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Gene: Nherf2 (NHERF family PDZ scaffold protein 2) Rattus norvegicus

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Symbol:

Nherf2

Name:

NHERF family PDZ scaffold protein 2

RGD ID:

620380

Description:

Enables low-density lipoprotein particle receptor binding activity and molecular adaptor activity. Involved in inner ear development and positive regulation of monoatomic ion transmembrane transport. Located in apical plasma membrane. Part of protein-containing complex. Biomarker of hypertension. Orthologous to human NHERF2 (NHERF family PDZ scaffold protein 2); PARTICIPATES IN parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; aldosterone signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3karp; na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A regulatory protein; NHE3 kinase A regulatory protein E3KARP; NHERF-2; SIP-1; SLC9A3 regulator 2; Slc9a3r2; sodium-hydrogen exchanger regulatory factor 2; sodium/hydrogen exchanger; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; solute carrier family 9 isoform 3 regulator 2; solute carrier family 9 isoform A3 regulatory factor 2; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; SRY-interacting protein 1; TKA-1; tyrosine kinase activator protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NHERF2 (NHERF family PDZ scaffold protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Nherf2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nherf2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NHERF2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NHERF2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nherf2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NHERF2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NHERF2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nherf2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nherf2 (NHERF family PDZ scaffold protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NHERF2 (NHERF family PDZ scaffold protein 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nherf2 (NHERF family PDZ scaffold protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10939	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10939	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nrfl-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nrfl-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc9a3r2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc9a3r2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,167,005 - 14,177,519 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	14,167,005 - 14,177,593 (-)	Ensembl				GRCr8
mRatBN7.2	10	13,662,461 - 13,672,975 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,662,461 - 13,673,049 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	18,409,255 - 18,419,776 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,898,101 - 17,908,626 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	13,397,300 - 13,407,821 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	14,003,330 - 14,015,066 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,003,320 - 14,013,870 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	13,820,310 - 13,830,824 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	13,890,293 - 13,900,807 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	13,342,543 - 13,353,058 (-)	NCBI		Celera
RGSC_v3.1	10	13,891,061 - 13,900,879 (-)	NCBI
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypertension (IEP,ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-naphthylamine (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

ampicillin (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

chlorpyrifos (ISO)

cisplatin (ISO)

coumarin (ISO)

cyclosporin A (EXP)

Deoxycorticosterone acetate (EXP)

dibutyl phthalate (EXP)

diclofenac (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fenthion (ISO)

FR900359 (ISO)

gentamycin (EXP)

hexadecanoic acid (ISO)

irinotecan (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury atom (ISO)

mercury(0) (ISO)

Mesaconitine (EXP)

methamphetamine (EXP)

methotrexate (ISO)

nickel atom (ISO)

nicotine (ISO)

okadaic acid (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

potassium chloride (EXP)

propiconazole (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inner ear development (IEP)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of monoatomic ion transmembrane transport (IDA)

protein localization to plasma membrane (IBA)

sensory perception of sound (ISO)

Cellular Component

apical part of cell (IEA)

apical plasma membrane (IBA,IDA,IEA,ISO)

cytoplasm (ISO)

endomembrane system (IEA)

nucleus (IEA,ISO)

plasma membrane (IEA,ISO)

protein-containing complex (IDA)

stereocilium (ISO)

stereocilium bundle (ISO)

Molecular Function

beta-catenin binding (IEA,ISO)

identical protein binding (IEA,ISO)

low-density lipoprotein particle receptor binding (IPI)

molecular adaptor activity (IEA,IMP)

phosphatase binding (IEA,ISO)

protein binding (IPI,ISO)

protein-membrane adaptor activity (IBA)

signaling receptor binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

aldosterone signaling pathway (IEA)

parathyroid hormone signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1.	Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
2.	Ezrin-radixin-moesin-binding phosphoprotein 50 is expressed at the apical membrane of rat liver epithelia.	Fouassier L, etal., Hepatology 2001 Jan;33(1):166-76.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	The interaction between megalin and ClC-5 is scaffolded by the Na(+)-H(+) exchanger regulatory factor 2 (NHERF2) in proximal tubule cells.	Hryciw DH, etal., Int J Biochem Cell Biol. 2012 May;44(5):815-23. doi: 10.1016/j.biocel.2012.02.007. Epub 2012 Feb 13.
6.	Postnatal developmental expression of the PDZ scaffolds Na+ -H+ exchanger regulatory factors 1 and 2 in the rat cochlea.	Kanjhan R, etal., Cell Tissue Res. 2006 Jan;323(1):53-70. Epub 2005 Sep 14.
7.	Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats.	Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
8.	The parathyroid hormone receptorsome and the potential for therapeutic intervention.	Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton.	Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.

Additional References at PubMed

PMID:8889548	PMID:10410901	PMID:11786550	PMID:12169661	PMID:15115658	PMID:15143197	PMID:16456542	PMID:17048262	PMID:17242191	PMID:19056867	PMID:20720114	PMID:21423176
PMID:23376485	PMID:23482569	PMID:23533145	PMID:23612977	PMID:24920589	PMID:25468996	PMID:26173747	PMID:28669731

Genomics

Comparative Map Data

Nherf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,167,005 - 14,177,519 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	14,167,005 - 14,177,593 (-)	Ensembl				GRCr8
mRatBN7.2	10	13,662,461 - 13,672,975 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,662,461 - 13,673,049 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	18,409,255 - 18,419,776 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,898,101 - 17,908,626 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	13,397,300 - 13,407,821 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	14,003,330 - 14,015,066 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,003,320 - 14,013,870 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	13,820,310 - 13,830,824 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	13,890,293 - 13,900,807 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	13,342,543 - 13,353,058 (-)	NCBI		Celera
RGSC_v3.1	10	13,891,061 - 13,900,879 (-)	NCBI
Cytogenetic Map	10	q12	NCBI

NHERF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	2,026,902 - 2,039,026 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	2,025,356 - 2,039,026 (+)	Ensembl			hg38	GRCh38
GRCh37	16	2,076,903 - 2,089,027 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	2,016,930 - 2,028,484 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	2,016,911 - 2,028,481	NCBI
Celera	16	2,289,067 - 2,301,134 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	2,001,109 - 2,013,254 (+)	NCBI		HuRef
CHM1_1	16	2,076,850 - 2,089,007 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	2,046,859 - 2,058,835 (+)	NCBI		T2T-CHM13v2.0

Nherf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	24,858,255 - 24,869,279 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	24,858,260 - 24,869,301 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	24,639,281 - 24,650,305 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	24,639,286 - 24,650,327 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	24,776,227 - 24,787,250 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	24,366,888 - 24,377,878 (-)	NCBI		MGSCv36	mm8
Celera	17	25,161,671 - 25,172,581 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.43	NCBI

Nherf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,224,214 - 15,235,379 (-)	Ensembl
ChiLan1.0	NW_004955442	15,224,214 - 15,235,372 (-)	NCBI	ChiLan1.0	ChiLan1.0

NHERF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	2,307,556 - 2,319,737 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	6,089,244 - 6,101,377 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	664,310 - 676,640 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	2,121,215 - 2,127,069 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	2,115,583 - 2,127,069 (+)	Ensembl			panPan2	panpan1.1

NHERF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	38,905,070 - 38,915,028 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	38,905,635 - 38,942,774 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,144,686 - 40,155,043 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	39,214,038 - 39,216,647 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	39,213,735 - 39,216,642 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	38,898,838 - 38,909,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	38,871,153 - 38,881,488 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	39,349,958 - 39,360,323 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nherf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,703,346 - 104,707,696 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	2,000,854 - 2,006,567 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	2,000,977 - 2,006,102 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NHERF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	39,942,367 - 39,952,825 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	39,942,366 - 39,952,824 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	42,205,136 - 42,239,173 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NHERF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	1,923,773 - 1,935,641 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	1,924,131 - 1,939,062 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666068	29,129,026 - 29,140,946 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nherf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	210,315 - 221,538 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624913	210,315 - 220,936 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nherf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	1,920,530 - 1,930,703 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nherf2
12 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	178
Count of miRNA genes:	117
Interacting mature miRNAs:	141
Transcripts:	ENSRNOT00000004172
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	30004247	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	1	17749933	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat

Markers in Region

AA957994

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,662,550 - 13,662,736 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,003,420 - 14,003,605	NCBI	Rnor6.0
Rnor_5.0	10	13,820,400 - 13,820,585	UniSTS	Rnor5.0
RGSC_v3.4	10	13,890,383 - 13,890,568	UniSTS	RGSC3.4
Celera	10	13,342,633 - 13,342,818	UniSTS
RH 3.4 Map	10	189.9	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	76	171	91	90	59	75	59	6	368	188	15	148	97	106	31	24	24

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC093937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF259898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF294257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK840521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004172 ⟹ ENSRNOP00000004172

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	14,167,005 - 14,177,519 (-)	Ensembl
mRatBN7.2 Ensembl	10	13,662,461 - 13,672,975 (-)	Ensembl
Rnor_6.0 Ensembl	10	14,003,320 - 14,013,870 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094821 ⟹ ENSRNOP00000095231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	14,168,026 - 14,177,593 (-)	Ensembl
mRatBN7.2 Ensembl	10	13,663,482 - 13,673,049 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097124 ⟹ ENSRNOP00000085544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	14,167,005 - 14,172,513 (-)	Ensembl
mRatBN7.2 Ensembl	10	13,662,967 - 13,667,875 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098088 ⟹ ENSRNOP00000080200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	14,167,005 - 14,177,519 (-)	Ensembl
mRatBN7.2 Ensembl	10	13,662,461 - 13,672,975 (-)	Ensembl

RefSeq Acc Id:

NM_053811 ⟹ NP_446263

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,167,005 - 14,177,519 (-)	NCBI
mRatBN7.2	10	13,662,461 - 13,672,975 (-)	NCBI
Rnor_6.0	10	14,003,330 - 14,013,844 (-)	NCBI
Rnor_5.0	10	13,820,310 - 13,830,824 (-)	NCBI
RGSC_v3.4	10	13,890,293 - 13,900,807 (-)	RGD
Celera	10	13,342,543 - 13,353,058 (-)	RGD

Sequence:

show sequence

TGCCGCCTCCGCGCTCCAGCCTGCGGGTGGTGTGAGCCGTGGCCAGTCGCGGGCAGCCAGGGGG
CAGCGGGTGCCATGGCCGCGCCGGAGTCGCTGCGGCCCCGCTTGTGTCGCCTGGTGCGGGGCGA
GCAAGGGTACGGCTTCCACCTGCATGGCGAGAAAGGCCGCCGTGGCCAGTTCATCCGGCGCGTG
GAGCCAGGCTCCCCAGCCGAGGCGGCCGCGCTGCGCGCCGGGGACCGCCTGGTTGAGGTCAACG
GCGTCAACGTAGAGGGCGAGACGCATCACCAGGTGGTCCAGAGGATCAAGGCTGTGGAGGGACA
GACCCAGCTGCTTGTGGTGGACAAGGAGACAGATGAGGAACTCTGCCGGCGGCAACTGACCTGC
ACTGAGGAGATGGCCCATCGAGGGCTTCCGCCAGCCCACAACCCCTGGGAGCCAAAGCCGGACT
GGGCATGCTCAGGCAGTCTTGGCTCGGACACAGGCCAGAAGGATGTCAATGGGCCCCCAAGAGA
GCTGCGTCCCCGGCTCTGCCACTTACGAAGGGGACCCCAGGGCTACGGATTCAACCTGCACAGT
GACAAGTCTCGGCCTGGCCAATACATCCGCTCTGTGGACCCTGGCTCTCCTGCTTCTCTCTCTG
GCCTCCGGGCCCAAGACCGGCTCATTGAGGTGAATGGGCAGAATGTGGAGGGGCTGCGCCATGC
CGAAGTTGTTGCCAGAATCAAGGCACAGGAGGATGAGGCCCGGTTGCTGGTTGTAGACCCCGAG
ACTGATGAACACTTCAAACGGTTGCGGGTCGTACCCACCGAGGATCACGTGGAAGGTCCACTGC
CATCACCAGTCACGAACGGGACCAGCCTTGCCCAGCTCAATGGTGGCTCCGTGTGCTCTTCCCG
AAGCGACCTGCCAGGCTCAGAGAAGGACAATGAGGATGGCAGTGCTTGGAAGAGAGACCCCTTC
CAGGAAAGTGGTCTCCACCTGAGCCCCACAGCAGCCGAGGCCAAGGAGAAGGCTCGAGCTACTC
GGGTCAATAAGAGAGCACCACAGATGGACTGGAACCGGAAGCGAGAGATCTTCAGCAACTTCTG
AGCCCCTCTCTGCCTGTCCAGGGGTCCCACGGTCTCTTCCTGCACGGACCTTGGGCCTCTCCAG
AGCTCCCCAAGCCTCAGCAGACTGGAAGGTGGTATTACACCACCCAGAAACCAACCCACGACCC
CATGAACCCTTGTCTTGTCCACTGGGTGCTGCGGCTGTCATAGCAAGATCAGAGAAGAGAGAAA
CCGAGAGAGAGAAAGAGAGAAAGAGGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA
GAGAGAAAGAAAGATAGGCACAGCCAGCCAAGACAGACACAGAGACAGAAAAGAGTGAGAGAGG
GAGTATGCGTGGTGGTCTGCCAAGGGCCTTAGCCGTTCTGCCTTGGGCCTGCTGACTGAAAGGA
ATTCATGTTTTCGCTTTTTTTTTTTTCCTAAAAGTTCTCCAGCTCCACATATGTTTGTAGTTAA
TAGTGGAGCCCCCTCCCCCAACCCCTTGGGACTCACTCCTAATACTTGCAATAAAACAGAACCT
TTCTCTGCAAACCCCTTCTTACCCGCCCTGTCAGCAGCGCCACCCTGAGAAGAGACCAGGGAAC
AGACAGTCAGGGGACCTCAGGCCCAGCTGTGCCTGGAGGAGCTGTCCCTCTGTCCCATCCCTCA
TATGGGATGGTCCCTGGACCAGGCCTCTCTTCTCTGCCTAGCTACCCCTGTGCTGCCTCCCACA
TGCTGGGTTCTGGAATGCAGAGCCTAGGCTCTCTGAGGGGCCAGAGGATGGGTGTTCCATGACT
CTTAAGAGGGCAGCCTCCGGACAAGCCGCTTATCCTGCTGTGCAACTCCAGGACCTGGAATGTG
GGCCTGGGCAAGCCATTCCCGGGTATGATCCTAGGCACCTGGGCCTGGCCCCTGCCTTATGCCT
ACCAGGTTCCTACCCTTGGCCTCTCTTCAGTGCTCTCAACTCCCCAGACTCACTCACTGGCACC
GCAGTCTGCCTCATAAGCCATAGCGCACGCGCGCCCTCGAATTAAACAGGCCTTGCCTCGAA

hide sequence

RefSeq Acc Id:

XM_006245893 ⟹ XP_006245955

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,167,005 - 14,172,489 (-)	NCBI
mRatBN7.2	10	13,662,461 - 13,667,932 (-)	NCBI
Rnor_6.0	10	14,003,333 - 14,011,109 (-)	NCBI
Rnor_5.0	10	13,820,310 - 13,830,824 (-)	NCBI

Sequence:

show sequence

TGGGCTTTTGTCTGTGGGAACAATGAGTCTTTCCCAGAACCACCATCGCTGACTGCCTCTTGAT
AACAATCTTCCCTTTGGTCACTCCTATAAGCCTCCGTTTCCTCTTAGGGCTCTTTCCCTACTGC
AGTAGCCACTCTGTGCCATTGGTGACCACCTGAAGCAACTCTTTTGGCCTTTGTTCCCTCTGCT
GGAGGTCCCAGTGGCTGAGGAGTTACTGTGGCTCTAAAGATCTGAATGTCTGTGTTAGGTATCT
GTCATCCTGGGTTTTGTCCACGACTCTGTCTGAAGCATCCATGTCTAAGCCATCCGTGTGCTCT
GAAGCCCTTGGGTGGATTAGATCCTACATCAGGGATTAGTGCTGTAGCCGCTCAGTGATGGGGG
TGGGCGGGAGTGTGTGGGATCCAGAACACAGGGGCTTCCTAGGGAAAGGGAGTGGAGGGCCCAC
GTGCGGACGCTTCTTATGAGGACACAGGTACAGCTCAACTGGGTTCCAGTTCCTGTCCTTGTTC
CCACTTCCCGAGGGTGCTGGAACCCTGTGTACTGCGGTCCCAGGGCCCCTGATGGGTAGCCCCT
CCTCTCACCTTTATCCTTCTGGGATAGGAGACCCAGAAAAAAACAAGAGAGGGTCTGTTCCACC
TTCCTCTAGGAAGCCTACCTAGGCAGAACCTGAGGCAGGGAGGAAGGGCCTGAGGGTATTTGTT
CTACTTCTCGGGAGGACCTGGTACTACTGTTTCTTTTGTCTTCTAATTACTACTTGAGCCAAGT
GGTTCCTCACATCCAACTTTGAGAACCATTGGCTTACCACAGGTGGAGTGTCAGGTTTGAAATT
TCTGGATGTGTTTCAGATCTTAACATTTACCTCTGATCTCACCCACGTGTCTCCTACTGGTTAG
GCGTGGGCTGGTCCCTGTGGGACCTGTCTGGAGGTTAGGAGATGACATCCCCAGTTAGGTCAAC
CTGGGCCAAGGCCTGTGCTTTGCATCCGTTGAATTCTTTCCCTTGGAGACCTGAAGGCAGGTGG
CAAGCCTAGTGTGGATTCTGCATTCTGGCTGGGCTGTTTAAGATCAGGAGTCTTAGTAGGAATT
TTGTGGGAAGAAGATGGTGCCAGGCCCACCTTCCTCTGGATGGGGACTAGGAGCCTCCCTTTTT
CCCCAGCACCCCTTTCTCCTCCTTAGGAAGAAGCCCCCCCACCCTCAGGCGTGTGTCCATTCAT
TTAGAAGCAAACAGCCCAGTTCACCTTCCTGTGGAAAAATCCACCCTGGGGCCTTATCTGGAGA
TGGGGTGGCCCAGGCCCCTTGGCTGTGGGTGGGTCCTTCCCTGTCACTGCTATTTCAGGCTTGG
AGGGGTTGCAGGAAGCCCTAGGAGGGGGCTTCCTCTGGGTATATTTTTAGAGGAACAAAAGGGG
GTACAATGGGCTTGTCCCATTGTAGATGGGTCAAACCTAGGGACAAGGACTTCAGGAGGTAGAG
GAACCCAAGGGACATTCTTACCGTGGAAGAGAAAGGGGAGCCTCGTAAGACCTGTACGAACCAG
GTTCATTGACAGCCTGTCTCAGGCTGGGTGTAGGCACTGCAGAGGGTTACCCTCTGTGAAGTTG
AGCTCTGCTGGGGGTACTGGTGGCTGGCAGACTGGTGAGGCCTGCACACCTCTGCTCTGTGCAG
GGTGAATGTCCACTGGGTGCCCCCCCCCCCCCAGTCTAGGGTCCTTTCATCCTCGCTGATCCTG
TGTTCTCAGCTTTCCTGATAGGGGAGGTGGGACAAGGGAGAATGCTGATATGGTCTGCCCCTCC
CTTTGGGGGCGGGAAGGCCTAGTCAGTGGTGACTCAGCCCCAGGCCATTCAGGGCTGGGGGTGG
CTGCAGCTGCAGTGAGCTGATTCTAACAGTGAGGACAGGGACAGCCCCCAAACGGAGACCCGGC
AGCTAGCAGTGCCAGGGACAGGGAGGCAGTGTTGGCCCTTGCCTCTCCACCCCTTTGGCCCTAC
CATGTGTGCACCTCCTGGAGGACTTGGGGGACTGAGTTATGGCTGGCACGACTCTGCAGGTGTG
GTCATGGAACAGGATGGTGTACAGCAAAGTGATAGCATGACCGCTTTGGGGGCTCCCCTGGTTC
CCGCTTTTCTCTTTTCCCTCCCCCATCCACCGTCTTCTGTTCTCCAGCCAAGGTTCCCTCCCTT
GACTCCCCGTCTCCACTGCCCTGGGTCCTGGAGCAGGGCAGGGCCTCCAGCAGCTTCCTTCCTT
CCTTTCTTGGGACGGAAACCAAGCTGGGTGGGGGGGACGCCAGACAGGGGAGGGGGCTCAGTAA
CCACCCTGCTATCCAAAATGAGTCAGTCCCTACTACGTCCCCACCCATCCCCAGGGATCCTGGG
TCACAGTGGGAGGTAGATAAGTGGGGTGACAGTCTCATCTGGTCCAAGAGCTCTGCCACTCCAG
GCTGGCCACCTCCTGCCAGCCACCCCTAGCCACGTCTCATGGCTCGCTCCTGGATTACCATGCT
GCCTGCCTCCACCTCAGGAGCCCCTCCTGTGAACTCTCAACTGGGGTTTGTTCAGGATGTCAAT
GGGCCCCCAAGAGAGCTGCGTCCCCGGCTCTGCCACTTACGAAGGGGACCCCAGGGCTACGGAT
TCAACCTGCACAGTGACAAGTCTCGGCCTGGCCAATACATCCGCTCTGTGGACCCTGGCTCTCC
TGCTTCTCTCTCTGGCCTCCGGGCCCAAGACCGGCTCATTGAGGTGAATGGGCAGAATGTGGAG
GGGCTGCGCCATGCCGAAGTTGTTGCCAGAATCAAGGCACAGGAGGATGAGGCCCGGTTGCTGG
TTGTAGACCCCGAGACTGATGAACACTTCAAACGGTTGCGGGTCGTACCCACCGAGGATCACGT
GGAAGGTCCACTGCCATCACCAGTCACGAACGGGACCAGCCTTGCCCAGCTCAATGGTGGCTCC
GTGTGCTCTTCCCGAAGCGACCTGCCAGGCTCAGAGAAGGACAATGAGGATGGCAGTGCTTGGA
AGAGAGACCCCTTCCAGGAAAGTGGTCTCCACCTGAGCCCCACAGCAGCCGAGGCCAAGGAGAA
GGCTCGAGCTACTCGGGTCAATAAGAGAGCACCACAGATGGACTGGAACCGGAAGCGAGAGATC
TTCAGCAACTTCTGAGCCCCTCTCTGCCTGTCCAGGGGTCCCACGGTCTCTTCCTGCACGGACC
TTGGGCCTCTCCAGAGCTCCCCAAGCCTCAGCAGACTGGAAGGTGGTATTACACCACCCAGAAA
CCAACCCACGACCCCATGAACCCTTGTCTTGTCCACTGGGTGCTGCGGCTGTCATAGCAAGATC
AGAGAAGAGAGAAACCGAGAGAGAGAAAGAGAGAAAGAGGGAGAGAGAGAGAGAGAGAGAGAGA
GAGAGAGAGAGAGAGAGAGAAAGAAAGATAGGCACAGCCAGCCAAGACAGACACAGAGACAGAA
AAGAGTGAGAGAGGGAGTATGCGTGGTGGTCTGCCAAGGGCCTTAGCCGTTCTGCCTTGGGCCT
GCTGACTGAAAGGAATTCATGTTTTCGCTTTTTTTTTTTTCCTAAAAGTTCTCCAGCTCCACAT
ATGTTTGTAGTTAATAGTGGAGCCCCCTCCCCCAACCCCTTGGGACTCACTCCTAATACTTGCA
ATAAAACAGAACCTTTCTCTGCAAACCCCTTCTTACCCGCCCTGTCAGCAGCGCCACCCTGAGA
AGAGACCAGGGAACAGACAGTCAGGGGACCTCAGGCCCAGCTGTGCCTGGAGGAGCTGTCCCTC
TGTCCCATCCCTCATATGGGATGGTCCCTGGACCAGGCCTCTCTTCTCTGCCTAGCTACCCCTG
TGCTGCCTCCCACATGCTGGGTTCTGGAATGCAGAGCCTAGGCTCTCTGAGGGGCCAGAGGATG
GGTGTTCCATGACTCTTAAGAGGGCAGCCTCCGGACAAGCCGCTTATCCTGCTGTGCAACTCCA
GGACCTGGAATGTGGGCCTGGGCAAGCCATTCCCGGGTATGATCCTAGGCACCTGGGCCTGGCC
CCTGCCTTATGCCTACCAGGTTCCTACCCTTGGCCTCTCTTCAGTGCTCTCAACTCCCCAGACT
CACTCACTGGCACCGCAGTCTGCCTCATAAGCCATAGCGCACGCGCGCCCTCGAATTAAACAGG
CCTTGCCTC

hide sequence

RefSeq Acc Id:

XM_039085043 ⟹ XP_038940971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,167,005 - 14,172,973 (-)	NCBI
mRatBN7.2	10	13,662,461 - 13,668,446 (-)	NCBI

RefSeq Acc Id:

XM_039085044 ⟹ XP_038940972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,167,005 - 14,172,483 (-)	NCBI
mRatBN7.2	10	13,662,461 - 13,667,639 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446263	(Get FASTA)	NCBI Sequence Viewer
	XP_006245955	(Get FASTA)	NCBI Sequence Viewer
	XP_038940971	(Get FASTA)	NCBI Sequence Viewer
	XP_038940972	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK49392	(Get FASTA)	NCBI Sequence Viewer
	AAK97088	(Get FASTA)	NCBI Sequence Viewer
	EDM03851	(Get FASTA)	NCBI Sequence Viewer
	EDM03852	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004172
	ENSRNOP00000085544
GenBank Protein	Q920G2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446263 ⟸ NM_053811

- UniProtKB:

Q91Y70 (UniProtKB/Swiss-Prot), Q920G2 (UniProtKB/Swiss-Prot), G3V6D9 (UniProtKB/TrEMBL), A6HCU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAPESLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNV
EGETHHQVVQRIKAVEGQTQLLVVDKETDEELCRRQLTCTEEMAHRGLPPAHNPWEPKPDWACS
GSLGSDTGQKDVNGPPRELRPRLCHLRRGPQGYGFNLHSDKSRPGQYIRSVDPGSPASLSGLRA
QDRLIEVNGQNVEGLRHAEVVARIKAQEDEARLLVVDPETDEHFKRLRVVPTEDHVEGPLPSPV
TNGTSLAQLNGGSVCSSRSDLPGSEKDNEDGSAWKRDPFQESGLHLSPTAAEAKEKARATRVNK
RAPQMDWNRKREIFSNF

hide sequence

RefSeq Acc Id:	XP_006245955 ⟸ XM_006245893
- Peptide Label:	isoform X1
- UniProtKB:	A6HCU7 (UniProtKB/TrEMBL), A0A8I6A0E3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARSWITMLPASTSGAPPVNSQLGFVQDVNGPPRELRPRLCHLRRGPQGYGFNLHSDKSRPGQY IRSVDPGSPASLSGLRAQDRLIEVNGQNVEGLRHAEVVARIKAQEDEARLLVVDPETDEHFKRL RVVPTEDHVEGPLPSPVTNGTSLAQLNGGSVCSSRSDLPGSEKDNEDGSAWKRDPFQESGLHLS PTAAEAKEKARATRVNKRAPQMDWNRKREIFSNF hide sequence

Ensembl Acc Id:

ENSRNOP00000004172 ⟸ ENSRNOT00000004172

RefSeq Acc Id:	XP_038940971 ⟸ XM_039085043
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A0E3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038940972 ⟸ XM_039085044
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A0E3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095231 ⟸ ENSRNOT00000094821

Ensembl Acc Id:

ENSRNOP00000080200 ⟸ ENSRNOT00000098088

Ensembl Acc Id:

ENSRNOP00000085544 ⟸ ENSRNOT00000097124

Protein Domains

PDZ

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q920G2-F1-model_v2	AlphaFold	Q920G2	1-337	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697018

Promoter ID:

EPDNEW_R7543

Type:

multiple initiation site

Name:

Slc9a3r2_1

Description:

SLC9A3 regulator 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	14,013,924 - 14,013,984	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620380	AgrOrtholog
BioCyc Gene	G2FUF-25843	BioCyc
Ensembl Genes	ENSRNOG00000002997	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000004172	ENTREZGENE
	ENSRNOT00000097124	ENTREZGENE
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
InterPro	EBP50_C-term	UniProtKB/Swiss-Prot
	NHER	UniProtKB/Swiss-Prot
	NHERF-1/NHERF-2	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:116501	UniProtKB/Swiss-Prot
NCBI Gene	116501	ENTREZGENE
PANTHER	PDZ DOMAIN CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	PTHR14191:SF4	UniProtKB/Swiss-Prot
Pfam	EBP50_C	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
PhenoGen	Nherf2	PhenoGen
PIRSF	EBP50	UniProtKB/Swiss-Prot
PROSITE	PDZ	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002997	RatGTEx
SMART	PDZ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50156	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZPM4_RAT	UniProtKB/TrEMBL
	A0A8I6A0E3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANC3_RAT	UniProtKB/TrEMBL
	A6HCU6	ENTREZGENE, UniProtKB/TrEMBL
	A6HCU7	ENTREZGENE, UniProtKB/TrEMBL
	G3V6D9	ENTREZGENE, UniProtKB/TrEMBL
	NHRF2_RAT	UniProtKB/Swiss-Prot
	Q91Y70	ENTREZGENE
	Q920G2	ENTREZGENE
UniProt Secondary	Q91Y70	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-11-28	Nherf2	NHERF family PDZ scaffold protein 2	Slc9a3r2	SLC9A3 regulator 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-24	Slc9a3r2	SLC9A3 regulator 2	Slc9a3r2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc9a3r2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-31	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the hepatocytes and cholangiocytes; distributed distinctly in the cytoplasm and nucleus	634170
gene_physical_interaction	binds Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 (EBP50) by utilizing 2 PSD-95/DIg/ZO-1 (PDZ) domains and an ERM binding site	634170
gene_process	regulates ion-transport in the liver epithelia	634170
gene_product	member of the ERM family	634170

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)