Gsk3a (glycogen synthase kinase 3 alpha) - Rat Genome Database

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Gene: Gsk3a (glycogen synthase kinase 3 alpha) Rattus norvegicus
Analyze
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
RGD ID: 620351
Description: Enables protein kinase A catalytic subunit binding activity; protein serine/threonine kinase activity; and protein serine/threonine kinase binding activity. Involved in negative regulation of dendrite development; negative regulation of insulin receptor signaling pathway; and positive regulation of neuron apoptotic process. Located in microtubule. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha); PARTICIPATES IN glycogen biosynthetic pathway; nuclear factor, erythroid 2 like 2 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FA; factor A; glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,943,669 - 89,953,514 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,943,669 - 89,953,593 (-)EnsemblGRCr8
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,208,062 - 86,217,908 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,759,217 - 94,769,063 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,963,839 - 87,973,686 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,259,483 - 75,269,362 (-)NCBICelera
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cocaine  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
Fusaric acid  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
IC-87114  (ISO)
indometacin  (ISO)
kenpaullone  (EXP)
lead diacetate  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
lonafarnib  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N-acetylsphingosine  (ISO)
nicotine  (ISO)
nordihydroguaiaretic acid  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paraquat  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium atom  (EXP)
propylparaben  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (EXP)
rottlerin  (EXP)
ruthenium atom  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sphingosine 1-phosphate  (ISO)
sucrose  (EXP)
tacrolimus hydrate  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autosome genomic imprinting  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cell differentiation  (IBA)
cell migration  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-3  (ISO,ISS)
cellular response to lithium ion  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO,ISS)
glycogen metabolic process  (IEA)
insulin receptor signaling pathway  (IBA,ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IBA)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of D-glucose import across plasma membrane  (ISO)
negative regulation of dendrite development  (IEA,IMP)
negative regulation of developmental process  (IEA)
negative regulation of insulin receptor signaling pathway  (IDA,IEA,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of TOR signaling  (IBA,ISO)
nervous system development  (IEA)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of autophagy  (IBA,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of heart contraction  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO,ISS)
positive regulation of neuron apoptotic process  (IBA,IEA,IMP)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,ISS)
protein phosphorylation  (ISO)
regulation of microtubule cytoskeleton organization  (IBA)
regulation of mitophagy  (ISO)
regulation of neuron projection development  (IBA)
regulation of systemic arterial blood pressure  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component
axon  (IBA)
cytoplasm  (IBA)
cytosol  (IBA,TAS)
microtubule  (IDA)
mitochondrion  (IEA)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, etal., Nature. 1995 Dec 21-28;378(6559):785-9.
2. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
3. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Fang X, etal., Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5.
4. Glycogen synthase kinase 3: a key regulator of cellular fate. Forde JE and Dale TC, Cell Mol Life Sci. 2007 Aug;64(15):1930-44.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria. Hoshi M, etal., J Biochem. 1995 Oct;118(4):683-5.
7. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
8. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. Hurtado DE, etal., J Neurosci. 2012 May 23;32(21):7392-402. doi: 10.1523/JNEUROSCI.0889-12.2012.
9. Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Morris JK, etal., Brain Res. 2008 Nov 13;1240:185-95. doi: 10.1016/j.brainres.2008.08.089. Epub 2008 Sep 11.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. Rao PV, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):250-6.
14. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Rezai-Zadeh K, etal., J Cell Mol Med. 2009 Mar;13(3):574-88. doi: 10.1111/j.1582-4934.2008.00344.x. Epub 2008 Apr 9.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Seo YH, etal., Aging Cell. 2008 Dec;7(6):894-907. doi: 10.1111/j.1474-9726.2008.00436.x. Epub 2008 Sep 8.
18. Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. Song B, etal., J Biol Chem. 2010 Dec 24;285(52):41122-34. doi: 10.1074/jbc.M110.130351. Epub 2010 Sep 14.
19. GSK-3alpha/beta-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. Tan M, etal., J Neurochem. 2013 Jun;125(5):685-97. doi: 10.1111/jnc.12230. Epub 2013 Mar 25.
20. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Woodgett JR EMBO J 1990 Aug;9(8):2431-8.
21. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. Zhai P, etal., J Biol Chem. 2007 Nov 9;282(45):33181-91. Epub 2007 Sep 12.
22. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:8382613   PMID:10995739   PMID:12055200   PMID:12761548   PMID:14698990   PMID:14730361   PMID:15572200   PMID:15673614   PMID:16537926   PMID:16543145   PMID:16912034   PMID:17569761  
PMID:17986005   PMID:17993264   PMID:18285345   PMID:19583853   PMID:19706605   PMID:19840222   PMID:20371704   PMID:20516643   PMID:21047779   PMID:21266584   PMID:21316358   PMID:22539723  
PMID:23192081   PMID:23246341   PMID:23999152   PMID:24631206   PMID:24912190   PMID:25897075   PMID:25935310   PMID:26514267   PMID:28440874   PMID:29161257  


Genomics

Comparative Map Data
Gsk3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,943,669 - 89,953,514 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,943,669 - 89,953,593 (-)EnsemblGRCr8
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx186,208,062 - 86,217,908 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,759,217 - 94,769,063 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,963,839 - 87,973,686 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,259,483 - 75,269,362 (-)NCBICelera
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Cytogenetic Map1q21NCBI
GSK3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,230,190 - 42,242,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,226,225 - 42,242,625 (-)Ensemblhg38GRCh38
GRCh371942,734,342 - 42,746,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,426,178 - 47,438,576 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341947,426,177 - 47,438,576NCBI
Celera1939,535,133 - 39,547,532 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,164,764 - 39,177,148 (-)NCBIHuRef
CHM1_11942,736,013 - 42,748,418 (-)NCBICHM1_1
T2T-CHM13v2.01945,049,560 - 45,061,976 (-)NCBIT2T-CHM13v2.0
Gsk3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)Ensemblmm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBIMGSCv36mm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
Gsk3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)Ensembl
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
GSK3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,335,581 - 48,348,020 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,204,206 - 50,216,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,710,197 - 47,722,531 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)EnsemblpanPan2panpan1.1
GSK3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,129,116 - 112,138,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,103,825 - 112,138,559 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1111,555,288 - 111,565,002 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01112,741,760 - 112,751,476 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,741,641 - 112,751,092 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,295,962 - 112,305,677 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,931,910 - 111,941,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,858,454 - 112,868,171 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gsk3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,919,119 - 15,929,912 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706269,126 - 277,256 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706266,462 - 277,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,690,370 - 49,701,189 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,690,319 - 49,700,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,607,906 - 45,618,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,434,966 - 36,447,676 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,435,578 - 36,447,633 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607314,679,200 - 14,692,630 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsk3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907511,889 - 522,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907511,919 - 522,106 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gsk3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,476,084 - 169,485,866 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gsk3a
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:3
Interacting mature miRNAs:6
Transcripts:ENSRNOT00000027677
Prediction methods:Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
AI044641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,817,592 - 80,817,772 (+)MAPPERmRatBN7.2
Rnor_6.0182,100,103 - 82,100,282NCBIRnor6.0
Rnor_5.0183,366,607 - 83,366,786UniSTSRnor5.0
RGSC_v3.4180,506,039 - 80,506,218UniSTSRGSC3.4
Celera175,261,262 - 75,261,441UniSTS
RH 3.4 Map1824.5UniSTS
Cytogenetic Map1q21UniSTS
AU048392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,827,014 - 80,827,144 (+)MAPPERmRatBN7.2
Rnor_6.0182,109,527 - 82,109,658NCBIRnor6.0
Rnor_5.0183,376,031 - 83,376,162UniSTSRnor5.0
RGSC_v3.4180,515,463 - 80,515,594UniSTSRGSC3.4
Celera175,270,686 - 75,270,817UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027677   ⟹   ENSRNOP00000027677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,943,669 - 89,953,593 (-)Ensembl
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)Ensembl
Rnor_6.0 Ensembl182,097,848 - 82,108,083 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084530   ⟹   ENSRNOP00000074376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147391   ⟹   ENSRNOP00000106761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,943,669 - 89,953,514 (-)Ensembl
RefSeq Acc Id: NM_017344   ⟹   NP_059040
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,943,669 - 89,953,514 (-)NCBI
mRatBN7.2180,815,847 - 80,825,691 (-)NCBI
Rnor_6.0182,097,244 - 82,108,203 (-)NCBI
Rnor_5.0183,365,717 - 83,374,707 (-)NCBI
RGSC_v3.4180,505,517 - 80,514,139 (-)RGD
Celera175,259,483 - 75,269,362 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA37518 (Get FASTA)   NCBI Sequence Viewer  
  EDM08037 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000106761
GenBank Protein P18265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059040   ⟸   NM_017344
- UniProtKB: P18265 (UniProtKB/Swiss-Prot),   A6J947 (UniProtKB/TrEMBL),   A0A8L2QGG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074376   ⟸   ENSRNOT00000084530
Ensembl Acc Id: ENSRNOP00000027677   ⟸   ENSRNOT00000027677
Ensembl Acc Id: ENSRNOP00000106761   ⟸   ENSRNOT00000147391
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18265-F1-model_v2 AlphaFold P18265 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689811
Promoter ID:EPDNEW_R336
Type:initiation region
Name:Gsk3a_1
Description:glycogen synthase kinase 3 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,108,178 - 82,108,238EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620351 AgrOrtholog
BioCyc Gene G2FUF-60396 BioCyc
Ensembl Genes ENSRNOG00000020417 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000147391 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro GSK-3 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STKc_GSK3 UniProtKB/Swiss-Prot
KEGG Report rno:50686 UniProtKB/Swiss-Prot
NCBI Gene 50686 ENTREZGENE
PANTHER GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/Swiss-Prot
  GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Gsk3a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020417 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2QGG1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LM95_RAT UniProtKB/TrEMBL
  A6J947 ENTREZGENE, UniProtKB/TrEMBL
  GSK3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gsk3a  glycogen synthase kinase 3 alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gsk3a  glycogen synthase kinase 3 alpha      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 51 kDa 70757