RGD Reference Report - The role of myoglobin in retarding oxygen depletion in anoxic heart. - Rat Genome Database

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The role of myoglobin in retarding oxygen depletion in anoxic heart.

Authors: Marzouki, L  Jarry, G  Janati-Idrissi, R  Amri, M 
Citation: Marzouki L, etal., Arch Physiol Biochem. 2002 Dec;110(5):400-7.
RGD ID: 1582429
Pubmed: PMID:12530625   (View Abstract at PubMed)
DOI: DOI:10.1076/apab.110.5.400.11834   (Journal Full-text)

The present study explores the role of myoglobin (Mb) in retarding the development of anoxia in the perfused working rat heart. We examine this phenomenon by analyzing the behavior and the kinetics of Mb oxygenation and cytochrome aa3 (cytaa3) redoxation. Absorbance changes, measured at wavelength pairs specific to Mb and cytaa3, show parallelism between the Mb oxygenation status and the redox states of cytaa3. Induction of anoxia leads to early and accelerated Mb deoxygenation whereas cytaa3 reduction marks a slight delay and its rate is twice slower than that of Mb. Then, when Mb is desatured above 50%, the cytaa3 reduction becomes accelerated. With the reoxygenated perfusion following the anoxia, the rate of Mb reoxygenation is twice faster than that of the cytaa3 reoxidation. When the oxygen-binding function of Mb, in situ in the heart, is abolished by treatment with sodium nitrite (NaNO2), the redox kinetics of cytaa3 show significant perturbations. Induction of anoxia leads to a precocious and accelerated reduction of cytaa3, compared to the same anoxic heart before the treatment. At reoxygenation, the reoxidation rate of cytaa3 decreases significantly, compared to that before the treatment. Similarly, in the nitrite treated heart, the phosphocreatine (PCr) level decreases to 60% of the control, whereas the inorganic phosphate (Pi) level increases to 300%. ATP concentration, however, remains constant. We conclude from these results that Mb may support mitochondrial respiration at the critical levels of the myocardial O2 supply.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypoxia  ISOMb (Rattus norvegicus)1582429; 1582429 RGD 
Hypoxia  IDA 1582429 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mb  (myoglobin)

Genes (Mus musculus)
Mb  (myoglobin)

Genes (Homo sapiens)
MB  (myoglobin)


Additional Information