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Gene: Cyth1 (cytohesin 1) Rattus norvegicus

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Symbol:

Cyth1

Name:

cytohesin 1

RGD ID:

620397

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in presynaptic modulation of chemical synaptic transmission. Is active in neuromuscular junction. Is extrinsic component of presynaptic membrane. Orthologous to human CYTH1 (cytohesin 1); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cytohesin-1; PH, SEC7 and coiled-coil domain-containing protein 1; pleckstrin homology Sec7 and coiled/coil domains 1(cytohesin 1); pleckstrin homology, Sec7 and coiled-coil domains 1; pleckstrin homology, Sec7 and coiled/coil domains 1; pleckstrin homology, Sec7 and coiled/coil domains 1(cytohesin 1); Pscd1; rSec7-1; Sec7; SEC7 homolog A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYTH1 (cytohesin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Treefam
Mus musculus (house mouse):	Cyth1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cyth1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CYTH1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYTH1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cyth1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYTH1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYTH1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cyth1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cyth1 (cytohesin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CYTH2 (cytohesin 2)	HGNC	OrthoDB
Homo sapiens (human):	CYTH4 (cytohesin 4)	HGNC	OrthoDB
Homo sapiens (human):	CYTH3 (cytohesin 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CYTH1 (cytohesin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cyth1 (cytohesin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyth1b (cytohesin 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyth1b (cytohesin 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyth1a (cytohesin 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	grp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	step	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	step	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SYT1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cyth1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cyth2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	103,901,376 - 103,984,496 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	103,864,804 - 103,984,383 (-)	Ensembl				GRCr8
mRatBN7.2	10	103,402,727 - 103,485,826 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	103,366,145 - 103,485,760 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	108,504,648 - 108,586,066 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	107,967,775 - 108,049,197 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	103,325,189 - 103,406,482 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	107,197,983 - 107,281,285 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	107,197,989 - 107,281,235 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	106,832,873 - 106,916,383 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	108,189,311 - 108,253,419 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	101,964,776 - 102,046,060 (-)	NCBI		Celera
RGSC_v3.1	10	108,203,814 - 108,267,923 (-)	NCBI
Cytogenetic Map	10	q32.2-q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

8-Br-cAMP (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

belinostat (ISO)

benzene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

Bufotalin (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

carmustine (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

flavonoids (EXP)

genistein (EXP,ISO)

gold atom (ISO)

gold(0) (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methamphetamine (ISO)

N,N-diethyl-m-toluamide (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (EXP,ISO)

zinc(0) (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of epithelial cell polarity (ISO,ISS)

presynaptic modulation of chemical synaptic transmission (IDA,IMP)

regulation of ARF protein signal transduction (IEA)

regulation of cell adhesion (ISO)

vesicle-mediated transport (IBA)

Cellular Component

adherens junction (IEA)

bicellular tight junction (IEA,ISO,ISS)

cell junction (IEA)

cytoplasm (IEA,ISO)

cytoplasmic side of plasma membrane (ISO,ISS)

cytosol (IEA,ISO,ISS)

extrinsic component of presynaptic membrane (IDA,IMP)

extrinsic component of synaptic membrane (IEA)

neuromuscular junction (IDA,IMP)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO,ISS)

lipid binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1.	Ashery U, etal., Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1094-9.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate.	Stricker R, etal., Biochim Biophys Acta 2003 Sep 23;1651(1-2):102-15.
8.	Rat homologues of yeast sec7p.	Telemenakis I, etal., Eur J Cell Biol. 1997 Oct;74(2):143-9.

Additional References at PubMed

PMID:10652308	PMID:12477932	PMID:12606567	PMID:17398095	PMID:18042453	PMID:20080746	PMID:25931508	PMID:29420262

Genomics

Comparative Map Data

Cyth1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	103,901,376 - 103,984,496 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	103,864,804 - 103,984,383 (-)	Ensembl				GRCr8
mRatBN7.2	10	103,402,727 - 103,485,826 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	103,366,145 - 103,485,760 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	108,504,648 - 108,586,066 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	107,967,775 - 108,049,197 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	103,325,189 - 103,406,482 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	107,197,983 - 107,281,285 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	107,197,989 - 107,281,235 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	106,832,873 - 106,916,383 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	108,189,311 - 108,253,419 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	101,964,776 - 102,046,060 (-)	NCBI		Celera
RGSC_v3.1	10	108,203,814 - 108,267,923 (-)	NCBI
Cytogenetic Map	10	q32.2-q32.3	NCBI

CYTH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	78,674,048 - 78,782,273 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	78,674,048 - 78,782,298 (-)	Ensembl			hg38	GRCh38
GRCh37	17	76,670,130 - 76,778,355 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	74,181,725 - 74,289,971 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	74,181,726 - 74,289,971	NCBI
Celera	17	73,266,644 - 73,376,096 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	72,092,940 - 72,200,967 (-)	NCBI		HuRef
CHM1_1	17	76,733,895 - 76,842,282 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	79,568,970 - 79,677,073 (-)	NCBI		T2T-CHM13v2.0

Cyth1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	118,054,996 - 118,139,452 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	118,022,845 - 118,139,386 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	118,164,170 - 118,248,616 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	118,132,019 - 118,248,592 (-)	Ensembl			mm10	GRCm38
MGSCv37	11	118,025,480 - 118,109,906 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	117,980,265 - 118,064,650 (-)	NCBI		MGSCv36	mm8
Celera	11	129,909,098 - 129,993,513 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	82.96	NCBI

Cyth1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	3,920,807 - 3,984,146 (+)	Ensembl
ChiLan1.0	NW_004955506	3,920,803 - 3,997,012 (+)	NCBI	ChiLan1.0	ChiLan1.0

CYTH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	94,722,058 - 94,830,553 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	99,551,796 - 99,660,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	72,749,310 - 72,857,992 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	78,295,437 - 78,358,662 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	78,295,437 - 78,358,735 (-)	Ensembl			panPan2	panpan1.1

CYTH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	2,636,553 - 2,677,356 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	2,605,084 - 2,675,661 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	3,256,600 - 3,334,363 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	3,250,463 - 3,328,274 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	3,250,242 - 3,326,578 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	3,273,781 - 3,351,532 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	3,398,418 - 3,476,204 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	3,479,378 - 3,557,189 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cyth1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	3,259,592 - 3,295,412 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	3,116,541 - 3,152,361 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	3,116,547 - 3,147,992 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYTH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	3,356,245 - 3,432,641 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	3,356,265 - 3,432,644 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	3,396,111 - 3,464,765 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYTH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	70,652,979 - 70,755,697 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	70,652,860 - 70,713,199 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	41,782,888 - 41,885,822 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cyth1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	8,064,012 - 8,165,701 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624801	8,064,205 - 8,165,672 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cyth1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	65,806,232 - 65,887,806 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cyth1
722 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	316
Count of miRNA genes:	183
Interacting mature miRNAs:	227
Transcripts:	ENSRNOT00000004196
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93723381	107556066	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
1576313	Pia25	Pristane induced arthritis QTL 25			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	97202388	107556066	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1576307	Cia28	Collagen induced arthritis QTL 28			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91727883	107713808	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	97202388	107556066	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U83895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004196 ⟹ ENSRNOP00000004196

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	103,901,377 - 103,984,383 (-)	Ensembl
mRatBN7.2 Ensembl	10	103,402,728 - 103,485,760 (-)	Ensembl
Rnor_6.0 Ensembl	10	107,197,989 - 107,281,235 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082529 ⟹ ENSRNOP00000075144

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	103,864,804 - 103,984,383 (-)	Ensembl
mRatBN7.2 Ensembl	10	103,366,145 - 103,485,760 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108086 ⟹ ENSRNOP00000093390

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	103,901,377 - 103,948,121 (-)	Ensembl
mRatBN7.2 Ensembl	10	103,402,728 - 103,485,760 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000166720 ⟹ ENSRNOP00000109533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	103,901,377 - 103,928,054 (-)	Ensembl

RefSeq Acc Id:

NM_053910 ⟹ NP_446362

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	103,903,088 - 103,984,383 (-)	NCBI
mRatBN7.2	10	103,404,439 - 103,485,760 (-)	NCBI
Rnor_6.0	10	107,199,695 - 107,281,235 (-)	NCBI
Rnor_5.0	10	106,832,873 - 106,916,383 (-)	NCBI
RGSC_v3.4	10	108,189,311 - 108,253,419 (-)	RGD
Celera	10	101,964,776 - 102,046,060 (-)	RGD

Sequence:

show sequence

GCGAGCTGGTGTCTGGCAGGACGCGGGCTGCGGGAGGTCAGTGGCGGTCGGTGGCCGGAGTCGG
TCGCCGGCACCATGGAGGACGATGACAGCTATGTCCCCAGTGACCTGACTGCAGAGGAGCGTCA
AGAACTGGAGAACATCCGGCGGAGGAAGCAGGAGCTGCTGGCTGACATCCAGAGGCTGAAGGAA
GAGATAGCAGAGGTTGCTAATGAAATTGAAAGCCTGGGATCCACAGAGGAACGGAAAAACATGC
AGAGGAACAAACAGGTAGCCATGGGCAGAAAGAAATTCAACATGGATCCTAAGAAGGGGATCCA
GTTCTTAATCGAGAATGGCCTGCTGAAAAACACTTGTGAGGACATTGCCCAGTTCCTGTATAAA
GGGGAAGGGCTCAACAAAACAGCCATCGGTGACTACCTTGGGGAGAGAGATGAGTTCAGCATCC
AGGTCTTGCATGCATTTGTGGAGCTGCACGAGTTCACCGACCTGAACCTCGTCCAGGCCTTGCG
GCAGTTCCTGTGGAGCTTCCGGCTCCCTGGAGAGGCCCAGAAGATTGACCGGATGATGGAGGCC
TTTGCGCAGCGGTACTGTCAGTGCAATACTGGGGTGTTCCAGTCTACAGACACTTGCTATGTCC
TGTCCTTTGCAATCATCATGCTGAACACCAGCCTACACAACCCCAACGTCAAAGACAAGCCTAC
GGTGGAGAGGTTCATCGCCATGAACCGAGGCATCAATGACGGAGGAGACCTGCCCGAGGAGCTG
CTGCGGAATCTCTATGAGAGCATCAAAAACGAACCCTTTAAAATCCCAGAAGATGACGGCAATG
ATCTCACTCACACTTTCTTCAATCCAGACCGAGAGGGCTGGCTACTAAAGCTCGGAGGTGGCAG
GGTAAAGACTTGGAAGAGGCGCTGGTTCATTCTGACTGACAACTGCCTTTACTACTTTGAATAC
ACCACGGACAAAGAGCCCCGCGGGATCATCCCCCTGGAGAACCTGAGTATCCGAGAGGTGGAAG
ACTCCAAGAAGCCGAACTGCTTTGAGCTTTATATCCCTGACAATAAAGACCAGGTGATTAAGGC
CTGCAAGACAGAGGCTGACGGACGAGTGGTGGAAGGGAACCACACTGTGTACCGCATCTCGGCC
CCCACTCCTGAGGAGAAGGAAGACTGGATCAAGTGCATCAAAGCCGCCATCAGCAGAGACCCGT
TCTACGAGATGCTTGCAGCACGGAAAAAGAAGGTCTCCTCCACAAAGAGGCACTGAGGGTGCAC
CAGGGCACGGCCAGCCCGTGAAGCTGTGGCCCCTTCTCCTGCCTCCCCTGAGGGCGCTGTGGAG
CCCAGCAGAGGAGAGCAGAGGGCTTCTCTGCCAGTTCCTGCCCACTCCGCTCCTA

hide sequence

RefSeq Acc Id:

XM_006247784 ⟹ XP_006247846

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	103,901,376 - 103,984,496 (-)	NCBI
mRatBN7.2	10	103,402,727 - 103,485,826 (-)	NCBI
Rnor_6.0	10	107,197,983 - 107,281,285 (-)	NCBI
Rnor_5.0	10	106,832,873 - 106,916,383 (-)	NCBI

Sequence:

show sequence

TGCGGGCGCGGTGCGGGGGGCGGGGCTCCGCGGTTCGTAGCTGGACTGTGGCGAGCTGGTGTCT
GGCAGGACGCGGGCTGCGGGAGGTCAGTGGCGGTCGGTGGCCGGAGTCGGTCGCCGGCACCATG
GAGGACGATGACAGCTATGTCCCCAGTGACCTGACTGCAGAGGAGCGTCAAGAACTGGAGAACA
TCCGGCGGAGGAAGCAGGAGCTGCTGGCTGACATCCAGAGGCTGAAGGAAGAGATAGCAGAGGT
TGCTAATGAAATTGAAAGCCTGGGATCCACAGAGGAACGGAAAAACATGCAGAGGAACAAACAG
GTAGCCATGGGCAGAAAGAAATTCAACATGGATCCTAAGAAGGGGATCCAGTTCTTAATCGAGA
ATGGCCTGCTGAAAAACACTTGTGAGGACATTGCCCAGTTCCTGTATAAAGGGGAAGGGCTCAA
CAAAACAGCCATCGGTGACTACCTTGGGGAGAGAGATGAGTTCAGCATCCAGGTCTTGCATGCA
TTTGTGGAGCTGCACGAGTTCACCGACCTGAACCTCGTCCAGGCCTTGCGGCAGTTCCTGTGGA
GCTTCCGGCTCCCTGGAGAGGCCCAGAAGATTGACCGGATGATGGAGGCCTTTGCGCAGCGGTA
CTGTCAGTGCAATACTGGGGTGTTCCAGTCTACAGACACTTGCTATGTCCTGTCCTTTGCAATC
ATCATGCTGAACACCAGCCTACACAACCCCAACGTCAAAGACAAGCCTACGGTGGAGAGGTTCA
TCGCCATGAACCGAGGCATCAATGACGGAGGAGACCTGCCCGAGGAGCTGCTGCGGAATCTCTA
TGAGAGCATCAAAAACGAACCCTTTAAAATCCCAGAAGATGACGGCAATGATCTCACTCACACT
TTCTTCAATCCAGACCGAGAGGGCTGGCTACTAAAGCTCGGTGGCAGGGTAAAGACTTGGAAGA
GGCGCTGGTTCATTCTGACTGACAACTGCCTTTACTACTTTGAATACACCACGGACAAAGAGCC
CCGCGGGATCATCCCCCTGGAGAACCTGAGTATCCGAGAGGTGGAAGACTCCAAGAAGCCGAAC
TGCTTTGAGCTTTATATCCCTGACAATAAAGACCAGGTGATTAAGGCCTGCAAGACAGAGGCTG
ACGGACGAGTGGTGGAAGGGAACCACACTGTGTACCGCATCTCGGCCCCCACTCCTGAGGAGAA
GGAAGACTGGATCAAGTGCATCAAAGCCGCCATCAGCAGAGACCCGTTCTACGAGATGCTTGCA
GCACGGAAAAAGAAGGTCTCCTCCACAAAGAGGCACTGAGGGTGCACCAGGGCACGGCCAGCCC
GTGAAGCTGTGGCCCCTTCTCCTGCCTCCCCTGAGGGCGCTGTGGAGCCCAGCAGAGGAGAGCA
GAGGGCTTCTCTGCCAGTTCCTGCCCACTCCGCTCCTAGAGACTTGCTTCAGCTTTTGCAGTTT
TCTAAGTGGGAGACGGGTGGGTGGGCGGAGAGGGCTCAGCTGGAGACGCTGCCCCACTCATGGG
CTCTGGAGCTGCTCAGAACCAGCGCTGCTTCACCGCCTCAGCTCAGCAGGACTGAGGGCACCGC
AGGGAGCTGGCTCTTTACCTCTAAGTGTTCCTGGCCCAGGGCCTTCACCTCTGCTCCATGAATG
CCTGTGAGGATGTACTCTTATGTACTGAGGAGAGAGGAGGAAAGGAAGAGAAGCCACACACTAT
AAAGATTTATTTTTGTTTTTTAAAGCAAAAGTGAACGTAGCACTGTTCTCTGCCCTCCTGTGCC
CTGCTTAGGGAGCGTCCCCTAAAAAGGGGGCTCTGGGGCTGCGGGCACCCCAGGGGCTGCTGCC
TCATGACTGTGTGGGCAAGAGGGGCAGAAGCAGGATTGCTGGCAGGGCCCAGCAGACACGGGGA
GGCCTCAGGGCCCCAGCAGGGCAGCAGGCAGGCAGTATGGGCAGCTCCCACTCAGTGCCTGTGG
GACAGGGTGAAGGTGGTTAGCGCCTTGCCCGGCCCTCAGTACCCAGGCCCACTGCTCTTTAAAA
TGGAAAGTCTTCATTTTCCTAATAACCAAAACTGTGAGGAGCTCACCCATGGTGCTGGGTGGCG
ACTGTTTCATAGCTGGTTTTTCTTTCTCCTCCCCAAGAGCTCCACTCCTCGTTCTAGAGGAAGG
AGCAGGTCTTACCTGATCCCCTTGGGGCTTCAGCCTTTTCTGCCTCAAAAGCTGCCCCAACTGG
ACTATTCTGGTGCACTCTGTGGTAGCCTCCAGGAGCAGGGGCCTTGCTCAGTAGGTTGCAGTGC
AGTCAGGCAAGGGTAAGGTGGCCTTTTTGTCCCCTGCCCTCTATGGCATGGCATACCACAGCAC
ACACATGAGTGAACCCTGGCCTCCTAACTCAGTGTGAAGGGAGCCATGAAACGCAGCATCTCCT
GCCGTTCTCTCAGGGACTCTCAAGGGCAGCTCCTGTTCCTTGGCCAGGGCTAGCATGCCAGTCT
AGGCAGAGCAGGTGGCAGGTGATGTCTTGGCACACTCCTCCACATGGCCAAGGCCTTGGTGGCA
GAATGCTGCCTCCAGGCAGGTGGAGGAGCCATGGGTCCCCACTGGGCTGTGTGAGCTCAGCCTC
TGATCTCAGAAGGAGGTCAGCATCTCTGGAAATAGCTTTGCAGAGAAGGGTGGGGGTGGGGGTA
GCACTCGGTCCCTCCTGTGGATCCAGCAGGATCCGGCCTCGAGTGGCTTTAGGTGCTCGATGCT
CAGTGTGTGAAGGTGACAGTGACTGCTGAGGTCCAGGCTGGAAACCTGAGCCTCCTGCCACAGA
GCCAGTCAATGCCTGCCCAGGCTGTGTGGGGAGTCAGGCCAGTGCCGGAGCCCCTCCTGCACAC
GGGTTCTCACAGGTGTGTCCCAGGCAGGCCCACACGGCTCAGCGTCAGTCTATTTATCAGAGGT
GTACATAATCCACACATAGTTTTTCTCCTTTTAGATTATTTTGTATTTGTTTAAAAAAAGATTT
GTCAAAATACAAAGAAATGACTGAAACTTGTTGACAGGGTTTTTAAAAAATATTATTATTATTA
TTATTATTGTTGTTGTTGTTTCGTTTTTGCCTTGTAAACTAGCTCCAAGGAACTGCAGCAAATA
AACTCCAAATCTGCCCAAACCA

hide sequence

RefSeq Acc Id:

XM_006247785 ⟹ XP_006247847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	103,901,376 - 103,938,511 (-)	NCBI
mRatBN7.2	10	103,402,727 - 103,442,055 (-)	NCBI
Rnor_6.0	10	107,197,983 - 107,236,534 (-)	NCBI
Rnor_5.0	10	106,832,873 - 106,916,383 (-)	NCBI

Sequence:

show sequence

AGGCAAGCGCTCTACCACTGAGCTACTACCCCAGCCCCGAGCCATGCACTCTTAAAGAACTCTG
GCTTAGTTCAGTGATGCATTTTCTGTTTTCTTTCCCTTCTTATTTGGTGCATGTTTAAGAGCCC
CCTCTCCCCTTCACAGCCCCAAGCAGTGCTTCTTGAGTCAGCAGTCAGTCACCTTGTAGCCCTT
CAGTATCAGGTCTGGACCTGTGGAATCTCTGTCCTGGGCCCGGGATCCCAGTTGGCTAGCCTAG
TAGGTATCCTTGTGACCCTTGCAGTCCTTGAAGAATCAGAGATACTGCTTGTGCCTAGGATGTA
GCCATGTCCCCTGTCACCAGCCATCTCGCACAGTCACCCCCAGAAGGTGACTGCCTAACCCTAC
CCTGCCCTGCCCTGCTACCCAGCGCACTTAGCAAGCATGGTTCACACATGCCTCTGGTAAAGAA
CACATGGGTAGCAGCACACATGTACAGCAGAAGAGAGAAAGGCTGCAGTATCCCAGGAGGAGGC
AGAGGGAGGAGATTCTCCAGGGGTGGGTCTTGTAGGATGCTGCCTCCCAAGACCCTCCCAGATG
GCGTGTATGGGGGAGCAGGCTGGTCTGATGTAGGACTGGCACAAGGACTGAGATTATGCCGACT
TAGGTAATAGATGTTTGACCCCGATCTAGTCTGTTTGAGCCGACATCTTAAGTAAGGGTTATCC
CCTTCCTGGAGAGAGCAACCGCCAAGCTTTGCTTCTGAGGGGAAGAAGAAAGCAAGCGCAGCCT
ATGAGCAAACGCTAGCAGTGCCTCCCCTCCCCCAGGAGGCCAGGAAGAGGGTAGTAGGAGGGGC
GGTGTGATTACATTCATGGAAATGAGCCTGCTAGGAGAGGAGTCGCGCACACCGAGTGTCAGCT
GCTGCTGCAGCTCCGTGCACCATCCCCATCCCCGGGGCTGTGCCAGCCTTCCCCACCAGGCTCT
GTTCACTCCCGCCCGCTGTTTGGCCATTCGGCTTTTGTCTCCTCTGGACGCCTCCTCCCCTGCC
CTTGTGTGCTGGCACACAAATGCTGTCCTGACTCCAGCTCTCCCTGAACCCAGAGCTGGGAGAG
CTCCGGGGAGCCTGGGCCTGTGGGATTGCTGTACAGATCCACCATGGCCTCTGACTGGAGAACT
GCGGATCAGCTGAGGCTTTGATGTTGCTGCCCAGAGCTTGACAGGACGAGGGGGCCACAGGAGA
GGGGACACGCTGCCGTCCCCAGTGACCTGACTGCAGAGGAGCGTCAAGAACTGGAGAACATCCG
GCGGAGGAAGCAGGAGCTGCTGGCTGACATCCAGAGGCTGAAGGAAGAGATAGCAGAGGTTGCT
AATGAAATTGAAAGCCTGGGATCCACAGAGGAACGGAAAAACATGCAGAGGAACAAACAGGTAG
CCATGGGCAGAAAGAAATTCAACATGGATCCTAAGAAGGGGATCCAGTTCTTAATCGAGAATGG
CCTGCTGAAAAACACTTGTGAGGACATTGCCCAGTTCCTGTATAAAGGGGAAGGGCTCAACAAA
ACAGCCATCGGTGACTACCTTGGGGAGAGAGATGAGTTCAGCATCCAGGTCTTGCATGCATTTG
TGGAGCTGCACGAGTTCACCGACCTGAACCTCGTCCAGGCCTTGCGGCAGTTCCTGTGGAGCTT
CCGGCTCCCTGGAGAGGCCCAGAAGATTGACCGGATGATGGAGGCCTTTGCGCAGCGGTACTGT
CAGTGCAATACTGGGGTGTTCCAGTCTACAGACACTTGCTATGTCCTGTCCTTTGCAATCATCA
TGCTGAACACCAGCCTACACAACCCCAACGTCAAAGACAAGCCTACGGTGGAGAGGTTCATCGC
CATGAACCGAGGCATCAATGACGGAGGAGACCTGCCCGAGGAGCTGCTGCGGAATCTCTATGAG
AGCATCAAAAACGAACCCTTTAAAATCCCAGAAGATGACGGCAATGATCTCACTCACACTTTCT
TCAATCCAGACCGAGAGGGCTGGCTACTAAAGCTCGGAGGTGGCAGGGTAAAGACTTGGAAGAG
GCGCTGGTTCATTCTGACTGACAACTGCCTTTACTACTTTGAATACACCACGGACAAAGAGCCC
CGCGGGATCATCCCCCTGGAGAACCTGAGTATCCGAGAGGTGGAAGACTCCAAGAAGCCGAACT
GCTTTGAGCTTTATATCCCTGACAATAAAGACCAGGTGATTAAGGCCTGCAAGACAGAGGCTGA
CGGACGAGTGGTGGAAGGGAACCACACTGTGTACCGCATCTCGGCCCCCACTCCTGAGGAGAAG
GAAGACTGGATCAAGTGCATCAAAGCCGCCATCAGCAGAGACCCGTTCTACGAGATGCTTGCAG
CACGGAAAAAGAAGGTCTCCTCCACAAAGAGGCACTGAGGGTGCACCAGGGCACGGCCAGCCCG
TGAAGCTGTGGCCCCTTCTCCTGCCTCCCCTGAGGGCGCTGTGGAGCCCAGCAGAGGAGAGCAG
AGGGCTTCTCTGCCAGTTCCTGCCCACTCCGCTCCTAGAGACTTGCTTCAGCTTTTGCAGTTTT
CTAAGTGGGAGACGGGTGGGTGGGCGGAGAGGGCTCAGCTGGAGACGCTGCCCCACTCATGGGC
TCTGGAGCTGCTCAGAACCAGCGCTGCTTCACCGCCTCAGCTCAGCAGGACTGAGGGCACCGCA
GGGAGCTGGCTCTTTACCTCTAAGTGTTCCTGGCCCAGGGCCTTCACCTCTGCTCCATGAATGC
CTGTGAGGATGTACTCTTATGTACTGAGGAGAGAGGAGGAAAGGAAGAGAAGCCACACACTATA
AAGATTTATTTTTGTTTTTTAAAGCAAAAGTGAACGTAGCACTGTTCTCTGCCCTCCTGTGCCC
TGCTTAGGGAGCGTCCCCTAAAAAGGGGGCTCTGGGGCTGCGGGCACCCCAGGGGCTGCTGCCT
CATGACTGTGTGGGCAAGAGGGGCAGAAGCAGGATTGCTGGCAGGGCCCAGCAGACACGGGGAG
GCCTCAGGGCCCCAGCAGGGCAGCAGGCAGGCAGTATGGGCAGCTCCCACTCAGTGCCTGTGGG
ACAGGGTGAAGGTGGTTAGCGCCTTGCCCGGCCCTCAGTACCCAGGCCCACTGCTCTTTAAAAT
GGAAAGTCTTCATTTTCCTAATAACCAAAACTGTGAGGAGCTCACCCATGGTGCTGGGTGGCGA
CTGTTTCATAGCTGGTTTTTCTTTCTCCTCCCCAAGAGCTCCACTCCTCGTTCTAGAGGAAGGA
GCAGGTCTTACCTGATCCCCTTGGGGCTTCAGCCTTTTCTGCCTCAAAAGCTGCCCCAACTGGA
CTATTCTGGTGCACTCTGTGGTAGCCTCCAGGAGCAGGGGCCTTGCTCAGTAGGTTGCAGTGCA
GTCAGGCAAGGGTAAGGTGGCCTTTTTGTCCCCTGCCCTCTATGGCATGGCATACCACAGCACA
CACATGAGTGAACCCTGGCCTCCTAACTCAGTGTGAAGGGAGCCATGAAACGCAGCATCTCCTG
CCGTTCTCTCAGGGACTCTCAAGGGCAGCTCCTGTTCCTTGGCCAGGGCTAGCATGCCAGTCTA
GGCAGAGCAGGTGGCAGGTGATGTCTTGGCACACTCCTCCACATGGCCAAGGCCTTGGTGGCAG
AATGCTGCCTCCAGGCAGGTGGAGGAGCCATGGGTCCCCACTGGGCTGTGTGAGCTCAGCCTCT
GATCTCAGAAGGAGGTCAGCATCTCTGGAAATAGCTTTGCAGAGAAGGGTGGGGGTGGGGGTAG
CACTCGGTCCCTCCTGTGGATCCAGCAGGATCCGGCCTCGAGTGGCTTTAGGTGCTCGATGCTC
AGTGTGTGAAGGTGACAGTGACTGCTGAGGTCCAGGCTGGAAACCTGAGCCTCCTGCCACAGAG
CCAGTCAATGCCTGCCCAGGCTGTGTGGGGAGTCAGGCCAGTGCCGGAGCCCCTCCTGCACACG
GGTTCTCACAGGTGTGTCCCAGGCAGGCCCACACGGCTCAGCGTCAGTCTATTTATCAGAGGTG
TACATAATCCACACATAGTTTTTCTCCTTTTAGATTATTTTGTATTTGTTTAAAAAAAGATTTG
TCAAAATACAAAGAAATGACTGAAACTTGTTGACAGGGTTTTTAAAAAATATTATTATTATTAT
TATTATTGTTGTTGTTGTTTCGTTTTTGCCTTGTAAACTAGCTCCAAGGAACTGCAGCAAATAA
ACTCCAAATCTGCCCAAACCA

hide sequence

RefSeq Acc Id:

XM_063268306 ⟹ XP_063124376

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	103,901,376 - 103,977,681 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446362	(Get FASTA)	NCBI Sequence Viewer
	XP_006247846	(Get FASTA)	NCBI Sequence Viewer
	XP_006247847	(Get FASTA)	NCBI Sequence Viewer
	XP_063124376	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB41443	(Get FASTA)	NCBI Sequence Viewer
	AAI66417	(Get FASTA)	NCBI Sequence Viewer
	EDM06749	(Get FASTA)	NCBI Sequence Viewer
	EDM06750	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004196
	ENSRNOP00000004196.6
	ENSRNOP00000093390
GenBank Protein	P97694	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446362 ⟸ NM_053910

- UniProtKB:

P97694 (UniProtKB/Swiss-Prot), A0A8I6AK04 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNK
QVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLH
AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFA
IIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTH
TFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKK
PNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEM
LAARKKKVSSTKRH

hide sequence

RefSeq Acc Id:	XP_006247846 ⟸ XM_006247784
- Peptide Label:	isoform X2
- UniProtKB:	B2GUV0 (UniProtKB/TrEMBL), D4A8L6 (UniProtKB/TrEMBL), A0A8I6AK04 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNK QVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLH AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFA IIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTH TFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKP NCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEML AARKKKVSSTKRH hide sequence

RefSeq Acc Id:	XP_006247847 ⟸ XM_006247785
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6AK04 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFS IQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCY VLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG NDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV EDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRD PFYEMLAARKKKVSSTKRH hide sequence

Ensembl Acc Id:

ENSRNOP00000004196 ⟸ ENSRNOT00000004196

Ensembl Acc Id:

ENSRNOP00000075144 ⟸ ENSRNOT00000082529

Ensembl Acc Id:

ENSRNOP00000093390 ⟸ ENSRNOT00000108086

RefSeq Acc Id:	XP_063124376 ⟸ XM_063268306
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AK04 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109533 ⟸ ENSRNOT00000166720

Protein Domains

PH SEC7

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97694-F1-model_v2	AlphaFold	P97694	1-398	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697935

Promoter ID:

EPDNEW_R8460

Type:

initiation region

Name:

Cyth1_1

Description:

cytohesin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	107,281,249 - 107,281,309	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620397	AgrOrtholog
BioCyc Gene	G2FUF-22521	BioCyc
Ensembl Genes	ENSRNOG00000043381	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004196	ENTREZGENE
	ENSRNOT00000004196.7	UniProtKB/Swiss-Prot
	ENSRNOT00000108086	ENTREZGENE
Gene3D-CATH	1.10.1000.11	UniProtKB/Swiss-Prot
	1.10.220.20	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:9028626	IMAGE-MGC_LOAD
InterPro	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Sec7_C_sf	UniProtKB/Swiss-Prot
	Sec7_dom	UniProtKB/Swiss-Prot
	Sec7_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:116691	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187345	IMAGE-MGC_LOAD
NCBI Gene	116691	ENTREZGENE
PANTHER	CYTOHESIN-1	UniProtKB/Swiss-Prot
	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	UniProtKB/Swiss-Prot
Pfam	PF00169	UniProtKB/Swiss-Prot
	Sec7	UniProtKB/Swiss-Prot
PhenoGen	Cyth1	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot
	SEC7	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000043381	RatGTEx
SMART	Sec7	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF48425	UniProtKB/Swiss-Prot
UniProt	A0A0G2K9V4_RAT	UniProtKB/TrEMBL
	A0A8I6AK04	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LTZ3_RAT	UniProtKB/TrEMBL
	B2GUV0	ENTREZGENE, UniProtKB/TrEMBL
	CYH1_RAT	UniProtKB/Swiss-Prot
	D4A8L6	ENTREZGENE
	P97694	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-04	Cyth1	cytohesin 1	Pscd1	pleckstrin homology, Sec7 and coiled-coil domains 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Pscd1	pleckstrin homology, Sec7 and coiled-coil domains 1		pleckstrin homology, Sec7 and coiled/coil domains 1	Name updated	1299863	APPROVED
2004-12-14	Pscd1	pleckstrin homology, Sec7 and coiled/coil domains 1			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Pscd1				Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_homology	has homology to S. cerevisiae sec7p	729512

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)