Xpo1 (exportin 1) - Rat Genome Database

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Gene: Xpo1 (exportin 1) Rattus norvegicus
Analyze
Symbol: Xpo1
Name: exportin 1
RGD ID: 620517
Description: Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to salt; cellular response to triglyceride; and protein export from nucleus. Predicted to be located in annulate lamellae; kinetochore; and nucleolus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1); PARTICIPATES IN CRM1 export pathway; Hedgehog signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome region maintenance 1 protein homolog; exp1; exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; exportin 1, CRM1 homolog (yeast); exportin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,434,450 - 101,476,705 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14101,434,517 - 101,476,714 (+)EnsemblGRCr8
mRatBN7.21497,233,282 - 97,275,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,233,270 - 97,275,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14101,571,539 - 101,607,053 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,815,887 - 102,851,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,287,455 - 99,322,969 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,007,421 - 108,049,088 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)Ensemblrn6Rnor6.0
Rnor_5.014108,082,784 - 108,124,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414103,943,249 - 103,978,717 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1496,216,463 - 96,251,770 (+)NCBICelera
RGSC_v3.114103,962,459 - 103,997,928 (+)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
aurantio-obtusin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
leptomycin B  (ISO)
levofloxacin  (EXP)
menadione  (ISO)
methidathion  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulindac  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
annulate lamellae  (IEA,ISO)
Cajal body  (IEA)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
kinetochore  (IEA,ISO,ISS)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)
ribonucleoprotein complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of XPO1 Overexpression with NF-κB and Ki67 in Colorectal Cancer. Aladhraei M, etal., Asian Pac J Cancer Prev. 2019 Dec 1;20(12):3747-3754. doi: 10.31557/APJCP.2019.20.12.3747.
2. Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice. Bodendorf U, etal., J Virol 1999 Sep;73(9):7769-79.
3. Prognostic roles of the transcriptional expression of exportins in hepatocellular carcinoma. Chen L, etal., Biosci Rep. 2019 Aug 19;39(8). pii: BSR20190827. doi: 10.1042/BSR20190827. Print 2019 Aug 30.
4. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. Fei E, etal., J Biol Chem. 2010 Dec 3;285(49):38630-40. doi: 10.1074/jbc.M110.107912. Epub 2010 Oct 4.
5. XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer. Ferreiro-Neira I, etal., Clin Cancer Res. 2016 Apr 1;22(7):1663-73. doi: 10.1158/1078-0432.CCR-15-0978. Epub 2015 Nov 24.
6. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site. Fukasawa M, etal., Biochem Biophys Res Commun. 2010 Jan 8;391(2):1166-9. doi: 10.1016/j.bbrc.2009.11.115. Epub 2009 Dec 17.
7. Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy. Gao W, etal., J Thorac Oncol. 2015 May;10(5):815-25. doi: 10.1097/JTO.0000000000000485.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Rat CRM1 is responsible for the poor activity of human T-cell leukemia virus type 1 Rex protein in rat cells. Hakata Y, etal., J Virol 2001 Dec;75(23):11515-25.
11. A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1. Huang Q, etal., Cell Death Dis. 2020 Dec 2;11(12):1031. doi: 10.1038/s41419-020-03237-8.
12. Prognostic value of CRM1 in pancreas cancer. Huang WY, etal., Clin Invest Med. 2009 Dec 1;32(6):E315.
13. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Inoue A, etal., Gastroenterology. 2021 Jul;161(1):196-210. doi: 10.1053/j.gastro.2021.03.022. Epub 2021 Mar 19.
14. CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1. Luo J, etal., Int J Mol Med. 2016 Aug;38(2):381-90. doi: 10.3892/ijmm.2016.2628. Epub 2016 Jun 7.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. RNA Export through the NPC in Eukaryotes. Okamura M, etal., Genes (Basel). 2015 Mar 20;6(1):124-49. doi: 10.3390/genes6010124.
19. Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. Ortega JF, etal., Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer. Sexton R, etal., Int J Mol Sci. 2019 Sep 28;20(19). pii: ijms20194826. doi: 10.3390/ijms20194826.
26. Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor. Subhash VV, etal., Sci Rep. 2018 Aug 16;8(1):12248. doi: 10.1038/s41598-018-30686-1.
27. KPT-330 has antitumour activity against non-small cell lung cancer. Sun H, etal., Br J Cancer. 2014 Jul 15;111(2):281-91. doi: 10.1038/bjc.2014.260. Epub 2014 Jun 19.
28. Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer. Sun YQ, etal., World J Gastroenterol. 2017 Mar 21;23(11):2012-2022. doi: 10.3748/wjg.v23.i11.2012.
29. Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma. van der Watt PJ, etal., Oncol Rep. 2014 Aug;32(2):730-8. doi: 10.3892/or.2014.3231. Epub 2014 Jun 4.
30. Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma. Yang X, etal., Med Oncol. 2014 Sep;31(9):155. doi: 10.1007/s12032-014-0155-9. Epub 2014 Aug 23.
31. Nuclear export and cytoplasmic maturation of ribosomal subunits. Zemp I and Kutay U, FEBS Lett. 2007 Jun 19;581(15):2783-93. Epub 2007 May 11.
32. KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma. Zheng Y, etal., Cancer Chemother Pharmacol. 2014 Sep;74(3):487-95. doi: 10.1007/s00280-014-2495-8. Epub 2014 Jul 17.
33. Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer. Zhou F, etal., APMIS. 2016 Dec;124(12):1046-1053. doi: 10.1111/apm.12604. Epub 2016 Oct 6.
34. CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Zhou F, etal., Med Oncol. 2013 Dec;30(4):726. doi: 10.1007/s12032-013-0726-1. Epub 2013 Sep 12.
35. XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. Zhu ZC, etal., Cell Death Dis. 2019 May 21;10(6):395. doi: 10.1038/s41419-019-1627-9.
Additional References at PubMed
PMID:10557333   PMID:11000203   PMID:11092755   PMID:11796723   PMID:12210765   PMID:12446771   PMID:12724356   PMID:12773398   PMID:14981260   PMID:15572669   PMID:15574332   PMID:15767664  
PMID:16236793   PMID:16297385   PMID:16316410   PMID:16459298   PMID:16997396   PMID:17363900   PMID:18496528   PMID:18606808   PMID:18809582   PMID:19064729   PMID:19699716   PMID:19946888  
PMID:19952108   PMID:21251165   PMID:22250199   PMID:22427340   PMID:23494640   PMID:23782956   PMID:28131823   PMID:29666234  


Genomics

Comparative Map Data
Xpo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,434,450 - 101,476,705 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14101,434,517 - 101,476,714 (+)EnsemblGRCr8
mRatBN7.21497,233,282 - 97,275,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,233,270 - 97,275,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14101,571,539 - 101,607,053 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,815,887 - 102,851,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,287,455 - 99,322,969 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,007,421 - 108,049,088 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)Ensemblrn6Rnor6.0
Rnor_5.014108,082,784 - 108,124,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414103,943,249 - 103,978,717 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1496,216,463 - 96,251,770 (+)NCBICelera
RGSC_v3.114103,962,459 - 103,997,928 (+)NCBI
Cytogenetic Map14q22NCBI
XPO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,477,849 - 61,538,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,476,032 - 61,538,753 (-)Ensemblhg38GRCh38
GRCh37261,704,984 - 61,765,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,558,573 - 61,618,922 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34261,616,719 - 61,677,069NCBI
Celera261,550,297 - 61,610,634 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,445,666 - 61,506,245 (-)NCBIHuRef
CHM1_1261,635,341 - 61,695,639 (-)NCBICHM1_1
T2T-CHM13v2.0261,483,936 - 61,544,825 (-)NCBIT2T-CHM13v2.0
Xpo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,205,768 - 23,248,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,206,055 - 23,248,249 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381123,255,909 - 23,297,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,256,041 - 23,298,249 (+)Ensemblmm10GRCm38
MGSCv371123,156,041 - 23,197,597 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361123,156,041 - 23,197,597 (+)NCBIMGSCv36mm8
Celera1125,383,230 - 25,424,813 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.28NCBI
Xpo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542422,370,006 - 22,420,568 (+)Ensembl
ChiLan1.0NW_00495542422,370,006 - 22,420,568 (+)NCBIChiLan1.0ChiLan1.0
XPO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21264,845,566 - 64,906,271 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A64,849,384 - 64,910,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,562,372 - 61,622,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,698,935 - 62,759,059 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,698,935 - 62,757,793 (-)EnsemblpanPan2panpan1.1
XPO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,541,647 - 61,588,397 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,542,211 - 61,585,054 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1061,432,066 - 61,478,799 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01062,551,228 - 62,597,765 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,549,829 - 62,598,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11062,236,087 - 62,282,603 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,538,737 - 62,585,449 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,833,751 - 62,880,490 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xpo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,608,933 - 21,649,530 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,921,319 - 6,962,343 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,921,753 - 6,962,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XPO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,255,146 - 80,300,327 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1380,255,016 - 80,300,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,163,542 - 84,182,141 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XPO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,428,279 - 45,487,965 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,432,619 - 45,488,723 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604566,319,346 - 66,401,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xpo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833375,820 - 424,499 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624833375,817 - 424,499 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Xpo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11193,639,648 - 93,681,865 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Xpo1
452 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:75
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000014062
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014062   ⟹   ENSRNOP00000014062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14101,434,541 - 101,476,164 (+)Ensembl
mRatBN7.2 Ensembl1497,233,382 - 97,275,498 (+)Ensembl
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101915   ⟹   ENSRNOP00000087052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14101,434,517 - 101,476,714 (+)Ensembl
mRatBN7.2 Ensembl1497,252,482 - 97,275,458 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114310   ⟹   ENSRNOP00000097648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14101,434,517 - 101,476,714 (+)Ensembl
mRatBN7.2 Ensembl1497,233,270 - 97,275,432 (+)Ensembl
RefSeq Acc Id: NM_053490   ⟹   NP_445942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,434,450 - 101,476,705 (+)NCBI
mRatBN7.21497,233,282 - 97,275,536 (+)NCBI
Rnor_6.014108,013,281 - 108,048,950 (+)NCBI
Rnor_5.014108,082,784 - 108,124,516 (+)NCBI
RGSC_v3.414103,943,249 - 103,978,717 (+)RGD
Celera1496,216,463 - 96,251,770 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445942 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC65240 (Get FASTA)   NCBI Sequence Viewer  
  CAB41422 (Get FASTA)   NCBI Sequence Viewer  
  EDL97984 (Get FASTA)   NCBI Sequence Viewer  
  EDL97985 (Get FASTA)   NCBI Sequence Viewer  
  EDL97986 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087052
GenBank Protein Q80U96 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445942   ⟸   NM_053490
- UniProtKB: Q80U96 (UniProtKB/Swiss-Prot),   A6JQ67 (UniProtKB/TrEMBL),   A0A8I6AT26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014062   ⟸   ENSRNOT00000014062
Ensembl Acc Id: ENSRNOP00000097648   ⟸   ENSRNOT00000114310
Ensembl Acc Id: ENSRNOP00000087052   ⟸   ENSRNOT00000101915
Protein Domains
Exportin-1 C-terminal   Importin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80U96-F1-model_v2 AlphaFold Q80U96 1-1071 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620517 AgrOrtholog
BioCyc Gene G2FUF-14777 BioCyc
Ensembl Genes ENSRNOG00000009935 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000101915 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  CRM1_repeat UniProtKB/Swiss-Prot
  Exp1_repeat_2 UniProtKB/Swiss-Prot
  Exportin-1/Importin-b-like UniProtKB/Swiss-Prot
  Importin-beta_N UniProtKB/Swiss-Prot
  XPO1/5 UniProtKB/Swiss-Prot
  XPO1_C_dom UniProtKB/Swiss-Prot
  XPO1_repeat_3 UniProtKB/Swiss-Prot
KEGG Report rno:85252 UniProtKB/Swiss-Prot
NCBI Gene 85252 ENTREZGENE
PANTHER EXPORTIN-1 UniProtKB/Swiss-Prot
  PTHR11223 UniProtKB/Swiss-Prot
Pfam CRM1_C UniProtKB/Swiss-Prot
  CRM1_repeat UniProtKB/Swiss-Prot
  CRM1_repeat_2 UniProtKB/Swiss-Prot
  CRM1_repeat_3 UniProtKB/Swiss-Prot
  IBN_N UniProtKB/Swiss-Prot
  Xpo1 UniProtKB/Swiss-Prot
PhenoGen Xpo1 PhenoGen
PROSITE IMPORTIN_B_NT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009935 RatGTEx
SMART CRM1_C UniProtKB/Swiss-Prot
  IBN_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I6A738_RAT UniProtKB/TrEMBL
  A0A8I6AT26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q6V5_RAT UniProtKB/TrEMBL
  A6JQ67 ENTREZGENE, UniProtKB/TrEMBL
  A6JQ69_RAT UniProtKB/TrEMBL
  Q80U96 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Xpo1  exportin 1  Xpo1  exportin 1, CRM1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Xpo1  exportin 1, CRM1 homolog (yeast)    exportin 1 (CRM1, yeast, homolog)  Name updated 1299863 APPROVED
2002-08-07 Xpo1  exportin 1 (CRM1, yeast, homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL