Mb (myoglobin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Mb (myoglobin) Rattus norvegicus
Analyze
Symbol: Mb
Name: myoglobin
RGD ID: 620411
Description: Enables oxygen binding activity. Involved in several processes, including cellular response to nitric oxide; cold acclimation; and oxygen transport. Located in cytosol and mitochondrion. Used to study acute kidney failure. Biomarker of acute kidney failure; hyperthyroidism; hypothyroidism; iron deficiency anemia; and pulmonary hypertension. Orthologous to human MB (myoglobin); INTERACTS WITH (R,R,R)-alpha-tocopherol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glng; globin g; nitrite reductase MB; pseudoperoxidase MB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mbem6Mcwi
Genetic Models: WKY-Mbem6Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,640,511 - 110,647,742 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7110,640,512 - 110,647,958 (-)EnsemblGRCr8
mRatBN7.27108,759,903 - 108,767,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7110,502,181 - 110,509,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,725,771 - 112,733,003 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,687,217 - 112,694,445 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)Ensemblrn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7105,108,137 - 105,115,366 (-)NCBICelera
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
cerium trichloride  (ISO)
cerivastatin  (EXP)
CGP 52608  (ISO)
ciprofloxacin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corilagin  (EXP)
corticosterone  (EXP)
CU-O LINKAGE  (EXP)
cumene hydroperoxide  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
Echimidine  (EXP)
entinostat  (ISO)
erastin  (ISO)
ethanol  (EXP)
gallic acid  (ISO)
genistein  (EXP,ISO)
glycerol  (EXP)
glyphosate  (EXP)
graphite  (ISO)
Heliotrine  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
rosuvastatin calcium  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sinapic acid  (EXP)
sodium arsenite  (EXP,ISO)
sodium nitrate  (ISO)
succinylcholine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triamcinolone  (EXP)
triclosan  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)
mitochondrion  (IDA)
sarcoplasm  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting. Anwaruddin S, etal., Am J Clin Pathol. 2005 Jan;123(1):140-5.
2. Detection of ferryl myoglobin in the isolated ischemic rat heart. Arduini A, etal., Free Radic Biol Med. 1990;9(6):511-3. doi: 10.1016/0891-5849(90)90130-b.
3. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Boutaud O, etal., Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2699-704. doi: 10.1073/pnas.0910174107. Epub 2010 Feb 1.
4. Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Detweiler CD, etal., Free Radic Biol Med. 2002 Aug 1;33(3):364-9.
5. Myoglobin function and energy metabolism of isolated cardiac myocytes: effect of sodium nitrite. Doeller JE and Wittenberg BA, Am J Physiol. 1991 Jul;261(1 Pt 2):H53-62. doi: 10.1152/ajpheart.1991.261.1.H53.
6. An observational study on rhabdomyolysis in the intensive care unit. Exploring its risk factors and main complication: acute kidney injury. El-Abdellati E, etal., Ann Intensive Care. 2013 Mar 14;3(1):8. doi: 10.1186/2110-5820-3-8.
7. Contribution of myoglobin-induced increases in vascular resistance to shock decompensation in experimental Crush-syndrome in anesthetized rats. Emig U, etal., Shock. 2003 Jan;19(1):79-84.
8. Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. Finch CA, etal., J Clin Invest. 1976 Aug;58(2):447-53. doi: 10.1172/JCI108489.
9. Role of myoglobin in the antioxidant defense of the heart. Flogel U, etal., FASEB J. 2004 Jul;18(10):1156-8. Epub 2004 May 7.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
12. Thyroid hormone stimulates myoglobin gene expression in rat cardiac muscle. Giannocco G, etal., Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26.
13. Immunohistochemical study of myoglobin and oxidative injury-related markers in the kidney of methamphetamine abusers. Ishigami A, etal., Leg Med (Tokyo). 2003 Mar;5(1):42-8. doi: 10.1016/s1344-6223(03)00005-1.
14. Deuterium oxide protects against myocardial injury induced by ischemia and reperfusion in rats. Ishikawa Y, etal., Scand Cardiovasc J. 2019 Dec;53(6):329-336. doi: 10.1080/14017431.2019.1657939. Epub 2019 Aug 28.
15. Release of redox-active iron by muscle crush trauma: no liberation into the circulation. Kerkweg U, etal., Shock. 2010 May;33(5):513-8. doi: 10.1097/SHK.0b013e3181c4f56e.
16. Role of myoglobin as a scavenger of cellular NO in myocardium. Kreutzer U and Jue T, Am J Physiol Heart Circ Physiol 2004 Mar;286(3):H985-91.
17. Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity. Levi MS, etal., Neurotoxicology. 2013 Jul;37:40-50. doi: 10.1016/j.neuro.2013.04.003. Epub 2013 Apr 19.
18. Myoglobin Translational Diffusion in Myocardium and Its Implication on Intracellular Oxygen Transport. Lin PC, etal., J Physiol. 2006 Oct 12;.
19. Myocardial and skeletal muscle function in habitual alcoholics and its relation to serum myoglobin. Lundin L, etal., Am J Cardiol. 1986 Oct 1;58(9):795-9. doi: 10.1016/0002-9149(86)90356-5.
20. The role of myoglobin in retarding oxygen depletion in anoxic heart. Marzouki L, etal., Arch Physiol Biochem. 2002 Dec;110(5):400-7.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. Moore KP, etal., J Biol Chem. 1998 Nov 27;273(48):31731-7.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Myoglobin gene expression attenuates hepatic ischemia reperfusion injury. Nitta T, etal., J Surg Res. 2003 Apr;110(2):322-31.
25. Early loss of myocardial myoglobin detected immunohistochemically following occlusion of the coronary artery in rats. Nomoto K, etal., Exp Mol Pathol. 1987 Dec;47(3):390-402. doi: 10.1016/0014-4800(87)90021-9.
26. Muscle myoglobin as determined by electrophoresis in thermally acclimated rat. Ohno T and Kuroshima A, Jpn J Physiol. 1986;36(4):733-44. doi: 10.2170/jjphysiol.36.733.
27. Proteomic analysis of slow- and fast-twitch skeletal muscles. Okumura N, etal., Proteomics. 2005 Jul;5(11):2896-906.
28. Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Rayner BS, etal., Biochem J. 2009 Sep 25;423(2):169-77. doi: 10.1042/BJ20090716.
29. GOA pipeline RGD automated data pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Association of elevated umbilical cord blood creatine kinase and myoglobin levels with the presence of cocaine metabolites in maternal urine. Roby PV, etal., Am J Perinatol. 1996 Nov;13(8):453-5. doi: 10.1055/s-2007-994427.
32. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Ruan Q, etal., Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3.
33. Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension. Ruiter G, etal., J Heart Lung Transplant. 2013 Feb;32(2):231-40. doi: 10.1016/j.healun.2012.09.025. Epub 2012 Nov 9.
34. Virtual cooperativity in myoglobin oxygen saturation curve in skeletal muscle in vivo. Seiyama A Dyn Med. 2006 Jan 24;5:3.
35. Neonatal hyper- and hypothyroidism alter the myoglobin gene expression program in adulthood. Souza Kde P and Nunes MT, Braz J Med Biol Res. 2014 Aug;47(8):670-8. doi: 10.1590/1414-431x20142875.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle. Takakura H, etal., Sci Rep. 2015 Mar 24;5:9403. doi: 10.1038/srep09403.
38. Evaluation of coronary artery patency using cardiac markers. Tanasijevic MJ J Thromb Thrombolysis. 2005 Feb;19(1):21-4.
39. A Novel Rabbit Anti-Myoglobin Monoclonal Antibody's Potential Application in Rhabdomyolysis Associated Acute Kidney Injury. Wang X, etal., Int J Mol Sci. 2023 Apr 25;24(9):7822. doi: 10.3390/ijms24097822.
40. The contrast of immunohistochemical studies of myocardial fibrinogen and myoglobin in early myocardial ischemia in rats. Xiaohong Z, etal., Leg Med (Tokyo). 2002 Mar;4(1):47-51.
41. Interaction between myoglobin and mitochondria in rat skeletal muscle. Yamada T, etal., J Appl Physiol (1985). 2013 Feb 15;114(4):490-7. doi: 10.1152/japplphysiol.00789.2012. Epub 2012 Nov 29.
42. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
43. [Effects of myocardial ischemia reperfusion injury on L-arginine/nitric oxide system in rat heart] Zheng HZ, etal., Sheng Li Xue Bao. 1999 Feb;51(1):25-30.
Additional References at PubMed
PMID:11304494   PMID:14656764   PMID:15048578   PMID:15489334   PMID:17218454   PMID:17293481   PMID:18492766   PMID:19308875   PMID:19545623   PMID:23533145   PMID:24256333   PMID:26945066  
PMID:27329933   PMID:29476059   PMID:30658240   PMID:35352799  


Genomics

Comparative Map Data
Mb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,640,511 - 110,647,742 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7110,640,512 - 110,647,958 (-)EnsemblGRCr8
mRatBN7.27108,759,903 - 108,767,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7110,502,181 - 110,509,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,725,771 - 112,733,003 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,687,217 - 112,694,445 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)Ensemblrn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7105,108,137 - 105,115,366 (-)NCBICelera
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Cytogenetic Map7q34NCBI
MB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,606,764 - 35,623,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,606,764 - 35,637,951 (-)Ensemblhg38GRCh38
GRCh372236,002,811 - 36,019,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,332,757 - 34,349,347 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342234,327,310 - 34,338,055NCBI
Celera2219,806,063 - 19,822,655 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,963,313 - 18,979,770 (-)NCBIHuRef
CHM1_12235,961,646 - 35,978,237 (-)NCBICHM1_1
T2T-CHM13v2.02236,065,732 - 36,082,323 (-)NCBIT2T-CHM13v2.0
Mb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,899,687 - 76,934,868 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,899,687 - 76,934,870 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381577,015,487 - 77,050,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,015,487 - 77,050,670 (-)Ensemblmm10GRCm38
MGSCv371576,845,917 - 76,881,098 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361576,842,742 - 76,877,923 (-)NCBIMGSCv36mm8
Celera1578,503,595 - 78,538,817 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.36NCBI
Mb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,215,007 - 43,222,052 (-)Ensembl
ChiLan1.0NW_00495540543,215,404 - 43,221,606 (-)NCBIChiLan1.0ChiLan1.0
MB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,546,697 - 45,557,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,243,165 - 48,253,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,612,519 - 16,645,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,452,451 - 34,485,581 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,452,451 - 34,463,224 (-)EnsemblpanPan2panpan1.1
MB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,573,819 - 28,583,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,356,425 - 29,369,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,880,637 - 11,887,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,890,871 - 4,897,665 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,890,871 - 4,897,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MB
(Sus scrofa - pig)		 No map positions available.
MB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,369,234 - 18,385,922 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,369,174 - 18,380,270 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045107,562,452 - 107,578,780 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750259,041 - 266,238 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624750259,559 - 266,124 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11249,357,584 - 249,365,001 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mb
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:50
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000006184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH134536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,759,948 - 108,760,150 (+)MAPPERmRatBN7.2
Rnor_6.07118,101,679 - 118,101,880NCBIRnor6.0
Rnor_5.07118,094,437 - 118,094,638UniSTSRnor5.0
RGSC_v3.47115,087,604 - 115,087,805UniSTSRGSC3.4
Celera7105,108,183 - 105,108,384UniSTS
RH 3.4 Map7800.0UniSTS
Cytogenetic Map7q34UniSTS
MB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,761,978 - 108,762,175 (+)MAPPERmRatBN7.2
Rnor_6.07118,103,709 - 118,103,905NCBIRnor6.0
Rnor_5.07118,096,467 - 118,096,663UniSTSRnor5.0
RGSC_v3.47115,089,634 - 115,089,830UniSTSRGSC3.4
Celera7105,110,213 - 105,110,409UniSTS
Cytogenetic Map7q34UniSTS


Genetic Models
This gene Mb is modified in the following models/strains:
WKY-Mbem6Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 12 62 53 54 57 26 34 26 6 213 127 11 27 41 65 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF197916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF278533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT548174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006184   ⟹   ENSRNOP00000006184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7110,640,512 - 110,647,958 (-)Ensembl
mRatBN7.2 Ensembl7108,759,904 - 108,767,350 (-)Ensembl
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116985   ⟹   ENSRNOP00000092328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)Ensembl
RefSeq Acc Id: NM_021588   ⟹   NP_067599
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,640,511 - 110,647,742 (-)NCBI
mRatBN7.27108,759,903 - 108,767,134 (-)NCBI
Rnor_6.07118,101,633 - 118,108,864 (-)NCBI
Rnor_5.07118,094,391 - 118,101,622 (-)NCBI
RGSC_v3.47115,087,558 - 115,094,789 (-)RGD
Celera7105,108,137 - 105,115,366 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067599 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF05848 (Get FASTA)   NCBI Sequence Viewer  
  AAH70511 (Get FASTA)   NCBI Sequence Viewer  
  EDM15922 (Get FASTA)   NCBI Sequence Viewer  
  EDM15923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006184
  ENSRNOP00000006184.3
GenBank Protein Q9QZ76 (Get FASTA)   NCBI Sequence Viewer  
  SAI82221 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067599   ⟸   NM_021588
- UniProtKB: Q9QZ76 (UniProtKB/Swiss-Prot),   A0A1K0FUB2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006184   ⟸   ENSRNOT00000006184
Ensembl Acc Id: ENSRNOP00000092328   ⟸   ENSRNOT00000116985
Protein Domains
GLOBIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ76-F1-model_v2 AlphaFold Q9QZ76 1-154 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695443
Promoter ID:EPDNEW_R5968
Type:single initiation site
Name:Mb_1
Description:myoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07118,108,894 - 118,108,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620411 AgrOrtholog
BioCyc Gene G2FUF-32892 BioCyc
Ensembl Genes ENSRNOG00000004583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006184 ENTREZGENE
  ENSRNOT00000006184.7 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.2100 UniProtKB/Swiss-Prot
  6.10.140.2110 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103504 IMAGE-MGC_LOAD
InterPro Globin UniProtKB/Swiss-Prot
  Globin-like_sf UniProtKB/Swiss-Prot
  Myoglobin UniProtKB/Swiss-Prot
KEGG Report rno:59108 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91707 IMAGE-MGC_LOAD
NCBI Gene 59108 ENTREZGENE
PANTHER MYOGLOBIN UniProtKB/Swiss-Prot
  PTHR47132 UniProtKB/Swiss-Prot
Pfam Globin UniProtKB/Swiss-Prot
PhenoGen Mb PhenoGen
PRINTS MYOGLOBIN UniProtKB/Swiss-Prot
PROSITE GLOBIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004583 RatGTEx
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot
UniProt A0A1K0FUB2 ENTREZGENE, UniProtKB/TrEMBL
  MYG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mb  myoglobin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mb  myoglobin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may act as a scavenger of cellular Nitric Oxide in the myocardium 1300476