Cyth2 (cytohesin 2) - Rat Genome Database

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Gene: Cyth2 (cytohesin 2) Rattus norvegicus
Analyze
Symbol: Cyth2
Name: cytohesin 2
RGD ID: 620398
Description: Predicted to enable guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Involved in negative regulation of dendrite development. Located in ruffle. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human CYTH2 (cytohesin 2); PARTICIPATES IN Arf family mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARF nucleotide binding site opener; ARF nucleotide-binding site opener; Arno; CLM2; cytohesin-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; pleckstrin homology, Sec7 and coiled/coil domains 2; Pscd2; Sec7; SEC7 homolog B; Sec7B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,419,631 - 105,427,542 (-)NCBIGRCr8
mRatBN7.2196,283,182 - 96,291,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,284,252 - 96,291,092 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,669,326 - 101,677,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,141,308 - 110,149,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,431,683 - 103,439,594 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,796,349 - 101,803,407 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,796,349 - 101,803,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,875,334 - 102,882,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,284,658 - 96,291,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,362,775 - 96,369,565 (-)NCBI
Celera190,536,747 - 90,543,596 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Regulation of dendritic development by the ARF exchange factor ARNO. Hernandez-Deviez DJ, etal., Nat Neurosci 2002 Jul;5(7):623-4.
3. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Localization of mRNAs for subfamily of guanine nucleotide-exchange proteins (GEP) for ARFs (ADP-ribosylation factors) in the brain of developing and mature rats under normal and postaxotomy conditions. Suzuki I, etal., Brain Res Mol Brain Res 2002 Jan 31;98(1-2):41-50.
12. Rat homologues of yeast sec7p. Telemenakis I, etal., Eur J Cell Biol. 1997 Oct;74(2):143-9.
13. Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity. Venkateswarlu K J Biol Chem 2003 Oct 31;278(44):43460-9. Epub 2003 Aug 14.
Additional References at PubMed
PMID:12586822   PMID:15359279   PMID:17398095   PMID:17897316   PMID:18042453   PMID:20080746   PMID:21276423   PMID:23288846  


Genomics

Comparative Map Data
Cyth2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,419,631 - 105,427,542 (-)NCBIGRCr8
mRatBN7.2196,283,182 - 96,291,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,284,252 - 96,291,092 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,669,326 - 101,677,237 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,141,308 - 110,149,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,431,683 - 103,439,594 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,796,349 - 101,803,407 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,796,349 - 101,803,200 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,875,334 - 102,882,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,284,658 - 96,291,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,362,775 - 96,369,565 (-)NCBI
Celera190,536,747 - 90,543,596 (-)NCBICelera
Cytogenetic Map1q22NCBI
CYTH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,469,369 - 48,482,314 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,469,208 - 48,482,314 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,972,626 - 48,985,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,664,424 - 53,674,457 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,664,423 - 53,674,457NCBI
Celera1945,837,706 - 45,850,811 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,352,658 - 45,365,766 (+)NCBIHuRef
CHM1_11948,974,285 - 48,987,392 (+)NCBICHM1_1
T2T-CHM13v2.01951,463,531 - 51,476,477 (+)NCBIT2T-CHM13v2.0
Cyth2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,456,058 - 45,463,857 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,456,061 - 45,464,005 (-)EnsemblGRCm39 Ensembl
GRCm38745,806,637 - 45,814,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,806,637 - 45,814,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,062,007 - 53,069,686 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,674,679 - 45,682,328 (-)NCBIMGSCv36mm8
Celera741,270,769 - 41,278,444 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.52NCBI
Cyth2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555592,014,740 - 2,021,891 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555592,014,740 - 2,021,234 (-)NCBIChiLan1.0ChiLan1.0
CYTH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,574,668 - 54,585,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,500,996 - 56,511,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,471,277 - 45,481,350 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,063,497 - 54,072,676 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,063,560 - 54,073,017 (+)Ensemblpanpan1.1panPan2
CYTH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,794,560 - 107,803,345 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,794,560 - 107,803,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,316,439 - 107,324,675 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,319,539 - 108,327,772 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,319,538 - 108,327,992 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,985,663 - 107,993,894 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,632,979 - 107,641,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,468,837 - 108,477,074 (-)NCBIUU_Cfam_GSD_1.0
Cyth2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934920,948,752 - 20,957,005 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,556,750 - 2,577,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,566,744 - 2,575,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYTH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,868,409 - 53,878,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,869,475 - 53,878,856 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,539,911 - 49,549,295 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYTH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,730,710 - 41,741,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,730,589 - 41,744,435 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,515,518 - 21,525,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cyth2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,335,168 - 5,342,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyth2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:102
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000028588
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
RH140625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,284,471 - 96,284,757 (+)MAPPERmRatBN7.2
Rnor_6.01101,796,569 - 101,796,854NCBIRnor6.0
Rnor_5.01102,875,554 - 102,875,839UniSTSRnor5.0
RGSC_v3.4196,284,878 - 96,285,163UniSTSRGSC3.4
Celera190,536,967 - 90,537,252UniSTS
RH 3.4 Map1963.7UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 7 10 74 35 41 11 7
Low 1 1 1 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028588   ⟹   ENSRNOP00000028588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,284,252 - 96,291,090 (-)Ensembl
Rnor_6.0 Ensembl1101,796,349 - 101,803,200 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100389   ⟹   ENSRNOP00000097083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,284,259 - 96,290,738 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115939   ⟹   ENSRNOP00000087507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,284,260 - 96,291,092 (-)Ensembl
RefSeq Acc Id: NM_001395066   ⟹   NP_001381995
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,419,631 - 105,427,542 (-)NCBI
mRatBN7.2196,283,182 - 96,291,094 (-)NCBI
RefSeq Acc Id: NM_053911   ⟹   NP_446363
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,419,631 - 105,427,542 (-)NCBI
mRatBN7.2196,283,182 - 96,291,094 (-)NCBI
Rnor_6.01101,796,349 - 101,803,186 (-)NCBI
Rnor_5.01102,875,334 - 102,882,766 (-)NCBI
RGSC_v3.4196,284,658 - 96,291,450 (-)RGD
Celera190,536,747 - 90,543,596 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_446363   ⟸   NM_053911
- Peptide Label: isoform 1
- UniProtKB: P63035 (UniProtKB/Swiss-Prot),   F1LSU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028588   ⟸   ENSRNOT00000028588
RefSeq Acc Id: ENSRNOP00000097083   ⟸   ENSRNOT00000100389
RefSeq Acc Id: ENSRNOP00000087507   ⟸   ENSRNOT00000115939
RefSeq Acc Id: NP_001381995   ⟸   NM_001395066
- Peptide Label: isoform 2
- UniProtKB: F1LSU6 (UniProtKB/TrEMBL)
Protein Domains
PH   SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63035-F1-model_v2 AlphaFold P63035 1-400 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690053
Promoter ID:EPDNEW_R578
Type:initiation region
Name:Cyth2_1
Description:cytohesin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,803,142 - 101,803,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620398 AgrOrtholog
BioCyc Gene G2FUF-59646 BioCyc
Ensembl Genes ENSRNOG00000021051 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006702 UniProtKB/Swiss-Prot
  ENSRNOG00060010648 UniProtKB/Swiss-Prot
  ENSRNOG00065031527 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028588 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000028588.7 UniProtKB/Swiss-Prot
  ENSRNOT00000100389.1 UniProtKB/TrEMBL
  ENSRNOT00000115939.1 UniProtKB/TrEMBL
  ENSRNOT00055010954 UniProtKB/Swiss-Prot
  ENSRNOT00060018075 UniProtKB/Swiss-Prot
  ENSRNOT00065054392 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1000.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096614 IMAGE-MGC_LOAD
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116692 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91551 IMAGE-MGC_LOAD
NCBI Gene 116692 ENTREZGENE
PANTHER CYTOHESIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyth2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEC7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021051 RatGTEx
  ENSRNOG00055006702 RatGTEx
  ENSRNOG00060010648 RatGTEx
  ENSRNOG00065031527 RatGTEx
SMART Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5Z0_RAT UniProtKB/TrEMBL
  A0A8I6AS05_RAT UniProtKB/TrEMBL
  CYH2_RAT UniProtKB/Swiss-Prot
  F1LSU6 ENTREZGENE, UniProtKB/TrEMBL
  P63035 ENTREZGENE
UniProt Secondary O89099 UniProtKB/Swiss-Prot
  P97695 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-04 Cyth2  cytohesin 2  Pscd2  pleckstrin homology, Sec7 and coiled-coil domains 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pscd2  pleckstrin homology, Sec7 and coiled-coil domains 2    pleckstrin homology, Sec7 and coiled/coil domains 2  Name updated 1299863 APPROVED
2004-12-14 Pscd2  pleckstrin homology, Sec7 and coiled/coil domains 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pscd2  pleckstrin homology, Sec7 and coiled/coil domains 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to membrane fractions of cells at the embryonic stage 625544
gene_expression expressed in embryonic and adult hippocampus 625544
gene_function functions as an ARF regulator acting as a GTP exchange factor for ARF1 and ARF6 625544
gene_homology has homology to S. cerevisiae sec7p 729512
gene_pathway upstream to ARF6 pathway 625544
gene_process may play an important role in the regulation of dendritic development and branching 625544