Slc31a1 (solute carrier family 31 member 1) - Rat Genome Database

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Gene: Slc31a1 (solute carrier family 31 member 1) Rattus norvegicus
Analyze
Symbol: Slc31a1
Name: solute carrier family 31 member 1
RGD ID: 620059
Description: Enables copper ion transmembrane transporter activity. Involved in cellular response to cisplatin; copper ion import; and copper ion import across plasma membrane. Located in apical plasma membrane and neuronal cell body. Orthologous to human SLC31A1 (solute carrier family 31 member 1); PARTICIPATES IN cisplatin drug pathway; cisplatin response pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: copper transporter 1; Copper uptake transporter 1; Ctr1; high affinity copper uptake protein 1; liver regeneration-related protein LRRGT00200; LRRGT00200; rCTR1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,830,574 - 80,859,810 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl580,830,389 - 80,859,809 (+)EnsemblGRCr8
mRatBN7.2575,814,744 - 75,844,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,814,743 - 75,844,228 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,214,842 - 78,241,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,031,936 - 80,058,869 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,007,446 - 80,034,378 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,222,504 - 78,249,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,222,504 - 78,249,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0582,341,969 - 82,371,285 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,359,420 - 79,385,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera574,756,941 - 74,783,647 (+)NCBICelera
RGSC_v3.1579,364,532 - 79,391,101 (+)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2,2-tetramine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-iodothyronamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiloride  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carboplatin  (EXP,ISO)
carnosine  (EXP,ISO)
casticin  (ISO)
celecoxib  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cytochalasin D  (ISO)
D-penicillamine  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
Ondansetron  (EXP)
oxaliplatin  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Membrane transporters as mediators of Cisplatin effects and side effects. Ciarimboli G Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.
2. Iron deficiency in the pregnant rat has differential effects on maternal and fetal copper levels. Gambling L, etal., J Nutr Biochem 2004 Jun;15(6):366-72.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. Klomp AE, etal., Biochem J 2003 Mar 15;370(Pt 3):881-9.
6. Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons. Liu JJ, etal., Biochem Pharmacol. 2013 Jan 15;85(2):207-15. doi: 10.1016/j.bcp.2012.10.023. Epub 2012 Nov 1.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Monnot AD, etal., Exp Biol Med (Maywood). 2012 Mar;237(3):327-33. doi: 10.1258/ebm.2011.011170.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. Nose Y, etal., J Biol Chem. 2010 Oct 15;285(42):32385-92. doi: 10.1074/jbc.M110.143826. Epub 2010 Aug 10.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Subcellular targets of cisplatin cytotoxicity: an integrated view. Sancho-Martinez SM, etal., Pharmacol Ther. 2012 Oct;136(1):35-55. doi: 10.1016/j.pharmthera.2012.07.003. Epub 2012 Jul 14.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. Tokuda E, etal., J Neurochem. 2009 Oct;111(1):181-91. doi: 10.1111/j.1471-4159.2009.06310.x. Epub 2009 Jul 27.
Additional References at PubMed
PMID:12177073   PMID:15489334   PMID:16501047   PMID:16637264   PMID:16741141   PMID:19240214   PMID:20004225   PMID:20836889   PMID:22465424   PMID:24167251   PMID:24316150  


Genomics

Comparative Map Data
Slc31a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,830,574 - 80,859,810 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl580,830,389 - 80,859,809 (+)EnsemblGRCr8
mRatBN7.2575,814,744 - 75,844,241 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,814,743 - 75,844,228 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,214,842 - 78,241,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,031,936 - 80,058,869 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,007,446 - 80,034,378 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,222,504 - 78,249,358 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,222,504 - 78,249,358 (+)Ensemblrn6Rnor6.0
Rnor_5.0582,341,969 - 82,371,285 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,359,420 - 79,385,988 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera574,756,941 - 74,783,647 (+)NCBICelera
RGSC_v3.1579,364,532 - 79,391,101 (+)NCBI
Cytogenetic Map5q24NCBI
SLC31A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,221,544 - 113,264,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,221,191 - 113,264,492 (+)Ensemblhg38GRCh38
GRCh379115,983,824 - 116,026,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,023,689 - 115,066,593 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349113,063,421 - 113,106,325NCBI
Celera986,631,426 - 86,674,386 (+)NCBICelera
Cytogenetic Map9q32ENTREZGENE
HuRef985,591,243 - 85,634,236 (+)NCBIHuRef
CHM1_19116,130,594 - 116,173,508 (+)NCBICHM1_1
T2T-CHM13v2.09125,420,370 - 125,463,332 (+)NCBIT2T-CHM13v2.0
Slc31a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,278,821 - 62,310,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,278,964 - 62,310,006 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38462,360,583 - 62,391,769 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,360,727 - 62,391,769 (+)Ensemblmm10GRCm38
MGSCv37462,021,735 - 62,052,803 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36461,847,110 - 61,878,123 (+)NCBIMGSCv36mm8
Celera461,032,896 - 61,063,964 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.11NCBI
Slc31a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,220,495 - 14,264,699 (-)Ensembl
ChiLan1.0NW_00495541914,221,258 - 14,264,288 (-)NCBIChiLan1.0ChiLan1.0
SLC31A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21126,113,476 - 26,156,513 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1926,115,835 - 26,158,851 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,319,304 - 84,362,288 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,691,503 - 112,734,352 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,691,503 - 112,734,352 (+)EnsemblpanPan2panpan1.1
SLC31A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,590,087 - 67,628,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,591,080 - 67,625,798 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1165,994,878 - 66,033,741 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01168,714,951 - 68,753,806 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,715,210 - 68,812,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,232,618 - 67,271,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,254,684 - 67,293,582 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,000,439 - 68,039,329 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc31a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947182,901,798 - 182,934,079 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559331,917 - 364,852 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936559333,461 - 364,737 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC31A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,868,332 - 253,894,449 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11253,868,389 - 253,893,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,727,786 - 284,753,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q28-q2.13NCBI
SLC31A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,307,308 - 26,348,701 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,311,334 - 26,348,694 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603516,453,718 - 16,495,422 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc31a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,832,908 - 21,849,576 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476021,832,924 - 21,879,089 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc31a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1191,140,609 - 91,169,756 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc31a1
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000019544
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
RH129201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2575,841,763 - 75,841,976 (+)MAPPERmRatBN7.2
Rnor_6.0578,249,080 - 78,249,292NCBIRnor6.0
Rnor_5.0582,368,812 - 82,369,024UniSTSRnor5.0
RGSC_v3.4579,385,710 - 79,385,922UniSTSRGSC3.4
Celera574,783,369 - 74,783,581UniSTS
RH 3.4 Map5559.0UniSTS
Cytogenetic Map5q24UniSTS
RH133724  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8580,837,998 - 80,838,705 (+)Marker Load Pipeline
mRatBN7.2575,822,418 - 75,823,125 (+)MAPPERmRatBN7.2
Rnor_6.0578,229,663 - 78,230,369NCBIRnor6.0
Rnor_5.0582,349,514 - 82,350,220UniSTSRnor5.0
RGSC_v3.4579,366,579 - 79,367,285UniSTSRGSC3.4
Celera574,764,120 - 74,764,826UniSTS
RH 3.4 Map5558.4UniSTS
Cytogenetic Map5q24UniSTS
RH128029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2575,841,747 - 75,841,937 (+)MAPPERmRatBN7.2
Rnor_6.0578,249,064 - 78,249,253NCBIRnor6.0
Rnor_5.0582,368,796 - 82,368,985UniSTSRnor5.0
RGSC_v3.4579,385,694 - 79,385,883UniSTSRGSC3.4
Celera574,783,353 - 74,783,542UniSTS
RH 3.4 Map5559.9UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019544   ⟹   ENSRNOP00000019544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl575,814,743 - 75,840,470 (+)Ensembl
Rnor_6.0 Ensembl578,222,504 - 78,249,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114775   ⟹   ENSRNOP00000096861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl580,830,389 - 80,859,809 (+)Ensembl
mRatBN7.2 Ensembl575,815,254 - 75,844,228 (+)Ensembl
RefSeq Acc Id: NM_133600   ⟹   NP_598284
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,830,840 - 80,857,620 (+)NCBI
mRatBN7.2575,815,258 - 75,842,042 (+)NCBI
Rnor_6.0578,222,504 - 78,249,358 (+)NCBI
Rnor_5.0582,341,969 - 82,371,285 (+)NCBI
RGSC_v3.4579,359,420 - 79,385,988 (+)RGD
Celera574,756,941 - 74,783,647 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109222   ⟹   XP_038965150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,830,574 - 80,859,810 (+)NCBI
mRatBN7.2575,814,744 - 75,844,241 (+)NCBI
RefSeq Acc Id: XM_063287116   ⟹   XP_063143186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,853,542 - 80,859,810 (+)NCBI
RefSeq Acc Id: NP_598284   ⟸   NM_133600
- UniProtKB: Q53YN6 (UniProtKB/Swiss-Prot),   Q9JK41 (UniProtKB/Swiss-Prot),   A6J7U0 (UniProtKB/TrEMBL),   A0A8I6AQ78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019544   ⟸   ENSRNOT00000019544
RefSeq Acc Id: XP_038965150   ⟸   XM_039109222
- Peptide Label: isoform X1
- UniProtKB: Q9JK41 (UniProtKB/Swiss-Prot),   Q53YN6 (UniProtKB/Swiss-Prot),   A6J7U0 (UniProtKB/TrEMBL),   A0A8I6AQ78 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096861   ⟸   ENSRNOT00000114775
RefSeq Acc Id: XP_063143186   ⟸   XM_063287116
- Peptide Label: isoform X1
- UniProtKB: Q9JK41 (UniProtKB/Swiss-Prot),   Q53YN6 (UniProtKB/Swiss-Prot),   A6J7U0 (UniProtKB/TrEMBL),   A0A8I6AQ78 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JK41-F1-model_v2 AlphaFold Q9JK41 1-187 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693787
Promoter ID:EPDNEW_R4311
Type:initiation region
Name:Slc31a1_1
Description:solute carrier family 31 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,222,526 - 78,222,586EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620059 AgrOrtholog
BioCyc Gene G2FUF-41100 BioCyc
Ensembl Genes ENSRNOG00000014475 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000114775 ENTREZGENE
IMAGE_CLONE IMAGE:7126088 IMAGE-MGC_LOAD
InterPro Cop_transporter UniProtKB/Swiss-Prot
KEGG Report rno:171135 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93210 IMAGE-MGC_LOAD
NCBI Gene 171135 ENTREZGENE
PANTHER HIGH AFFINITY COPPER UPTAKE PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR12483 UniProtKB/Swiss-Prot
Pfam Ctr UniProtKB/Swiss-Prot
PhenoGen Slc31a1 PhenoGen
RatGTEx ENSRNOG00000014475 RatGTEx
UniProt A0A8I6AQ78 ENTREZGENE, UniProtKB/TrEMBL
  A6J7U0 ENTREZGENE, UniProtKB/TrEMBL
  COPT1_RAT UniProtKB/Swiss-Prot
  Q53YN6 ENTREZGENE
  Q9JK41 ENTREZGENE
UniProt Secondary Q53YN6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc31a1  solute carrier family 31 member 1  Slc31a1  solute carrier family 31 (copper transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc31a1  solute carrier family 31 (copper transporter), member 1  Slc31a1  solute carrier family 31 (copper transporters), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc31a1  solute carrier family 31 (copper transporters), member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc31a1  solute carrier family 31 (copper transporters), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL