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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620351 Species: Rattus norvegicus RGD Object: Gene Symbol: Gsk3a Name: glycogen synthase kinase 3 alpha

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:731783	6480464	CTD	Cisplatin results in decreased phosphorylation of GSK3A protein	PMID:21821001