MB (myoglobin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MB (myoglobin) Canis lupus familiaris
Analyze
Symbol: MB
Name: myoglobin
RGD ID: 12084946
Description: ENCODES a protein that exhibits nitrite reductase activity (ortholog); oxygen binding (ortholog); oxygen carrier activity (ortholog); INVOLVED IN brown fat cell differentiation (ortholog); enucleate erythrocyte differentiation (ortholog); heart development (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); adenylosuccinase lyase deficiency (ortholog); Coronary Disease (ortholog); FOUND IN sarcoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nitrite reductase MB; pseudoperoxidase MB
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,573,819 - 28,583,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,356,425 - 29,369,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,573,819 - 28,583,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,356,425 - 29,369,888 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBIUU_Cfam_GSD_1.0
MB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,606,764 - 35,623,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,606,764 - 35,637,951 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,002,811 - 36,019,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,332,757 - 34,349,347 (-)NCBINCBI36Build 36hg18NCBI36
Build 342234,327,310 - 34,338,055NCBI
Celera2219,806,063 - 19,822,655 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,963,313 - 18,979,770 (-)NCBIHuRef
CHM1_12235,961,646 - 35,978,237 (-)NCBICHM1_1
T2T-CHM13v2.02236,065,732 - 36,082,323 (-)NCBIT2T-CHM13v2.0
Mb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,899,687 - 76,934,868 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,899,687 - 76,934,870 (-)EnsemblGRCm39 Ensembl
GRCm381577,015,487 - 77,050,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,015,487 - 77,050,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,845,917 - 76,881,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,842,742 - 76,877,923 (-)NCBIMGSCv36mm8
Celera1578,503,595 - 78,538,817 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.36NCBI
Mb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,640,511 - 110,647,742 (-)NCBIGRCr8
mRatBN7.27108,759,903 - 108,767,134 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,759,904 - 108,767,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,502,181 - 110,509,413 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,725,771 - 112,733,003 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,687,217 - 112,694,445 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,101,633 - 118,108,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,101,634 - 118,108,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,094,391 - 118,101,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,087,558 - 115,094,789 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,121,788 - 115,129,019 (-)NCBI
Celera7105,108,137 - 105,115,366 (-)NCBICelera
Cytogenetic Map7q34NCBI
Mb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,215,007 - 43,222,052 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,215,404 - 43,221,606 (-)NCBIChiLan1.0ChiLan1.0
MB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,546,697 - 45,557,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,243,165 - 48,253,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,612,519 - 16,645,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,452,451 - 34,485,581 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,452,451 - 34,463,224 (-)Ensemblpanpan1.1panPan2
Mb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,880,637 - 11,887,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,890,871 - 4,897,665 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,890,871 - 4,897,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MB
(Sus scrofa - pig)		 No map positions available.
MB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,369,234 - 18,385,922 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,369,174 - 18,380,270 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,562,452 - 107,578,780 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750259,041 - 266,238 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750259,559 - 266,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MB
175 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 6
Medium 2 1 1 2
Low 1 9 1 2 9 4
Below cutoff 4 10 5 5 5 6 8 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002669   ⟹   ENSCAFP00000002477
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1028,552,749 - 28,583,522 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000060052   ⟹   ENSCAFP00000044151
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1028,552,749 - 28,582,786 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000073888   ⟹   ENSCAFP00000060770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1028,570,058 - 28,582,786 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078169   ⟹   ENSCAFP00000053123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1028,569,049 - 28,582,786 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090553   ⟹   ENSCAFP00000066045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1028,569,049 - 28,583,522 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845016740   ⟹   ENSCAFP00845013021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1029,356,425 - 29,369,152 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845016807   ⟹   ENSCAFP00845013070
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1029,360,388 - 29,369,888 (+)Ensembl
RefSeq Acc Id: XM_005625921   ⟹   XP_005625978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11028,573,819 - 28,583,526 (+)NCBI
Dog10K_Boxer_Tasha1028,513,611 - 28,523,318 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038488771   ⟹   XP_038344699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11029,085,598 - 29,095,292 (+)NCBI
RefSeq Acc Id: XM_038550726   ⟹   XP_038406654
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01029,575,155 - 29,584,857 (+)NCBI
RefSeq Acc Id: XM_038614651   ⟹   XP_038470579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01029,394,667 - 29,404,374 (+)NCBI
RefSeq Acc Id: XM_038680024   ⟹   XP_038535952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01029,360,185 - 29,369,892 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005625978   ⟸   XM_005625921
- UniProtKB: P63113 (UniProtKB/Swiss-Prot),   P02158 (UniProtKB/Swiss-Prot),   A0A1K0GV43 (UniProtKB/TrEMBL),   A0A8C0QVD5 (UniProtKB/TrEMBL),   A0A8P0N4T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000044151   ⟸   ENSCAFT00000060052
RefSeq Acc Id: ENSCAFP00000060770   ⟸   ENSCAFT00000073888
RefSeq Acc Id: ENSCAFP00000053123   ⟸   ENSCAFT00000078169
RefSeq Acc Id: ENSCAFP00000066045   ⟸   ENSCAFT00000090553
RefSeq Acc Id: ENSCAFP00000002477   ⟸   ENSCAFT00000002669
RefSeq Acc Id: XP_038344699   ⟸   XM_038488771
RefSeq Acc Id: XP_038470579   ⟸   XM_038614651
RefSeq Acc Id: XP_038535952   ⟸   XM_038680024
- UniProtKB: P63113 (UniProtKB/Swiss-Prot),   P02158 (UniProtKB/Swiss-Prot),   A0A1K0GV43 (UniProtKB/TrEMBL),   A0A8C0QVD5 (UniProtKB/TrEMBL),   A0A8P0N4T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406654   ⟸   XM_038550726
- UniProtKB: P63113 (UniProtKB/Swiss-Prot),   P02158 (UniProtKB/Swiss-Prot),   A0A1K0GV43 (UniProtKB/TrEMBL),   A0A8C0QVD5 (UniProtKB/TrEMBL),   A0A8P0N4T5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013070   ⟸   ENSCAFT00845016807
RefSeq Acc Id: ENSCAFP00845013021   ⟸   ENSCAFT00845016740
Protein Domains
Globin family profile

Promoters
RGD ID:13684995
Promoter ID:EPDNEW_C3062
Type:multiple initiation site
Name:MB_1
Description:myoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11028,574,004 - 28,574,064EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001705 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006718 UniProtKB/TrEMBL
  ENSCAFG00040005219 UniProtKB/TrEMBL
  ENSCAFG00845009496 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002669.5 UniProtKB/TrEMBL
  ENSCAFT00000073888.2 UniProtKB/TrEMBL
  ENSCAFT00030012446.1 UniProtKB/TrEMBL
  ENSCAFT00040009854.1 UniProtKB/TrEMBL
  ENSCAFT00845016740.1 UniProtKB/TrEMBL
  ENSCAFT00845016807 ENTREZGENE
  ENSCAFT00845016807.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.2100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.2110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Globin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:608715 UniProtKB/TrEMBL
NCBI Gene MB ENTREZGENE
PANTHER MYOGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47132 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Globin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MYOGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1K0GV43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MLJ4_CANLF UniProtKB/TrEMBL
  A0A8C0QVD5 ENTREZGENE
  A0A8I3NE77_CANLF UniProtKB/TrEMBL
  A0A8P0N4T5 ENTREZGENE, UniProtKB/TrEMBL
  MYG_CANLF UniProtKB/Swiss-Prot
  P02158 ENTREZGENE
  P63113 ENTREZGENE
UniProt Secondary P02158 UniProtKB/Swiss-Prot
VGNC ID VGNC:43046 ENTREZGENE