checkpoint kinase 1 homolog (S. pombe)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Chek1  checkpoint kinase 1 homolog (S. pombe)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 634611
gene_function protein kinase 70230
gene_process mammalian homologs are involved in DNA damage and replication checkpoints 70230