Cxcr4 (C-X-C motif chemokine receptor 4) - Rat Genome Database

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Gene: Cxcr4 (C-X-C motif chemokine receptor 4) Rattus norvegicus
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Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
RGD ID: 620465
Description: Enables small molecule binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Located in endosome. Used to study pulmonary hypertension and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C chemokine receptor type 4; chemokine (C-X-C motif) receptor 4; Chemokine receptor (LCR1); CXC chemokine receptor; CXC-R4; CXCR-4; fusin; LESTR; leukocyte-derived seven transmembrane domain receptor; MGC108696; SDF-1 receptor; stromal cell-derived factor 1 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp327
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,630,383 - 42,634,288 (-)NCBIGRCr8
mRatBN7.21340,077,976 - 40,081,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,673,402 - 42,677,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,961,532 - 43,965,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01341,206,597 - 41,210,496 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01345,314,952 - 45,318,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,394,128 - 50,398,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,308,286 - 41,312,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,322,328 - 41,326,213 (-)NCBI
Celera1340,447,190 - 40,451,093 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Cxcr4Ratacute myeloid leukemia disease_progressionISOCXCR4 (Homo sapiens)11352273 RGD 
Cxcr4Ratacute myeloid leukemia treatmentISOCXCR4 (Homo sapiens)11352265 RGD 
Cxcr4RatBone Metastasis disease_progressionISOCXCR4 (Homo sapiens)9068941associated with hepatocellular carcinoma and protein:increased expression:liver (human)RGDPMID:19508713 and REF_RGD_ID:152023653
Cxcr4RatCancer Pain  IMP 13838657 RGD 
Cxcr4RatCancer Pain  IEP 13463594mRNA and protein:increased expression:spinal cord:RGD 
Cxcr4RatCerebral Hemorrhage treatmentIMP 11352686 RGD 
Cxcr4RatChronic Periodontitis  ISOCXCR4 (Homo sapiens)6480655mRNA:increased expression:gingival tissues (human)RGD 
Cxcr4Ratclear cell renal cell carcinoma  ISOCXCR4 (Homo sapiens)155804290mRNA:increased expression:kidney:RGD 
Cxcr4Ratcolorectal cancer exacerbatesISOCXCR4 (Homo sapiens)151893497mRNA and protein:increased expression:colon (human)RGD 
Cxcr4Ratcolorectal cancer  ISOCXCR4 (Homo sapiens)151665323mRNA:increased expression:colonic epithelium (human)RGD 
Cxcr4Ratcolorectal cancer disease_progressionISOCXCR4 (Homo sapiens)151708720protein:increased expression:blood serum (human)RGD 
Cxcr4Ratcolorectal cancer disease_progressionISOCXCR4 (Homo sapiens)151709000mRNA:increased expression:colorectum (human)RGD 
Cxcr4Ratcolorectal cancer  ISOCXCR4 (Homo sapiens)151708721human cells in mouse model and protein:increased expression:colorectum (human)RGD 
Cxcr4Ratcolorectal cancer amelioratesISOCXCR4 (Homo sapiens)151893498human cells in mouse modelRGD 
Cxcr4Ratcolorectal cancer severityISOCXCR4 (Homo sapiens)151708726protein:increased expression:colorectum (human)RGD 
Cxcr4Ratcolorectal cancer disease_progressionISOCXCR4 (Homo sapiens)151665332mRNA:increased expression:colorectum (human)RGD 
Cxcr4Ratcolorectal carcinoma disease_progressionISOCXCR4 (Homo sapiens)151893518mRNA and protein:increased expression:colorectum (human)RGD 
Cxcr4RatCOVID-19  ISOCXCR4 (Homo sapiens)9068941mRNA:decreased expression:memory B cells (human)RGDPMID:32377375 and REF_RGD_ID:32716422
Cxcr4Ratesophagus squamous cell carcinoma disease_progressionISOCXCR4 (Homo sapiens)152023646protein:increased expression:esophagus squamous epithelium (human)RGD 
Cxcr4Ratextranodal marginal zone lymphoma of mucosa-associated lymphoid tissue  ISOCXCR4 (Homo sapiens)152023632protein:increased expression: mucosa-associated lymphoid tissue (human)RGD 
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Cxcr4Ratgenetic disease  ISOCXCR4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Cxcr4Ratprimary immunodeficiency disease  ISOCXCR4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:25741868
Cxcr4RatWHIM Syndrome  ISOCXCR4 (Homo sapiens)8554872ClinVar Annotator: match by term: Warts more ...ClinVarPMID:10400757 more ...
Cxcr4RatWHIM syndrome 1  ISOCXCR4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12692554 more ...
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Cxcr4RatBreast Neoplasms  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25753200
Cxcr4Ratjuvenile rheumatoid arthritis  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504 and PMID:26387944
Cxcr4RatNeoplasm Invasiveness  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25753200
Cxcr4RatNeoplasm Metastasis  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21312072 and PMID:23743303
Cxcr4RatNeoplastic Cell Transformation  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23743303
Cxcr4Ratnephrosclerosis  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30818366
Cxcr4RatNeuralgia  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17292584
Cxcr4Ratrheumatoid arthritis  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19192274
Cxcr4RatWHIM syndrome 1  ISOCXCR4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23734232
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Cxcr4Ratcardiomyopathy  ISSCxcr4 (Mus musculus)13592920 MouseDO 
Cxcr4Ratcongestive heart failure  ISSCxcr4 (Mus musculus)13592920 MouseDO 
Cxcr4RatWHIM syndrome 1  ISSCxcr4 (Mus musculus)13592920OMIM:193670MouseDO 
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Cxcr4RatWHIM syndrome 1  ISOCXCR4 (Homo sapiens)7240710 OMIM 

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Cxcr4Rat(S)-nicotine increases expressionISOCXCR4 (Homo sapiens)6480464Nicotine results in increased expression of CXCR4 mRNA and Nicotine results in increased expression of CXCR4 proteinCTDPMID:20457658
Cxcr4Rat(S)-nicotine multiple interactionsISOCXCR4 (Homo sapiens)6480464[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]CTDPMID:20457658
Cxcr4Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases response to substanceISOCXCR4 (Homo sapiens)6480464CXCR4 protein results in decreased susceptibility to 2 more ...CTDPMID:22549810
Cxcr4Rat1,2-dimethylhydrazine increases expressionISOCxcr4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of CXCR4 mRNACTDPMID:22206623
Cxcr4Rat1,4-phenylenediamine decreases expressionISOCxcr4 (Mus musculus)64804644-phenylenediamine results in decreased expression of CXCR4 proteinCTDPMID:15924226
Cxcr4Rat1-chloro-2,4-dinitrobenzene decreases expressionISOCXCR4 (Homo sapiens)6480464Dinitrochlorobenzene results in decreased expression of CXCR4 mRNACTDPMID:19371601
Cxcr4Rat1-chloro-2,4-dinitrobenzene decreases expressionISOCxcr4 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of CXCR4 mRNACTDPMID:28219650
Cxcr4Rat1-chloro-2,4-dinitrobenzene increases expressionISOCXCR4 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of CXCR4 mRNACTDPMID:17374397 and PMID:20146380
Cxcr4Rat1-chloro-2,4-dinitrobenzene increases expressionISOCxcr4 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CXCR4 mRNACTDPMID:19647056
Cxcr4Rat1-fluoro-2,4-dinitrobenzene decreases expressionISOCxcr4 (Mus musculus)6480464Dinitrofluorobenzene results in decreased expression of CXCR4 proteinCTDPMID:15924226
Cxcr4Rat15-acetyldeoxynivalenol increases expressionISOCXCR4 (Homo sapiens)648046415-acetyldeoxynivalenol results in increased expression of CXCR4 mRNACTDPMID:23792671
Cxcr4Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of CXCR4 mRNACTDPMID:17351261
Cxcr4Rat17beta-estradiol multiple interactionsISOCXCR4 (Homo sapiens)64804643 more ...CTDPMID:19619570 more ...
Cxcr4Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CXCR4 mRNACTDPMID:32741896
Cxcr4Rat17beta-estradiol increases expression ISOCXCR4 (Homo sapiens)15202555817beta-estradiol increases expression of CXCR4 protein in multiple cellsRGD 
Cxcr4Rat17beta-estradiol increases expressionISOCXCR4 (Homo sapiens)6480464Estradiol results in increased expression of CXCR4 mRNA and Estradiol results in increased expression of CXCR4 proteinCTDPMID:28844962 and PMID:29654831
Cxcr4Rat17beta-estradiol decreases response to substanceISOCXCR4 (Homo sapiens)6480464CXCR4 protein results in decreased susceptibility to EstradiolCTDPMID:22549810
Cxcr4Rat17beta-estradiol increases expressionISOCxcr4 (Mus musculus)6480464Estradiol results in increased expression of CXCR4 mRNA and Estradiol results in increased expression of CXCR4 proteinCTDPMID:17578864 and PMID:39298647
Cxcr4Rat17beta-estradiol decreases expressionISOCXCR4 (Homo sapiens)6480464Estradiol results in decreased expression of CXCR4 mRNACTDPMID:19619570 and PMID:24758408
Cxcr4Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CXCR4 mRNACTDPMID:32741896

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Biological Process
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Cxcr4Ratameboidal-type cell migration acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291MGI:1934442 PMID:15626744RGDPMID:15626744
Cxcr4Rataorta development acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291 PMID:25807483RGDPMID:25807483
Cxcr4Ratblood vessel endothelial cell migration acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291MGI:1934442 PMID:15626744RGDPMID:15626744
Cxcr4Ratbrain development involved_inIBAMGI:109563 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4Ratbrain development acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291MGI:1934407 PMID:12183377RGDPMID:12183377
Cxcr4Ratbranching involved in blood vessel morphogenesis acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291MGI:1934442 PMID:15626744RGDPMID:15626744
Cxcr4Ratcalcium-mediated signaling acts_upstream_of_or_withinISOCXCR4 (Homo sapiens)1624291 PMID:19064997RGDPMID:19064997
Cxcr4Ratcalcium-mediated signaling involved_inIBAPANTHER:PTN001628461 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4Ratcardiac muscle contraction  IMP 1600772 RGD 
Cxcr4Ratcell chemotaxis involved_inIBAMGI:103567 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4Ratcell migration  IMP 1600768 RGD 
Cxcr4Ratcellular response to cytokine stimulus involved_inISSUniProtKB:P610731600115GO_REF:0000024UniProtGO_REF:0000024
Cxcr4Ratcellular response to cytokine stimulus acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291 PMID:8962122RGDPMID:8962122
Cxcr4Ratcellular response to cytokine stimulus involved_inISOCXCR4 (Homo sapiens)1624291 PMID:21540189RGDPMID:21540189
Cxcr4Ratcellular response to xenobiotic stimulus  IEP 11352688 RGD 
Cxcr4Ratchemokine-mediated signaling pathway involved_inIEAARBA:ARBA000335831600115GO_REF:0000117UniProtGO_REF:0000117
Cxcr4Ratchemotaxis involved_inIEAInterPro:IPR0003551600115GO_REF:0000002InterProGO_REF:0000002
Cxcr4RatCXCL12-activated CXCR4 signaling pathway involved_inISOCXCR4 (Homo sapiens)1624291UniProtKB:P48061 more ...RGDPMID:24912431 more ...
Cxcr4RatCXCL12-activated CXCR4 signaling pathway acts_upstream_of_or_withinISOCxcr4 (Mus musculus)1624291 PMID:31845480RGDPMID:31845480
Cxcr4RatCXCL12-activated CXCR4 signaling pathway involved_inISSUniProtKB:P610731600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Cxcr4Ratanchoring junction located_inIEAUniProtKB-SubCell:SL-00381600115GO_REF:0000044UniProtGO_REF:0000044
Cxcr4Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Cxcr4Ratcell leading edge located_inISOCXCR4 (Homo sapiens)1624291 PMID:12421915RGDPMID:12421915
Cxcr4Ratcell surface located_inISOCXCR4 (Homo sapiens)1624291 PMID:10521508 more ...RGDPMID:10521508 more ...
Cxcr4Ratcell surface located_inISOCxcr4 (Mus musculus)1624291 PMID:22265737RGDPMID:22265737
Cxcr4Ratcell-cell junction located_inISOCxcr4 (Mus musculus)1624291 PMID:23793062RGDPMID:23793062
Cxcr4Ratcytoplasmic vesicle located_inISOCXCR4 (Homo sapiens)1624291 PMID:10521508 and PMID:19106094RGDPMID:10521508 and PMID:19106094
Cxcr4Ratearly endosome located_inISSUniProtKB:P610731600115GO_REF:0000024UniProtGO_REF:0000024
Cxcr4Ratearly endosome located_inIEAUniProtKB-SubCell:SL-00941600115GO_REF:0000044UniProtGO_REF:0000044
Cxcr4Ratearly endosome located_inISOCXCR4 (Homo sapiens)1624291 PMID:21540189 and PMID:24790097RGDPMID:21540189 and PMID:24790097
Cxcr4Ratendosome  IDA 1600771 RGD 
Cxcr4Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Cxcr4Ratexternal side of plasma membrane is_active_inIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4Ratexternal side of plasma membrane located_inISOCxcr4 (Mus musculus)1624291 PMID:19008373RGDPMID:19008373
Cxcr4Ratgrowth cone located_inISOCxcr4 (Mus musculus)1624291 PMID:16129397RGDPMID:16129397
Cxcr4Ratlate endosome located_inISSUniProtKB:P610731600115GO_REF:0000024UniProtGO_REF:0000024
Cxcr4Ratlate endosome located_inIEAUniProtKB-SubCell:SL-01521600115GO_REF:0000044UniProtGO_REF:0000044
Cxcr4Ratlate endosome located_inISOCXCR4 (Homo sapiens)1624291 PMID:21540189RGDPMID:21540189
Cxcr4Ratlysosome located_inISOCXCR4 (Homo sapiens)1624291 PMID:21540189 and PMID:24790097RGDPMID:21540189 and PMID:24790097
Cxcr4Ratlysosome located_inIEAUniProtKB-SubCell:SL-01581600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Cxcr4Ratactin binding enablesISOCXCR4 (Homo sapiens)1624291 PMID:12421915RGDPMID:12421915
Cxcr4RatC-C chemokine binding enablesISOCXCR4 (Homo sapiens)1624291UniProtKB:Q98157 and PMID:25612609RGDPMID:25612609
Cxcr4RatC-C chemokine binding enablesIBAMGI:104616 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4RatC-C chemokine receptor activity  TAS 632605 RGD 
Cxcr4RatC-C chemokine receptor activity enablesIBAMGI:103011 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cxcr4RatC-X-C chemokine receptor activity  TAS 632605 RGD 
Cxcr4RatC-X-C motif chemokine 12 receptor activity enablesISSUniProtKB:P610731600115GO_REF:0000024UniProtGO_REF:0000024
Cxcr4RatC-X-C motif chemokine 12 receptor activity enablesISOCXCR4 (Homo sapiens)1624291 PMID:28978524RGDPMID:28978524
Cxcr4Ratchemokine receptor activity enablesIEAInterPro:IPR0003551600115GO_REF:0000002InterProGO_REF:0000002
Cxcr4Ratcytokine binding enablesIEAInterPro:IPR0227261600115GO_REF:0000002InterProGO_REF:0000002
Cxcr4RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Cxcr4RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Cxcr4Ratmyosin light chain binding enablesISOCXCR4 (Homo sapiens)1624291 PMID:12421915RGDPMID:12421915
Cxcr4Ratprotein binding enablesISOCXCR4 (Homo sapiens)1624291UniProtKB:O15541 more ...RGDPMID:10644702 more ...
Cxcr4Ratprotein binding enablesISOCxcr4 (Mus musculus)1624291PR:Q8BGW2 more ...RGDPMID:18227060 and PMID:31845480
Cxcr4Ratsmall molecule binding  IMP 6480473 RGD 
Cxcr4Ratubiquitin binding enablesISOCXCR4 (Homo sapiens)1624291 PMID:20228059RGDPMID:20228059
Cxcr4Ratubiquitin protein ligase binding enablesISOCXCR4 (Homo sapiens)1624291UniProtKB:Q96J02 and PMID:19116316RGDPMID:19116316
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Imported Annotations - KEGG (archival)

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Cxcr4Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Cxcr4Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Cxcr4Ratendocytosis pathway  IEA 6907045 KEGGrno:04144

Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. In vitro model of vasculo-angiogenesis: demonstration that bone marrow derived endothelial progenitor cells form new hybrid capillary blood vessels jointly with gastric endothelial cells. Ahluwalia A, etal., J Physiol Pharmacol. 2017 Dec;68(6):841-846.
3. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Albee LJ, etal., Open Biol. 2018 Jan;8(1). pii: rsob.170207. doi: 10.1098/rsob.170207.
4. Eculizumab treatment modifies the immune profile of PNH patients. Alfinito F, etal., Immunobiology. 2012 Jul;217(7):698-703. doi: 10.1016/j.imbio.2011.11.009. Epub 2011 Dec 3.
5. In vivo knockdown of CXCR4 using jetPEI/CXCR4 shRNA nanoparticles inhibits the pulmonary metastatic potential of B16‑F10 melanoma cells. André ND, etal., Mol Med Rep. 2015 Dec;12(6):8320-6. doi: 10.3892/mmr.2015.4487. Epub 2015 Oct 26.
6. miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4. Azar MRMH, etal., Int Immunopharmacol. 2021 Mar;92:107355. doi: 10.1016/j.intimp.2020.107355. Epub 2021 Jan 8.
7. The chemokine SDF1 regulates migration of dentate granule cells. Bagri A, etal., Development 2002 Sep;129(18):4249-60.
8. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Banisadr G, etal., Eur J Neurosci 2002 Nov;16(9):1661-71.
9. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation. Baudouin SJ, etal., Mol Cell Neurosci. 2006 Oct;33(2):160-9. Epub 2006 Sep 6.
10. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Benedicto A, etal.
11. CD4 dependence of gp120IIIB-CXCR4 interaction is cell-type specific. Bodner A, etal., J Neuroimmunol 2003 Jul;140(1-2):1-12.
12. Adenosine A2A receptor activation reduces brain metastasis via SDF-1/CXCR4 axis and protecting blood-brain barrier. Chen L, etal., Mol Carcinog. 2020 Apr;59(4):390-398. doi: 10.1002/mc.23161. Epub 2020 Feb 9.
13. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Cho BS, etal., Blood. 2015 Jul 9;126(2):222-32. doi: 10.1182/blood-2015-02-628677. Epub 2015 Jun 1.
14. The prognostic role of serum C-X-C chemokine receptor type 4 in patients with metastatic or recurrent colorectal cancer. Choi YJ, etal., Onco Targets Ther. 2016 Jun 1;9:3307-12. doi: 10.2147/OTT.S104511. eCollection 2016.
15. A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. D'Alterio C, etal., Int J Cancer. 2014 Jul 15;135(2):379-90. doi: 10.1002/ijc.28689. Epub 2014 Jan 10.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Guleng B, etal., Cancer Res. 2005 Jul 1;65(13):5864-71. doi: 10.1158/0008-5472.CAN-04-3833.
18. Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer. Guo ZJ, etal., Oncotarget. 2016 Apr 12;7(15):20999-1012. doi: 10.18632/oncotarget.8236.
19. Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis. Habasque C, etal., Mol Hum Reprod 2002 May;8(5):419-25.
20. Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4. He L, etal.
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1 to 10 of 13 rows
PMID:8962122   PMID:10521508   PMID:10644702   PMID:12421915   PMID:12477932   PMID:12507773   PMID:12707343   PMID:12900445   PMID:14732474   PMID:15174142   PMID:15467356   PMID:15626744  
PMID:15731012   PMID:16005638   PMID:16129397   PMID:16166380   PMID:16469439   PMID:16553776   PMID:16702540   PMID:16837851   PMID:16841089   PMID:17520275   PMID:17530714   PMID:18031680  
PMID:18064521   PMID:18201717   PMID:18206136   PMID:18308860   PMID:18606818   PMID:18753332   PMID:18850076   PMID:18978811   PMID:19008373   PMID:19024651   PMID:19053768   PMID:19064997  
PMID:19066630   PMID:19106094   PMID:19116316   PMID:19228460   PMID:19285061   PMID:19340530   PMID:19380869   PMID:19586611   PMID:19665027   PMID:19703720   PMID:20026091   PMID:20032115  
PMID:20045921   PMID:20127490   PMID:20133817   PMID:20228059   PMID:20412823   PMID:20458337   PMID:20534485   PMID:20547684   PMID:20586815   PMID:20729750   PMID:20847314   PMID:20882566  
PMID:21171825   PMID:21418513   PMID:21438014   PMID:21540189   PMID:22058039   PMID:22159319   PMID:22166584   PMID:22265737   PMID:22280945   PMID:22345572   PMID:22355073   PMID:22694179  
PMID:22978573   PMID:23029422   PMID:23148226   PMID:23170857   PMID:23223293   PMID:23289420   PMID:23576796   PMID:23620790   PMID:23671625   PMID:23793062   PMID:23832528   PMID:23969990  
PMID:24086760   PMID:24122226   PMID:24312447   PMID:24373940   PMID:24557113   PMID:24581269   PMID:24587052   PMID:24626964   PMID:24637920   PMID:24751384   PMID:24790097   PMID:24912431  
PMID:25032954   PMID:25299045   PMID:25420576   PMID:25492872   PMID:25549045   PMID:25612609   PMID:25807483   PMID:25824297   PMID:25825119   PMID:26164455   PMID:26398409   PMID:26444377  
PMID:26597700   PMID:26818151   PMID:26886751   PMID:27011380   PMID:27269634   PMID:27340942   PMID:28002632   PMID:28233339   PMID:28412763   PMID:28585910   PMID:28903152   PMID:28978524  
1 to 10 of 13 rows



Cxcr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81342,630,383 - 42,634,288 (-)NCBIGRCr8
mRatBN7.21340,077,976 - 40,081,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1342,673,402 - 42,677,295 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01343,961,532 - 43,965,425 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01341,206,597 - 41,210,496 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01345,314,952 - 45,318,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01350,394,128 - 50,398,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41341,308,286 - 41,312,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11341,322,328 - 41,326,213 (-)NCBI
Celera1340,447,190 - 40,451,093 (-)NCBICelera
Cytogenetic Map13q13NCBI
CXCR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,114,349 - 136,118,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2136,114,349 - 136,119,177 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,871,919 - 136,875,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362136,588,389 - 136,592,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 342136,705,651 - 136,709,457NCBI
Celera2130,582,637 - 130,586,442 (-)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2128,864,423 - 128,868,228 (-)NCBIHuRef
CHM1_12136,877,321 - 136,881,126 (-)NCBICHM1_1
T2T-CHM13v2.02136,558,831 - 136,562,630 (-)NCBIT2T-CHM13v2.0
Cxcr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391128,515,936 - 128,520,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1128,515,936 - 128,520,030 (-)EnsemblGRCm39 Ensembl
GRCm381128,588,199 - 128,592,299 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1128,588,199 - 128,592,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371130,484,776 - 130,488,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361130,415,745 - 130,419,822 (-)NCBIMGSCv36mm8
Celera1131,222,729 - 131,226,820 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.43NCBI
Cxcr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554403,455,153 - 3,460,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554403,456,165 - 3,460,024 (-)NCBIChiLan1.0ChiLan1.0
CXCR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21338,813,034 - 38,816,868 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B38,828,003 - 38,831,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B23,744,271 - 23,748,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B140,185,803 - 140,189,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B140,181,829 - 140,189,647 (-)Ensemblpanpan1.1panPan2
CXCR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11938,874,650 - 38,877,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1938,874,145 - 38,877,740 (-)NCBICanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1939,115,923 - 39,119,630 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01940,316,370 - 40,320,084 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1940,316,772 - 40,320,037 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11938,959,603 - 38,963,312 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01939,119,612 - 39,123,328 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01940,352,845 - 40,356,556 (-)NCBIUU_Cfam_GSD_1.0
Cxcr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303101,819,271 - 101,823,136 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646939,794,584 - 39,798,459 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646939,794,613 - 39,798,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1515,663,494 - 15,667,232 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11515,663,652 - 15,666,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21518,125,415 - 18,128,469 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11020,336,470 - 20,340,308 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1020,336,247 - 20,340,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660612,116,532 - 2,120,394 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473235,472,760 - 35,477,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473235,473,740 - 35,477,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cxcr4
24 total Variants

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000005143
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat

1 to 10 of 35 rows
D13Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81342,630,718 - 42,631,031 (+)Marker Load Pipeline
mRatBN7.21340,078,310 - 40,078,623 (+)MAPPERmRatBN7.2
Rnor_6.01345,315,287 - 45,315,599NCBIRnor6.0
Rnor_5.01350,394,463 - 50,394,775UniSTSRnor5.0
RGSC_v3.41341,308,620 - 41,308,933RGDRGSC3.4
RGSC_v3.41341,308,621 - 41,308,933UniSTSRGSC3.4
RGSC_v3.11341,322,663 - 41,322,976RGD
Celera1340,447,525 - 40,447,837UniSTS
RH 2.0 Map11096.8RGD
Cytogenetic Map13q12UniSTS
RH129152  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81342,630,441 - 42,630,656 (+)Marker Load Pipeline
mRatBN7.21340,078,033 - 40,078,248 (+)MAPPERmRatBN7.2
Rnor_6.01345,315,010 - 45,315,224NCBIRnor6.0
Rnor_5.01350,394,186 - 50,394,400UniSTSRnor5.0
RGSC_v3.41341,308,344 - 41,308,558UniSTSRGSC3.4
Celera1340,447,248 - 40,447,462UniSTS
Cytogenetic Map13q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005143   ⟹   ENSRNOP00000005143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1340,077,976 - 40,081,883 (-)Ensembl
Rnor_6.0 Ensembl1345,314,933 - 45,318,878 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091514   ⟹   ENSRNOP00000075128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1345,315,215 - 45,318,822 (-)Ensembl
RefSeq Acc Id: NM_022205   ⟹   NP_071541
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81342,630,384 - 42,634,288 (-)NCBI
mRatBN7.21340,077,976 - 40,081,883 (-)NCBI
Rnor_6.01345,314,952 - 45,318,856 (-)NCBI
Rnor_5.01350,394,128 - 50,398,032 (-)NCBI
RGSC_v3.41341,308,286 - 41,312,190 (-)RGD
Celera1340,447,190 - 40,451,093 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272571   ⟹   XP_063128641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81342,630,383 - 42,634,171 (-)NCBI
RefSeq Acc Id: NP_071541   ⟸   NM_022205
- UniProtKB: O08565 (UniProtKB/Swiss-Prot),   F1LPN8 (UniProtKB/Swiss-Prot),   Q8VD47 (UniProtKB/TrEMBL),   A9CMB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005143   ⟸   ENSRNOT00000005143
Ensembl Acc Id: ENSRNOP00000075128   ⟸   ENSRNOT00000091514
RefSeq Acc Id: XP_063128641   ⟸   XM_063272571
- Peptide Label: isoform X1
- UniProtKB: A9CMB9 (UniProtKB/TrEMBL)
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-O08565-F1-model_v2 AlphaFold O08565 1-349 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698797
Promoter ID:EPDNEW_R9307
Type:multiple initiation site
Name:Cxcr4_1
Description:C-X-C motif chemokine receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01345,318,870 - 45,318,930EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18399 BioCyc
Ensembl Genes ENSRNOG00000003866 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005143 ENTREZGENE
  ENSRNOT00000005143.7 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7380432 IMAGE-MGC_LOAD
InterPro Chemokine_CXCR4_N_dom UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  CXCR4/ACKR2 UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:60628 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108696 IMAGE-MGC_LOAD
NCBI Gene 60628 ENTREZGENE
PANTHER C-X-C CHEMOKINE RECEPTOR TYPE 4 UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
  CXCR4_N UniProtKB/Swiss-Prot
PharmGKB CXCR4 RGD
PhenoGen Cxcr4 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot
  CXCCHMKINER4 UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003866 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6IBX5_RAT UniProtKB/TrEMBL
  A9CMB9 ENTREZGENE, UniProtKB/TrEMBL
  CXCR4_RAT UniProtKB/Swiss-Prot
  F1LPN8 ENTREZGENE
  O08565 ENTREZGENE
  Q8VD47 ENTREZGENE
UniProt Secondary F1LPN8 UniProtKB/Swiss-Prot
  Q8VD47 UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cxcr4  C-X-C motif chemokine receptor 4  Cxcr4  chemokine (C-X-C motif) receptor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcr4  chemokine (C-X-C motif) receptor 4    Chemokine receptor (LCR1)  Name updated 1299863 APPROVED
2002-08-07 Cxcr4        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in adult brain, glial cells (astrocytes, microglia but not oligodendrocytes) and neurons 632605
gene_expression mRNA expressed in spleen, liver, heart, and brain 632606
gene_expression in brain, expressed at high levels in ependymal layer and lower levels in cerebral cortex, hippocampus, cerebellum, and brainstem 632606