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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620007
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2j4
Name: cytochrome P450, family 2, subfamily j, polypeptide 4
Acc ID: CHEBI:31528
Term: Ebastine
Definition: null
Chemical ID: MESH:C058249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2j4decreases activityISOCYP2J2 (Homo sapiens)6480464CTDebastine results in decreased activity of CYP2J2 proteinPMID:12851038
Cyp2j4increases hydroxylationISOCYP2J2 (Homo sapiens)6480464CTDCYP2J2 protein results in increased hydroxylation of ebastinePMID:12386130 PMID:15861034 PMID:17162467
Cyp2j4multiple interactionsISOCYP2J2 (Homo sapiens)6480464CTDebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]PMID:12386130
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