Cyp2j4 (cytochrome P450, family 2, subfamily j, polypeptide 4) - Rat Genome Database

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Gene: Cyp2j4 (cytochrome P450, family 2, subfamily j, polypeptide 4) Rattus norvegicus
Analyze
Symbol: Cyp2j4 (Ensembl: Cyp2j3)
Name: cytochrome P450, family 2, subfamily j, polypeptide 4 (Ensembl:cytochrome P450, family 2, subfamily j, polypeptide 3)
RGD ID: 620007
Description: Enables NADPH-hemoprotein reductase activity and arachidonic acid monooxygenase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and positive regulation of cellular biosynthetic process. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYP2J2; CYPIIJ4; cytochrome P450 2J4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Cyp2j4em1Sage  
Genetic Models: WKY-Cyp2j4em1Sage/Tja
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85116,295,691 - 116,323,219 (-)NCBIGRCr8
mRatBN7.25111,179,981 - 111,207,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5113,748,215 - 113,775,559 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05115,473,589 - 115,500,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05115,536,117 - 115,563,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05119,546,458 - 119,564,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05123,437,429 - 123,455,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05119,130,644 - 119,130,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45116,702,370 - 116,729,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15116,707,598 - 116,734,948 (-)NCBI
Celera5109,770,343 - 109,797,690 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
arachidonic acid  (ISO)
arsenous acid  (ISO)
astemizole  (ISO)
atrazine  (ISO)
Azelnidipine  (ISO)
barnidipine  (ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Cannabichromene  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
Cannabinol  (ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cilnidipine  (ISO)
cimetidine  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
danazol  (ISO)
Delapril hydrochloride  (ISO)
delta8-THC  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl malate  (ISO)
difenoconazole  (ISO)
doxorubicin  (ISO)
Ebastine  (ISO)
efonidipine hydrochloride  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
fluconazole  (ISO)
flutamide  (EXP)
gemfibrozil  (ISO)
glabridin  (ISO)
glafenine  (EXP)
glutathione  (ISO)
graphite  (EXP)
ketoconazole  (ISO)
L-ethionine  (EXP)
manidipine  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
methapyrilene  (EXP)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
metyrapone  (ISO)
Muraglitazar  (EXP)
N-desmethylclozapine  (ISO)
N-methyl-N-nitrosourea  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
Nilvadipine  (ISO)
nisoldipine  (ISO)
nitrendipine  (ISO)
ochratoxin A  (EXP)
omeprazole  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pomalidomide  (ISO)
pravastatin  (EXP)
prochloraz  (ISO)
propanal  (ISO)
propiconazole  (EXP)
purine-6-thiol  (EXP)
quercetin  (ISO)
quinapril hydrochloride  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
Salvianolic acid A  (ISO)
Salvianolic acid C  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
telmisartan  (ISO)
Terfenadine  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tranylcypromine  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Macrophage epoxygenase determines a profibrotic transcriptome signature. Behmoaras J, etal., J Immunol. 2015 May 15;194(10):4705-16. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.
2. Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice. Chen G, etal., Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):63-71. doi: 10.1016/j.prostaglandins.2011.06.009. Epub 2011 Jun 30.
3. Differential expression of cytochrome P450 isoforms in the lungs of septic animals. Cui X, etal., Crit Care Med. 2004 May;32(5):1186-91.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. Herse F, etal., Circulation. 2012 Dec 18;126(25):2990-9. doi: 10.1161/CIRCULATIONAHA.112.127340. Epub 2012 Nov 15.
7. Epoxyeicosatrienoic Acid inhibition alters renal hemodynamics during pregnancy. Huang H, etal., Exp Biol Med (Maywood). 2006 Dec;231(11):1744-52.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. Lee CR, etal., FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.
10. CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. Lee CR, etal., Pharmacogenet Genomics. 2007 May;17(5):349-58.
11. Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. Liu PY, etal., Atherosclerosis. 2006 Nov 24;.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Olona A, etal., Mol Metab. 2018 May;11:18-32. doi: 10.1016/j.molmet.2018.03.003. Epub 2018 Mar 9.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Evidence for Association of Polymorphisms in CYP2J2 and Susceptibility to Essential Hypertension. Wu SN, etal., Ann Hum Genet. 2007 Jul;71(Pt 4):519-25. Epub 2007 Feb 5.
20. Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide. Xiao B, etal., J Pharmacol Exp Ther. 2010 Sep 1;334(3):784-94. doi: 10.1124/jpet.110.167510. Epub 2010 May 25.
21. Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia. Yaghi A, etal., Am J Physiol Lung Cell Mol Physiol 2003 Nov;285(5):L1099-105. Epub 2003 Jul 25.
22. Excess nitric oxide decreases cytochrome P-450 2J4 content and P-450-dependent arachidonic acid metabolism in lungs of rats with acute pneumonia. Yaghi A, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1260-7. Epub 2004 Feb 6.
23. Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Yu Z, etal., Mol Pharmacol. 2000 May;57(5):1011-20.
24. CDNA cloning, heterologous expression, and characterization of rat intestinal CYP2J4. Zhang QY, etal., Arch Biochem Biophys 1997 Apr 15;340(2):270-8.
25. Characterization of the cytochrome P450 CYP2J4: expression in rat small intestine and role in retinoic acid biotransformation from retinal. Zhang QY, etal., Arch Biochem Biophys. 1998 May 15;353(2):257-64.
26. Induction of rat small intestinal cytochrome P-450 2J4. Zhang QY, etal., Drug Metab Dispos. 1999 Oct;27(10):1123-7.
27. Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis. Zhao G, etal., Hum Gene Ther. 2012 Jul;23(7):688-99. doi: 10.1089/hum.2011.135. Epub 2012 Mar 29.
28. Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats. Zheng C, etal., Am J Respir Cell Mol Biol. 2010 Dec;43(6):740-9. doi: 10.1165/rcmb.2009-0161OC. Epub 2010 Jan 29.
Additional References at PubMed
PMID:8631948   PMID:11901223   PMID:12477932   PMID:18570454   PMID:19737933   PMID:19801493   PMID:24903033   PMID:25450017   PMID:30219518   PMID:36269280   PMID:37385478  


Genomics

Comparative Map Data
Cyp2j4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85116,295,691 - 116,323,219 (-)NCBIGRCr8
mRatBN7.25111,179,981 - 111,207,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5113,748,215 - 113,775,559 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05115,473,589 - 115,500,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05115,536,117 - 115,563,461 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05119,546,458 - 119,564,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05123,437,429 - 123,455,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05119,130,644 - 119,130,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45116,702,370 - 116,729,722 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15116,707,598 - 116,734,948 (-)NCBI
Celera5109,770,343 - 109,797,690 (-)NCBICelera
Cytogenetic Map5q33NCBI
CYP2J2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38159,893,308 - 59,969,212 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl159,893,308 - 59,926,773 (-)EnsemblGRCh38hg38GRCh38
GRCh37160,358,980 - 60,392,445 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36160,131,568 - 60,165,011 (-)NCBINCBI36Build 36hg18NCBI36
Build 34160,071,001 - 60,104,444NCBI
Celera158,647,783 - 58,681,160 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef158,469,963 - 58,503,340 (-)NCBIHuRef
CHM1_1160,474,448 - 60,507,891 (-)NCBICHM1_1
T2T-CHM13v2.0159,771,763 - 59,847,665 (-)NCBIT2T-CHM13v2.0
Cyp2j9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39496,456,661 - 96,480,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl496,456,666 - 96,479,815 (-)EnsemblGRCm39 Ensembl
GRCm38496,568,424 - 96,592,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl496,568,429 - 96,591,578 (-)EnsemblGRCm38mm10GRCm38
MGSCv37496,235,120 - 96,258,176 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36496,060,447 - 96,083,503 (-)NCBIMGSCv36mm8
Celera494,937,695 - 94,960,750 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map444.66NCBI
CYP2J2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21166,925,746 - 166,962,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,076,935 - 166,110,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0159,151,079 - 59,184,625 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1160,856,269 - 60,899,562 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl160,856,269 - 60,889,810 (-)Ensemblpanpan1.1panPan2
CYP2J2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1549,942,241 - 49,986,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl549,942,193 - 49,984,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha550,009,133 - 50,053,501 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0550,122,223 - 50,166,600 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl550,122,301 - 50,223,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1550,073,683 - 50,118,028 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0550,019,070 - 50,063,225 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0550,301,607 - 50,345,982 (+)NCBIUU_Cfam_GSD_1.0
LOC110261221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6152,321,848 - 152,648,979 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16152,321,816 - 152,358,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP2J2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12073,083,312 - 73,115,174 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2073,083,389 - 73,115,077 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603344,276,757 - 44,308,738 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp2j4
292 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000012977
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat

Markers in Region
D5Got242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25111,179,889 - 111,180,021 (+)MAPPERmRatBN7.2
Rnor_6.05119,546,367 - 119,546,498NCBIRnor6.0
Rnor_5.05123,437,338 - 123,437,469UniSTSRnor5.0
RGSC_v3.45116,702,279 - 116,702,410UniSTSRGSC3.4
Celera5109,770,252 - 109,770,383UniSTS
Cytogenetic Map5q33UniSTS


Genetic Models
This gene Cyp2j4 is modified in the following models/strains:
WKY-Cyp2j4em1Sage/Tja    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 31 31 1 9 4 3
Low 43 25 10 19 10 8 10 66 26 33 8 8
Below cutoff 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012503   ⟹   ENSRNOP00000012503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,178,703 - 111,244,794 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000012977   ⟹   ENSRNOP00000012977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,179,984 - 111,207,332 (-)Ensembl
Rnor_6.0 Ensembl5119,546,461 - 119,564,846 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000058163   ⟹   ENSRNOP00000054968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,220,049 - 111,244,789 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079786   ⟹   ENSRNOP00000074827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5111,179,984 - 111,198,902 (-)Ensembl
RefSeq Acc Id: NM_023025   ⟹   NP_075414
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,295,691 - 116,323,042 (-)NCBI
mRatBN7.25111,179,981 - 111,207,332 (-)NCBI
Rnor_6.05119,546,458 - 119,564,843 (-)NCBI
Rnor_5.05119,130,644 - 119,130,903 (-)NCBI
Rnor_5.05123,437,429 - 123,455,814 (-)NCBI
RGSC_v3.45116,702,370 - 116,729,722 (-)RGD
Celera5109,770,343 - 109,797,690 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110733   ⟹   XP_038966661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85116,296,399 - 116,323,219 (-)NCBI
mRatBN7.25111,180,689 - 111,207,490 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_075414   ⟸   NM_023025
- UniProtKB: Q9QXF7 (UniProtKB/Swiss-Prot),   Q5BKA2 (UniProtKB/TrEMBL),   F7FF10 (UniProtKB/TrEMBL),   A0A9K3Y868 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012977   ⟸   ENSRNOT00000012977
RefSeq Acc Id: XP_038966661   ⟸   XM_039110733
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000054968   ⟸   ENSRNOT00000058163
RefSeq Acc Id: ENSRNOP00000012503   ⟸   ENSRNOT00000012503
RefSeq Acc Id: ENSRNOP00000074827   ⟸   ENSRNOT00000079786

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FF10-F1-model_v2 AlphaFold F7FF10 1-432 view protein structure
AF-Q9QXF7-F1-model_v2 AlphaFold Q9QXF7 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620007 AgrOrtholog
BioCyc Gene G2FUF-40624 BioCyc
Ensembl Genes ENSRNOG00000031004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012503.9 UniProtKB/TrEMBL
  ENSRNOT00000012977 ENTREZGENE
  ENSRNOT00000012977.6 UniProtKB/TrEMBL
  ENSRNOT00000079786.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323516 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2J-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65210 UniProtKB/TrEMBL
MGC_CLONE MGC:108684 IMAGE-MGC_LOAD
NCBI Gene 65210 ENTREZGENE
PANTHER CYTOCHROME P450 2J2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 CYP2J9-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2J2 RGD
PhenoGen Cyp2j4 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2J UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031004 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A0G2K921_RAT UniProtKB/TrEMBL
  A0A9K3Y868 ENTREZGENE, UniProtKB/TrEMBL
  CP2J4_RAT UniProtKB/Swiss-Prot
  F1LVB0_RAT UniProtKB/TrEMBL
  F7FF10 ENTREZGENE
  Q5BKA2 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXF7 ENTREZGENE
UniProt Secondary F7FF10 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2j4  cytochrome P450, family 2, subfamily j, polypeptide 4  Cyp2j4  cytochrome P450, family 2, subfamily J, polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-02 Cdk5rap3  cytochrome P450, family 2, subfamily J, polypeptide 4  Cyp2j4  CYP2J4  Name updated 1299863 APPROVED
2002-08-07 Cyp2j4  CYP2J4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved with rat model of acute Pseudomonas pneumonia 1299258
gene_expression expressed in liver, intestine, olfactory mucosa, kidney, heart, and lung 632631
gene_homology 72.5 and 75.8% amino acid identity to rabbit and human, respectively 632631
gene_protein 501 amino acids 632631