Masp1 (MBL associated serine protease 1) - Rat Genome Database

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Gene: Masp1 (MBL associated serine protease 1) Rattus norvegicus
Analyze
Symbol: Masp1
Name: MBL associated serine protease 1
RGD ID: 620213
Description: Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, alternative pathway; complement activation, lectin pathway; and negative regulation of complement activation. Predicted to act upstream of or within several processes, including activation of membrane attack complex; opsonization; and zymogen activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement factor MASP-3; complement-activating component of Ra-reactive factor; LOC100910195; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine protease 1; mannan-binding lectin serine protease 2-like; mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; MASP-1; Masp1/3; Masp3; ra-reactive factor serine protease p100; raRF; serine protease 5; serine protease MASP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,839,081 - 90,909,922 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,839,061 - 90,917,470 (+)EnsemblGRCr8
mRatBN7.21177,334,794 - 77,405,271 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,085,686 - 86,155,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,719,505 - 78,789,732 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,799,974 - 77,870,072 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,736,424 - 80,806,278 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,736,576 - 80,803,382 (+)Ensemblrn6Rnor6.0
Rnor_5.01179,928,629 - 79,998,787 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41179,532,504 - 79,602,755 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1176,211,586 - 76,281,374 (+)NCBICelera
RGSC_v3.11179,590,092 - 79,660,344 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fragrance  (ISO)
furan  (EXP)
genistein  (ISO)
graphite  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
metam  (ISO)
methimazole  (EXP)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
oxycodone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA)
cytosol  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
symbiont cell surface  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. Chen CB and Wallis R, J Biol Chem. 2004 Jun 18;279(25):26058-65. Epub 2004 Apr 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo. Knittel T, etal., Lab Invest 1997 Sep;77(3):221-30.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene. Stover CM, etal., Genes Immun 2003 Jul;4(5):374-84.
13. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations. Wallis R and Dodd RB, J Biol Chem 2000 Oct 6;275(40):30962-9.
Additional References at PubMed
PMID:10946292   PMID:11485744   PMID:11527969   PMID:12421953   PMID:12477932   PMID:12538697   PMID:17182967   PMID:18424734   PMID:18596036   PMID:22078562   PMID:28111019  


Genomics

Comparative Map Data
Masp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,839,081 - 90,909,922 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1190,839,061 - 90,917,470 (+)EnsemblGRCr8
mRatBN7.21177,334,794 - 77,405,271 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,085,686 - 86,155,786 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,719,505 - 78,789,732 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,799,974 - 77,870,072 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,736,424 - 80,806,278 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,736,576 - 80,803,382 (+)Ensemblrn6Rnor6.0
Rnor_5.01179,928,629 - 79,998,787 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41179,532,504 - 79,602,755 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1176,211,586 - 76,281,374 (+)NCBICelera
RGSC_v3.11179,590,092 - 79,660,344 (+)NCBI
Cytogenetic Map11q23NCBI
MASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,217,282 - 187,291,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,217,282 - 187,291,980 (-)Ensemblhg38GRCh38
GRCh373186,935,070 - 187,009,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,418,632 - 188,492,446 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343188,434,575 - 188,492,172NCBI
Celera3185,365,700 - 185,441,644 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,338,300 - 184,414,290 (-)NCBIHuRef
CHM1_13186,897,245 - 186,973,187 (-)NCBICHM1_1
T2T-CHM13v2.03190,034,704 - 190,109,174 (-)NCBIT2T-CHM13v2.0
Masp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,261,778 - 23,340,127 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,268,167 - 23,339,565 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381623,451,785 - 23,521,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,449,417 - 23,520,815 (-)Ensemblmm10GRCm38
MGSCv371623,451,858 - 23,520,663 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361623,364,751 - 23,435,937 (-)NCBIMGSCv36mm8
Celera1624,010,198 - 24,079,173 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1614.23NCBI
Masp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542020,540,016 - 20,605,854 (+)Ensembl
ChiLan1.0NW_00495542020,540,266 - 20,605,830 (+)NCBIChiLan1.0ChiLan1.0
MASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,088,774 - 185,161,617 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,093,829 - 185,165,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,241,611 - 184,317,272 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,707,784 - 192,782,196 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,707,784 - 192,782,196 (-)EnsemblpanPan2panpan1.1
MASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,689,426 - 19,750,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,691,630 - 19,750,587 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3423,782,100 - 23,843,357 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03419,609,256 - 19,670,494 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,611,470 - 19,670,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,638,187 - 19,699,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,632,188 - 19,693,442 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,871,376 - 19,932,651 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Masp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,712,588 - 116,779,787 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,804,460 - 2,869,582 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,804,460 - 2,857,731 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,955,030 - 125,054,463 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113124,938,469 - 125,028,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,301,366 - 134,391,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,488,306 - 81,563,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,488,099 - 81,563,679 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604154,981,423 - 55,054,231 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Masp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,568,915 - 69,632,470 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473069,569,046 - 69,632,401 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Masp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v148,256,597 - 8,327,395 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:116
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000002507, ENSRNOT00000002512, ENSRNOT00000047678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH129005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,385,537 - 77,385,748 (+)MAPPERmRatBN7.2
Rnor_6.01180,787,133 - 80,787,343NCBIRnor6.0
Rnor_5.01179,947,894 - 79,948,104UniSTSRnor5.0
RGSC_v3.41179,582,971 - 79,583,181UniSTSRGSC3.4
Celera1176,262,055 - 76,262,265UniSTS
RH 3.4 Map11641.9UniSTS
Cytogenetic Map11q23UniSTS
RH140729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,373,960 - 77,374,172 (+)MAPPERmRatBN7.2
Rnor_6.01180,775,556 - 80,775,767NCBIRnor6.0
Rnor_5.01179,959,470 - 79,959,681UniSTSRnor5.0
RGSC_v3.41179,571,394 - 79,571,605UniSTSRGSC3.4
Celera1176,250,478 - 76,250,689UniSTS
RH 3.4 Map11638.0UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 84 171 91 90 59 72 59 6 386 199 21 139 102 118 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002507   ⟹   ENSRNOP00000002507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,839,722 - 90,917,470 (+)Ensembl
mRatBN7.2 Ensembl1177,340,870 - 77,402,974 (+)Ensembl
Rnor_6.0 Ensembl1180,742,467 - 80,803,382 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047678   ⟹   ENSRNOP00000044812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,839,061 - 90,878,911 (+)Ensembl
mRatBN7.2 Ensembl1177,335,067 - 77,374,247 (+)Ensembl
Rnor_6.0 Ensembl1180,736,576 - 80,775,847 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094154   ⟹   ENSRNOP00000079792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,839,722 - 90,909,922 (+)Ensembl
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111260   ⟹   ENSRNOP00000078578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,839,582 - 90,890,410 (+)Ensembl
mRatBN7.2 Ensembl1177,334,935 - 77,385,759 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131589   ⟹   ENSRNOP00000107083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1190,845,523 - 90,909,922 (+)Ensembl
RefSeq Acc Id: NM_022257   ⟹   NP_071593
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,722 - 90,909,922 (+)NCBI
mRatBN7.21177,335,069 - 77,405,271 (+)NCBI
Rnor_6.01180,736,666 - 80,806,278 (+)NCBI
Rnor_5.01179,928,629 - 79,998,787 (-)NCBI
RGSC_v3.41179,532,504 - 79,602,755 (+)RGD
Celera1176,211,586 - 76,281,374 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248526   ⟹   XP_006248588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,081 - 90,890,415 (+)NCBI
mRatBN7.21177,334,794 - 77,386,379 (+)NCBI
Rnor_6.01180,736,424 - 80,787,359 (+)NCBI
Rnor_5.01179,928,629 - 79,998,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768804   ⟹   XP_008767026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,111 - 90,878,914 (+)NCBI
mRatBN7.21177,334,839 - 77,374,263 (+)NCBI
Rnor_6.01180,736,430 - 80,775,858 (+)NCBI
Sequence:
RefSeq Acc Id: NP_071593   ⟸   NM_022257
- Peptide Label: precursor
- UniProtKB: Q8CHN8 (UniProtKB/Swiss-Prot),   Q8CG41 (UniProtKB/Swiss-Prot),   Q5U365 (UniProtKB/Swiss-Prot),   O09020 (UniProtKB/Swiss-Prot),   Q9JJS9 (UniProtKB/Swiss-Prot),   A0A0H2UHA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248588   ⟸   XM_006248526
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZL57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767026   ⟸   XM_008768804
- Peptide Label: isoform X2
- UniProtKB: A6JS17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044812   ⟸   ENSRNOT00000047678
Ensembl Acc Id: ENSRNOP00000002507   ⟸   ENSRNOT00000002507
Ensembl Acc Id: ENSRNOP00000079792   ⟸   ENSRNOT00000094154
Ensembl Acc Id: ENSRNOP00000078578   ⟸   ENSRNOT00000111260
Ensembl Acc Id: ENSRNOP00000107083   ⟸   ENSRNOT00000131589
Protein Domains
CUB   EGF-like   Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHN8-F1-model_v2 AlphaFold Q8CHN8 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698242
Promoter ID:EPDNEW_R8767
Type:initiation region
Name:Masp1_1
Description:mannan-binding lectin serine peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01180,736,699 - 80,736,759EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620213 AgrOrtholog
BioCyc Gene G2FUF-20871 BioCyc
Ensembl Genes ENSRNOG00000001827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047678 ENTREZGENE
  ENSRNOT00000047678.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094154 ENTREZGENE
  ENSRNOT00000094154.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111260 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  2.60.120.290 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191018 IMAGE-MGC_LOAD
InterPro CUB_dom UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:64023 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93068 IMAGE-MGC_LOAD
NCBI Gene 64023 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot
  MANNAN-BINDING LECTIN SERINE PROTEASE 1 UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Masp1 PhenoGen
PIRSF C1r_C1s_MASP UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  SUSHI UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001827 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF49854 UniProtKB/Swiss-Prot
  SSF50494 UniProtKB/Swiss-Prot
  SSF57535 UniProtKB/Swiss-Prot
UniProt A0A0H2UHA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL57 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9J3_RAT UniProtKB/TrEMBL
  A6JS17 ENTREZGENE, UniProtKB/TrEMBL
  MASP1_RAT UniProtKB/Swiss-Prot
  O09020 ENTREZGENE
  Q5U365 ENTREZGENE
  Q8CG41 ENTREZGENE
  Q8CHN8 ENTREZGENE
  Q8CIR7_RAT UniProtKB/TrEMBL
  Q9JJS9 ENTREZGENE
UniProt Secondary O09020 UniProtKB/Swiss-Prot
  Q5U365 UniProtKB/Swiss-Prot
  Q8CG41 UniProtKB/Swiss-Prot
  Q9JJS9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Masp1  MBL associated serine protease 1  Masp1  mannan-binding lectin serine peptidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-13 Masp1  mannan-binding lectin serine peptidase 1  LOC100910195  mannan-binding lectin serine protease 2-like  Data merged from RGD:6499887 737654 PROVISIONAL
2012-07-05 LOC100910195  mannan-binding lectin serine protease 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Masp1  mannan-binding lectin serine peptidase 1    mannose-binding protein associated serine protease-1  Name updated 1299863 APPROVED
2002-08-07 Masp1  mannose-binding protein associated serine protease-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript serine proteases Masp1 and Masp3 are alternative splicing/processing products of a single gene 633273