Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) - Rat Genome Database

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Gene: Cited2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) Rattus norvegicus
Analyze
Symbol: Cited2
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
RGD ID: 620112
Description: Predicted to enable several functions, including LBD domain binding activity; histone acetyltransferase binding activity; and transcription coregulator activity. Involved in several processes, including cellular senescence; negative regulation of cardiac muscle cell proliferation; and regulation of gene expression. Predicted to be located in chromatin and cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Used to study osteosarcoma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cbp/p300-interacting transactivator 2; MGC93288; Mrg1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,132,303 - 14,134,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl114,103,457 - 14,134,782 (+)EnsemblGRCr8
mRatBN7.2112,312,426 - 12,314,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx112,084,290 - 12,086,734 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0118,086,206 - 18,088,650 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,292,779 - 12,295,222 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,823,363 - 12,825,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)Ensemblrn6Rnor6.0
Rnor_5.0114,515,629 - 14,518,072 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,721,500 - 12,723,943 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera110,778,037 - 10,780,480 (+)NCBICelera
RGSC_v3.1112,721,561 - 12,724,003 (+)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
drometrizole  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP)
kenpaullone  (EXP)
ketamine  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naled  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (ISO)
adrenal gland development  (ISO)
blood vessel development  (ISO)
bone morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cardiac septum morphogenesis  (ISO)
cell differentiation  (IEA)
cell population proliferation  (ISO,ISS)
cellular response to growth factor stimulus  (IEP)
cellular response to hypoxia  (ISO)
cellular senescence  (IEP)
central nervous system development  (ISO)
cranial nerve morphogenesis  (ISO)
decidualization  (ISO)
determination of heart left/right asymmetry  (ISO)
determination of left/right asymmetry in lateral mesoderm  (ISO)
determination of left/right symmetry  (ISO,ISS)
embryonic camera-type eye morphogenesis  (ISO)
embryonic heart tube left/right pattern formation  (ISO)
embryonic placenta development  (ISO)
embryonic process involved in female pregnancy  (ISO)
endocardial cushion development  (ISO)
erythrocyte development  (ISO)
granulocyte differentiation  (ISO)
heart development  (ISO,ISS)
heart looping  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
in utero embryonic development  (ISO)
kidney development  (ISO)
left/right axis specification  (ISO)
left/right pattern formation  (IBA)
lens morphogenesis in camera-type eye  (ISO)
leukocyte differentiation  (ISO)
liver development  (ISO)
male gonad development  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of gene expression  (IMP,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
neural tube closure  (ISO)
neural tube formation  (ISO)
nodal signaling pathway  (ISO)
outflow tract morphogenesis  (ISO)
peripheral nervous system development  (ISO)
positive regulation of cell cycle  (ISO,ISS)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (IMP,ISO,ISS)
positive regulation of male gonad development  (ISO)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO,ISS)
pulmonary artery morphogenesis  (ISO)
regulation of animal organ formation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to estrogen  (ISO)
response to fluid shear stress  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (IEP)
sex determination  (IBA,ISO)
skeletal muscle cell differentiation  (ISO)
spleen development  (ISO)
thymus development  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
trophectodermal cell differentiation  (ISO)
uterus development  (ISO)
vasculature development  (ISO)
vasculogenesis  (ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Folic acid prevents exencephaly in Cited2 deficient mice. Barbera JP, etal., Hum Mol Genet 2002 Feb 1;11(3):283-93.
2. MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2. Clark AL and Naya FJ, J Biol Chem. 2015 Sep 18;290(38):23162-72. doi: 10.1074/jbc.M115.672659. Epub 2015 Aug 3.
3. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
4. Identification of new Nerve Growth Factor-responsive immediate-early genes. Dijkmans TF, etal., Brain Res. 2009 Jan 16;1249:19-33. Epub 2008 Oct 31.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identification of CITED2 as a negative regulator of fracture healing. Lee JY, etal., Biochem Biophys Res Commun. 2009 Oct 2;387(4):641-5. Epub 2009 Jul 14.
8. Physiological loading of joints prevents cartilage degradation through CITED2. Leong DJ, etal., FASEB J. 2011 Jan;25(1):182-91. Epub 2010 Sep 8.
9. Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. Leung MK, etal., Genomics 1999 Nov 1;61(3):307-13.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Induction of CITED2 expression in the rat hippocampus following transient global ischemia. Sun W, etal., Brain Res. 2006 Feb 9;1072(1):15-8. Epub 2006 Jan 24.
19. Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fate. Zhou Z, etal., Aging Cell. 2010 Oct;9(5):911-5.
Additional References at PubMed
PMID:9434189   PMID:9811838   PMID:9887100   PMID:10593900   PMID:11581164   PMID:11694877   PMID:12149478   PMID:12477932   PMID:12586840   PMID:12960175   PMID:14594809   PMID:15051727  
PMID:15475956   PMID:15615595   PMID:15750185   PMID:16287139   PMID:16579983   PMID:16619037   PMID:17537799   PMID:17615577   PMID:17644732   PMID:17906695   PMID:17932483   PMID:18054336  
PMID:18653562   PMID:19035510   PMID:19457926   PMID:20549734   PMID:22147266   PMID:22735262   PMID:27680315   PMID:36626551   PMID:38291157   PMID:38922923  


Genomics

Comparative Map Data
Cited2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,132,303 - 14,134,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl114,103,457 - 14,134,782 (+)EnsemblGRCr8
mRatBN7.2112,312,426 - 12,314,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx112,084,290 - 12,086,734 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0118,086,206 - 18,088,650 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,292,779 - 12,295,222 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,823,363 - 12,825,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)Ensemblrn6Rnor6.0
Rnor_5.0114,515,629 - 14,518,072 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4112,721,500 - 12,723,943 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera110,778,037 - 10,780,480 (+)NCBICelera
RGSC_v3.1112,721,561 - 12,724,003 (+)NCBI
Cytogenetic Map1p12NCBI
CITED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,371,807 - 139,374,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6139,371,807 - 139,375,909 (-)Ensemblhg38GRCh38
GRCh376139,692,944 - 139,695,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,735,089 - 139,737,478 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346139,735,088 - 139,737,478NCBI
Celera6140,433,459 - 140,435,848 (-)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,254,618 - 137,257,015 (-)NCBIHuRef
CHM1_16139,956,432 - 139,958,827 (-)NCBICHM1_1
T2T-CHM13v2.06140,555,711 - 140,558,549 (-)NCBIT2T-CHM13v2.0
Cited2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,598,452 - 17,601,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,598,966 - 17,601,422 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381017,723,228 - 17,725,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,723,218 - 17,725,674 (+)Ensemblmm10GRCm38
MGSCv371017,443,034 - 17,445,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361017,412,662 - 17,415,072 (+)NCBIMGSCv36mm8
Celera1017,602,360 - 17,604,805 (+)NCBICelera
Cytogenetic Map10A2NCBI
cM Map107.18NCBI
Cited2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,370,950 - 20,372,677 (+)Ensembl
ChiLan1.0NW_00495543620,370,950 - 20,372,677 (+)NCBIChiLan1.0ChiLan1.0
CITED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25159,340,343 - 159,342,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16157,233,726 - 157,236,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06137,134,142 - 137,136,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16141,213,671 - 141,215,919 (-)NCBIPanPan1.1PanPan1.1panPan2
CITED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,522,911 - 31,525,342 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,523,799 - 31,524,995 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha132,396,275 - 32,398,722 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0131,684,411 - 31,686,856 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,685,298 - 31,686,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,559,687 - 31,562,137 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,442,285 - 31,444,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,753,743 - 31,756,214 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cited2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,574,685 - 126,577,867 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,354,338 - 6,356,735 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365606,353,901 - 6,356,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CITED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,155,664 - 25,160,279 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1125,155,652 - 25,158,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,295,042 - 28,297,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CITED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,009,527 - 34,011,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1334,010,228 - 34,011,046 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660406,152,738 - 6,155,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cited2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475314,630,827 - 14,632,536 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475314,630,842 - 14,633,245 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cited2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12219,190,449 - 219,192,930 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cited2
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:486
Count of miRNA genes:244
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000016244
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
RH12860  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,314,585 - 12,314,716 (+)MAPPERmRatBN7.2
Rnor_6.0112,825,523 - 12,825,653NCBIRnor6.0
Rnor_5.0114,517,789 - 14,517,919UniSTSRnor5.0
RGSC_v3.4112,723,660 - 12,723,790UniSTSRGSC3.4
Celera110,780,197 - 10,780,327UniSTS
Cytogenetic Map1p12UniSTS
RH128281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,313,796 - 12,313,983 (+)MAPPERmRatBN7.2
Rnor_6.0112,824,734 - 12,824,920NCBIRnor6.0
Rnor_5.0114,517,000 - 14,517,186UniSTSRnor5.0
RGSC_v3.4112,722,871 - 12,723,057UniSTSRGSC3.4
Celera110,779,408 - 10,779,594UniSTS
RH 3.4 Map1130.04UniSTS
Cytogenetic Map1p12UniSTS
AI835299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,314,555 - 12,314,664 (+)MAPPERmRatBN7.2
Rnor_6.0112,825,493 - 12,825,601NCBIRnor6.0
Rnor_5.0114,517,759 - 14,517,867UniSTSRnor5.0
RGSC_v3.4112,723,630 - 12,723,738UniSTSRGSC3.4
Celera110,780,167 - 10,780,275UniSTS
Cytogenetic Map1p12UniSTS
Meis2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2112,313,403 - 12,313,589 (+)MAPPERmRatBN7.2
Rnor_6.0112,824,341 - 12,824,526NCBIRnor6.0
Rnor_5.0114,516,607 - 14,516,792UniSTSRnor5.0
Celera110,779,015 - 10,779,200UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000086790   ⟹   ENSRNOP00000074276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl114,103,457 - 14,134,782 (+)Ensembl
mRatBN7.2 Ensembl112,312,160 - 12,314,897 (+)Ensembl
Rnor_6.0 Ensembl112,823,363 - 12,825,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124538   ⟹   ENSRNOP00000107079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl114,130,989 - 14,134,746 (+)Ensembl
RefSeq Acc Id: NM_053698   ⟹   NP_446150
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8114,132,303 - 14,134,746 (+)NCBI
mRatBN7.2112,312,426 - 12,314,869 (+)NCBI
Rnor_6.0112,823,363 - 12,825,806 (+)NCBI
Rnor_5.0114,515,629 - 14,518,072 (+)NCBI
RGSC_v3.4112,721,500 - 12,723,943 (+)RGD
Celera110,778,037 - 10,780,480 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87005 (Get FASTA)   NCBI Sequence Viewer  
  AAK30621 (Get FASTA)   NCBI Sequence Viewer  
  EDL93758 (Get FASTA)   NCBI Sequence Viewer  
  EDL93759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074276.1
  ENSRNOP00000107079
  ENSRNOP00000107079.1
RefSeq Acc Id: NP_446150   ⟸   NM_053698
- UniProtKB: Q99MA1 (UniProtKB/TrEMBL),   A0A0G2K7N2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074276   ⟸   ENSRNOT00000086790
Ensembl Acc Id: ENSRNOP00000107079   ⟸   ENSRNOT00000124538

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MA1-F1-model_v2 AlphaFold Q99MA1 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689502
Promoter ID:EPDNEW_R27
Type:single initiation site
Name:Cited2_1
Description:Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminaldomain, 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0112,823,355 - 12,823,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620112 AgrOrtholog
BioCyc Gene G2FUF-62285 BioCyc
Ensembl Genes ENSRNOG00000056940 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086790.3 UniProtKB/TrEMBL
  ENSRNOT00000124538 ENTREZGENE
  ENSRNOT00000124538.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.2200 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191504 IMAGE-MGC_LOAD
InterPro CITED UniProtKB/TrEMBL
KEGG Report rno:114490 UniProtKB/TrEMBL
MGC_CLONE MGC:93288 IMAGE-MGC_LOAD
NCBI Gene 114490 ENTREZGENE
PANTHER CBP/P300-INTERACTING TRANSACTIVATOR 2 UniProtKB/TrEMBL
  CITED UniProtKB/TrEMBL
Pfam CITED UniProtKB/TrEMBL
PhenoGen Cited2 PhenoGen
RatGTEx ENSRNOG00000056940 RatGTEx
UniProt A0A0G2K7N2 ENTREZGENE, UniProtKB/TrEMBL
  A6JP87_RAT UniProtKB/TrEMBL
  Q99MA1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cited2  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cited2  Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 634741