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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cited2
Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cited2decreases methylationISOCITED2 (Homo sapiens)6480464CTDtitanium dioxide results in decreased methylation of CITED2 gene; titanium dioxide results in decreased methylation of CITED2 promoterPMID:34973136
Cited2increases expressionISOCited2 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of CITED2 mRNAPMID:29264374
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